78 results about "Calcium phosphate coating" patented technology

The present invention provides a biocompatible coating comprising calcium phosphate that is functionally graded across the thickness of the coating. The coating, which preferably includes hydroxyapatite, is particularly useful for coating implants, such as dental or orthopedic implants. The functionally graded coating is generally crystalline near the interface with the surface of the implant, with crystallinity and crystal diameter decreasing toward the outer layer of the coating. The invention further provides methods for preparing a coated implant comprising a functionally graded calcium phosphate coating thereon.

A biodegradable, biocompatible porous matrix as a scaffold for tissue engineering cartilage is formed of a copolymer of a polyalkylene glycol and an aromatic polyester such as a polyethylene glycol / polybutylene terephtalate copolymer. A ceramic coating such as a calcium phosphate coating may be provided on the scaffold by soaking the scaffold in a solution containing calcium and phosphate ions. A composite scaffold which is preferably a two-layer system may be formed having an outer surface of a layer of the porous matrix formed of the copolymer, and an outer surface of a layer of a ceramic material. The composite scaffold may be prepared by casting the copolymer on top of the ceramic material in a mould. Cells are preferably seeded on the scaffold prior to implanting, and the scaffold may contain bioactive agents that are released on degradation of the scaffold in vivo.

This invention relates to novel calcium phosphate-coated implantable medical devices and processes of making same. The calcium-phosphate coatings are designed to minimize the immune response to the implant (e.g. restenosis in stenting procedures) and can be used to store and release a medicinally active agent in a controlled manner. Such coatings can be applied to any implantable medical devices and are useful for a number of medical procedures including (but not limited to) balloon angioplasty in cardiovascular stenting, ureteral stenting and catheterisation. The calcium phosphate coatings can be applied to a substrate as one or more coatings by a sol-gel deposition process, an aerosol-gel deposition process, a biomimetic deposition process, a calcium phosphate cement deposition process, an electro-phoretic deposition process or an electrochemical deposition process. The coating can contain and elude a drug in an engineered manner.

The present invention relates to one kind of medical material used for hard tissue. It consists of medical base body and surface fluorinated calcium phosphate coating, which is fluorinated hydroxyapatite, fluorinated calciprivic hydroxyapatite, fluorinated tricalcium phosphate or carbonate radical substituted hydroxyapatite. During the preparation, alcohol solution of the mixture of alcohol soluble calcium salt and phosphate or partially esterified phosphoric acid is used as precursor and surface coating is formed on alumina ceramic or medical metal base body via conventional sol-gel soaking pulling process, rotary painting process, combined soaking pulling and centrifuging process or hot solution spraying process. The coating has high crystalline phase content, no impurity phase and high phase purity. The preparation process of th present invention can obtain coating with thickness adjustable from several hundred nanometers to several decade microns.

The present invention relates to a method of coating a porous material such as a medical implant with a layer of calcium phosphate, wherein the material is submersed in an aqueous solution of calcium, phosphate and carbonate ions, and the pH of the solution is gradually increased. A calcium phosphate coating is formed on an internal surface of the porous material by agitating the solution during coating formation.

The invention relates to a preparation method of a hydroxyapatite / polylactic acid composite coating on the surface of medical magnesium alloy, which comprises the following steps of polishing a magnesium alloy basal body to remove an oxidation layer on the surface; carrying out acid etching pretreatment and neutralizing treatment on the magnesium alloy basal body; preparing transfer solution from sodium dihydrogen phosphate dihydrate and calcium nitrate terahydrate; preparing a biomimetic calcium-phosphate coating; dissolving polylactic acid in a chloroform solvent to prepare polylactic acid solution; immersing the prepared magnesium alloy / hydroxyapatite composite material in the polylactic acid solution, and coating the polylactic acid coating on the surface of the magnesium alloy / hydroxyapatite composite material by adopting the solution dip-coating method; and putting the magnesium alloy material for 2-3 days till chloroform in the polylactic acid solution is completely volatilized, thereby obtaining the composite material of which the surface of magnesium alloy is wrapped with the hydroxyapatite / polylactic acid composite coating. Compared with the prior art, the preparation method of the hydroxyapatite / polylactic acid composite coating on the surface of medical magnesium alloy overcomes the disadvantages of the single coating, and therefore, the corrosion resistance and the biocompatibility of magnesium alloy are obviously increased.

The invention belongs to the technical field of medical material, and relates to a method for preparing a bioactive calcium phosphate coating on a magnesium alloy surface for an endosseous implant. The method comprises: sequential soaking the magnesium alloy surface layer for the endosseous implant in hydrofluoric acid and a mixed solution containing phosphate at a constant temperature to preparethe bioactive calcium phosphate coating. With adopting a chemical deposition method provided by the present invention, surface bioactivity of the magnesium alloy is improved, and corrosion rate of the magnesium alloy substrate is reduced. The method has simple operation process, easy operation and no requirement of special equipment. The bioactive calcium phosphate coating prepared by the method has strong combining power with the magnesium alloy substrate, and has controllable thickness.

The invention discloses a biomedical calcium phosphate / zinc oxide nano-rod array composite coating on the surface of a medical metal and a preparation method thereof. The biomedical calcium phosphate / zinc oxide nano-rod array composite coating is obtained by compounding biomedical calcium phosphate and a zinc oxide nano-rod array growing on the surface of a medical metal. One part of the biomedical calcium phosphate / zinc oxide nano-rod array composite coating comprises exposed zinc oxide nano-rod tips and the other part comprises calcium phosphate wrapping zinc oxide nano-rods. The biomedical calcium phosphate / zinc oxide nano-rod array composite coating has light-adjustable surface hydrophilicity and zinc ion slow-release properties. The preparation method comprises the following steps that a zinc oxide nano-rod array grows on the surface of a medical metal matrix with a zinc oxide crystal seed layer by a hydrothermal method; and a calcium phosphate coating is prepared by a sol-gel spin-coating method or a dip-coating method so that a part of zinc oxide nano-rods are exposed and calcium phosphate can wrap and strengthen the zinc oxide nano-rods. The biomedical calcium phosphate / zinc oxide nano-rod array composite coating has adjustable surface hydrophilicity and zinc ion slow-release properties and can be widely used for medical metal implants and other biomedical engineering fields.

The invention relates to a method for preparing a strontium-containing hydroxyapatite coating on the surface of a biodegradable magnesium alloy. The method comprises the following steps: polishing a magnesium alloy matrix to remove a surface oxidation layer, and cleaning; preparing a hydrothermal solution from calcium nitrate tetrahydrate, EDTA-2 Na, sodium dihydrogen phosphate dihydrate and strontium nitrate; and placing the well treated magnesium alloy matrix into the hydrothermal solution for hydrothermal reaction to obtain the strontium-containing hydroxyapatite coating, a biomimetic calcium phosphate coating, wrapping the magnesium alloy matrix. Compared with the prior art, as the hydrothermal method is adopted to prepare hydroxyapatite, not only is the degradation rate of the magnesium alloy in a human body effectively slowed down, but also the biocompatibility of the magnesium alloy is further improved. As strontium element is added into the hydroxyapatite coating, and as one of trace elements of the human body, strontium has the functions of promoting bone formation and inhibiting bone breakage, both the biological activity and the biocompatibility are improved.

The present invention discloses a surface treatment method of a dental implant, wherein a titanium or titanium alloy artificial implant is used. Through partial treatments which comprise sand spraying, acid pickling and coating hydroxyl calcium phosphate with biocompatibility, a specific porous structure is generated on the surface of the artificial dental implant, and the artificial dental implant is also provided with a partial porous hydroxyl calcium phosphate coating. Therefore osteoblast-like cell and bone integration speed can be increased, and furthermore the treatment period in artificial tooth implantation is reduced.

The invention belongs to the field of biomedical materials, and particularly relates to a biomedical material with good antibacterial, hemostatic and osteogenic activities and a porous calcium phosphate-chitosan composite coating, and a preparation method thereof. The preparation method comprises the following steps of: firstly, preparing a porous calcium phosphate coating by using plasma spraying; and secondly, directly compounding a water-soluble chitosan surface layer on the surface of the porous coating by a soaking method, a dropping method and the like. Thus, the prepared biomedical material not only can play a good role in resisting bacteria and stopping bleeding in early days after an operation, but also can minimize potential adverse effects of surface bioactivity and osteogenic performance of an implant. The biomedical material has a simple process and a low production cost, can endow an implantation appliance with two additional effects of stopping bleeding and stopping bleeding, can greatly improve the safety and the success rate of the existing implantation appliance, and alleviating pains of patients.

The present invention provides a biocompatible coating comprising calcium phosphate that is functionally graded across the thickness of the coating. The coating, which preferably includes hydroxyapatite, is particularly useful for coating implants, such as dental or orthopedic implants. The functionally graded coating is generally crystalline near the interface with the surface of the implant, with crystallinity and crystal diameter decreasing toward the outer layer of the coating. The invention further provides methods for preparing a coated implant comprising a functionally graded calcium phosphate coating thereon. Furthermore, an antimicrobial agent can be dispersed within the calcium phosphate coating at discrete locations to provide for a coating with tailored release of the antimicrobial agent.

The invention provides a method of preparing a calcium phosphate coating containing third-party beneficial ions in a microwave-assisted manner within a short time. The method comprises the following steps: microwave heating a reaction solution containing phosphate anions and calcium ions to form the calcium phosphate coating; and adding the third-party beneficial ions into the reaction solution to prepare the calcium phosphate coating containing the third-party beneficial ions. The method provided by the invention has the advantages of efficiency, low energy consumption, low investment and easiness in control and can fully coat orthopaedical or dental implantation apparatuses and stents with complex structures and the like. The obtained calcium phosphate coating containing the third-party beneficial ions can be applied to the biomedical engineering field of hard tissue repair.

The invention discloses a preparation method of a carbon-carbon composite material / hydroxyapatite / polylactic acid biological material. The method comprises a pretreatment procedure of a carbon-carbon composite material, a preparation procedure of a calcium phosphate coating and a preparation procedure of a polylactic acid coating, wherein the preparation procedure of the calcium phosphate coating comprises the following steps of: (a) preparing an electro-deposition solution; and (b) carrying out electrochemical deposition. Compared with the prior art, on the basis of the traditional electrochemical deposition method, an ultrasonic process is introduced, and by utilizing the oscillation cavitation effect of ultrasonic waves, coatings which are deposited on the surface of a substrate but insufficiently bonded fall off and are renewedly deposited, thereby the defect that the electrochemical deposition coatings are impractical due to insufficient bonding force is overcome; and meanwhile, the method has the advantage of simple process and is easy for application.

An adherent bioactive calcium phosphate coating is formed on a titanium or titanium alloy substrate by immersing the substrate in an acidic calcium phosphate solution to form a non-apatitic calcium phosphate coating on the substrate. In a second step the coated substrate can be converted to a less reactive coating by being immersed into a basic or neutral solution to convert the coating into an apatite. However if a relatively reactive coating is desired, the second step can be dispensed with.

The invention relates to a preparation method of a biodegradable magnesium alloy / calcium phosphate coating composite material. The preparation method comprises the steps of pre-treating a matrix, preparing a conversion liquid, and preparing a bionic calcium phosphate coating to obtain the biodegradable magnesium alloy / calcium phosphate coating composite material. Compared with the prior art, the preparation method has the advantages that the prepared ZK60 magnesium alloy / calcium phosphate coating composite material can be used for remarkably improving the corrosion resistance of a ZK60 magnesium alloy, greatly reducing the degradation rate of the ZK60 magnesium alloy in a bionic body liquid and promoting the research and application of the ZK60 magnesium alloy in the medical field.

The invention discloses an active polypeptide capable of promoting osteogenesis and inhibiting osteoclast and application of the active polypeptide. N-terminal serine is phosphorylated on the basis ofPTH1-34, and three repeated sequences of glutamic acid or aspartic acid are introduced at a C terminal; the sequence of the polypeptide is shown in SEQ ID NO:1 or SEQ ID NO:2, and the polypeptide hasosteoinductive activity similar to BMP2 and an osteoclast inhibiting effect similar to parathyroid hormones (PTH). Random coils of the polypeptide can be avoided by bonding the C-terminal repeated sequences of the polypeptide to the surface of a calcium phosphate material or a material with a calcium phosphate coating, no addition of organic reagents is needed, and therefore the activity of the polypeptide is protected effectively; furthermore, slow controlled release can be achieved through cleavage of peptide bonds, and long-term intermittent injection of the PTH1-34 can be avoided, so thatthe injection pain of patients is reduced, and effects of osteoblast promotion and osteoporosis inhibition are achieved; a conventional viewpoint that the PTH1-34 cannot be administered locally is changed.

The invention relates to a method carrying out electrochemical treatment on the surface of a biomedical magnesium or magnesium alloy with high biological activity and a low degradation rate. The method mainly solves the problem that an existing biomedical magnesium or magnesium alloy is low in biological activity and high in corrosion rate in human body fluid. The method comprises the steps of pretreating a base material, treating the base material in a micro-arc oxidation mode, treating micro-arc oxide magnesium in an electro-deposition mode, and covering the surface of the material with a calcium phosphate coating. The method is used for treating the surface of the biomedical magnesium or magnesium alloy.

The invention discloses an antibacterial peptide bionic calcium phosphate coating. The antibacterial peptide bionic calcium phosphate coating includes an amorphous calcium phosphate coating body and an antibacterial peptide-containing crystalline calcium phosphate coating body, wherein the amorphous calcium phosphate coating body and the antibacterial peptide-containing crystalline calcium phosphate coating body are sequentially coated on the surface layer of a to-be-coated material from inside to outside. The invention also discloses a preparation method and application of the antibacterial peptide bionic calcium phosphate coating. The antibacterial peptide bionic calcium phosphate coating can deposit under the conditions of the physiological temperature and physiological pH values, the activity of biologically active protein is not destroyed, and the structure of a formed crystal is similar to the bone structure. With formation of the calcium phosphate coating crystal, the antibacterial peptide is incorporated into the network crystal of the coating through co-deposition, and the activity is maintained, and is slowly released under physiological conditions, so that antibacterialproperties are given to the material without influences on attachment, survival and growth and differentiation of cells, and broad application prospects are achieved.

A method for the formation of a surface coating of an ion substituted calcium phosphate on a substrate, the coating itself and the use of the coating.

The invention relates to a biomimetic mineralization method for preparing a magnesium alloy-calcium phosphate coating composite material. The method comprises single preprocessing, acid etching preprocessing, bionic solution configuration, immersing in the bionic solution and the like to obtain the magnesium alloy-calcium phosphate coating composite material. Compared with other magnesium alloy-calcium phosphate coating composite materials, a magnesium alloy base body is firstly subjected to acid etching preprocessing, so that the calcium phosphate coating and the surface of the base body can be combined well; and the calcium-phosphate ratio of the bionic solution is 1.67:1, besides, the content of the calcium and the phosphate is higher than that of ordinary bionic solutions in the prior art, the biomimetic mineralization efficiency can be improved remarkably, and the calcium phosphate products are similar to human bone components and have good biocompatibility and corrosion resistance.

Disclosed herein are medical devices, such as stents, coated with calcium phosphate and processes for making the same. The stent can comprise a cobalt chromium alloy that has been treated to improve surface adhesion to the calcium phosphate and / or improve surface finish properties. A pharmaceutically active agent can be present in the calcium phosphate coating.

The present invention relates to a copolymer using nano calcium phosphate coated polymethyl methacrylate (PMMA) as a substrate and a coating method thereof. The method comprises compounding copolymer microspheres using PMMA including a hydroxyl pendant group as a substrate, reacting calcium salt and phosphoric acid solution with the hydroxyl pendant group of the PMMA-based copolymer microspheres, and increasing the thickness of nano calcium phosphate coatings of the PMMA-based copolymer microspheres.

An orthopedic implant having a metal surface and a calcium phosphate layer disposed on at least part of the metal surface is described. The calcium phosphate layer has an average crystallite size of less than about 100 nm in at least one direction and dissolves for more than 2 hours in vitro. The calcium phosphate layer is substantially free of carbonate. The coating, which is formed on a sodium titanate surface, has increased shear strength and tensile strength. The coating is formed by a solution deposited hydroxyapatite process under inert conditions. The pH of the solution varies by less than 0.1 pH unit / hour during coating formation.

This invention relates to a method for crystallizing an amorphous calcium phosphate (Cap) by high energy laser light irradiation. The method is particularly suited for crystallizing CaP coatings on polymeric substrates, particularly implant objects.

The invention discloses a filling material for a bone defect part caused after the giant bone cell tumor removal operation. The filling material comprises a magnesium alloy matrix and a calcium phosphate coating arranged on the surface of the magnesium alloy matrix, and diphosphonate is loaded on the calcium phosphate coating. The invention further discloses a preparation method of the filling material for the bone defect part caused after the giant bone cell tumor removal operation. The filling material for the bone defect part caused after the giant bone cell tumor removal operation takes amagnesium alloy material as a matrix, the calcium phosphate coating and a diphosphonate double-film layer are arranged on the matrix, the materials are taken as a filling material for a tumor cavity left after the giant bone cell tumor removal operation, the purpose of releasing the drug to the nidus is fulfilled, the effects that the diphosphonate drug inhibits the bone destruction of the tumor defect part and the bone absorption is prevented are achieved, meanwhile, the effect that the degradable magnesium alloy repairs the bone defect is achieved, the reconstruction of the bone defect caused after the giant bone cell tumor removal operation is realized, and the relapse rate of the tumor is reduced.

Disclosed herein are medical devices, such as stents, coated with calcium phosphate and processes for making the same. The stent can comprise a cobalt chromium alloy that has been treated to improve surface adhesion to the calcium phosphate and / or improve surface finish properties. A pharmaceutically active agent can be present in the calcium phosphate coating.

The invention provides a bone restoration support and a preparation method thereof. The bone restoration support comprises a support main body prepared from autologous bone powder and autologous bone glue, a nano calcium phosphate coating deposited on the surface of the support main body, and the autologous bone glue covering the surface of the nano calcium phosphate coating and / or filled in pores of the support main body. The support main body has good biological compatibility and bone cell inductive activity, so that a bone defect portion is better restored, the bone restoration support has large specific surface area by virtue of the nano calcium phosphate coating, so that the adhesion, crawling and growth of cells are facilitated; and moreover, due to the existence of the autologous bone glue, at a preliminary period when the bone restoration support is implanted into a human body, a great number of active factors can be released, and osteoclast and osteoblast can be absorbed to induce the formation of new bones. In addition, by adopting a 3D (three dimensional) printing technology, the prepared bone restoration support is highly matched with the bone defect portion of a patient.

The invention discloses a carbon / carbon composite material containing bioactive calcium phosphate coating on surface and a preparation method for the carbon / carbon composite material. The preparation method for the carbon / carbon composite material containing bioactive calcium phosphate coating on surface comprises the following steps: performing hydro-thermal treatment on the carbon / carbon composite material, and growing the bioactive calcium phosphate coating on the surface of the carbon / carbon composite material through a cathode differential-arc method. According to the preparation method for the carbon / carbon composite material containing bioactive calcium phosphate coating on surface disclosed by the invention, the bioactive calcium phosphate coating is grown on the surface of the carbon / carbon composite material through the cathode differential-arc method, so that the grown bioactive calcium phosphate coating has very high adhesive strength and high stability which can be as good as those of an induction heating method. The preparation method can overcome the limitation that an existing high-frequency induction heating / hydrothermal method is only suitable for a rotary body, and the preparation method is suitable for the rotary body, and also can be suitable for growing the bioactive calcium phosphate coating on a complex molding surface.