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143 results about "Coronary vessel" patented technology

Coronary vessels Two pairs of blood vessels (the coronary arteries and coronary veins) that supply the muscles of the heart itself. The coronary arteries arise from the aorta and divide into branches that encircle the heart.

Implantable coronary sinus lead and lead system

An implantable stimulation lead is disclosed for placement in the coronary sinus region and its associated coronary vessels overlying the left side of a patient's heart. The lead comprises at least one proximal connector; at least one tissue stimulation electrode; at least one conductor coupled between the at least one proximal connector and the at least one stimulation electrode; and a lead body including a housing of insulating material enclosing the at least one conductor, the lead body having a relatively flexible distal portion of, for example, silicone rubber, having a length corresponding to the coronary sinus region of the heart, and a stiffer proximal portion of, for example, polyurethane. A robust transition joint comprising telescoped sections of the distal and proximal portions of the lead body couples the two portions of the lead body.Also provided is a versatile lead delivery system including a stylet stop disposed within the distal portion of the lead body. The stylet stop defines an aperture dimensioned to pass a guide wire but not the enlarged distal tip of a stylet. The lead includes a tip electrode having a longitudinally extending bore dimensioned to permit passage of the guide wire through the tip electrode.
Owner:PACESETTER INC

Method and apparatus for transmyocardial direct coronary revascularization

InactiveUS6929009B2Facilitate valvingShortening and thickeningEar treatmentCannulasVeinHeart chamber
Methods and apparatus for direct coronary revascularization wherein a transmyocardial passageway is formed between a chamber of the heart and a coronary blood vessel to permit blood to flow therebetween. In some embodiments, the transmyocardial passageway is formed between a chamber of the heart and a coronary vein. The invention includes unstented transmyocardial passageways, as well as transmyocardial passageways wherein protrusive stent devices extend from the transmyocardial passageway into an adjacent coronary vessel or chamber of the heart. The apparatus of the present invention include protrusive stent devices for stenting of transmyocardial passageways, intraluminal valving devices for valving of transmyocardial passageways, intracardiac valving devices for valving of transmyocardial passageways, endogenous tissue valves for valving of transmyocardial passageways, and ancillary apparatus for use in conjunction therewith.
Owner:MEDTRONIC VASCULAR INC

Immobilizing mediator molecules via anchor molecules on metallic implant materials containing oxide layer

A mediator molecule is immobilized on the surface of a metallic or ceramic implant material. An anchor molecule such as a dialdehyde having a functional group that covalently binds the mediator molecule is covalently bound to the surface, and the mediator molecule is coupled to the functional group of the anchor molecule. The implant material may be composed of titanium, titanium alloy, aluminum, stainless steel or hydroxylapatite. Oxide units on the surface of the implant material can be increased preferably by treating with hot chromic-sulphuric acid for 0.5 to 3 hours at a temperature between 100 to 250° C. prior to binding the anchor molecule. Also, prior to binding the anchor molecule, the surface of the implant material can be activated by reacting with a silane derivative. Mediator molecules include BMP protein, ubiquitin and antibiotics, and the implant material may be an artificial joint or coronary vessel support such as a stent.
Owner:MORPHOPLANT

Cardiac and or respiratory gated image acquisition system and method for virtual anatomy enriched real time 2d imaging in interventional radiofrequency ablation or pace maker replacement procecure

The present invention refers to the field of cardiac electrophysiology (EP) and, more specifically, to image-guided radio frequency ablation and pacemaker placement procedures. For those procedures, it is proposed to display the overlaid 2D navigation motions of an interventional tool intraoperatively obtained from the same projection angle for tracking navigation motions of an interventional tool during an image-guided intervention procedure while being navigated through a patient's bifurcated coronary vessel or cardiac chambers anatomy in order to guide e.g. a cardiovascular catheter to a target structure or lesion in a cardiac vessel segment of the patient's coronary venous tree or to a region of interest within the myocard. In such a way, a dynamically enriched 2D reconstruction of the patient's anatomy is obtained while moving the interventional instrument. By applying a cardiac and / or respiratory gating technique, it can be provided that the 2D live images are acquired during the same phases of the patient's cardiac and / or respiratory cycles. Compared to prior-art solutions which are based on a registration and fusion of image data independently acquired by two distinct imaging modalities, the accuracy of the two-dimensionally reconstructed anatomy is significantly enhanced.
Owner:KONINKLIJKE PHILIPS ELECTRONICS NV

Methods and devices for delivering a ventricular stent

A method, and related tools for performing the method, of delivering a stent or other like device to the heart to connect the left ventricle to the coronary artery to thereby supply blood directly from the ventricle to the coronary artery may be used to bypass a total or partial occlusion of a coronary artery. The method may include placing a guide device and a dilation device through an anterior wall and a posterior wall of the coronary vessel and through a heart wall between the heart chamber and the coronary vessel. The dilation device may be used to form a passageway in the heart wall at a location defined by the guide device. The method may then include placing a stent within the passageway.
Owner:HORIZON TECH FUNDING CO LLC

Optical navigation positioning system based on CT (computed tomography) registration results and navigation method thereby

ActiveCN102999902AResolve uncertaintyImage analysisDiagnosticsImage segmentationIntraoperative ultrasound
Disclosed are an optical navigation positioning system based on CT (computed tomography) registration results and a navigation method thereby. The system comprises a preoperative CT image guide input module, an image segmentation module, a body surface initial-registration module, a preoperative CT image and intraoperative two-dimensional ultrasound image module and an intraoperative navigation module. By combining virtual reality and intraoperative ultrasound, intraoperative positioning errors caused by factors such as breathing are compensated, and accordingly a target point for coronary artery bypass grafting is accurately positioned and navigated. Cardiac and coronary vessel tree in preoperative cardiac CT image data is manually segmented and reconstructed, an augmented virtual reality environment integrating endoscope and virtual endoscope is built by the aid of optical navigation apparatus and CT-ultrasound-based intraoperative registration error correction, and accordingly the target point of coronary artery bypass grafting is accurately positioned and navigated.
Owner:RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE

Method for acquiring 3-dimensional images of coronary vessels, particularly of coronary veins

A method and an apparatus for acquiring 3-dimensional images of coronary vessels (11), particularly of coronary veins, is proposed. 2-dimensional X-ray images (13) are acquired within a same phase of a cardiac motion. Then, a 3-dimensional centerline model (15) is generated based on these 2-dimensional images. From 2-dimensional projections of the centerline model into respective projection planes, the local diameters (w) of the vessels in the projection plane can be derived. Having the diameters, a 3-dimensional hull model of the vessel system can be generated and, optionally, 4-dimensional information about the vessel movement can be derived.
Owner:KONINKLIJKE PHILIPS ELECTRONICS NV

Dedicated display for processing and analyzing multi-modality cardiac data

For diagnosis and treatment of cardiac disease, images of the heart muscle and coronary vessels are captured using different medical imaging modalities; e.g., single photon emission computed tomography (SPECT), positron emission tomography (PET), electron-beam X-ray computed tomography (CT), magnetic resonance imaging (MRI), or ultrasound (US). For visualizing the multi-modal image data, the data is presented using a technique of volume rendering, which allows users to visually analyze both functional and anatomical cardiac data simultaneously. The display is also capable of showing additional information related to the heart muscle, such as coronary vessels. Users can interactively control the viewing angle based on the spatial distribution of the quantified cardiac phenomena or atherosclerotic lesions.
Owner:SIEMENS MEDICAL SOLUTIONS USA INC

Transmyocardial implant procedure and tools

A blood flow path is formed from a heart chamber to a coronary vessel on an exterior surface of a heart wall. A hollow conduit has a vessel portion and a myocardial portion. The vessel portion has an open leading end sized to be inserted into the coronary vessel. The myocardial portion has an open leading end and the myocardium portion is sized to extend through a thickness of the heart wall. The myocardial portion is placed in the heart wall with the open leading end of the myocardial portion protruding into the heart chamber. Blood flow through the conduit from the heart chamber is at least partially blocked. The leading end of the vessel portion is placed in the coronary vessel. Blood flow through the conduit from the heart chamber and into the vessel is then opened.
Owner:HORIZON TECH FUNDING CO LLC

System and method for coronary artery segmentation of cardiac CT volumes

A method for segmenting coronary vessels in digitized cardiac images includes providing a digitized cardiac image, providing a seed point in the image, selecting a volume-of-interest about the seed point, performing a local segmentation in the volume-of-interest, including initializing a connected component with the seed point and a threshold intensity value to the intensity of the seed point, adding a point to the connected component if the point is adjacent to the connected component and if the intensity of the point is greater than or equal to the threshold value, lowering the threshold intensity value, and computing an attribute value of the connected component, wherein if a discontinuity in the attribute value is detected, the local segmentation is terminated, wherein a local segmentation mask of a vessel is obtained.
Owner:SIEMENS MEDICAL SOLUTIONS USA INC

Hinged tissue implant and related methods and devices for delivering such an implant

A device for treating a heart may comprise a myocardial section configured to be positioned in a heart wall between a coronary vessel and a chamber of the heart and a vessel section configured to be positioned in the coronary vessel. The vessel section may be connected to the myocardial section and be configured to articulate relative to the myocardial section. The myocardial section and the vessel section may form an integral, single piece structure.
Owner:PERCARDIA INC

Expandable biodegradable polymeric stents for combined mechanical support and pharmacological or radiation therapy

An expandable biodegradable polymeric stent is fabricated with biodegradable polymer fibers (Poly-L-lactic acid, PLLA) in a coil shape that is constructed with both central and external or internal peripheral lobes. It is delivered and expanded using a conventional angioplasty balloon system. The disclosed stent can serve as a temporary scaffold for coronary vessels after PTCA or for peripheral endovascular stenting, or it can provide mechanical palliation for strictures of ductile organs (trachea, esophagus, bile and pancreatic ducts, ureter etc.). The disclosed stent also serves as a unique device for specific local drug delivery. Therapeutic agents (chemical compounds, protein enzyme and DNA sequences) and cells can be loaded into the stent and gradually released to target tissues. Local radiation therapy can also be delivered by a specially adapted stent.
Owner:DUNING

Transmyocardial implant procedure

A blood flow path is formed from a heart chamber to a coronary vessel on an exterior surface of a heart wall. A hollow conduit has a vessel portion and a myocardial portion. The vessel portion has an open leading end sized to be inserted into the coronary vessel. The myocardial portion has an open leading end and the myocardium portion is sized to extend through a thickness of the heart wall. The myocardial portion is placed in the heart wall with the open leading end of the myocardial portion protruding into the heart chamber. Blood flow through the conduit from the heart chamber is at least partially blocked. The leading end of the vessel portion is placed in the coronary vessel. Blood flow through the conduit from the heart chamber and into the vessel is then opened.
Owner:HORIZON TECH FUNDING CO LLC

System and Method for Coronary Digital Subtraction Angiography

A method and system for extracting coronary vessels fluoroscopic image sequences using coronary digital subtraction angiography (DSA) are disclosed. A set of mask images of a coronary region is received, and a sequence of contrast images for the coronary region is received. For each contrast image, vessel regions are detected in the contrast image using learning-based vessel segment detection and a background region of the contrast image is determined based on the detected vessel regions. Background motion is estimated between one of the mask images and the background region of the contrast image by estimating a motion field between the mask image and the background image and performing covariance-based filtering over the estimated motion field. The mask image is then warped based on the estimated background motion to generate an estimated background layer. The estimated background layer is subtracted from the contrast image to extract a coronary vessel layer for the contrast image.
Owner:SIEMENS HEALTHCARE GMBH

Organic Compounds

Disclosed are δ-amino-γ-hydroxy-ω-aryl-alkanoic acid amide compounds of formula (I)and the salts thereof, having renin-inhibiting properties. Also disclosed are pharmaceutical compositions comprising these compounds and methods of administering them for the treatment of hypertension, atherosclerosis, unstable coronary syndrome, congestive heart failure, cardiac hypertrophy, cardiac fibrosis, cardiomyopathy postinfarction, unstable coronary syndrome, diastolic dysfunction, chronic kidney disease, hepatic fibrosis, complications resulting from diabetes, such as nephropathy, vasculopathy and neuropathy, diseases of the coronary vessels, restenosis following angioplasty, raised intra-ocular pressure, glaucoma, abnormal vascular growth, hyperaldosteronism, cognitive impairment, alzheimers, dementia, anxiety states and cognitive disorders.
Owner:MAIBAUM JUERGEN KLAUS +2

Delivering a conduit into a heart wall to place a coronary vessel in communication with a heart chamber and removing tissue from the vessel or heart wall to facilitate such communication

Devices and methods for delivering conduits into the wall of a patient's heart to communicate a coronary vessel with a heart chamber. The devices are passed through the coronary vessel and the heart wall to place the conduit and establish a blood flow path between the vessel and the heart chamber. Additional devices and methods are provided for removing tissue from a coronary vessel or the heart wall to establish a flow path between the coronary vessel in communication with the heart chamber.
Owner:MEDTRONIC INC

Methods and apparatus for transmyocardial direct coronary revascularization

InactiveUS20060184089A1Easy to movePromote formationCannulasDiagnosticsCoronary revascularizationCoronary revascularisation
Methods and apparatus for direct coronary revascularization wherein a transmyocardial passageway is formed between a chamber of the heart and a coronary blood vessel to permit blood to flow therebetween. In some embodiments, the transmyocardial passageway is formed between a chamber of the heart and a coronary vein. The invention includes unstented transmyocardial passageways, as well as transmyocardial passageways wherein protrusive stent devices extend from the transmyocardial passageway into an adjacent coronary vessel or chamber of the heart. The apparatus of the present invention include protrusive stent devices for stenting of transmyocardial passageways, intraluminal valving devices for valving of transmyocardial passageways, intracardiac valving devices for valving of transmyocardial passageways, endogenous tissue valves for valving of transmyocardial passageways, and ancillary apparatus for use in conjunction therewith.
Owner:GOWAN L L C

Devices and methods for use in performing transmyocardial coronary bypass

Devices and methods utilized in performing transmyocardial coronary bypass include retractors used to engage and support myocardial tissue, and mechanisms for supporting coronary vessels so as to allow precise entry into a vessel lumen. In addition, various conduits are provided having a configuration that permits their positioning in a heart wall to place a coronary vessel in communication with a heart chamber.
Owner:GITTINGS DARIN C +3

Healing transmyocardial implant

A transmyocardial implant establishes a blood flow path through a myocardium between a heart chamber and a lumen of a coronary vessel residing on an exterior of the heart. The implant includes a coronary portion sized to be received within the vessel. A myocardial portion is sized to pass through the myocardium into the heart chamber. A transition portion connects the coronary and myocardial portions for directing blood flow from the myocardial portion to the coronary portion. The coronary portion and the myocardial portion have an open construction for permitting tissue growth across a wall thickness of the coronary portion and the myocardial portion. The myocardial portion includes an agent for controlling a coagulation cascade and platelet formation.
Owner:WILK PATENT DEVMENT +1

High-precision matching model-based method for calculating coronary artery parameters

The invention discloses a high-precision matching model-based method for calculating coronary artery parameters. According to the method, firstly, the angiography imaging means and the intravascular imaging means of a coronary vessel part are acquired. After that, an angiography image and an intravascular image are matched to form a high-precision matching model. The blood flow amount, the blood fractional Flow Reserve (FFR) and the microcirculation resistance index of microcirculatory resistance (IMR) of coronary vessels are calculated on the basis of the high-precision matching model. According to the method for calculating the coronary parameter blood flow, the blood flow reserve score and the microcirculation resistance index, the high-precision matching model of images is acquired through two ways, namely the angiography imaging means and the intravascular imaging means. The calculation result of the method is more accurate than the image of either the angiography imaging means orthe intravascular imaging means alone, so that the method is high in practicability.
Owner:QUANJING HENGSHENG BEIJING SCI & TECH CO LTD

Vascular four-dimensional reconstruction method in NOT gate-controlled ICUS (intravascular ultrasound) image sequence

The invention discloses a vascular four-dimensional reconstruction method in a NOT gate-controlled ICUS (intravascular ultrasound) image sequence. The method comprises the following steps: accurately positioning an ultrasonic catheter retracement path by utilizing a pair of approximate orthorhombic CAG (chronic atrophic gastritis) image sequences collected with an ICUS image synchronously; carrying out four-dimensional reconstruction on a morphological structure of a target vessel section containing possibly existing plaques through combining the cross section information of a vessel lomen extracted from the ICUS image; and reproducing true forms of coronary vessels at each time phase in a cardiac cycle. With the adoption of the vascular four-dimensional reconstruction method in the NOT gate-controlled ICUS image sequence, the four-dimensional reconstruction of the morphological structure of a coronary artery target vessel section containing the possibly existing plaques is realized, the true forms of the target vessel section at different time phases in the cardiac cycle can be comprehensively and truly reflected; and more reliable accordance can be provided for clinical diagnosis and treatment of coronary arteriesarteriosclerosis osteolytic lesions and research of biomechanical characteristics of coronary artery vascular tissues and the like. The method does not need an ECG-gating acquisition device, and also does not need ECG signals, so that the interventional examination time is greatly shortened, and the requirements on the original image data are reduced.
Owner:NORTH CHINA ELECTRIC POWER UNIV (BAODING)

Methods for inducing vascular remodeling and related methods for treating diseased vascular structures

A method for inducing vascular remodeling and related methods for treating patients having diseased vasculature. The method of inducing remodeling of the vascular system includes altering the blood flow dynamics in portions of the vascular system via mechanical mechanisms. Remodeling of certain coronary vasculature may be induced by creating a passage in a heart wall between a heart chamber and a blood vessel so as to permit blood flow communication, for example, direct blood flow communication, between the chamber and the vessel. A method of inducing vascular remodeling may include providing a blood flow passage between a heart chamber and the coronary vessel, or other flow dynamics altering structure, such that enlargement of at least a portion of the coronary vessel occurs.
Owner:HORIZON TECH FUNDING CO LLC

Three-dimensional reconstruction method and device for coronary vessels, equipment and storage medium

The invention, which is applicable to the field of the computer technology, provides a three-dimensional reconstruction method and device for coronary vessels, equipment and a storage medium. The method comprises: carrying out pretreatment and extraction of a blood vessel edge contour and two-dimensional guide wires on a coronary artery angiography (CAG) image and carrying out inner and outer membrane segmentation on an IVUS image; carrying out translation of two-dimensional guide wires in the CAG image on a first radiography plane and a second radiography plane to a same starting point, constructing a vertical intersecting surface, and setting intersecting lines as three-dimensional guide wired; arranging each frame of IVUS image on the three-dimensional guide wire at equal interval and rotating the each frame of IVUS image to be perpendicular to a tangent vector at a corresponding position; and rotating the IVUS image on the tangent vector vertical plane and carrying out back projection to the CAG image, obtaining distances between the three-dimensional guide wires based on the back projection and the blood vessel edge contour, determining an optimal orientation angle, and then rebuilding a blood vessel surface. Therefore, the external morphological structure of the blood vessel and the inner cavity lesion information are checked simultaneously; and the efficiency and accuracy of three-dimensional reconstruction of the coronary vessel are improved.
Owner:SHENZHEN UNIV

Spectroscopic unwanted signal filters for discrimination of vulnerable plaque and method therefor

Spectral variation contributed from the absorbance of unwanted correlated signals, such as blood at variable pathlengths between an in vivo catheter optic probe and a coronary vessel wall is an obstacle in the detection of vulnerable plaque. Preprocessing methods are described to reduce the impact of blood upon the spectral signal, based on the principles of Orthogonal Subspace Projection (OSP) and Generalized Least Square (GLS). The multivariate discrimination models used on the processed spectral information reduce the number of independent factors that include contributions from blood. The disclosed chemometric processing including preprocessing methods provide for in vivo spectral detection of medical analytes within the human body and in particular within the coronary vessel wall. A demonstration of how the preprocessing methods impact a discrimination modeling technique is provided, how the blood filters were developed and optimized, and finally how the OSP and GLS blood filters correct the spectral signal and improve the discrimination results of the models.
Owner:INFRAREDX INC

Method and apparatus for temporarily immobilizing a local area of tissue

InactiveUS7048683B2Improve performanceWithout significant deterioration of the pumping function of the beating heartDiagnosticsSurgical instrument detailsThoracic boneCardiac surface
A method and apparatus for temporarily immobilizing a local area of tissue. In particular, the present invention provides a method and apparatus for temporarily immobilizing a local area of heart tissue to thereby permit surgery on a coronary vessel in that area without significant deterioration of the pumping function of the beating heart. The local area of heart tissue is immobilized to a degree sufficient to permit minimally invasive or micro-surgery on that area of the heart. The present invention features a suction device to accomplish the immobilization. The suction device is coupled to a source of negative pressure. The suction device has a series of suction ports on one surface. Suction through the device causes suction to be maintained at the ports. The device further is shaped to conform to the surface of the heart. Thus, when the device is placed on the surface of the heart and suction is created, the suction through the ports engages the surface of the heart. The suction device is further fixed or immobilized to a stationary object, such as an operating table or a sternal or rib retractor. Thus, the local area of the heart near the suction device is temporarily fixed or immobilized relative to the stationary object while suction is maintained. In such a fashion, the coronary artery may be immobilized even though the heart itself is still beating so that a bypass graft may be performed. In addition the suction device may be used in either a conventional, open-chest environment or in a minimally-invasive environment, e.g. endoscopic.
Owner:MEDTRONIC INC

Devices and methods for improving intravascular uptake of agents

This invention is generally related to therapeutic treatment of a coronary vessel wall, and more particularly, to systems and methods for improving uptake of therapeutic agents within the endothelium for enhanced delivery of therapeutic agents to a treatment site. A medical device is provided that is capable of reducing the pressure applied to a vessel wall and delivering a therapeutic agent into the vessel wall. Also, methods are described for using the device to facilitate delivery and uptake of a therapeutic agent into the vessel wall.
Owner:ABBOTT CARDIOVASCULAR
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