Cefadroxil dry suspension and preparing method

Abstract

A cefadroxil dry suspension and a preparation method thereof belong to the technical field of medicine and are used for solving the problems of improving the water solubility and bioavailability of cefadroxil. It consists of the main drug cefadroxil and auxiliary materials. The content of each main and auxiliary material in the total prescription by weight unit is as follows: cefadroxil 80-120, inclusion agent 16-60, water-soluble filler 440-520, disintegrant Solution 55-70, suspending agent 5-10, binder 30-45. The product of the invention has the characteristics of high drug solubility and bioavailability, good chemical stability, good taste, convenient taking, strong patient compliance and the like. The invention is made into a dry suspension dosage form, which can be widely distributed in the gastrointestinal tract, has more absorption points, more sufficient absorption, and reduces the local stimulation of the drug on the gastrointestinal tract.

Description

technical field [0001] The invention relates to an antibiotic oral preparation and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Cefadroxil is a first-generation oral cephalosporin that is a broad-spectrum antibiotic. It has high antibacterial activity against Staphylococcus aureus, various streptococci and anaerobic cocci, and has a strong effect on some enterobacteriaceae. Its bactericidal mechanism of action is achieved by inhibiting the formation of bacterial cell walls. This product has low toxicity, good absorption, long-lasting antibacterial effect and long action time. It is mainly used to treat respiratory tract infection, genitourinary tract infection, skin and soft tissue infection, digestive tract infection, etc., with remarkable curative effect and few and mild adverse reactions, mostly gastrointestinal reactions. Cefadroxil is widely used at home and abroad, and has been approved for marketing in ma...

AI Technical Summary

Problems solved by technology

However, because cefadroxil has an unpleasant special smell, it is difficult for patients to take it due to the smell when it is made into granules, especially for children and the elderly.

At the same time, cefadroxil granules are easy to absorb moisture, have poor stability and are insoluble in water, so they are made into granules, which have the disadvantages of loss of content and low bioavailability during brewing

However, the tablet and capsule dosage forms need to disintegrate after taking, and the drug effect is slow

In summary, the existing dosage forms of cefadroxil cannot meet the clinical needs, and there is an urgent need to develop more advanced dosage forms