A kind of super lubricating antibacterial medical coating and application method thereof

Abstract

The invention discloses an ultra-lubricating antibacterial medical coating, which is prepared by mixing the following raw materials in parts by mass: 0.5 to 10 parts of N-allylbenimidazole-modified vinylpyrrolidone polymer, 0.1 parts to 5 parts of isocyanate, 0.1 to 5 parts of crosslinking agent, 0.05 to 1 part of epoxy resin, and 79 to 99.25 parts of solvent. The invention has the following beneficial effects: the ultra-lubricating antibacterial medical coating of the present invention has excellent antibacterial effect, good biocompatibility, low cytotoxicity, and the polyurethane-epoxy resin elastic double network structure formed after the coating is cured It can realize the firm adhesion and adhesion of the coating on the medical device, and is suitable for popularization and use on the implantation / interventional medical device.

Description

technical field [0001] The invention belongs to the field of new medical materials, in particular to an ultra-lubricating antibacterial medical coating and an application method thereof. Background technique [0002] Nosocomial infections can occur while patients are being treated in a medical facility, which is caused by bacteria that are transferred to the patient during treatment. More than 25% of nosocomial infections are bacterial infections mediated by medical devices during diagnosis and treatment, such as various medical devices inserted into the body, medical devices that produce wounds, etc. Although my country has strict classification management for medical devices, and strictly controls the safety, effectiveness, and disinfection and sterilization of medical devices, nosocomial infections will still occur in patients using sterilized medical devices. This is because sterilizing medical devices can only prevent patients from contacting the bacteria on the medica...

AI Technical Summary

Problems solved by technology

But the antimicrobial substances used in these coatings have their own drawbacks

(1) Industrial fungicides represented by chlorhexidine: their antibacterial effect can be maintained for a short time. After the medical device is left in the human body for 1-2 days, the release of antibacterial substances will drop sharply, leaving behind after being washed off. The surface of the medical device under the surface is rough and has no antibacterial effect. This rough surface can even promote bacterial adhesion, and the chlorhexidine released in the blood stream has some side effects; (2) Silver ion sterilization represented by nano-silver Agent: Due to technical reasons, the nano-silver antibacterial coating only contains a small amount of silver, and the amount of released silver ions is very small. The concentration of released silver ions is less than the concentration of silver ions required for local antibacterial treatment, and the time for which the antibacterial effect can be maintained is also short. It is very short, and due to the accumulation of silver in the human body, it is still inconclusive whether the use of nano-silver as an antibacterial agent in the body is still inconclusive; (3) Using antibiotics as bactericides: the use of antibiotics has the risk of promoting antibiotic resistance, and antibiotics The rough surface left after release will still promote bacterial adhesion; (4) New antibacterial agents represented by modified chitosan: chitosan is a natural polysaccharide biopolymer compound with good biodegradability and biocompatibility, but the current products are still insufficient in application performance, and the antibacterial effect cannot well meet the requirements of practical applications

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