31results about How to "Does not affect biocompatibility" patented technology

The invention discloses a silk fibroin gel microneedle system and a manufacturing method of the silk fibroin gel system microneedle system. Silk fibroin solution with the mass concentration between 3 percent to 15 percent is processed through ultrasonic oscillation and then is poured on a polydimethylsiloxane film needle hole die array obtained through laser boring, dies are placed in a vacuum drying box and vacuumized, the solution is made to enter holes, the vacuum degree is kept, the dies are dried to constant weight, and then the silk fibroin gel microneedle system is obtained. The microneedle system is an insoluble gel microneedle and has certain brute force to puncture into the skin, the microneedle system swells after making contact with body fluid in the skin, and medicine in the microneedle system is released. The gel microneedle system is good in biocompatibility, easy to prepare, moderate in condition and capable of biodegradation, and the system can be used in the aspects of cosmetology, transdermal drug absorption devices and the like.

The invention provides a fibroin / bacterial cellulose composite hydrogel, and a preparation method and application thereof. According to the invention, bacterial cellulose hydrogel surface-modified by glycidyl trimethyl ammonium chloride, bone morphogenetic protein-2 and fibroin are used as raw materials; electrical gel technology is employed for formation of a network pore structure by the fibroin on the surface and in the internal network pore structure of the surface-modified bacterial cellulose hydrogel so as to compose a dual-network pore structure; and the morphogenetic protein-2 is adhered into the dual-network pore structure so as to form the fibroin / bacterial cellulose composite hydrogel. The preparation method is simple, highly efficient, green and environment-friendly; and the prepared composite hydrogel has high mechanical strength, high porosity, good connectivity of the interiors of pores and good biocompatibility, and is applicable as a cartilage repairing scaffold to the field of cartilage-repairing tissue engineering.

The invention belongs to the technical field of biological materials and provides a biological glass fiber-modified polyester composite dressing and a preparation method thereof. The composite dressing obtained by the method at least comprises a modified polyester binder and borate bio-glass fibers. The modified polyester binder is a tetraethoxysilane-modified polyester binder. The composite dressing obtained by the preparation method has good biocompatibility, biological activity and biodegradability, reduces the patient pain caused by dressing exchange, stimulates the blood vessel regeneration around the wound, promotes the rapid healing of the wound and can also be used as a carrier for various types of functional ions and lipid-soluble drug carriers. The preparation method is simple and realizes a low cost.

A titanium alloy packaging barrel manufacturing process is provided. The surface of the titanium barrel body of the present invention is polished sequentially by rough polishing with a nylon wheel, fine polishing with a wool wheel, and superfine polishing with a yellow cloth wheel, so that scratches, trachoma, and mottling do not exist on the surface , rough grain defects, achieve a complete mirror effect, improve the uniformity of polishing quality, simple process steps, convenient implementation, high polishing efficiency; for the surface treatment of the titanium barrel, firstly clean it with cleaning solution, rinse with ultra-pure water by RO penetration, After drying, the electrolytic polishing liquid is electrolyzed, and RO is infiltrated with ultra-pure water to rinse, so as to ensure that the impurities and oil stains on the inner surface of the titanium alloy barrel are completely removed, so that the surface can achieve the purpose of ultra-clean; A dense oxide layer improves the corrosion resistance of the titanium barrel and prolongs the service life of the titanium barrel.

The invention relates to a multi-purpose gelatin fiber preparing method based on closed type waterborne polyurethane in-situ cross linking .The preparing method comprises the steps that firstly, a gelatin aqueous solution and closed type waterborne polyurethane emulsion are mixed evenly, and a spinning solution is obtained; secondly, the spinning solution is spun into gelatin / closed type waterborne polyurethane composite fibers with a dry or wet spinning technology; finally, in the subsequent drying process, closed type waterborne polyurethane is subjected to closed-form solution, isocyanate groups obtained through closed-form solution further react with active groups in gelatin, and thus the effects of in-situ cross linking and great improvement of the mechanical property of the composition fibers are achieved .Due to the fact that waterborne polyurethane and gelatin are in good compatibility, the adding quantity of the gelatin component in the composite fibers is large, and the excellent performance of gelatin is fully embodied; besides, waterborne polyurethane is nontoxic, and the biological compatibility of the composite fibers cannot be influenced after cross-linking modification is performed on gelatin; a covalence reaction exists between waterborne polyurethane and gelatin, the mechanical property of the composition fibers can be greatly improved in a lasting mode, and the composite fibers have application prospects in biomedical, tissue engineering and textile and garment fields and the like .