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Method for preparing strontium-containing hydroxyapatite coating on surface of biodegradable magnesium alloy

A technology of strontium hydroxyapatite and magnesium alloy is applied in the field of preparation of strontium hydroxyapatite coating on the surface of biodegradable magnesium alloys, so as to improve corrosion resistance, good biocompatibility and osteoconductivity, and promote biodegradation. Bone effect

Inactive Publication Date: 2015-09-09
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, magnesium alloys are used as bone implant scaffold materials, especially in terms of corrosion resistance, there are some key problems: as bone tissue engineering scaffold materials, the degradation speed of the implant material is required to match the speed of bone tissue repair and reconstruction
[0010] At present, many researchers have prepared nano strontium-doped hydroxyapatite powder, and also prepared hydroxyapatite on the surface of magnesium alloy by different methods, and added strontium (Sr) to the hydroxyapatite coating on the surface of magnesium alloy. There are very few of them, on the one hand, because many previous studies mainly focused on how to improve the corrosion resistance of the magnesium alloy material system to achieve the matching of the degradation rate of the material and the speed of bone tissue reconstruction; on the other hand, due to the existing Various methods, such as sol-gel method, electrochemical deposition, micro-arc oxidation method, magnetron sputtering, solution dipping, etc., are difficult to achieve a balance in terms of bonding strength, porosity and formability on complex surfaces.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] (1) Cut the ZK60 magnesium alloy into moderate-sized samples with a wire cutting machine, and then polish them with 800#, 1500#, and 2000# alumina water-resistant sandpaper to remove the oxide layer on the surface of the magnesium alloy, then rinse with deionized water, and Place in absolute ethanol for ultrasonic cleaning for 15 minutes, then use 90% phosphoric acid and sodium hydroxide for pickling and alkali washing respectively, and dry at room temperature for later use;

[0025] (2) Preparation of Ca 2+ Concentration is 0.2mol / L, EDTA-2 sodium concentration is 0.2mol / L, P 5+ The concentration is 0.06mol / L, Sr 2+ The concentration is 0.005mol / L, and PH=10 is adjusted by sodium hydroxide. The calcium source of the solution is calcium nitrate tetrahydrate, the phosphorus source is sodium dihydrogen phosphate dihydrate, and the strontium source is strontium nitrate;

[0026] (3) Place the matrix sample obtained by the pretreatment in step (1) in the high-pressure hyd...

Embodiment 2

[0029] (1) Cut the ZK60 magnesium alloy into moderate-sized samples with a wire cutting machine, and then polish them with 800#, 1500#, and 2000# alumina water-resistant sandpaper to remove the oxide layer on the surface of the magnesium alloy, then rinse with deionized water, and Place in absolute ethanol for ultrasonic cleaning for 15 minutes, then use 90% phosphoric acid and sodium hydroxide for pickling and alkali washing respectively, and dry at room temperature for later use;

[0030] (2) Preparation of Ca 2+ Concentration is 0.2mol / L, EDTA-2 sodium concentration is 0.2mol / L, P 5+ The concentration is 0.06mol / L, Sr 2+The concentration is 0.005mol / L, and PH=10 is adjusted by sodium hydroxide. The calcium source of the solution is calcium nitrate tetrahydrate, the phosphorus source is sodium dihydrogen phosphate dihydrate, and the strontium source is strontium nitrate;

[0031] (3) Place the matrix sample obtained by the pretreatment in step (1) in the high-pressure hydr...

Embodiment 3

[0034] (1) Cut the ZK60 magnesium alloy into moderate-sized samples with a wire cutting machine, and then polish them with 800#, 1500#, and 2000# alumina water-resistant sandpaper to remove the oxide layer on the surface of the magnesium alloy, then rinse with deionized water, and Place in absolute ethanol for ultrasonic cleaning for 15 minutes, then use 90% phosphoric acid and sodium hydroxide for pickling and alkali washing respectively, and dry at room temperature for later use;

[0035] (2) Preparation of Ca 2+ Concentration is 0.2mol / L, EDTA-2 sodium concentration is 0.2mol / L, P 5+ The concentration is 0.06mol / L, Sr 2+ The concentration is 0.005mol / L, and PH=10 is adjusted by sodium hydroxide. The calcium source of the solution is calcium nitrate tetrahydrate, the phosphorus source is sodium dihydrogen phosphate dihydrate, and the strontium source is strontium nitrate;

[0036] (3) Place the matrix sample obtained by the pretreatment in step (1) in the high-pressure hyd...

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Abstract

The invention relates to a method for preparing a strontium-containing hydroxyapatite coating on the surface of a biodegradable magnesium alloy. The method comprises the following steps: polishing a magnesium alloy matrix to remove a surface oxidation layer, and cleaning; preparing a hydrothermal solution from calcium nitrate tetrahydrate, EDTA-2 Na, sodium dihydrogen phosphate dihydrate and strontium nitrate; and placing the well treated magnesium alloy matrix into the hydrothermal solution for hydrothermal reaction to obtain the strontium-containing hydroxyapatite coating, a biomimetic calcium phosphate coating, wrapping the magnesium alloy matrix. Compared with the prior art, as the hydrothermal method is adopted to prepare hydroxyapatite, not only is the degradation rate of the magnesium alloy in a human body effectively slowed down, but also the biocompatibility of the magnesium alloy is further improved. As strontium element is added into the hydroxyapatite coating, and as one of trace elements of the human body, strontium has the functions of promoting bone formation and inhibiting bone breakage, both the biological activity and the biocompatibility are improved.

Description

technical field [0001] The invention belongs to the technical field of biomaterials, and in particular relates to a method for preparing a strontium hydroxyapatite coating on the surface of a biodegradable magnesium alloy. Background technique [0002] In recent years, magnesium and its alloys have gradually become a research hotspot in the field of degradable biomaterials due to their excellent degradation properties, mechanical properties, and biocompatibility, and have attracted extensive attention from researchers at home and abroad. Compared with the existing bone repair materials, the elastic modulus of magnesium alloy is close to that of bone, and the stress shielding is small; it can be degraded in vivo, avoiding secondary surgery; the degradation products are non-cytotoxic, and magnesium ions can also induce osteogenesis, promote fracture healing, and Stimulates bone formation. These properties make magnesium and its alloys likely to be ideal bone repair materials....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/32A61L27/04A61L27/58A61L27/54
CPCC23C22/22C23C22/73
Inventor 陆伟夏卡达牛俊超
Owner TONGJI UNIV
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