166 results about "Vascular Stenosis" patented technology

The present invention relates to medical devices and methods for treating a lesion such as a vascular stenosis using non-thermal irreversible electroporation (NTIRE). Embodiments of the present invention provide a balloon catheter type NTIRE device for treating a target lesion comprising a plurality of electrodes positioned along the balloon that are electrically independent from each other so as to be individually selectable in order to more precisely treat an asymmetrical lesion in which the lesion extends only partially around the vessel.

A system for enabling the insertion and removal of an embolic protection device, for capturing and retaining embolic debris which may be created during the performance of a therapeutic interventional procedure in a stenosed or occluded region of a blood vessel. The system, in an embodiment thereof, is capable of enabling at least one operator to control the delivery and removal of an embolic protection device to a position in a patient's vasculature distal to an interventional procedure site, to enable the exchange of the delivery and recovery system. The system, in another embodiment thereof, includes a delivery system and a recovery system which are capable of enabling the delivery and recovery of an embolic protection device so as to maintain a clinically acceptable profile and flexibility through the patient's vasculature.

The present invention discloses the method of inhibiting complement activation mediated by factor B inhibitors, that involves: (a) inhibiting factor B binding to properdin-bound C3b; (b) inhibiting the release of Bb; (c) inhibiting the activation of neutrophils, monocytes, platelets, and endothelium; or (d) inhibiting / reducing the formation of PC3bBb, C3a, C5a, and MAC. The present invention also discloses the novel use of factor B inhibitors in the treatment of various immunological disorders, resulting either primarily from direct immune responses such as rheumatoid arthritis, anaphylactic shock, myasthenia gravis, asthma, Alzheimer's disease, and the like, or secondarily from clinical conditions such as cardiopulmonary bypass inflammation, vascular stenosis and restenosis, burn injury, and the like.

This invention features a method of treatment for vascular stenosis or restenosis using a combination of N-phenyl-2-pyrimidine derivatives such as imatinib mesylate and PI3K inhibitors, such as rapamycin.

The invention provides compositions and methods for targeted controlled drug release. The compositions and methods can be used for treating or imaging vascular stenosis, stenotic lesions, occluded lumens, embolic phenomena, thrombotic disorders and internal hemorrhage.

The invention relates to a vascular recanalization system for cardiovascular stenosis lesions. The vascular recanalization system comprises a balloon, an energy generation controller and a catheter. The catheter comprises a main body tube, one end of the catheter is connected with the energy generation controller, and the main body tube at the other end of the catheter is connected with one end ofthe balloon; wherein the balloon mainly comprises a balloon main body, an inner tube and an electrode pair, and the inner tube is arranged in the balloon main body; and the energy generation controller can send out and regulate a vibration signal with a specific frequency to enable the electrode pair to generate a vibration wave. The system further has a drug delivery function, can inhibit increase of endovascular membranes after recanalization and avoid restenosis after recanalization, thereby achieving the function of long-term treatment of stenotic lesions. For many vascular diseases needing to be implanted with stents, the purpose of achieving long-term patency rate without stent implantation is achieved, and therefore real intervention implantation-free is achieved.

Apparatus and methods are disclosed for vascular stenosis and vulnerable plaque therapies, including enhancing permeability of the vessel wall using ultrasound energy and delivering a therapeutic agent into the arterial wall. Ultrasound energy may also be delivered at frequencies less than 10 MHz and power less than 20 watts using transcutaneous techniques and endovascular methods. Therapeutic agents may be delivered to the treatment area via intravenous and endovascular methods. In some embodiments, ultrasound energy and therapeutic agent application may be combined with angioplasty techniques and with blood flow protection devices. In some other embodiments, a therapeutic agent may be removed from the body after exposure to the vessel wall to minimize a systemic effect of the therapeutic drug.

The present invention relates to medical devices and methods for treating a lesion such as a vascular stenosis using non-thermal irreversible electroporation (NTIRE). Embodiments of the present invention provide a balloon catheter type NTIRE device for treating a target lesion comprising a plurality of electrodes positioned along the balloon that are electrically independent from each other so as to be individually selectable in order to more precisely treat an asymmetrical lesion in which the lesion extends only partially around the vessel.

The present invention relates to compositions containing an mTOR inhibitor, such as rapamycin or a rapamycin derivative, in combination with a PI3 kinase inhibitor and / or a leptin inhibitor, intraluminal devices configured to release such compositions, and methods for the treatment and / or prevention of intimal hyperplasia, vascular stenosis and / or restenosis comprising delivery of such compositions or intraluminal devices to subjects in need thereof. The compositions, intraluminal devices, and methods of the invention are particularly well-suited for the treatment or prevention of vascular stenosis and restenosis in obese and diabetic subjects.

An apparatus, method and system comprising an imaging tool for imaging an interventional device and its target organ using Doppler ultrasound are disclosed. The apparatus comprises an imaging tool and an interventional medical device; in some embodiments the imaging tool itself may be an interventional device or may comprise components of the interventional device. The imaging tool comprises a vibratory transducer and a vibratable element. The vibratory transducer is energized to generate a vibration motion in the vibratable element at first imaging frequency, which in turn is capable of oscillating a target organ at a second imaging frequency, the imaging frequencies being detectable by an ultrasound imaging system with Doppler mode. In certain applications the vibratory transducer may be energized to vibrate at a therapeutic frequency to effect treatment of the target organ, for example to clear a lumenal or vascular stenosis or to penetrate a vascular occlusion.

Doppler ultrasound may be used to detect stenosis in a blood vessel using a variety of approaches. In one approach, the flow envelope is extracted from the Doppler ultrasound measurements, and the extracted flow envelope is parameterized. Classification is then done based on those parameters (and optionally other parameters), to determine whether a stenosis exists. A second approach uses Doppler data that is acquired in a direction that is perpendicular to the direction of blood flow, and detects artifacts that are consistent with turbulences that usually appear downstream from stenoses.

The invention discloses a vascular stenosis detection method and device. The method comprises the steps of acquiring a computed tomography angiography (CTA) image for a blood vessel to be detected; straightening and imaging the CTA image at a plurality of set angles to obtain a plurality of straightened images at a plurality of set angles; carrying out width measurement on the straightened imagesone by one, and outputting a width curve corresponding to the straightened image with the set angle; and performing plaque positioning screening on the width curve one by one, and determining a narrowarea of the blood vessel to be detected according to a plaque positioning screening result. By implementing the method and the equipment provided by the invention, the accuracy of vascular stenosis detection can be improved.

The invention provides a method, a device and a system for acquiring a vascular stenosis lesion interval and performing three-dimensional synthesis. The method for accurately acquiring the stenosis lesion interval of the blood vessel comprises the following steps: reading coronary artery two-dimensional contrast image groups of at least two body positions; extracting a vascular skeleton; obtainingan interested blood vessel segment; extracting a center line and a contour line of the interested blood vessel section according to the blood vessel skeleton; obtaining geometric structure information of the blood vessel section; and obtaining a stenosis lesion interval and a stenosis point of the interested blood vessel segment. Coronary artery two-dimensional contrast image groups of at least two body positions are read; a vascular skeleton, a center line and a contour line are extracted; the stenosis lesion interval is obtained according to the geometric structure information, a doctor does not need to judge stenosis manually according to experience, and the obtaining mode is more accurate.

A branched stent graft, a convey system comprising thereof and manufacturing method thereof, the branched stent graft includes a main body (100) and a side branch (200), at least a portion of a lowermost stent section of the side branch (200) closest to the main body (100) is not stitched to the cover of the side branch from a lower end to an upper end, the at least a portion of the lowermost stent section is located on a side of the side branch corresponding to a folding direction of the side branch. After deployed, the branched stent graft has an effective supporting force at the base portion of the side branch. In addition, during the deployment of the stent, the side branch can expand to a maximal extent even when the positioning is slightly inaccurate. Further, vascular stenosis or occlusion will not be caused even when subsequent endothelialization occurs.

The various embodiments disclosed herein relate to catheters for advancing past a vascular stenosis. Each of these catheters has at least one friction-reducing feature to reduce the friction between the catheter and the stenosis as the catheter is urged therethrough.

The invention discloses a method for identifying the local vascular stenosis degree in a DSA coronary artery image, and the method comprises the following steps: 1), preprocessing a contrast image, and segmenting a coronary artery structure; 2) performing edge detection on the coronary artery structure, and extracting blood vessel boundary information of a region of interest; identifying the topological structure of the blood vessel to obtain a blood vessel center line; and 3) calculating the radius of the blood vessel point by point along the central line of the blood vessel to obtain the local vascular stenosis degree. According to the invention, interactive measurement of coronary vessel lesions is realized, diagnosis deviation and underestimation problems caused by artificial participation are reduced, doctors are assisted in rapid and accurate processing and analysis of DSA images, and application efficiency and objective requirements in actual diagnosis are ensured.

The invention discloses a method and a device for detecting vascular stenosis in coronary artery X-ray sequential radiography, which can be used for effectively detecting a suspected stenosis area ona blood vessel in a sequential image to obtain an accurate coronary artery stenosis detection result, and can be used for really helping doctors to carry out effective and quick disease diagnosis. Themethod comprises the following steps: (1) acquiring sequence image information of an XRA image; (2) coronary artery stenosis detection: combining front and back frame information in the sequence image to realize coronary artery stenosis section detection on the single-frame image, performing depth sequence feature fusion on continuous multi-frame image detection results to obtain more accurate stenosis detection results on each frame of the continuous multi-frame image, and taking the detection results as initial sequence stenosis detection results; and (3) processing the initial sequence narrow detection result, and obtaining an accurate detection result by removing repeated detection boxes in the frame and reserving the detection box with high similarity in the sequence.

The invention discloses a vascular stenosis analysis method, and the method comprises the steps: determining a target image region comprising a blood vessel and a plaque from a target heart CT angiography image, carrying out the segmentation of the target image region, obtaining a segmented blood vessel image and a plaque image, and based on the segmented blood vessel image and plaque image, determining a target vascular stenosis analysis result corresponding to the target heart CT angiography image so that the patch size is very small compared with a blood vessel and a background, and compared with the target heart CT angiography image, a large amount of redundant information is removed from the target image area, thus the preset segmentation model can avoid the interference of a large amount of redundant information in the target heart CT angiography image, and accurately segment plaques and blood vessels in the target image region, i.e., the segmentation accuracy of the plaques andthe blood vessels is improved; therefore, the accuracy of the target vascular stenosis analysis result corresponding to the target heart CT angiography image can be improved.

The invention relates to an effectively anti-thrombotic restenosis blood vessel inner support, and comprises a blood vessel inner support body. The invention is characterized in that the surface of the support body has a surface modifying layer which has A20 or A20 and correlation factors which can capture auto-endothelial progenitor cells in vivo, the A20 is A20 eukaryotic expression carriers, viral vectors, or A20 protein, and the correlation factors which can capture auto-endothelial progenitor cells in vivo are selected from esoderma growth factor II type receptor KDR antibodies, CD34 antibodies, or CD133 antibodies. The invention further relates to the process for preparing the support, the support can in vivo induce the endothelial progenitor cells and endothelial cells in the circulating blood to plant, and inhibit smooth muscle cells from breeding, and the performances of antithrombotic formation and anti-vessel restenosis are provided. The invention is used in the support plasty after the blood vessel is clinically provided with restenosis.

Apparatus and methods are disclosed for vascular stenosis and vulnerable plaque therapies, including enhancing permeability of the vessel wall using ultrasound energy and delivering a therapeutic agent into the arterial wall. Ultrasound energy may also be delivered at frequencies less than 10 MHz and power less than 20 watts using transcutaneous techniques and endovascular methods. Therapeutic agents may be delivered to the treatment area via intravenous and endovascular methods. In some embodiments, ultrasound energy and therapeutic agent application may be combined with angioplasty techniques and with blood flow protection devices.

The invention provides a drug loading cutting balloon. The drug loading cutting balloon is applied to being fed into human blood vessels via catheters to cut and deliver drug to lesions on inner walls of the blood vessels. The drug loading cutting balloon is characterized by comprising a balloon body and a plurality of cutter sets, wherein the balloon body is in a hollow ellipsoidal shape; the plurality of cutter sets are arranged on the surface of the balloon body, and every cutter set is composed of a plurality of cutting blades, which are arranged on the same circumference and extend in the circumferential direction of the balloon body; the balloon body is provided with a plurality of drug loading areas for applying drug. According to the drug loading cutting balloon, the cutting blades extend in the circumferential direction of the balloon body, so that, when in a contracted state, the balloon body can easily pass through the devious blood vessels to reach the narrow parts of the blood vessels, and when in an expanded state, can avoid uneven stressing during cutting, and further can well cut and dilate the narrow parts of the blood vessels where calcified plaques exist.

The invention discloses a method for establishing an intracranial vessel simulation three-dimensional stenosis model based on transfer learning. The method comprises the following steps: acquiring a bright blood image group and an enhanced black blood image group of an intracranial vessel; preprocessing each bright blood image and the corresponding enhanced black blood image to obtain a first bright blood image and a first black blood image; performing image registration by using mutual information based on Gaussian distribution sampling and a registration method of an image pyramid; groupingthe registered bright blood images to obtain MIP images in all directions; obtaining a two-dimensional blood vessel segmentation image based on the MIP image and the fundus blood vessel image; performing back projection synthesis on the two-dimensional blood vessel segmentation image to obtain first three-dimensional blood vessel body data, and obtaining an intracranial blood vessel simulation three-dimensional model by utilizing the second three-dimensional blood vessel body data; and for each section of blood vessel in the model, obtaining a numerical value of a target parameter representingthe stenosis degree of the section of blood vessel, and marking the intracranial blood vessel simulation three-dimensional model by utilizing the numerical value of the target parameter to obtain a simulated three-dimensional intracranial blood vessel stenosis analysis model.

The invention provides a method, a device and a system for acquiring a vascular stenosis lesion interval and performing three-dimensional synthesis. A blood vessel center line is extracted from coronary artery two-dimensional contrast images of the at least two body positions in the direction from the coronary artery inlet to the coronary artery tail end; A straightened blood vessel image is acquired according to the coronary artery two-dimensional contrast image and a blood vessel center line; a straightened blood vessel contour line is acquired according to the straightened blood vessel center line and the straightened blood vessel image; geometric information of the straightened blood vessel is acquired. Three-dimensional modeling is carried out according to the geometric information, the center line and the contour line to obtain a three-dimensional blood vessel model with a narrow lesion interval. The stenosis lesion interval is stereoscopically displayed to a patient and a doctorin a three-dimensional blood vessel model mode, the stenosis lesion interval is more vivid, all angles of the stenosis lesion can be displayed, the influence of the shooting angle of the two-dimensional radiography image on the judgment result of coronary artery stenosis is reduced, and the stenosis lesion area of the blood vessel can be accurately judged.

The invention relates to an electrode device for generating seismic waves and a usage method. The electrode device is used for a cardiovascular stenosis lesion recanalization system. The electrode device comprises an electrode pair, a connecting wire and a catheter, the electrode device is arranged on the catheter, the arrangement mode of the electrode pair is coaxial radial arrangement, and the electrode pair comprises an electrode tip and a wire; the device can be matched with a balloon catheter to control a generator of a recanalization system to apply vibration waves to vibrate and expand a narrow blood vessel attached to the periphery of a balloon to a certain recanalization rate, the action direction and effect after the vibration waves are generated are controlled, the purpose of keeping the blood vessel normal for a long time is achieved, and finally cardiovascular stenosis is treated. The device is simple in structure, low in cost and easy to store.