Gatiflxacin eye gels based on HPMC medium and its preparing method
A technology of gatifloxacin and gel, which is applied in the field of medicine, can solve the problems that patients are not willing to use, low bioavailability, strong greasy feeling, etc., and achieve the goal of maintaining effective drug concentration, long residence time, and not easy to lose Effect
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Embodiment 1
[0026] Get 39kg of deionized water, add gatifloxacin 0.15kg, stir to dissolve. Take 1 kg of hydroxypropyl methylcellulose and sprinkle it into the above solution. After standing overnight, add 0.005 kg of benzalkonium bromide, 0.4 kg of sodium chloride, and 2 kg of hydroxypropyl-β-cyclodextrin, and stir to dissolve. Use 10% NaOH solution to adjust the pH to 7.4, pass the solution through a 0.22um microporous membrane, and add water from the filter to a total of 50kg. Sampling is carried out for quality identification, and after passing the test, it is subpackaged in eye drop bottles under a sterile environment, and then packaged to obtain the product.
Embodiment 2
[0028] Get 39kg of deionized water, add gatifloxacin 0.15kg, stir to dissolve. Take 4kg of hydroxypropyl methylcellulose and sprinkle it into the above solution. After standing overnight, add 0.005 kg of benzalkonium bromide, 0.4 kg of sodium chloride, and 2 kg of hydroxypropyl-β-cyclodextrin, and stir to dissolve. Adjust the pH to 7 with boric acid, pass the solution through a 0.22um microporous membrane, and add water from the filter to a total of 50kg. Sampling is carried out for quality identification, and after passing the test, it is subpackaged in eye drop bottles under a sterile environment, and then packaged to obtain the product.
Embodiment 3
[0030] Get 39kg of deionized water, add gatifloxacin 0.15kg, stir to dissolve. Take 1kg of methylcellulose and sprinkle it into the above solution. After standing overnight, add 0.005 kg of benzalkonium bromide, 0.4 kg of sodium chloride, and 2 kg of hydroxypropyl-β-cyclodextrin, and stir to dissolve. Adjust the pH to 7 with 10% NaOH solution, pass the solution through a 0.22um microporous membrane, and add water from the filter to a total of 50kg. Sampling is carried out for quality identification, and after passing the test, it is subpackaged in eye drop bottles under a sterile environment, and then packaged to obtain the product.
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