226 results about "Trachoma" patented technology

The present invention relates to nanosilver-containing antibacterial and antifungal granules ("NAGs"). The NAGs have longlasting inhibitory effect on a broad-spectrum of bacteria and fungi, which include, but are not limited to, Escherichia coli, Methicillin resistant Staphylococcus aureus, Chlamydia trachomatis, Providencia stuartii, Vibrio vulnificus, Pneumobacillus, Nitrate-negative bacillus, Staphylococcus aureus, Candida albicans, Bacillus cloacae, Bacillus allantoides, Morgan's bacillus (Salmonella morgani), Pseudomonas maltophila, Pseudomonas aeruginosa, Neisseria gonorrhoeae, Bacillus subtilis, Bacillus foecalis alkaligenes, Streptococcus hemolyticus B, Citrobacter, and Salmonella paratyphi C. The NAGs contain ground stalk marrow of the plant Juncus effuses L. which has been dispersed with nanosilver particles. The nanosilver particles are about 1-100 mn in diameter. Each of the nanosilver particles contain a metallic silver core which is surrounded by silver oxide. The present invention also provides a process for making the NAGs. The NAGs can be used in a variety of healthcare and industrial products. Examples of the healthcare products include, but are not limited to, ointments or lotions to treat skin trauma, soaking solutions or cleansing solutions for dental or women hygiene, medications for treating gastrointestinal bacteria infections, sexual related diseases, and eye diseases. Examples of industrial products include, but are not limited to, food preservatives, water disinfectants, paper disinfectants, construction filling materials (to prevent mold formation).

The invention relates to immunogenic compositions comprising combinations of Chlamydia trachomatis antigens and their use in vaccines. The composition may comprise at least two components, one component of which comprises Chlamydia trachomatis antigens for eliciting a Chlamydia trachomatis specific TH1 immune response and another component of which comprises antigens for eliciting a Chlamydia trachomatis specific TH2 immune response. The invention further relates to an immunogenic composition comprising a Chlamydia trachomatis Type III secretion system (TTSS) regulatory protein and a Chlamydia trachomatis Type III secretion system (TTSS) secreted protein or a fragment thereof. The invention further relates to the use of combinations of adjuvants for use with antigens associated with a sexually transmissible disease, such as Chlamydia trachomatis antigens. Preferred adjuvant combinations include mineral salts, such as aluminium salts and oligonucleotides comprising a CpG motif. The invention further provides a combination of Chlamydia trachomatis antigens comprising a Chlamydia trachomatis antigen that is conserved over at least two serovars.

A dripping pill of Chloromycetin eye drops for treating trachnoma, keratitis, conjunctivitis, eyelid inflammation, etc is proportionally prepared from polyethanediol as matrix and Chloromycetin. It is applied in conjunction with the buffer liquid prepared from borax, boric acid, hydroxyphenyl ethylether and the water for injection. Its preparing process is also disclosed.

The invention relates to a cranberry extract eye ophthalmic preparation and a preparation method and uses thereof, and belongs to the technical field of eye ophthalmic preparations. The technical problem to be solved is to provide a cranberry extract eye ophthalmic preparation. The cranberry extract eye ophthalmic preparation comprises an active ingredient of cranberry extract. The cranberry extract eye ophthalmic preparation can effectively treat, prevent or alleviate cataract, glaucoma, vitreous opacity, macular degeneration, retinopathy, optic atrophy, keratitis, epiphora induced by wind, presbyopia, myopia, visual fatigue, blurred vision, conjunctival burn, conjunctivitis, corneal ulcer, palpebral ecgema, floaters or trachoma and other eye diseases. A novel preparation is provided for treating cataract, glaucoma, vitreous opacity, macular degeneration, retinopathy, optic atrophy, keratitis, epiphora induced by wind, presbyopia, myopia, visual fatigue, blurred vision, conjunctival burn, conjunctivitis, corneal ulcer, palpebral ecgema, floaters or trachoma and other eye diseases, and meets the strong demand of people for loving and protecting eyes.

The present invention provides novel methods for determining the presence or absence of Chlamydia in a patient, as well as diagnostic kits useful in practicing the methods of the invention. The methods of the invention are based on nucleic acid amplification reactions to detect both Chlamydia genomic and cryptic plasmid sequences. In one embodiment, the methods involve using nucleic acid primers to specifically amplify the Chlamydia trachomatis ompA gene and cryptic plasmid. These methods provide both enhanced reliability and sensitivity of detection, thereby providing an accurate determination of the presence or absence of Chlamydia trachomatis in a patient.

The invention relates to a fluorescence PCR (polymerase chain reaction) detection method for diagnosing infection of Chlamydia trachomatis (CT), neisseria gonorrhoeae (NG) and ureaplasma urealyticum (UU), which belongs to the field of nucleic acid in vitro diagnosis. The method comprises a polymerase chain reaction (PCR) system based on fluorescence PCR technology, contains a forward primer and areverse primer aiming at the CT / the NG / the UU and a fluorescent probe, and can detects DNA of three pathogens such as the CT, the NG, the UU and the like simultaneously in a reaction tub under suitable PCR condition. The method can diagnosing the infection of the CT / the NG / the UU in a clinical sample simply, conveniently and rapidly, has high sensitivity and specificity, and has important clinical value to early control and prevention of relevant genitourinary tract infections, blocking of an infection sources, and infection reduction of related pathogen.

An ocular Jiatishaxing gel for treating eyelid inflammation, stye, conjunctivitis, dacryocystitis, keratitis, corneal ulcer and trachoma is prepared from Jiatishaxing, HPMC as matrix, antiseptic, isotonic regulator, osmotic promoter, pH regulator and water through dissolving Jiatishaxing in water, adding others, stirring, regulating pH=5-9, filter and adding water.

The invention provides a composition containing an effective dose of antofloxacin or a pharmaceutically acceptable salt thereof or / and an effective dose of an anti-inflammatory steroid or non-steroidanti-inflammatory medicine or / and an effective dose of a water-retaining or wetting agent or an anti-xerophthalmia medicine, and an application of the composition in the preparation of an externally used antofloxacin medicine for local eyes or ears or noses or skins, used for preventing or treating conjunctivitis, angular blepharitis, keratitis, scleritis, trachoma, xerophthalmia, cataract, otitisexterna, otitis media, folliculitis and impetigo in humans or mammals. The medicine obtained in the invention has good curative effects or good therapeutic compliance.

Methods and compositions for the treatment or prevention of ocular Chlamydia trachomatis infection. Compositions comprise one or more Chlamydia trachomatis proteins, immunogenic fragments thereof or polynucleotides encoding such proteins or fragments.

The invention provides an application of etimicin and pharmacologically acceptable salt or inclusion compounds thereof in preparation of a local eye medicine or medicine composition for preventing ortreating eye diseases, xerophthalmia or dry eye syndromes, caused by conjunctivitis, angular blepharitis, keratitis, scleritis, trachoma and sensitive bacterium infection, of people or mammals. Eye preparations comprise eye drops, eye gel and the like. The medicine has better safety and effectiveness in a certain range.

The present invention relates to a staining kit and its preparation method, staining method and its application in several detection items for detecting canceration cell, red blood cell, campylobacteriosis, vaginal cleaning degree, estrogen level, garlandosus, trichomoniasis, mycosis, diplococcus gonorrhoeae and chlamydi trachomatis on a cervical smear. Said invented kit is formed from fixatino fluid, staining solution and differentiatino solution. Its staining method includes the steps of fixation, staining, differentiation and water-washing. Its film-making speed is quick, only has need oftwo main, and its detection accuracy rate is high, can be up to 98%.

Disclosed are peptides or a mixture of peptides, or analogs thereof, derived from the variable domains of the Chlamydia trachomatis (C. trachomatis) immunodominant major outer membrane protein (MOMP). The peptides or mixtures of peptides are characterized by having specificity only to C. trachomatis anti-MOMP antibodies and being non-cross reactive with anti-MOMP antibodies of other Chlamydia species Specific peptides are described (SEQ ID Nos. 1 to 8) as well as their analogs, which have essentially the same biological activity.

The present invention is related to antigens from Chlamydia trachomatis which are recognized by specific antibodies from individuals infected with Chlamydia or which can induce T cells from the same individuals to secrete gamma-interferon. The T cell reactive antigens are present in a whole-cell lysate and have apparent molecular weights of 5-12, 16-20, 25-35 and 58-74 kDa as determined by SDS-PAGE. The antigens of the invention are useful in vaccines but also as diagnostic compositions.

The present invention provides antigenic proteins of Chlamydia trachomatis. The proteins of the present invention are useful for eliciting an immune response to Chlamydia in a patient. For example, an effective amount of protein of the present invention or fraction thereof may be administered to a patient for eliciting a Chlamydia specific immune response. In another example, a method of raising an antibody specific for Chlamydia trchomatis elementary bodies (EB) is provided in which a protein of the present invention is administered to a patient.

The present invention relates to primers and probes that can be used in various assays to detect a new strain of Chlamydia trachomatis. The invention further provides for the simultaneous detection of other diseases, especially Neisseria gonorrhoeae.

The present invention discloses a guiding object and a probe for testing the human urogenital tract pathogens, and a method for testing the human urogenital tract pathogens using the guiding object and the probe. The present invention can test three different pathogens including Neisseria gonorrhoeae, mycoplasma ureaplasma and chlamydia trachomatis in a same reaction tube simultaneously. The present invention not only can increase the early detection rate of the sexually transmitted diseases, but also can reduce the operating time of the medical personnel, lower the cost, and lighten the economic burden of the patient.

The present invention provides nucleic acids, proteins and vectors for a method of nucleic acid, including DNA, immunization of a host, including humans, against disease caused by infection by a strain of Chlamydia, specifically C. trachomatis. The method employs a vector containing a nucleotide sequence encoding a polypeptide of a strain of Chlamydia operably linked to a promoter to effect expression of the gene product in the host. The polypeptides are derived from the Chalmydia gene 60kCRMP gene including truncated forms of the gene. The invention further provides recombinant 60kCRMP protein useful for protecting against disease caused by infection with Chlamydia.

The present invention provides a composition containing an effective dose of etimicin or a pharmaceutically acceptable salt thereof and an anti-inflammatory effective dose of dexamethasone or a pharmaceutically acceptable derivative thereof, and applications of the composition in preparation of topical ophthalmic or aural or nasal or skin external application drugs for prevention or treatment of human or mammalian conjunctivitis, angular blepharitis, keratitis, scleritis, trachoma, xerophthalmia, otitis externa, otitis media, folliculitis, furuncle, impetigo and the like. According to the present invention, the drug has good safety and good efficacy compared to etimicin.

The invention discloses a triple nucleic acid detection kit for neisseria gonorrhoeae / ureaplasma urealyticum / chlamydia trachomatis. The kit comprises an RT-PCR (Reverse Transcription-Polymerase Chain Reaction) reaction liquid, an enzyme mixed liquid, a triple reaction liquid for neisseria gonorrhoeae / ureaplasma urealyticum / chlamydia trachomatis, positive control and negative control. The kit disclosed by the invention overcomes the deficiencies that in the prior art, neisseria gonorrhoeae / ureaplasma urealyticum / chlamydia trachomatis is poor in specificity, lower in sensitivity and the like, effectively prevents pollution, has the advantages of high sensitivity, good specificity, strong repeatability, quick and objective detection result and the like, and has good application prospect for detecting neisseria gonorrhoeae / ureaplasma urealyticum / chlamydia trachomatis.

The invention relates to the detection of three different bacterial species which are responsible for sexually-transmitted diseases, i.e., Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) and Mycoplasma genitalium (MG). The invention more particularly relates to the detection of these three species in real-time PCR, in multiplex PCR and in real-time multiplex PCR. The invention provides reference templates sequences, which are especially adapted to the design of primers and probes, which can be used together in the same tube to detect CT and / or MG and / or NG by real-time multiplex amplification.

The present invention relates to an eye preparation for curing trachoma. It is prepared by using 10 Chinese medicinal materials of calcined smithsonite, borneol, musk, prepared frankincense, prepared myrrh and others.

The invention discloses a kit for detecting sexually transmitted diseases. The kit comprises 1 to 3 pairs of primers which can specifically amplify genes of pathogens such as gonococcus, chlamydia trachomatis and / or ureaplasma urealyticum respectively; and the nucleotide sequences of the primers are shown as SEQ ID NO:1-6. The kit has high specificity and high sensitivity, can be used for detecting a single pathogen and detecting various pathogens at the same time, is convenient to use, provides exact results and has an extremely good clinical application prospect.

The invention relates to the technical field of detection of pathogenic microorganisms, in particular to primers, a probe, a kit and a detection method for multiple detection of chlamydia trachomatis,neisseria gonorrhoeae and ureaplasma. The kit comprises a CT / NG / UU conserved region-specific primer pair and the Taqman fluorescent probe. The kit can accurately detect CT / NG / UU infected samples by real-time fluorescent quantitative PCR, and is convenient and quick to use, high in sensitivity, good in specificity and high in repeatability.

The invention provides azithromycin ultrafine powder in-situ gel eye drops and a preparation method thereof. The method comprises the following steps of: firstly, micronizing a medicament by using a proper method to remarkably improve the dissolution rate and solubility of the medicament; and secondly, preparing an ophthalmic preparation which is in a liquid state in vitro and is in a gel state when dripped into eyes by adopting sodium alginate as an ion-sensitive gel matrix or adopting poloxamer 407 and poloxamer 188 as thermosensitive gel matrixes. The eye drops are steady in storage at 4 DEG C and uniform in content, and are not required for secondary preparation so as to reduce contamination. In the method, azithromycin ultrafine powder and in-situ gel are combined for the treatment of bacterial keratitis and trachoma; and by the dual effects of the ultrafine powder and the gel, the sustained release effect is achieved when the retention time of the preparation in the eyes is prolonged, so that the local bioavailability of the medicament and the compliance of patients are improved, and the medicament absorption of the cornea is increased to reduce the toxic or side effect caused by the systemic absorption of ophthalmic medicaments.

The invention relates to compositions comprising combinations of Chlamydia trachomatis antigens and their use in vaccines. Specific combinations may be selected from a first antigen group of PepA, LcrE, ArtJ, DnaK, and CT398, and a second antigen group of PepA, LcrE, ArtJ, DnaK, CT398, OmpH-like, L7 / L12, OmcA, AtoS, CT547, Eno, HtrA and MurG. The invention further relates to the use of combinations of adjuvants for use with antigens associated with a sexually transmissible disease, such as Chlamydia trachomatis antigens. Preferred adjuvant combinations include mineral salts, such as aluminium salts and oligonucleotides comprising a CpG motif.

The invention relates to a method and a device for detecting battery separator paper trachoma, wherein the method comprises shielding an external light source, leading only one surface of separator paper to be illuminated by the light source on one position of a transmission line, and then detecting whether the surface of the separator paper which is not illuminated has light to transmit or not, and then judging whether the separator paper has trachoma or not. The device for achieving the method comprises a detection box whose periphery is closed, and a light source and a photoreceptor which are respectively arranged on both sides of a plane wherein the separator paper is crossed over in the detection box, wherein the two lateral surfaces which are opposite of the detection box body are both provided with at least one permeating hole for the separator paper to cross over whose width is equal to the width of the separator paper, and the width of the permeating hole is equal to the width of the separator paper. The method can automatically, rapidly, effectively, efficiently and continuously detect battery separator paper trachoma, which overcomes the shortcomings of artificial naked eye detection which has big randomness, bad accuracy, low efficiency and the like, and can be widely used in the field of scroll trachoma detection.

Disclosed are isolated Chlamydia trachomatis proteins, methods of fusion protein and associated antibody production, and methods of using isolated proteins and antibodies in diagnosis and detection. Also disclosed are compositions comprising isolated proteins, wherein the compositions can further comprising pharmaceutically acceptable carriers, an adjuvant and / or an immunostimulant, and methods using the pharmaceutical compositions for treating or preventing an infection by Chlamydia in a subject. The compositions may also comprise a protein or immunogenic fragment of a pathogenic organism other than Chlamydia trachomatis.

Compositions and methods for detecting Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) are provided. The present invention also provides methods and compositions for screening for infection / inflammation based on genomic copy number. Described herein is a method that entails assaying a sample obtained from the urogenital tract of the mammal for an indicator of genomic copy number, wherein a genomic copy number level that is higher than a control genomic copy number level is indicative of the presence of infection or inflammation of the urogenital tract. Also described in a kit of the invention that includes a primer and / or probe for detecting or sequencing an indicator of genomic copy number, wherein the indicator of genomic copy number comprises a nucleic acid sequence that is expected to be present in the genome of the mammal in one or two copies; and a primer and / or probe for detecting or sequencing a nucleic acid sequence that is indicative of a pathogen that infects the urogenital tract or a miRNA correlated with inflammation.