A kind of super lubricating antibacterial medical coating and application method thereof

A super-lubricating and coating technology, applied in the field of new medical materials, can solve the problems that the antibacterial effect cannot meet the practical application, the application performance is insufficient, and the antibacterial effect can be maintained for a short time, and achieves good biocompatibility and low cost. Cytotoxicity, meeting cytotoxicity requirements, the effect of good biocompatibility

Active Publication Date: 2022-07-01
成都德信安创新医疗技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the antimicrobial substances used in these coatings have their own drawbacks
(1) Industrial fungicides represented by chlorhexidine: their antibacterial effect can be maintained for a short time. After the medical device is left in the human body for 1-2 days, the release of antibacterial substances will drop sharply, leaving behind after being washed off. The surface of the medical device under the surface is rough and has no antibacterial effect. This rough surface can even promote bacterial adhesion, and the chlorhexidine released in the blood stream has some side effects; (2) Silver ion sterilization represented by nano-silver Agent: Due to technical reasons, the nano-silver antibacterial coating only contains a small amount of silver, and the amount of released silver ions is very small. The concentration of released silver ions is less than the concentration of silver ions required for local antibacterial treatment, and the time for which the antibacterial effect can be maintained is also short. It is very short, and due to the accumulation of silver in the human body, it is still inconclusive whether the use of nano-silver as an antibacterial agent in the body is still inconclusive; (3) Using antibiotics as bactericides: the use of antibiotics has the risk of promoting antibiotic resistance, and antibiotics The rough surface left after release will still promote bacterial adhesion; (4) New antibacterial agents represented by modified chitosan: chitosan is a natural polysaccharide biopolymer compound with good biodegradability and biocompatibility, but the current products are still insufficient in application performance, and the antibacterial effect cannot well meet the requirements of practical applications

Method used

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  • A kind of super lubricating antibacterial medical coating and application method thereof
  • A kind of super lubricating antibacterial medical coating and application method thereof
  • A kind of super lubricating antibacterial medical coating and application method thereof

Examples

Experimental program
Comparison scheme
Effect test

Synthetic example 1

[0030] Pour 40g of ethyl lactate and 20g of N-methylpyrrolidone into the reaction flask, then add 11.11g of N-vinylpyrrolidone and 7.21g of N-allylpropylbenimidazole into the reaction flask and mix evenly , the temperature was raised to 90°C; then 0.05g of the initiator azobisisobutyronitrile was mixed with 11.76g of ethyl acetate, and then added to the reaction flask through a constant pressure dropping funnel, and the reaction was incubated at 90°C for 2 hours; 9.87g was added. Iodododecane, react at 90°C for 6 hours, reverse-phase precipitation, filter, freeze-dry to obtain N-allylbenzimidazole-modified vinylpyrrolidone polymer 1;

Synthetic example 2

[0032]Pour 60g of ethyl lactate and 10g of N,N-dimethylacetamide into the reaction flask, then add 11.11g of N-vinylpyrrolidone and 1.58g of N-allylbenimidazole into the reaction flask Mix evenly, heat up to 60°C; then mix 0.5g of initiator azobisisoheptanenitrile with 15.16g of butyl acetate, add it to the reaction flask through a constant pressure dropping funnel, and keep the reaction at 60°C for 6 hours; add 1.65 g of butyl acetate g bromohexane, react at 60°C for 24 hours, reverse-phase precipitation, filter, freeze-dry to obtain N-allylbenzimidazole-modified vinylpyrrolidone polymer 2;

Synthetic example 3

[0034] Pour 55g of methyl lactate and 10g of N,N-dimethylformamide into the reaction flask, then add 11.11g of N-vinylpyrrolidone and 4.65g of N-allylethylbenimidazole to the reaction flask Mix evenly in the bottle, heat up to 80°C; then mix 0.20g of initiator dimethyl azobisisobutyrate and 13.54g of absolute ethanol, add to the reaction flask through a constant pressure dropping funnel, and keep at 80°C The reaction was carried out for 4 hours; 5.50 g of bromododecane was added, reacted at 80° C. for 15 hours, reverse-phase precipitation, filtration, and freeze-drying were performed to obtain N-allylbenzimidazole-modified vinylpyrrolidone polymer 3;

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PUM

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Abstract

The invention discloses an ultra-lubricating antibacterial medical coating, which is prepared by mixing the following raw materials in parts by mass: 0.5 to 10 parts of N-allylbenimidazole-modified vinylpyrrolidone polymer, 0.1 parts to 5 parts of isocyanate, 0.1 to 5 parts of crosslinking agent, 0.05 to 1 part of epoxy resin, and 79 to 99.25 parts of solvent. The invention has the following beneficial effects: the ultra-lubricating antibacterial medical coating of the present invention has excellent antibacterial effect, good biocompatibility, low cytotoxicity, and the polyurethane-epoxy resin elastic double network structure formed after the coating is cured It can realize the firm adhesion and adhesion of the coating on the medical device, and is suitable for popularization and use on the implantation / interventional medical device.

Description

technical field [0001] The invention belongs to the field of new medical materials, in particular to an ultra-lubricating antibacterial medical coating and an application method thereof. Background technique [0002] Nosocomial infections can occur while patients are being treated in a medical facility, which is caused by bacteria that are transferred to the patient during treatment. More than 25% of nosocomial infections are bacterial infections mediated by medical devices during diagnosis and treatment, such as various medical devices inserted into the body, medical devices that produce wounds, etc. Although my country has strict classification management for medical devices, and strictly controls the safety, effectiveness, and disinfection and sterilization of medical devices, nosocomial infections will still occur in patients using sterilized medical devices. This is because sterilizing medical devices can only prevent patients from contacting the bacteria on the medica...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/34A61L27/52A61L27/54A61L31/10A61L31/14A61L31/16C08F226/10
CPCA61L27/34A61L31/10A61L31/16A61L27/54A61L27/52A61L31/145C08F226/10A61L2300/404A61L2300/452A61L2420/02C08F226/06
Inventor 高帅武迪蒙刘政曾伟樊燚潘玉章张云凤戚海波刘涛舒丹丹宁春燕黄薇
Owner 成都德信安创新医疗技术有限公司
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