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128 results about "Irreversible electroporation" patented technology
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Irreversible electroporation is a soft tissue ablation technique using ultra short but strong electrical fields to create permanent and hence lethal nanopores in the cell membrane, to disrupt the cellular homeostasis. The resulting cell death results from apoptosis and not necrosis as in all other thermal or radiation based ablation techniques. The main use of IRE lies in tumor ablation in regions where precision and conservation of the extracellular matrix, blood flow and nerves are of importance. The technique, in the form of the NanoKnife System, became commercially available for research purposes in 2009, solely for the surgical ablation of soft tissue tumors.
Electroporation controlled with real time imaging
InactiveUS20060264752A1Ultrasonic/sonic/infrasonic diagnosticsElectrotherapyMedical imagingIrreversible electroporation
A method and a system for producing the method are disclosed whereby irreversible electroporation pulses are produced across an area of target tissue. A medical imaging device is used to create an image of the irreversible electroporation in real time thereby making it possible to determine the area of electroporation and the extent of results obtained and to adjust the positioning of electrodes and / or the current as needed based on the image being viewed.
Owner:ONCOBIONIC +1
Integration of very short electric pulses for minimally to noninvasive electroporation
ActiveUS20100261994A1Promote cell deathReduce the amount requiredUltrasonic/sonic/infrasonic diagnosticsElectrotherapyBrain tumorElectrical impulse
The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. The invention can be used to treat solid tumors, such as brain tumors. The methods rely on non-thermal irreversible electroporation (IRE) or supra-poration to cause cell death in treated tumors. In embodiments, the methods comprise the integration of ultra-short electric pulses, both temporally and spatially, to achieve the desired modality of cell death.
Owner:VIRGINIA TECH INTPROP INC
Tissue ablation with irreversible electroporation
ActiveUS20070043345A1High level of controlMinimize damageSurgical needlesInternal electrodesAbnormal tissue growthCell membrane
A new method for the ablation of undesirable tissue such as cells of a cancerous or non-cancerous tumor is disclosed. It involves the placement of electrodes into or near the vicinity of the undesirable tissue through the application of electrical pulses causing irreversible electroporation of the cells throughout the entire area of the undesirable tissue. The electric pulses irreversibly permeate the cell membranes, thereby invoking cell death. The irreversibly permeabilized cells are left in situ and are removed by the body immune system. The amount of tissue ablation achievable through the use of irreversible electroporation without inducing thermal damage is considerable.
Owner:RGT UNIV OF CALIFORNIA
Balloon catheter method for reducing restenosis via irreversible electroporation
InactiveUS20090247933A1Promote resultsPrevent excessive cell lysingElectrotherapyInfusion devicesPercent Diameter StenosisIrreversible electroporation
Restenosis or neointimal formation may occur following angioplasty or other trauma to an artery such as by-pass surgery. This presents a major clinical problem which narrows the artery. The invention provides a balloon catheter with a particular electrode configuration. Also provided is a method whereby vascular cells in the area of the artery subjected to the trauma are subjected to irreversible electroporation which is a non-thermal, non-pharmaceutical method of applying electrical pulses to the cells so that substantially all of the cells in the area are ablated while leaving the structure of the vessel in place and substantially unharmed due to the non-thermal nature of the procedure.
Owner:RGT UNIV OF CALIFORNIA +1
Treatment planning for electroporation-based therapies
ActiveUS20110106221A1Reduce adverse effectsMinimize charge buildupMedical simulationElectrotherapyElectroporation therapyIrreversible electroporation
Owner:VIRGINIA TECH INTPROP INC
Irreversible electroporation device and method for attenuating neointimal
InactiveUS20090248012A1Promote resultsPrevent excessive cell lysingElectrotherapyInfusion devicesPercent Diameter StenosisTunica intima
Restenosis or neointimal formation may occur following angioplasty or other trauma to an artery such as by-pass surgery. This presents a major clinical problem which narrows the artery. The invention provides a device and a method whereby vascular cells in the area of the artery subjected to the trauma are subjected to irreversible electroporation which is a non-thermal, non-pharmaceutical method of applying electrical pulses to the cells so that substantially all of the cells in the area are ablated while leaving the structure of the vessel in place and substantially unharmed due to the non-thermal nature of the procedure.
Owner:RGT UNIV OF CALIFORNIA
Irreversible electroporation to treat aberrant cell masses
The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. The invention can be used to treat solid tumors, such as brain tumors. The methods rely on non-thermal irreversible electroporation (IRE) to cause cell death in treated tumors.
Owner:VIRGINIA TECH INTPROP INC
Device and Method for Electroporation Based Treatment of Stenosis of a Tubular Body Part
ActiveUS20130184702A1Less powerLess complexDiagnosticsSurgical instrument detailsIrreversible electroporationBalloon catheter
The present invention relates to medical devices and methods for treating a lesion such as a vascular stenosis using non-thermal irreversible electroporation (NTIRE). Embodiments of the present invention provide a balloon catheter type NTIRE device for treating a target lesion comprising a plurality of electrodes positioned along the balloon that are electrically independent from each other so as to be individually selectable in order to more precisely treat an asymmetrical lesion in which the lesion extends only partially around the vessel.
Owner:VIRGINIA TECH INTPROP INC +1
High-frequency electroporation for cancer therapy
ActiveUS20120109122A1Enhanced couplingMore predictable and uniform treatment outcomesElectrotherapySurgical instruments for heatingDiseaseAdjuvant
The present invention relates to the field of biomedical engineering and medical treatment of diseases and disorders. Methods, devices, and systems for in vivo treatment of cell proliferative disorders are provided. In embodiments, the methods comprise the delivery of high-frequency bursts of bipolar pulses to achieve the desired modality of cell death. More specifically, embodiments of the invention relate to a device and method for destroying aberrant cells, including tumor tissues, using high-frequency, bipolar electrical pulses having a burst width on the order of microseconds and duration of single polarity on the microsecond to nanosecond scale. In embodiments, the methods rely on conventional electroporation with adjuvant drugs or irreversible electroporation to cause cell death in treated tumors. The invention can be used to treat solid tumors, such as brain tumors.
Owner:VIRGINIA TECH INTPROP INC
Irreversible electroporation using nanoparticles
The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. The invention can be used to treat solid tumors, such as brain tumors. The methods rely on non-thermal irreversible electroporation (IRE) to cause cell death in treated tumors. In embodiments, the methods comprise the use of high aspect ratio nanoparticles with or without modified surface chemistry.
Owner:VIRGINIA TECH INTPROP INC
System and Method for Electrical Stimulation of the Lumbar Vertebral Column
ActiveUS20120215218A1Inhibit migrationPrevent rotationSpinal electrodesSurgical instruments for heatingElectrical impulseElectrical stimulations
Disclosed methods and devices treat chronic lower back pain from degenerated or injured intervertebral discs. Electrodes connected to a pulse generator deliver electrical impulses to nerves located within the posterior longitudinal ligament and annulus fibrosus of lumbar intervertebral discs. The stimulation reduces back pain reversibly, adjustably, and with almost complete coverage of the pain-generating region. A temporary percutaneous lead and a permanent paddle lead are used. The percutaneous lead, designed to prevent inappropriate stimulation of the thecal sac, is inserted using a specially-designed introducer cannula and lead blank. The paddle lead is configured individually for implantation in the anterior epidural space of each patient. Electrical stimulation parameters may also be selected so as to ablate the nerves, using non-thermal irreversible electroporation, or using joule heating wherein a thermal insulator covers substantially all of the thecal sac, thereby shielding the thecal sac from potential heat damage.
Owner:LIPANI JOHN D
Irreversible electroporation to create tissue scaffolds
The present invention provides engineered tissue scaffolds, engineered tissues, and methods of using them. The scaffolds and tissues are derived from natural tissues and are created using non-thermal irreversible electroporation (IRE). Use of IRE allows for ablation of cells of the tissue to be treated, but allows vascular and neural structures to remain essentially unharmed. Use of IRE thus permits preparation of thick tissue scaffolds and tissues due to the presence of vasculature within the scaffolds. The engineered tissues can be used in methods of treating subjects, such as those in need of tissue replacement or augmentation.
Owner:VIRGINIA TECH INTPROP INC
Method for Treatment of Complications Associated with Arteriovenous Grafts and Fistulas Using Electroporation
Electroporation devices and methods for use in the treatment of complications, such as thrombosis, stenotic segments, or infections, associated with an arteriovenous graft or fistula are provided. The devices include at least two electrodes. The electrodes are adapted to be positioned near the target zone of complication for applying electrical pulses and thereby causing electroporation. In a preferred embodiment, the electroporation pulses are sufficient to subject substantially all cells within the target zone to irreversible electroporation without creating a thermally damaging effect.
Owner:ANGIODYNAMICS INC
Integration of very short electric pulses for minimally to noninvasive electroporation
ActiveUS8926606B2Reduce the amount requiredHigh energyUltrasonic/sonic/infrasonic diagnosticsSurgical needlesBrain tumorIrreversible electroporation
The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. The invention can be used to treat solid tumors, such as brain tumors. The methods rely on non-thermal irreversible electroporation (IRE) or supra-poration to cause cell death in treated tumors. In embodiments, the methods comprise the integration of ultra-short electric pulses, both temporally and spatially, to achieve the desired modality of cell death.
Owner:VIRGINIA TECH INTPROP INC
Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds
ActiveUS20130253415A1Easy to storeImprove breathabilityElectrotherapyIntravenous devicesDiseaseNatural source
The present invention relates to the field of medical treatment of diseases and disorders, as well as the field of biomedical engineering. Embodiments of the invention relate to the delivery of Irreversible Electroporation (IRE) through the vasculature of organs to treat tumors embedded deep within the tissue or organ, or to decellularize organs to produce a scaffold from existing animal tissue with the existing vasculature intact. In particular, methods of administering non-thermal irreversible electroporation (IRE) in vivo are provided for the treatment of tumors located in vascularized tissues and organs. Embodiments of the invention further provide scaffolds and tissues from natural sources created using IRE ex vivo to remove cellular debris, maximize recellularization potential, and minimize foreign body immune response. The engineered tissues can be used in methods of treating subjects, such as those in need of tissue replacement or augmentation.
Owner:VIRGINIA TECH INTPROP INC
Irreversible electroporation (IRE) for congestive obstructive pulmonary disease (COPD)
Owner:ANGIODYNAMICS INC
Irreversible electroporation (IRE) for esophageal disease
InactiveUS20100256630A1Function increaseSurgical instruments for heatingEsophageal diseaseIrreversible electroporation
A method for treating Barrett's esophagus and esophageal cancer by using non-thermal electroporation energy to ablate diseased portions of the esophagus which, in effect, prevents stomach acids and other fluids from entering the esophagus thereby alleviating continued deterioration of the esophagus and allows the columnar cells in the lining of the esophagus to assume their normal physical characteristics and functions and.
Owner:ANGIODYNAMICS INC
Treatment planning for electroporation-based therapies
ActiveUS9198733B2Reduce adverse effectsMinimize charge buildupMedical simulationDiagnosticsElectroporation therapyElectrical impulse
The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.
Owner:VIRGINIA TECH INTPROP INC
High frequency electroporation for cancer therapy
ActiveUS20160287314A1Enhanced couplingMore predictable and uniform treatment outcomesElectrotherapySurgical instruments for heatingDiseaseIn vivo
Owner:VIRGINIA TECH INTPROP INC
Intracardiac tools and methods for delivery of electroporation therapies
ActiveUS20160051324A1ElectrotherapySurgical instruments for heatingElectroporation therapyEngineering
A medical system, including a medical device having a plurality of deployable arms, and at least one electrode on at least one of the plurality of arms; and an electric signal generator in communication with the medical device, the electric signal generator programmed to deliver pulsed energy to the medical device sufficient to induce irreversible electroporation ablation.
Owner:HONDA MOTOR CO LTD +1
System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies
Systems and methods are provided for modeling and for providing a graphical representation of tissue heating and electric field distributions for medical treatment devices that apply electrical treatment energy through one or a plurality of electrodes. In embodiments, methods comprise: providing one or more parameters of a treatment protocol for delivering one or more electrical pulses to tissue through a plurality of electrodes; modeling electric and heat distribution in the tissue based on the parameters; and displaying a graphical representation of the modeled electric and heat distribution. In another embodiment, a treatment planning module is adapted to generate an estimated target ablation zone based on a combination of one or more parameters for an irreversible electroporation protocol and one or more tissue-specific conductivity parameters.
Owner:VIRGINIA TECH INTPROP INC
Myocardial ablation by irreversible electroporation
InactiveUS20160113709A1Lower the volumeSurgical instruments for heatingEccentric hypertrophyCardiac muscle
Selective cellular ablation by electroporation, applicable, for example, to bulk tissue in the beating heart. Protocol parameters potentially induce tissue loss without thermal damage. Device and method are potentially applicable for myocardial tissue ablation to treat arrhythmias, obstructive hypertrophy, and / or to generate natural scaffolds for myocardial tissue engineering.
Owner:TEL HASHOMER MEDICAL RES INFRASTRUCTURE & SERVICES
Acute blood-brain barrier disruption using electrical energy based therapy
ActiveUS20140039489A1Surgical needlesInternal electrodesIrreversible electroporationMacromolecular Substances
A method is provided for ablating brain tissue of a living mammal comprising: placing first and second electrodes in a brain of the living mammal; applying a plurality of electrical pulses through the first and second placed electrodes which are predetermined to: cause irreversible electroporation (IRE) of brain tissue of the mammal within a target ablation zone; and cause a temporary disruption of a blood brain barrier (BBB) within a surrounding zone that surrounds the target ablation zone to allow material in a blood vessel to be transferred to the surrounding zone through the temporarily disrupted BBB. Such methods are useful for delivering large molecule material within a blood vessel of the brain across the BBB, where the large molecule is otherwise blocked by the BBB from passing through the blood vessel into the brain.
Owner:VIRGINIA TECH INTPROP INC
Treatment planning for electroporation-based therapies
ActiveUS20150327944A1Reduce adverse effectsMinimize charge buildupMedical simulationDiagnosticsElectroporation therapyElectrical impulse
The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.
Owner:VIRGINIA TECH INTPROP INC
Gels with predetermined conductivity used in electroporation of tissue
Gel compositions with adjusted conductivity are disclosed which compositions are used for directing reversible electroporation and irreversible electroporation of cells and tissue. The gel compositions are also used in a similar manner in order to carry out thermotherapy on cells and tissues.
Owner:RGT UNIV OF CALIFORNIA
Methods of Sterilization and Treating Infection Using Irreversible Electroporation
ActiveUS20140378964A1Surgical needlesSurgical instruments for heatingIrreversible electroporationMedical device
A method for treating an infection using irreversible electroporation is presented. The method includes providing an ablation device that has at least one electrode and inserting the ablation device into a target tissue of a patient. The tissue at least partially surrounds the implanted medical device. The outer surface of the medical device is at least partially covered by infectious cells. The method also involves positioning at least one electrode in or near the implanted medical device and delivering electrical pulses to or near the implanted medical device sufficient to irreversibly electroporate the infectious cells.
Owner:ANGIODYNAMICS INC
Multi-Electrode Energy Delivery Device and Method of Using the Same
ActiveUS20120150172A1Uniform ablationMaintain resistanceSurgical needlesSurgical instruments for heatingElectrical resistance and conductanceIrreversible electroporation
An energy delivery device for treating a patient includes a probe body and a plurality of elongate electrode elements that extend radially away from the probe body when deployed into tissue of the patient. The electrode elements are adapted to receive electrical treatment energy such as irreversible electroporation (IRE) pulses from an energy source. In one embodiment, each electrode element has a longitudinally varying electrical resistance at the electrode-tissue interface along the electrode so as to provide a uniform electric field along the length of the electrode. The uniform electric field allows a more uniform ablation of tissue within a treatment zone.
Owner:ANGIODYNAMICS INC
Immunotherapeutic methods using irreversible electroporation
Methods for treating tissue with irreversible electroporation and immunotherapy are described. The methods include placing a probe in tissue within a human body, wherein the probe has at least a first electrode, applying a plurality of electrical pulses through the first electrode and a second electrode, causing irreversible electroporation (IRE) of the tissue within a target ablation zone, and administering one or more exogenous agents into the tissue within the target ablation zone or to the human, thereby stimulating or otherwise modulating an immune system response within the body.
Owner:VIRGINIA TECH INTPROP INC
Irreversible electroporation to create tissue scaffolds
ActiveUS9598691B2BiocideMammal material medical ingredientsNative tissueIrreversible electroporation
The present invention provides engineered tissue scaffolds, engineered tissues, and methods of using them. The scaffolds and tissues are derived from natural tissues and are created using non-thermal irreversible electroporation (IRE). Use of IRE allows for ablation of cells of the tissue to be treated, but allows vascular and neural structures to remain essentially unharmed. Use of IRE thus permits preparation of thick tissue scaffolds and tissues due to the presence of vasculature within the scaffolds. The engineered tissues can be used in methods of treating subjects, such as those in need of tissue replacement or augmentation.
Owner:VIRGINIA TECH INTPROP INC
Asymmetric balanced waveform for ac cardiac irreversible electroporation
ActiveUS20160331441A1ElectrotherapySurgical instruments for heatingElectricityElectroporation therapy
An electroporation therapy apparatus method, and system is provided. The apparatus, system, and method comprise an electroporation generator (26). The electroporation generator (26) is configured to output an asymmetric balanced waveform to a medical device, and the asymmetric balanced waveform comprises a first positive phase and a first negative phase. The first positive phase comprises a first current and a first time and the first negative phase comprises a second current and a second time. The first current is greater than the second current and the second time is greater than the first time. The asymmetric balanced waveform is configured to irreversibly electroporate a target tissue.
Owner:ST JUDE MEDICAL ATRIAL FIBRILLATION DIV
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