Coordination polymer nanodot simultaneously used for nuclear magnetism imaging and photothermal therapy and preparation method thereof

Abstract

The invention relates to a coordination polymer nanodot simultaneously used for nuclear magnetism imaging and a photothermal therapy and a preparation method of the coordination polymer nanodot. The coordination polymer nanodot comprises the raw materials of polyvinylpyrrolidone (PVP), Fe (ferrum) and gallic acid (GA) with the mass ratio of 66 to 20 to 10. The coordination polymer nanodot is prepared by firstly forming a chelate through the coordination of an amido bond of the PVP with iron ions, and then a coordination polymer is formed by the GA and the iron ions on the chelate through coordination. The coordination polymer nanodot provided by the invention can change the relaxation time of surrounding water molecules due to a paramagnetic action of the iron ions, thus can be used as a very good nuclear magnetism contrast medium, and after the iron ions are coordinated with the ligand gallic acid, very good absorption is achieved in a near infrared region, so the coordination polymer nanodot can also be used as a potential photothermal reagent. The preparation method is simple and easy to repeat, a complicated process and expensive equipment are not needed, the raw materials are only needed to be stirred overnight under room temperature, and the raw materials are not only cheap but also free of toxicity.

Description

technical field [0001] The invention belongs to the technical field of nanometer materials, and in particular relates to a coordination polymer nanodot used for both nuclear magnetic imaging and photothermal therapy and a preparation method thereof. Background technique [0002] Cancer is one of the major diseases that endanger human health. According to statistics, in 2012, cancer caused about 8.2 million deaths worldwide. With the continuous progress of science, nano-diagnosis and treatment medicine is more and more favored by scientists because of its unique characteristics of integrating diagnosis and treatment. Although great progress has been made in this field recently, from the perspective of practical application, it is still a great challenge to develop a highly efficient and non-toxic nano-diagnostic reagent. [0003] As a powerful non-invasive diagnostic mode, magnetic resonance imaging is often used to provide more in-depth anatomical details. In order to furth...

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Problems solved by technology

At present, the research on photothermal reagents mainly focuses on inorganic materials such as gold nanorods, and the potential toxicity of inorganic materials in vivo also hinders its further development to a certain extent. more important

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