Antisticking particle and powder containing sodium hyaluronate and their preparation process

Abstract

The present invention relates to medicine. Of the antisticking particle and powder, the main component is sodium hyaluronate, which is also named as sodium hyaluronate and may be also compounded into compounded preparation with other separating agent and pharmacological active matters, such as anticoagulant, antiphlogistic, calcium passage retarder, cytostatic agent and proteolytic enzyme. The antisticking particle and powder of the present invention consists of sodium hyaluronate 1-100 wt%, separating agent 0-99 wt% and active component in the amound based on relevant pharmacopeia. The antisticking particle and powder of the present invention is used for antisticking after operation in abdominal cavity, gynaecological and obstetrical operation, orthopedical operation and thoracic operation and has excellent antisticking effect.

Description

technical field [0001] The invention belongs to the technical field of medicines, and relates to granules and powder sprays for preventing and treating tissue adhesion after surgery. Background technique [0002] Adhesions often occur after abdominal, gynecological, orthopedic, cardiothoracic and orthopedic surgery, and can lead to serious clinical complications, such as intestinal obstruction, abdominal and pelvic pain, infertility, etc., increasing the difficulty of reoperation, and may Further complications occur, and currently there are two main ways to prevent adhesions: improving surgical skills and using adjuvants. Improving surgical skills includes reducing direct surgery, reducing trauma during surgery, and avoiding foreign bodies introduced into the body. Adhesions can be reduced to a certain extent by improving surgical skills, but due to its limitations, it cannot effectively prevent adhesions. Adjuvants are divided into drugs and isolation agents. Previously a...

AI Technical Summary

Problems solved by technology

Adhesions can be reduced to a certain extent by improving surgical skills, but due to its limitations, it cannot effectively prevent adhesions

Adjuvants are divided into drugs and isolation agents. Previously applied drugs such as hyaluronidase, streptokinase, urokinase, ibuprofen, dexamethasone, etc., and isolation agents such as dextran, polyvinylpyrrolidone (PVP), carboxymethyl Sodium cellulose (CMC), etc. have achieved certain effects, but there is still no effective method to prevent postoperative tissue adhesions.