Externally used antofloxacin medicine for local eyes or ears or noses or skins, and composition thereof
A technology for external use of drugs and compositions, applied in drug combinations, skin diseases, drug delivery, etc., can solve problems such as unsatisfactory effect of antofloxacin, worthless oral tablets or capsules, and intramuscular injection only
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[0163] In the preparation process or method of each embodiment of the present invention, in the case where the prescription of the embodiment has defined the name of each component, for the sake of simplicity, the names of each component in the prescription can be simplified or omitted.
[0164] Concentration units used in the description of the present invention have molar concentration (M) or (mol / L) or equivalent concentration (N), or percentage concentration etc., time unit can use second (s), minute (min), hour (h) Etc., volume unit can use liter (l or L), milliliter (ml), microliter (μl), mass unit can use gram (g), milligram (mg) and so on.
[0165] The appropriate amount in "appropriate amount of water for injection", "appropriate amount of sodium chloride", "appropriate amount of ethanol", etc. all refer to the appropriate small amount or the minimum amount or the optimal amount that can process the raw materials or preparations to the desired state or Optimal dosage....
Embodiment 1
[0169] Example 1 Preparation of Antofloxacin Hydrochloride Eye Drops
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[0172] Preparation process: Take the prescribed amount of sodium hyaluronate, add it to 700ml of water for injection, heat to dissolve and let it cool, and take another antofloxacin hydrochloride and dissolve it in 200ml of water for injection, and then add the prescribed amount of boric acid, borax, taurine, poly Quaternary ammonium salt-1, stir to dissolve, then add sodium hyaluronate solution to the solution, stir and mix, adjust the pH value to 6.6 with citric acid solution and sodium hydroxide solution, adjust the pH of the solution with an appropriate amount of sodium chloride The osmotic pressure is about 306mOsmol / k, add water to the full amount, pressurize and filter through a 0.45μm microporous membrane, after the measurement is qualified, fill in 5ml / bottle, seal, sterilize at 121°C, let cool, inspect, and pack.
[0173] Take 10 bottles of the above-mentioned samples and p...
Embodiment 2
[0174] Example 2 Preparation of Antofloxacin Hydrochloride Eye Drops
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[0176] Preparation process: Take the prescribed amount of sodium hyaluronate, add it to 700ml of water for injection, heat to dissolve and let it cool, and take another antofloxacin hydrochloride and dissolve it in 200ml of water for injection, and then add the prescribed amount of sodium dihydrogen phosphate and disodium hydrogen phosphate , polyquaternium-1, stirring to dissolve, then mixing it with sodium hyaluronate solution, stirring and mixing, adjusting the pH value to 6.7 with lactic acid solution and sodium citrate solution, adjusting the pH of the solution with an appropriate amount of sodium chloride The osmotic pressure is about 306mOsmol / k, add water to the full amount, pressurize and filter through a 0.65μm microporous membrane, after the measurement is qualified, fill in 8ml / bottle, seal, sterilize at 121°C, let cool, inspect, and pack.
[0177] Take 10 bottles of the above sample...
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