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Preparation method and application of core-shell magnetic/gold nanocomposite particles

A gold nanoparticle, magnetic nanoparticle technology, applied in the application, organic material/organic magnetic material magnetism, magnetic liquid and other directions, can solve the problems of poor dispersion of nanoparticles, high toxicity of reactants, and high reaction temperature, and achieves The preparation conditions are simple and feasible, the dispersibility is good, and the preparation conditions are mild.

Inactive Publication Date: 2010-01-06
CHENGDU ORGANIC CHEM CO LTD CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

These methods mainly have following shortcoming: (1) reaction temperature is high, and reaction temperature is usually about 200 ℃; (2) reaction time is long; (3) reactant toxicity is high, usually used reactant is iron pentacarbonyl, iron acetylacetonate etc. toxic compound
This method overcomes the shortcomings of high temperature and high toxicity of the thermal decomposition method, but the nano-Fe 3 o 4 Particles are easily oxidized and magnetically reduced under boiling conditions, and the dispersion of the prepared nanoparticles is not good

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] This example aims to clarify the practicability of the preparation of core-shell magnetic / gold nanocomposite particles of the present invention.

[0027] 1. Preparation of magnetic nanoparticles:

[0028] Weigh 4.1g FeCl 3 ·5H 2 O and 2.35 g FeCl 2 ·6H 2 O was dissolved in a flask by adding 100ml of water. After 0.5 hours, 10ml of 30% ammonia water was added dropwise, and the temperature was raised to 60°C. Under vigorous stirring, 0.1ml of oleic acid was slowly added dropwise. After the dropwise addition, it was aged at this temperature for 1 hour to obtain Water-based ferrofluid. Take 30ml of the magnetic fluid in a separatory funnel, add 200ml of toluene, shake well, let stand to separate layers. The upper black liquid is the oil magnetic fluid.

[0029] 2. Preparation of core-shell magnetic / gold nanocomposite particles:

[0030] Take 0.6ml of the above-mentioned oil-based magnetic fluid in a two-necked flask, add 0.3ml of hexadecenylamine, 2ml of dichlorometh...

Embodiment 2

[0032] This example aims to illustrate that the core-shell magnetic / gold nanocomposite particles of the present invention can be transferred from the solvent phase to the water phase.

[0033] Take 5ml of the toluene dispersion of core-shell magnetic / gold nanoparticles in a flask, add 0.05g of 11-mercaptoundecanoic acid, add 5ml of water, stir for 1 hour, and the nanoparticles are transferred from the toluene phase to the water phase.

Embodiment 3

[0035] This example aims to illustrate that the surface of the core-shell magnetic / gold nanocomposite particles of the present invention can be coupled with antibodies by conventional methods.

[0036] Take 0.35ml of the aqueous dispersion of core-shell magnetic / gold nanoparticles, add 0.5ml of 0.05M Tris-HCl (pH=7.6), let it act for 10 minutes, and discard the supernatant by magnetic separation. Use 0.35ml of 0.05M Tris-HCl (pH=7.6) to prepare the antibody stock solution to 0.2mg / ml, then take 0.15ml, add to the above liquid, and react for 1 hour. The reacted mixture was subjected to magnetic separation with a magnetic separator, and the separated antibody-coated magnetic / gold nanoparticles were washed with 0.02M PBS (pH=8.2).

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PUM

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Abstract

The invention relates to a preparation method and application of core-shell magnetic / gold nanocomposite particles. The preparation method is characterized by preparing magnetic nanoparticles by using a coprecipitation method; transferring the magnetic nanoparticles to an organic solvent through a surfactant; and then reducing a gold precursor with organic amine by using the magnetic particles as seed crystals to form a gold shell layer on the surface of the magnetic particles. After adding a chain transfer agent, the nanoparticles can be transferred from the solvent into aqueous phase. The nanoparticles can be used for marking, separation, enrichment and detection of biological and non-biological, and can also be used in the fields of magnetic resonance contrast agents, targeting drug carriers, photothermal therapy for cancer cells and the like.

Description

technical field [0001] The invention relates to a preparation method and application of core-shell magnetic / gold nanoparticles, belonging to the technical field of nano-magnetic materials. Background technique [0002] Magnetic nanoparticles have the characteristics of magnetic field responsiveness, nano-size effect, low toxicity and biocompatibility, and are widely used in many fields. For example: in the field of biomedicine, it can be used for magnetically targeted drug carriers, magnetic resonance imaging technology, separation and enrichment of cells or NDA, etc.; in the field of magnetic recording materials, it can replace traditional micron-sized magnetic powder for high-density magnetic recording materials; In the field of catalysis, using it as a catalyst carrier can not only greatly improve the activity of the catalyst, but also facilitate the recovery and reuse of the catalyst. However, magnetic nanoparticles are easily oxidized to reduce their magnetic propertie...

Claims

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Application Information

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IPC IPC(8): H01F1/44H01F1/42B22F1/00A61B5/05
Inventor 丁小斌武元鹏郑朝晖邓瑾妮彭宇行
Owner CHENGDU ORGANIC CHEM CO LTD CHINESE ACAD OF SCI
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