45 results about "Cefadroxil" patented technology

The invention relates to a cefadroxil compound and a preparation method thereof. The preparation method comprises the following steps: 1) adding ethanol or ethyl ether into cefadroxil serving as a raw material, keeping the temperature below 30 DEG C, fiercely stirring, filtering, washing filter cake with ethanol or ethyl ether at a temperature of below 15 DEG C, drying under vacuum or in the air;2) placing the filter cake in ammonia water, mildly stirring, keeping pH value below 9, obtaining ammonia water solution of cefadroxil, and filtering out precipitate; 3) slowly adding hydrochloric acid at concentration of 1 to 3 mol / L into the ammonia water solution of cefadroxil, keeping the temperature between 30 and 60 DEG C, keeping the final pH between 4.0 and 6.0, keeping the pH value for 30 minutes to 5 hours till crystals precipitate slowly, lowering the temperature to a minimum value of 10 DEG C, standing, crystallizing, filtering under vacuum, drying and thus obtaining refined cefadroxil; and 4) returning crystallization mother solution in which crystals precipitate to the step 3). When the method disclosed by the invention is used, the purity of the cefadroxil is increased, thecontent of related matters is lowered obviously, the quality of preparation product is improved, and the toxic and side effects are reduced.

A cefadroxil dry suspension and a preparation method thereof belong to the technical field of medicine and are used for solving the problems of improving the water solubility and bioavailability of cefadroxil. It consists of the main drug cefadroxil and auxiliary materials. The content of each main and auxiliary material in the total prescription by weight unit is as follows: cefadroxil 80-120, inclusion agent 16-60, water-soluble filler 440-520, disintegrant Solution 55-70, suspending agent 5-10, binder 30-45. The product of the invention has the characteristics of high drug solubility and bioavailability, good chemical stability, good taste, convenient taking, strong patient compliance and the like. The invention is made into a dry suspension dosage form, which can be widely distributed in the gastrointestinal tract, has more absorption points, more sufficient absorption, and reduces the local stimulation of the drug on the gastrointestinal tract.

The invention discloses a penicillin G acylation enzyme mutant, and application thereof in synthesis of cephalosporin antibiotics. An amino acid sequence of the penicillin G acylation enzyme mutant is shown in SEQ ID NO.1; a nucleotide sequence of an encoding gene is shown in SEQ ID NO.2. The invention also provides application of the penicillin G acylation enzyme mutant in synthesis of cefaclor. The invention provides a novel penicillin acylation enzyme mutant. Compared with the wild penicillin acylation enzyme mutant, the penicillin G acylation enzyme mutant has higher activity in synthesis of cephalosporin antibiotics, such as cefprozil, cefaclor or cefadroxil; especially when the penicillin G acylation enzyme mutant is used for catalyzing 7-ACCA and phenylglycine methyl ester to synthesize the cefaclor, the vitality is improved to 29.8U / mg from 1.2U / mg in the past, the synthesis and hydrolysis activity is almost consistent with that of the wild penicillin acylation enzyme mutant, the synthesis and hydrolysis ratio can be up to 1.7, and the yield of the cefaclor can be up to 71.5%.

The invention provides a cefadroxil tablet, which is prepared by compressing cefadroxil granules, microcrystalline cellulose and a lubricant after mixing; the cefadroxil granules include the following components: 250 parts by weight of cefadroxil; 10-20 parts by weight of crystalline cellulose; 2-4 parts by weight of starch; 4-6 parts by weight of sodium carboxymethyl starch. Compared with the prior art, the cefadroxil tablet provided by the invention uses sodium starch glycolate as a disintegrating agent, which has a unique swelling effect, and microcrystalline cellulose is added respectively in the granulation and tabletting process, so that the main drug The dispersion of cefadroxil is more uniform, so that not only the tablet core of the product has a better disintegration effect, but also the granules can disintegrate rapidly, and the product has a high dissolution rate and a short disintegration time limit. Experimental results show that the dissolution rate of the cefadroxil tablet provided by the invention is 87%-103%, and the disintegration time limit is 4min-6min.

The invention discloses a method for extracting and recycling penicillin sulfoxide. The method comprises the following steps that a, a penicillin sulfoxide solution is subjected to impurity separation through resin absorption; b, a penicillin sulfoxide desorption solution is obtained through resin desorption; c, a penicillin sulfoxide crystallization solution is obtained through the mechanical application of dissolution penicillin sulfoxide to the penicillin sulfoxide desorption solution or concentration of the penicillin sulfoxide desorption solution; d, the pH of the crystallization solution is adjusted with acid for crystallization, and the penicillin sulfoxide is obtained through filtration, washing and drying. The method can be used for extracting and recycling the penicillin sulfoxide from the low concentration penicillin sulfoxide solution, and therefore the yield of the penicillin sulfoxide is increased, the production cost is reduced, and environmental pollution is reduced. The quality of subsequent products like 7ADCA, cefradine, cefalexin and cefadroxil prepared from the penicillin sulfoxide produced through the technology is improved. Pharmaceutical compositions formed by cefradine, cefalexin, cefadroxil and a medically acceptable carrier can be utilized for treating respiratory tract infection like acute tonsillitis, angina, tympanitis, nasosinusitis, bronchitis and pneumonia, urinary tract infection, skin soft-tissue infection and the like caused by sensitive bacteria.

An oral disintegrating tablet of dracefal contains dracefal and the medicinal excipient (water-soluble filler, disintegrant, lubricant, wetting agent, or adhesive). Its preparing process is also disclosed. Its advantages are high disintegrating speed, quickly taking its effect, less residue and low by-effect.

The invention relates to cefadroxil chewable tablets and a preparation method thereof. The cefadroxil chewable tablets provided by the invention comprise the following raw material components in parts by weight: 110-550 parts of cefadroxil, 240-1,050 parts of mannitol, 110-500 parts of sucrose, 15-90 parts of maltodextrin, 0.5-5 parts of aspartame, 10-70 parts of sweet orange powder essence, 0.5-5 parts of menthol, a proper amount of water and 3-25 parts of magnesium stearate. The cefadroxil chewable tablets provided by the invention have high absorption speed, no lingering bitterness and excellent mouthfeel.