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Carbon nanosphere-based diagnosis and treatment integrated composite material as well as preparation method and application thereof

A carbon nanosphere, composite material technology, applied in nanotechnology, nanotechnology, nanomedicine, etc., can solve problems such as poor compatibility

Pending Publication Date: 2021-05-18
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to address the deficiencies in the prior art and provide a carbon nanosphere-based integrated composite material for diagnosis and treatment, which solves the problem of poor compatibility between materials through the unique design of material components and bonding structures The present invention also provides its preparation method, which makes the preparation process simple, efficient and highly repeatable, and is conducive to industrialization; the present invention also provides the application of the composite material in the integration of cancer diagnosis and treatment

Method used

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  • Carbon nanosphere-based diagnosis and treatment integrated composite material as well as preparation method and application thereof
  • Carbon nanosphere-based diagnosis and treatment integrated composite material as well as preparation method and application thereof
  • Carbon nanosphere-based diagnosis and treatment integrated composite material as well as preparation method and application thereof

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preparation example Construction

[0033] A method for preparing the aforementioned carbon nanosphere-based integrated composite material for diagnosis and treatment, comprising the following steps:

[0034] (1) Synthesize oil-soluble rare earth-doped nanocrystalline scintillator by high-temperature co-precipitation method, and disperse in chloroform; prepare polyethyleneimine chloroform solution, and mix with above-mentioned rare earth-doped nanocrystalline scintillator at normal temperature The chloroform dispersion was stirred, and after the chloroform was volatilized completely, deionized water was added to continue stirring, and the obtained product was washed with deionized water and then dispersed in deionized water to form the first dispersion; the glucose raw material was prepared, dissolved in After vigorously stirring in deionized water at room temperature, it was transferred to a Teflon liner for hydrothermal reaction. The obtained product is washed with ethanol and deionized water several times, an...

specific Embodiment 1

[0044] The carbon nanosphere-based integrated composite material for diagnosis and treatment provided by the embodiment of the present invention is specifically a nanocrystalline scintillator composite material with rare earth gadolinium / europium doped on the surface of carbon nanospheres, and its preparation method includes the following steps:

[0045] (1) Take 3 mL of oil-soluble rare earth gadolinium / europium doped nanocrystal scintillator chloroform dispersion and add it to 2.5-3.5 mL polyethyleneimine chloroform solution, stir at room temperature for 4-6 hours, and wait for the trichloro After the methane solvent evaporates completely, add 10-15 mL of deionized water and continue stirring for 1-2 hours. After the obtained product was washed with deionized water, it was dispersed in deionized water to form a first dispersion. Prepare 4 grams of glucose raw material, dissolve it in 25-35mL deionized water, stir vigorously at room temperature for 1-2 hours, transfer it to a...

specific Embodiment 2

[0049] The carbon nanosphere-based integrated composite material for diagnosis and treatment provided by the embodiment of the present invention is specifically a nanocrystalline scintillator composite material doped with rare earth gadolinium / terbium bonded to the surface of carbon nanospheres, which is basically the same as that of Example 1, except that The feature is that its preparation method comprises the following steps:

[0050] (1) Take 3 mL of oil-soluble rare earth gadolinium / terbium-doped nanocrystalline scintillator chloroform dispersion and add it to 2.5-3.5 mL polyethyleneimine chloroform solution, stir at room temperature for 4-6 hours, and wait for the trichloro After the methane solvent evaporates completely, add 10-15 mL of deionized water and continue stirring for 1-2 hours. After the obtained product was washed with deionized water, it was dispersed in deionized water to form a first dispersion. Prepare 4 grams of glucose raw material, dissolve it in 25-...

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Abstract

The invention discloses a carbon nanosphere-based diagnosis and treatment integrated composite material. The composite material is characterized in that the composite material is formed by bonding a rare earth doped nanocrystalline scintillator on the surface of a carbon nanosphere, wherein the rare earth doped nanocrystalline scintillator is lanthanide-doped fluoride-based nanoparticles, and the carbon nanosphere and the rare earth doped nanocrystalline scintillator are combined through amido bonds. The composite material has the advantages of good stability, good biocompatibility, luminescence property under X-ray excitation, and photothermal effect under near-infrared light irradiation. The invention further discloses a preparation method of the composite material. The method has the advantages of high repeatability, easiness in industrialization and the like. The invention further discloses an application of the composite material in integration of X-ray excited fluorescence imaging and near-infrared photothermal therapy.

Description

technical field [0001] The invention relates to the technical field of nanobiological materials, in particular to a carbon nanosphere-based integrated composite material for diagnosis and treatment, a preparation method and an application thereof. Background technique [0002] Cancer is the second leading cause of death worldwide. The detection and treatment of cancer has always been the focus and difficulty in today's medical field. For cancer imaging, fluorescence imaging excited by X-rays has the advantages of strong detection signal, no background fluorescence, and deep penetration depth. Fluorescence imaging excited by X-rays is based on nanocrystalline scintillators to achieve down-transfer luminescence, that is, after X-ray irradiation, nanocrystalline scintillators and X-rays undergo a photoelectric effect to absorb ray energy, and some electrons become excited electrons after absorbing ray energy, and the excited electrons transition Visible or near-infrared light...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K47/69A61K49/00A61P35/00B82Y5/00B82Y20/00B82Y30/00B82Y40/00
CPCA61K41/0052A61K47/6923A61K49/0019A61P35/00B82Y5/00B82Y20/00B82Y30/00B82Y40/00
Inventor 汤雪莉孙丽宁刘欣陶勤峰汪丰
Owner SHANGHAI UNIV
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