Super-lubricating anti-microorganism medical coating and use method thereof

Abstract

The invention discloses a super-lubricating anti-microorganism medical coating. The super-lubricating anti-microorganism medical coating is prepared by mixing the following raw materials in parts by mass: 0.5-10 parts of an N-allyl benzimidazole-modified vinyl pyrrolidone polymer, 0.1-5 parts of isocyanate, 0.1-5 parts of a cross-linking agent, 0.05-1 part of epoxy resin and 79-99.25 parts of a solvent. The super-lubricating anti-microorganism medical coating has an excellent anti-microorganism effect, good biocompatibility and low cytotoxicity. A polyurethane-epoxy resin elastic double-network structure formed after the coating is cured can achieve firm adhesion and attachment of the coating on a medical device. The super-lubricating anti-microorganism medical coating is suitable for being popularized and used on implantation / intervention medical devices.

Description

technical field [0001] The invention belongs to the field of new medical materials, and in particular relates to a super-lubricating antibacterial medical coating and an application method thereof. Background technique [0002] Nosocomial infections may occur when patients receive treatment in healthcare facilities, and nosocomial infections are induced by bacteria transferred to patients during treatment. More than 25% of nosocomial infections are caused by bacterial infections mediated by medical devices during diagnosis and treatment, such as various medical devices inserted into the body and medical devices that produce wounds. Although my country has strict classification management for medical devices, and strictly controls the safety, effectiveness, and disinfection and sterilization of medical devices, patients will still have nosocomial infections when they use sterilized medical devices. This is because the sterilization of medical devices can only prevent patient...

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Problems solved by technology

But the antimicrobial substances used in these coatings have their own drawbacks

(1) Industrial fungicides represented by chlorhexidine: their antibacterial effect can be maintained for a short time. After the medical device is left in the human body for 1-2 days, the release of antibacterial substances will drop sharply, leaving behind after being washed off. The surface of the medical device under the surface is rough and has no antibacterial effect. This rough surface can even promote bacterial adhesion, and the chlorhexidine released in the blood stream has some side effects; (2) Silver ion sterilization represented by nano-silver Agent: Due to technical reasons, the nano-silver antibacterial coating only contains a small amount of silver, and the amount of released silver ions is very small. The concentration of released silver ions is less than the concentration of silver ions required for local antibacterial treatment, and the time for which the antibacterial effect can be maintained is also short. It is very short, and due to the accumulation of silver in the human body, it is still inconclusive whether the use of nano-silver as an antibacterial agent in the body is still inconclusive; (3) Using antibiotics as bactericides: the use of antibiotics has the risk of promoting antibiotic resistance, and antibiotics The rough surface left after release will still promote bacterial adhesion; (4) New antibacterial agents represented by modified chitosan: chitosan is a natural polysaccharide biopolymer compound with good biodegradability and biocompatibility, but the current products are still insufficient in application performance, and the antibacterial effect cannot well meet the requirements of practical applications

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