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Ambroxol cefadroxil dispersible tablets

A technology for the content of cefadroxil and fadroxil, which is applied in the directions of organic active ingredients, medical preparations containing active ingredients, and pill delivery, and can solve problems such as large doses.

Inactive Publication Date: 2008-06-25
BEIJING D VENTUREPHARM TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The applicant is committed to developing a dispersible tablet of ambroxol and cefadroxil, which can not only play a synergistic role, antibacterial and reduce phlegm, and is convenient to take, but overcomes the shortcomings of combined medication and large dosage

Method used

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  • Ambroxol cefadroxil dispersible tablets
  • Ambroxol cefadroxil dispersible tablets
  • Ambroxol cefadroxil dispersible tablets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021]

[0022] Preparation Process:

[0023] 1. Mix cefadroxil, ambroxol hydrochloride, microcrystalline cellulose, starch, and croscarmellose sodium evenly, add an appropriate amount of water to make a soft material, granulate with a 18-mesh sieve, and granulate with a 24-mesh sieve to obtain dry granules ;

[0024] 2. Weigh croscarmellose sodium (external), orange powder essence, menthol, magnesium stearate, add to dry granules, and mix well;

[0025] 3. Tablet.

Embodiment 2

[0027]

[0028]

[0029] Preparation Process:

[0030] 1. Mix cefadroxil, ambroxol hydrochloride, microcrystalline cellulose, lactose, and hyprolose (inside) evenly;

[0031] 2. Prepare 2% povidone aqueous solution as adhesive and set aside;

[0032] 3. Add an appropriate amount of binder to the mixture, make a soft material, pass through a 18-mesh sieve to make wet granules, dry, and granulate with a 24-mesh sieve;

[0033] 4. Weigh hydroxypropyl cellulose (external), menthol, orange powder essence, aspartame, magnesium stearate, add in dry granules, and mix well;

[0034] 5. Tablet.

Embodiment 3

[0036]

[0037] Preparation Process:

[0038] 6. Mix cefadroxil, ambroxol hydrochloride, microcrystalline cellulose, lactose, and hyprolose (inside) evenly;

[0039] 7. Prepare 2% povidone aqueous solution as adhesive and set aside;

[0040] 8. Add an appropriate amount of binder to the mixture, make a soft material, pass through a 18-mesh sieve to make wet granules, dry, and granulate with a 24-mesh sieve;

[0041] 9. Weigh hydroxypropyl cellulose (external), acesulfame potassium, menthol, talcum powder, add to dry granules, and mix well;

[0042] 10. Tablet.

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PUM

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Abstract

The invention discloses a compound dispersible tablet, which contains active components of cefadroxil and ambroxol hydrochloride, and the pharmacologically-acceptable excipient. The compound dispersible tablet is used for curing the upper respiratory tract infection.

Description

technical field [0001] The invention relates to a compound pharmaceutical composition, in particular to a dispersible tablet containing cefadroxil and ambroxol hydrochloride. Background technique [0002] At present, there are many patients with respiratory tract infection every year due to factors such as air pollution in my country. It is a common disease and frequently-occurring disease. Cefadroxil has the advantages of broad antibacterial spectrum, strong antibacterial activity, and strong tissue penetration, so it is often used clinically for upper respiratory tract infections. disease treatment. However, in the case of breathing, infection, chronic bronchitis and other respiratory diseases, the respiratory tract often produces a large amount of secretions, which will hinder the absorption of drugs, thereby affecting the therapeutic effect. Ambroxol hydrochloride is a new generation of mucus dissolving agent, it can not only increase the secretion of serous glands in th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/545A61K31/7048A61P11/00A61P31/04
Inventor 岳本花
Owner BEIJING D VENTUREPHARM TECH DEV
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