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A kind of antibacterial and biocompatible bone implant material and its preparation method and application

A bone implant material and biocompatibility technology, applied in the field of antibacterial and biocompatible bone implant materials and their preparation, can solve the problems of inability to kill bacteria, affect the surface potential of the material, and affect the antibacterial performance of the material , to achieve the effect of not causing local inflammation, no hemolytic activity, and good biocompatibility

Active Publication Date: 2021-09-07
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method introduces a large amount of hydrogen and oxygen elements, which affects the surface potential of the material and cannot achieve the effect of killing bacteria. In addition, because this method increases the surface energy of the material, it is more conducive to the adhesion of bacteria, thus further affecting the material. antibacterial properties

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039]The preparation of antibacterial and biocompatible PEEK bone implant material comprises the following steps:

[0040] 1) Place the PEEK bone implant material in the injection cavity of the plasma injection equipment, inject 1.0×10 PEEK bone implant material 10 A dose of argon plasma was used for pretreatment, the injection voltage was 5KV, and the pressure in the cavity was kept at 1.0×10 -1 Pa, close the ion implanter after the injection, and keep the pressure in the injection chamber at 1.0×10 -1 Pa, keep the pressure for 1min;

[0041] 2) Choose graphite as the carbon plasma source, seal and vacuumize, the vacuum degree is 1.0×10 -1 Pa, then turn on the power of the ion implanter, adjust the accelerating voltage of the ion implanter to 5KV, and control the injection time to make the carbon plasma flow at 1.0×10 10 ions / cm 2 The dosage of the PEEK bone implant material is injected into the surface of the PEEK bone implant material to form a stable transition layer ...

Embodiment 2

[0045] The preparation of antibacterial and biocompatible zirconia ceramic bone implant material comprises the following steps:

[0046] 1) Place the zirconia ceramic bone implant material in the injection chamber of the plasma implantation equipment, select amorphous carbon as the carbon plasma source, seal and vacuumize, and the vacuum degree is 1.0×10 -4 Pa, then turn on the power of the ion implanter, adjust the accelerating voltage of the ion implanter to 8KV, and control the implantation time to make the carbon plasma 20 ions / cm 2 The dosage is injected into the surface of the zirconia ceramic implant and forms a stable transition layer with a carbon chemical structure. The mass percentage of carbon in the stable transition layer is higher than 50%. During the injection process, the pressure in the cavity is kept at 1.0×10 -4 Pa, turn off the power of the injection machine after the injection, and keep the pressure in the injection chamber at 1.0×10 -4 Pa, keep the pre...

Embodiment 3

[0050] The preparation of antibacterial and biocompatible titanium alloy bone implant material comprises the following steps:

[0051] 1) Put the titanium alloy bone implant material in the injection chamber of the plasma implantation equipment, choose graphite as the carbon plasma source, seal and vacuumize, the vacuum degree is 1.0×10 -6 Pa, then turn on the power of the ion implanter, adjust the accelerating voltage of the ion implanter to 12KV, and control the implantation time to make the carbon plasma 15 ions / cm 2 The dosage is injected into the surface of the titanium alloy implant and forms a stable transition layer with a carbon chemical structure. The mass percentage of carbon in the stable transition layer is higher than 50%, and the intracavity pressure is maintained at 1.0×10 during the injection process. -6 Pa, turn off the power of the injection machine after the injection, and keep the pressure in the injection chamber at 1.0×10 -6 Pa, hold pressure for 60 mi...

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Abstract

The present invention disclosed a method and application method and application of antibacterial and biocompatible bone bone implantation materials.The invention provides a antibacterial and biocompatible bone implant material, including bone implant material and a composite antibacterial layer formed on the surface of the bone implant material;The surface layer of the body is injected into the bone implant material to get the transition layer, and then the nitrogen -containing plasma or phosphorus -containing plasma is injected into the transition layer;The body does not contain hydrogen and oxygen; the relative surface potential of antibacterial and biochemical bone implant materials is 0.01 ~ 0.5V.The present invention uses plasma injection technology to build a high potential surface, giving bone implantation materials on the surface of antibacterial and biological safety.

Description

technical field [0001] The invention relates to the technical field of biomedical materials. More specifically, it relates to an antibacterial and biocompatible bone implant material and its preparation method and application. Background technique [0002] Implant materials mainly include joint replacement, bone plate, bone implant materials, and dental implant materials. Since the implant materials themselves do not have antibacterial and anti-infection capabilities, they are prone to bacterial colonization during clinical use and induce tissue inflammation. The method of inflammation around the bone implant material has the disadvantages of short action time and easy drug resistance. Therefore, antibacterial modification to enhance its antibacterial and anti-infection capabilities is the main method to prevent peri-implant inflammation and improve the success rate of clinical application. [0003] However, the current methods of endowing bone implant materials with antib...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/30A61L27/06A61L27/10A61L27/18A61L27/54
CPCA61L27/06A61L27/10A61L27/18A61L27/30A61L27/54A61L2300/10A61L2300/404A61L2300/608A61L2430/02C08L61/16
Inventor 张维刘可刘军
Owner TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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