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301 results about "Tissue scaffolds" patented technology
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Attachment of absorbable tissue scaffolds to fixation devices
The present invention relates to tissue scaffold implant devices useful in the repair and / or regeneration of diseased and / or damaged musculoskeletal tissue and that include a tissue scaffold component fixedly attached to a scaffold fixation component via at least one of sutures, fabrics, fibers, threads, elastomeric bands, reinforcing elements and interlocking protrusions for engaging and maintaining the scaffold component fixedly attached to the fixation component.
Owner:ETHICON INC
Scaffolds with viable tissue
ActiveUS20050177249A1Promote cell growthProsthesisTissue regenerationTissue defectBiomedical engineering
A composite implant is provided for repairing a tissue defect in a patient. In one embodiment, the implant is a porous tissue scaffold having at least one pocket formed therein and adapted to contain a viable tissue. The tissue scaffold can have a variety of configurations, and in one embodiment it includes top and bottom portions that can be at least partially mated to one another, and in an exemplary embodiment that are heated sealed to one another around a perimeter thereof to form an enclosed pocket therebetween. The pocket is preferably sealed with a viable tissue disposed therein. In another embodiment, the tissue scaffold is substantially wedge-shaped and the pocket comprises a hollow interior formed in the tissue scaffold, and / or at least one lumen extending into the tissue scaffold. The tissue scaffold can also optionally include at least one surface feature formed thereof to promote blood vessel formation.
Owner:DEPUY SYNTHES PROD INC
Modified hyaluronic acid for use in musculoskeletal tissue repair
The present invention includes hyaluronic acid complexes of a monovalent alkali metal salt of hyaluronic acid and a tetra alkyl ammonium halide that are suitable for incorporation with tissue scaffolds that are suitable for use in repair and / or regeneration of muscoloskeletal tissue and that include a biodegradable, porous substrate made from a biodegradable, hydrophobic polymer, where the hyaluronic acid complex is substantially insoluble in water at room temperature, yet soluble in mixtures of organic and aqueous solvents in which the selected hydrophobic polymer is soluble.
Owner:ADVANCED TECH & REGENERATIVE MEDICINE
Tubular patent foramen ovale (PFO) closure device with catch system
ActiveUS20050043759A1Minimize traumaMinimize distortion to the septal tissue surroundingSurgical veterinaryWound clampsEngineeringAtrial septal defects
The present invention provides a device for occluding an anatomical aperture, such as an atrial septal defect (ASD) or a patent foramen ovale (PFO). The occluder includes two sides connected by a central tube. The occluder is formed from a tube, which is cut to produce struts in each side. Upon the application of force, the struts deform into loops. The loops may be of various shapes, sizes, and configurations, and, in at least some embodiments, the loops have rounded peripheries. In some embodiments, at least one of the sides includes a tissue scaffold. The occluder further includes a catch system that maintains its deployed state in vivo. When the occluder is deployed in vivo, the two sides are disposed on opposite sides of the septal tissue surrounding the aperture and the catch system is deployed so that the occluder exerts a compressive force on the septal tissue and closes the aperture.
Owner:WL GORE & ASSOC INC
Tubular patent foramen ovale (PFO) closure device with catch system
ActiveUS7678123B2Minimize distortion to the septal tissue surroundingMinimize distortionSurgical veterinaryWound clampsAtrial septal defectsEngineering
The present invention provides a device for occluding an anatomical aperture, such as an atrial septal defect (ASD) or a patent foramen ovale (PFO). The occluder includes two sides connected by a central tube. The occluder is formed from a tube, which is cut to produce struts in each side. Upon the application of force, the struts deform into loops. The loops may be of various shapes, sizes, and configurations, and, in at least some embodiments, the loops have rounded peripheries. In some embodiments, at least one of the sides includes a tissue scaffold. The occluder further includes a catch system that maintains its deployed state in vivo. When the occluder is deployed in vivo, the two sides are disposed on opposite sides of the septal tissue surrounding the aperture and the catch system is deployed so that the occluder exerts a compressive force on the septal tissue and closes the aperture.
Owner:WL GORE & ASSOC INC
Tubular patent foramen ovale (PFO) closure device with catch system
ActiveUS20070010851A1Minimize traumaMinimize distortion to the septal tissue surroundingSurgical veterinaryWound clampsAtrial septal defectsEngineering
The present invention provides a device for occluding an anatomical aperture, such as an atrial septal defect (ASD) or a patent foramen ovale (PFO). The occluder includes two sides connected by a central tube. The occluder is formed from a tube, which is cut to produce struts in each side. Upon the application of force, the struts deform into loops. The loops may be of various shapes, sizes, and configurations, and, in at least some embodiments, the loops have rounded peripheries. In some embodiments, at least one of the sides includes a tissue scaffold. The occluder further includes a catch system that maintains its deployed state in vivo. When the occluder is deployed in vivo, the two sides are disposed on opposite sides of the septal tissue surrounding the aperture and the catch system is deployed so that the occluder exerts a compressive force on the septal tissue and closes the aperture.
Owner:WL GORE & ASSOC INC
Patent foramen ovale (PFO) closure device with radial and circumferential support
The present invention provides a device for occluding an anatomical aperture, such as a septal defect or patent foramen ovale (PFO). The occluder includes two sides connected by an intermediate joint. Each of the sides includes at least one elongate element, which is arranged to form non-overlapping loops. Each loop has at least one radially-extending segment that is adjacent to a radially-extending segment of another loop. In at least some embodiments, at least one pair of adjacent radially-extending segments is connected. The loops of the device may be of various shapes, sizes, and configurations, and, in at least some embodiments, the loops have rounded peripheries. In some embodiments, at least one of the sides includes a tissue scaffold. When the occluder is deployed in vivo, the two sides are disposed on opposite sides of the septal tissue surrounding the aperture, thereby exerting a compressive force on the septal tissue that is distributed along both the outer periphery of the occluder and the radially-extending segments.
Owner:NMT MEDICAL +1
Tissue scaffold having aligned fibrils, apparatus and method for producing the same, and artificial tissue and methods of use thereof
ActiveUS20050009178A1Improve structural strengthMinimal immunological responsePeptide/protein ingredientsHollow filament manufactureFiberRadial position
A tubular tissue scaffold is described which comprises a tube having a wall, wherein the wall includes biopolymer fibrils that are aligned in a helical pattern around the longitudinal axis of the tube where the pitch of the helical pattern changes with the radial position in the tube wall. The scaffold is capable of directing the morphological pattern of attached and growing cells to form a helical pattern around the tube walls. Additionally, an apparatus for producing such a tubular tissue scaffold is disclosed, the apparatus comprising a biopolymer gel dispersion feed pump that is operably connected to a tube-forming device having an exit port, where the tube-forming device is capable of producing a tube from the gel dispersion while providing an angular shear force across the wall of the tube, and a liquid bath located to receive the tubular tissue scaffold from the tube-forming device. A method for producing the tubular tissue scaffolds is also disclosed. Also, artificial tissue comprising living cells attached to a tubular tissue scaffold as described herein is disclosed. Methods for using the artificial tissue are also disclosed.
Owner:UNIVERSITY OF SOUTH CAROLINA
Arthroscopic tissue scaffold delivery device
A small diameter delivery device capable of delivering a tissue loaded scaffold arthroscopically to a tissue defect or injury site without reducing the pressure at the injury site is provided. The scaffold delivery device of the present invention comprises a plunger system that includes two main components: an insertion tube and an insertion rod. The insertion tube has a flared proximal end for holding a tissue scaffold prior to delivery. An elongate, hollow body extends from the flared proximal end to a distal end of the insertion tube, and defines a passageway that extends through the body for delivery of the tissue scaffold. The insertion rod has an elongate body that extends into a handle at a proximal end and a tip at a distal end. The insertion rod is configured to be removably disposed within the insertion tube for sliding along the passageway to effect delivery of the tissue scaffold through the insertion tube.
Owner:DEPUY SYNTHES PROD INC
Bioprinted Nanoparticles and Methods of Use
InactiveUS20110177590A1Improve accuracyRaise the ratioBioreactor/fermenter combinationsNanomagnetismNanoparticleBiology
The present invention provides compositions and methods that combine the initial patterning capabilities of a direct cell printing system with the active patterning capabilities of magnetically labeled cells, such as cells labeled with superparamagnetic nanoparticles. The present invention allows for the biofabrication of a complex three-dimensional tissue scaffold comprising bioactive factors and magnetically labeled cells, which can be further manipulated after initial patterning, as well as monitored over time, and repositioned as desired, within the tissue engineering construct.
Owner:DREXEL UNIV
Medical Device for Wound Closure and Method of Use
ActiveUS20100042144A1Improved wound closureSuture equipmentsSurgical veterinaryMaterial PerforationMedical device
A medical device for wound closure, e.g., repairing perforations and tissue wall defects. The medical device has a barbed elongate body and an outer member. The medical device may further include a foam structure. The medical device may also include an inner member which may be a tissue scaffold. A method for closing tissue is also disclosed.
Owner:TYCO HEALTHCARE GRP LP
Scaffold for tubular septal occluder device and techniques for attachment
InactiveUS20080077180A1Minimize traumaMinimize distortion to the septal tissue surroundingSurgical veterinaryWound clampsEngineeringSeptal Occluder Device
The present invention provides a device for occluding an anatomical aperture, such as an atrial septal defect (ASD) or a patent foramen ovale (PFO). The occluder includes two sides connected by a central tube. A tissue scaffold material is disposed on the occluder. The occluder is formed from a tube, which is cut to produce struts in each side. Upon the application of force, the struts deform into loops. The loops may be of various shapes, sizes, and configurations, and, in at least some embodiments, the loops have rounded peripheries. In some embodiments, at least one side of the occluder includes a tissue scaffold. The occluder further includes a catch system that maintains its deployed state in vivo. When the occluder is deployed in vivo, the two sides are disposed on opposite sides of the septal tissue surrounding the aperture and the catch system is deployed so that the occluder exerts a compressive force on the septal tissue and closes the aperture.
Owner:WL GORE & ASSOC INC
Irreversible electroporation to create tissue scaffolds
The present invention provides engineered tissue scaffolds, engineered tissues, and methods of using them. The scaffolds and tissues are derived from natural tissues and are created using non-thermal irreversible electroporation (IRE). Use of IRE allows for ablation of cells of the tissue to be treated, but allows vascular and neural structures to remain essentially unharmed. Use of IRE thus permits preparation of thick tissue scaffolds and tissues due to the presence of vasculature within the scaffolds. The engineered tissues can be used in methods of treating subjects, such as those in need of tissue replacement or augmentation.
Owner:VIRGINIA TECH INTPROP INC
Medical device for wound closure and method of use
ActiveUS20100087854A1Restrict movementSuture equipmentsOrganic chemistryMaterial PerforationMedical device
A wound closure device for repairing perforations and tissue wall defects is disclosed herein. The wound closure device has a barbed elongate body and a plug member. The wound closure device may further include a foam structure. The wound closure device may also include an inner member which may be a tissue scaffold. A method for closing tissue is also disclosed.
Owner:TYCO HEALTHCARE GRP LP
Tissue extraction and maceration device
Devices and methods are provided for extracting and macerating tissue, and optionally for depositing the tissue onto a tissue scaffold. The device generally includes an outer tube having a substantially open distal end that is adapted to be placed on and preferably to form a seal with a tissue surface, and a shaft rotatably disposed within the outer tube and movable between a first, proximal position in which the shaft is fully disposed within the outer tube, and a second, distal position in which a portion of a distal end of the shaft extends through the opening in the distal end of the outer tube. The device also includes a tissue harvesting tip formed on the distal end of the shaft that is effective to excise a tissue sample when the shaft is moved to the distal position, and a cutting member that is coupled to the shaft at a position proximal to the tissue harvesting tip. The cutting member is effective to macerate a tissue sample excised by the tissue harvesting tip.
Owner:DEPUY SYNTHES PROD INC
Methods for treating dental conditions using tissue scaffolds
The invention provides methods, apparatus and kits for regenerating dental tissue in vivo that are useful for treating a variety of dental conditions, exemplified by treatment of caries. The invention uses tissue scaffold wafers, preferably made of PGA, PLLA, PDLLA or PLGA dimensioned to fit into a hole of corresponding sized drilled into the tooth of subject to expose dental pulp in vivo. In certain embodiments the tissue scaffold wafer further comprises calcium phosphate and fluoride. The tissue scaffold wafer may be secured into the hole with a hydrogel, a cement or other suitable material. Either the wafer or the hydrogel or both contain a morphogenic agent, such as a member encoded by the TGF-β supergene family, that promotes regeneration and differentiation of healthy dental tissue in vivo, which in turn leads to remineralization of dentin and enamel. The tissue scaffold may further include an antibiotic or anti-inflammatory agent.
Owner:IVOCLAR VIVADENT INC
Enzyme-mediated modification of fibrin for tissue engineering
The invention provides fibrin-based, biocompatible materials useful in promoting cell growth, wound healing, and tissue regeneration. These materials are provided as part of several cell and tissue scaffolding structures that provide particular application for use in wound-healing and tissue regenerating. Methods for preparing these compositions and using them are also disclosed as part of the invention. A variety of peptides may be used in conjunction with the practice of the invention, in particular, the peptide IKVAV, and variants thereof. Generally, the compositions may be described as comprising a protein network (e.g., fibrin) and a peptide having an amino acid sequence that comprises a transglutaminase substrate domain (e.g., a factor XIIIa substrate domain) and a bioactive factor (e.g., a peptide or protein, such as a polypeptide growth factor), the peptide being covalently bound to the protein network. Other applications of the technology include their use on implantable devices (e.g., vascular graphs), tissue and cell scaffolding. Other applications include use in surgical adhesive or sealant, as well as in peripheral nerve regeneration and angiogenesis.
Owner:CALIFORNIA INST OF TECH
Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds
ActiveUS20130253415A1Easy to storeImprove breathabilityElectrotherapyIntravenous devicesDiseaseNatural source
The present invention relates to the field of medical treatment of diseases and disorders, as well as the field of biomedical engineering. Embodiments of the invention relate to the delivery of Irreversible Electroporation (IRE) through the vasculature of organs to treat tumors embedded deep within the tissue or organ, or to decellularize organs to produce a scaffold from existing animal tissue with the existing vasculature intact. In particular, methods of administering non-thermal irreversible electroporation (IRE) in vivo are provided for the treatment of tumors located in vascularized tissues and organs. Embodiments of the invention further provide scaffolds and tissues from natural sources created using IRE ex vivo to remove cellular debris, maximize recellularization potential, and minimize foreign body immune response. The engineered tissues can be used in methods of treating subjects, such as those in need of tissue replacement or augmentation.
Owner:VIRGINIA TECH INTPROP INC
Innovative bottom-up cell assembly approach to three-dimensional tissue formation using nano-or micro-fibers
The present invention provides a synthetic tissue scaffold, the scaffold comprising alternating layers of electrospun polymers and mammalian cells sandwiched within. A novel method is also provided for generating a three-dimensional tissue by electrospinning polymers and seeding cells in alternating layers on an aqueous solution in a desired shape. This invention is suitable for generating animal tissue as well as for delivery of drugs or other substances to a recipient.
Owner:WANG HONGJUN
Tissue extraction and maceration device
Owner:DEPUY SYNTHES PROD INC
Well-defined degradable poly(propylene fumarate) polymers and scalable methods for the synthesis thereof
ActiveUS20170355815A1Constrained and predictable material propertyCheap to makeAdditive manufacturing apparatusProsthesisOrganic chemistryMedical device
The present invention provides a low molecular mass PPF polymer (and related methods) that is suitable for 3D printing and other polymer device fabrication modalities and can be made inexpensively in commercially reasonable quantities. These novel low molecular mass PPF polymers have a low molecular mass distribution (m) and a wide variety of potential uses, particularly as a component in resins for 3D printing of medical devices. The ability to produce low m PPF creates a new opportunity for reliable GMP production of PPF. It provides low cost synthesis and scalability of synthesis, blending of well-defined mass and viscosity PPF, and reduced reliance on solvents or heat to (a) achieve mixing of 3D printable resins or (b) and flowability during 3D printing. These PPF polymers are non-toxic, degradable, and resorbable and can be used in tissue scaffolds and medical devices that are implanted within a living organism.
Owner:THE UNIVERSITY OF AKRON +1
Electromagnetic fields increase in vitro and in vivo angiogenesis through endothelial release of FGF-2
InactiveUS20050049640A1ElectrotherapyMagnetotherapy using coils/electromagnetsMedicineAngiogenesis growth factor
The present invention relates to a method of inducing angiogenesis in a cell or tissue by applying an electromagnetic field to the cell or tissue under conditions effective to induce angiogenesis. Also disclosed is a method of treating an ischemic condition in a patient by applying an electromagnetic field to ischemic tissue in a patient under conditions effective to treat the ischemic condition by inducing angiogenesis. A method of tissue engineering is also disclosed. This method involves providing a tissue scaffold and subjecting the tissue scaffold to an electromagnetic field under conditions effective to form a vascularized tissue scaffold. Further disclosed is a method of inducing activity of angiogenic growth factors by applying an electromagnetic field to a cell or tissue under conditions effective to induce activity of an angiogenic growth factor.
Owner:NEW YORK UNIV +1
Poly (vinyl alcohol) hydrogel
InactiveUS20010029399A1Exemption stepsOrganic active ingredientsEar treatmentEngineeringSacroiliac joint
The present invention comprises a poly (vinyl alcohol) hydrogel construct having a wide range of mechanical strengths for use as a human tissue replacement. The hydrogel construct may comprise a tissue scaffolding, a low bearing surface within a joint, or any other structure which is suitable for supporting the growth of tissue.
Owner:GEORGIA TECH RES CORP
Tissue scaffold having aligned fibrils and artificial tissue comprising the same
ActiveUS7338517B2Sufficient structural strength to withstand pressureMinimal immunological responsePeptide/protein ingredientsDough-sheeters/rolling-machines/rolling-pinsFiberFibril
Owner:UNIVERSITY OF SOUTH CAROLINA
Surgical sutures incorporated with stem cells or other bioactive materials
InactiveUS20090318962A1Reduce concentrationReducing cell migrationSuture equipmentsSurgical needlesSurgical siteSurgical department
Materials and Methods for immobilizing bioactive molecules, stem and other precursor cells, and other agents of therapeutic value in surgical sutures and other tissue scaffold devices are described herein. Broadly drawn to the integration and incorporation of bioactive materials into suture constructs, tissue scaffolds and medical devices, the present invention has particular utility in the development of novel systems that enable medical personnel performing surgical and other medical procedures to utilize and subsequently reintroduce bioactive materials extracted from a patient (or their allogenic equivalents) to a wound or target surgical site.
Owner:BIOACTIVE SURGICAL
Method of incorporating carbon nanotubes in a medical appliance, a carbon nanotube medical appliance, and a medical appliance coated using carbon nanotube technology
A method of coating an article is provided. The method includes: preparing a solution including a bioactive agent and a carbon nanotube precursor; treating the solution to form carbon nanotubes; and applying the solution to the article. A method of producing a medical device is provided. The method includes: forming a core of the medical device with a pattern on a surface of the core and assembling a multi-walled carbon nanotube array on the pattern on the surface. The pattern on the surface may determine an orientation of the multi-walled carbon nanotube array. A method of manufacturing a medical appliance is provided. The method includes creating a mixture of a carbon nanotube precursor and a polymer and injecting the mixture into a mold. The mold forms the mixture into a shape of the medical appliance. A method of forming a nanotube tissue scaffold is provided. The method includes forming a nanotube precursor and treating the nanotube precursor to form the nanotube tissue scaffold. The nanotube tissue scaffold is electrically conductive.
Owner:BOSTON SCI SCIMED INC
Nonwoven tissue scaffold
A biocompatible meniscal repair device is disclosed. The tissue repair device includes a scaffold adapted to be placed in contact with a defect in a meniscus, the scaffold comprising a high-density, dry laid nonwoven polymeric material and a biocompatible foam. The scaffold provides increased suture pull-out strength.
Owner:DEPUY SYNTHES PROD INC
Irreversible electroporation to create tissue scaffolds
ActiveUS9598691B2BiocideMammal material medical ingredientsNative tissueIrreversible electroporation
The present invention provides engineered tissue scaffolds, engineered tissues, and methods of using them. The scaffolds and tissues are derived from natural tissues and are created using non-thermal irreversible electroporation (IRE). Use of IRE allows for ablation of cells of the tissue to be treated, but allows vascular and neural structures to remain essentially unharmed. Use of IRE thus permits preparation of thick tissue scaffolds and tissues due to the presence of vasculature within the scaffolds. The engineered tissues can be used in methods of treating subjects, such as those in need of tissue replacement or augmentation.
Owner:VIRGINIA TECH INTPROP INC
Electrowetting Microarray Printing System and Methods for Bioactive Tissue Construct Manufacturing
InactiveUS20110076734A1Bioreactor/fermenter combinationsAdditive manufacturing apparatusDielectricTissue construct
Apparatuses and methods for manufacturing three-dimensional, bioactive, tissue scaffold fabrications with embedded cells and bioactive materials, such as growth factors, using biomimetic structure modeling, solid freeform fabrication, biocompatible hydrogel material, and electrowetting on dielectric-based multi-microarray printing.
Owner:DUKE UNIV +1
Fiber-reinforced, porous, biodegradable implant device
InactiveUS20050240281A1Promote regenerationProvide strengthBone implantLaminationArticular cartilagePolymer
A fiber-reinforced, polymeric implant material useful for tissue engineering, and method of making same are provided. The fibers are preferably aligned predominantly parallel to each other, but may also be aligned in a single plane. The implant material comprises a polymeric matrix, preferably a biodegradable matrix, having fibers substantially uniformly distributed therein. Inorganic particles may also be included in the implant material. In preferred embodiments, porous tissue scaffolds are provided which facilitate regeneration of load-bearing tissues such as articular cartilage and bone. Non-porous fiber-reinforced implant materials are also provided herein useful as permanent implants for load-bearing sites.
Owner:OSTEOBIOLOGICS
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