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Hydroxyapatite/aluminum oxide composite bioceramic and preparation method thereof

A technology of composite bioceramics and hydroxyapatite, applied in the field of biomaterials, can solve the problems of stainless steel fatigue, low strength, poor plastic stability, etc., achieve high biocompatibility, improve mechanical properties, and continue to be excellent.

Inactive Publication Date: 2015-07-01
SUZHOU VIVOTIDE BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Biological hard tissue substitute materials were first used body bones and animal bones, and later developed to use stainless steel and plastics. Due to the problems of dissolution, corrosion and fatigue of stainless steel, plastics have problems of poor stability and low strength.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A hydroxyapatite / alumina composite bioceramic, comprising the following components in parts by mass:

[0023] 40 parts of hydroxyapatite, 10 parts of shell powder, 15 parts of nano-alumina, 5 parts of zirconia, 3 parts of magnesium oxide, 5 parts of calcium hydrogen phosphate and 2 parts of nano-zinc oxide.

[0024] Prepare hydroxyapatite / alumina composite bioceramics according to the preparation method provided by the present invention, the steps are as follows:

[0025] (1) Weighing: Accurately weigh each component;

[0026] (2) Ball milling: Mix the components together and put them into a ball mill for grinding and mixing;

[0027] (3) Cold press forming: the mixed powder is pressed with a 60T press;

[0028] (4) Put the formed powder into the mold and perform high-temperature calcination at a temperature of 1300°C and a pressure of 550MPa for 4 hours;

[0029] (5) After calcination, take it out after cooling, and then obtain massive hydroxyapatite / alumina composi...

Embodiment 2

[0032] A hydroxyapatite / alumina composite bioceramic, comprising the following components in parts by mass:

[0033] 60 parts of hydroxyapatite, 20 parts of shell powder, 25 parts of nano-alumina, 12 parts of zirconia, 8 parts of magnesium oxide, 10 parts of calcium hydrogen phosphate and 5 parts of nano-zinc oxide.

[0034] Prepare hydroxyapatite / alumina composite bioceramics according to the preparation method provided by the present invention, the steps are as follows:

[0035] (1) Weighing: Accurately weigh each component;

[0036] (2) Ball milling: Mix the components together and put them into a ball mill for grinding and mixing;

[0037] (3) Cold press forming: the mixed powder is pressed with a 60T press;

[0038] (4) Put the formed powder into the mold and perform high-temperature calcination at a temperature of 1300°C and a pressure of 550MPa for 7 hours;

[0039] (5) After calcination, take it out after cooling, and then obtain massive hydroxyapatite / alumina compo...

Embodiment 3

[0042] A hydroxyapatite / alumina composite bioceramic, comprising the following components in parts by mass:

[0043] 45 parts of hydroxyapatite, 12 parts of shell powder, 18 parts of nano-alumina, 6 parts of zirconia, 4 parts of magnesium oxide, 6 parts of calcium hydrogen phosphate and 3 parts of nano-zinc oxide.

[0044] Prepare hydroxyapatite / alumina composite bioceramics according to the preparation method provided by the present invention, the steps are as follows:

[0045] (1) Weighing: Accurately weigh each component;

[0046] (2) Ball milling: Mix the components together and put them into a ball mill for grinding and mixing;

[0047] (3) Cold press forming: the mixed powder is pressed with a 60T press;

[0048] (4) Put the formed powder into the mold and perform high-temperature calcination at a temperature of 1220°C and a pressure of 450MPa for 6 hours;

[0049] (5) After calcination, take it out after cooling, and then obtain massive hydroxyapatite / alumina composi...

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Abstract

The invention discloses a hydroxyapatite / aluminum oxide composite bioceramic and a preparation method thereof, relating to the field of biomaterials. The hydroxyapatite / aluminum oxide composite bioceramic is prepared from the following components in parts by mass: 40-60 parts of hydroxyapatite, 10-20 parts of shell powder, 15-25 parts of nano aluminum oxide, 5-12 parts of zirconium oxide, 3-8 parts of magnesium oxide, 5-10 parts of calcium hydrogen phosphate and 2-5 parts of nano zinc oxide. The preparation method comprises the following steps: (1) weighing; (2) ball milling; (3) cold-press molding; (4) high-temperature calcination; and (5) cooling. The hydroxyapatite / aluminum oxide composite bioceramic has higher biocompatibility, maintains the excellent actions of the hydroxyapatite, further enhances the mechanical properties of the bioceramic, and thus, is a very ideal skeleton substitute repair material.

Description

technical field [0001] The invention belongs to the field of biological materials, in particular to a hydroxyapatite / alumina composite bioceramic and a preparation method of the bioceramic. Background technique [0002] With the development of material science and technology, biomaterials have become one of the important research directions in the field of biomedicine because of their special properties of repairing, replacing and regenerating body tissues. Biological hard tissue substitute materials were first used body bones and animal bones, and later developed to use stainless steel and plastics. Due to the problems of dissolution, corrosion and fatigue of stainless steel, plastics have problems of poor stability and low strength. Therefore, the bottleneck in the development of biomaterials is caused. The emergence of bioceramics has improved the shortage of existing alternative materials. Because of its many advantages, bioceramics has broad development prospects. [0...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C04B35/447C04B35/622
Inventor 邱东成刘大学李永超
Owner SUZHOU VIVOTIDE BIOTECH
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