Preparation method of oriented communicated porous biomedical stent, as well as stent prepared by method and application of stent in preparation of medical products

Abstract

The invention discloses a preparation method of a polycaprolactone oriented communicated porous biomedical stent. The method comprises the following steps of (1) melting and blending polycaprolactoneand polyethylene oxide to obtain a co-continuous blending material, and performing compression moulding on the co-continuous blending material to obtain a polycaprolactone / polyethylene oxide co-continuous substrate; (2) performing water extraction on the polycaprolactone / polyethylene oxide co-continuous substrate obtained in step (1) so as to remove a water-soluble polyethylene oxide phase to obtain a polycaprolactone porous stent; and (3) performing solid phase stretching on the polycaprolactone porous stent obtained in step (2) so as to enable the form of holes to generate orientation deformation in a stretching direction to obtain the polycaprolactone oriented communicated porous biomedical stent. The polycaprolactone oriented communicated porous biomedical stent prepared by the methodhas an obvious highly-communicated anisotropic porous structure. The invention further discloses the polycaprolactone oriented communicated porous biomedical stent and the application of the stent inthe preparation of medical products.

Description

technical field [0001] The invention belongs to the field of tissue engineering biomedical scaffolds, in particular, the invention relates to a preparation method of an orientation-connected porous biomedical scaffold, the prepared scaffold and the use of the scaffold in the preparation of medical products. Background technique [0002] With the aging of the population and the diversification of exercise methods, tissue damage has become one of the most common diseases that endanger human health and normal life. Nowadays, tissue engineering is mainly used for treatment. Tissue engineering research is one of the important components of modern biomedical engineering technology. The use of suitable biological scaffolds is of great significance for the regeneration and repair, reorganization and regeneration of organs and tissues (Czernuszka J T, et al.European cells&materials2003,5(5 ), 29; O'Brien F J, et al. Materials Today 2011, 14(3), 88). At present, it is generally belie...

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Problems solved by technology

However, the microtubular pores of the porous scaffold prepared by this method are only connected by micropores, the connectivity is poor and the pore structure is incomplete, resulting in poor mechanical properties (<1MPa), and the introduction of organic solvents during the preparation process will also affect the scaffold itself. Biocompatibility (Yang DZ, etal. Materials Letters 2018, 233, 78)

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