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Calcium phosphate coated stents comprising cobalt chromium alloy

A technology of cobalt-chromium alloy and calcium phosphate, which is applied in the direction of coating, electrophoretic plating, electrolytic coating, etc., and can solve problems such as narrowing

Inactive Publication Date: 2010-11-10
MIV SCI HLDG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In recent years, it has been found that although these two stents are effective in preventing restenosis, they can cause thrombosis (blood clots) months or years after implantation

Method used

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  • Calcium phosphate coated stents comprising cobalt chromium alloy
  • Calcium phosphate coated stents comprising cobalt chromium alloy
  • Calcium phosphate coated stents comprising cobalt chromium alloy

Examples

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Embodiment 1

[0042] Embodiment 1 (comparative example)

[0043] This example describes the deposition of hydroxyapatite on a scaffold composed of cobalt chromium alloy without the pretreatment described herein. Deposition of hydroxyapatite is also disclosed in the Master of Science thesis "Calcium Phosphate Coatings on Coronary Stents by Electrochemical Deposition" by Tsui, Manus Pui-Hung, Columbia University, 2006, the contents of which are incorporated herein by reference.

[0044] The stent used was an L605 cobalt-chromium stent (cobalt-chromium-tungsten-nickel alloy, MIV Therapeutics Company), and the dimensions of the stent were: length 19 mm, outer radius 1.6 mm. The surface of the stent was electropolished, then cleaned with distilled water in an ultrasonic bath followed by ethanol. Figure 1A and 1B are two photographs from different angles of the electropolished stent. It can be seen from these photographs that there are many precipitates on the surface of the stent.

[0045] A...

Embodiment 2

[0050] This example describes a method for coating cobalt chrome alloys after an acid etch pretreatment.

[0051]A concentrated etch reagent is prepared by mixing 95-98% sulfuric acid and 36-40% hydrochloric acid in a 1:1 ratio. A 25% acid etch working solution was prepared by diluting the 1:1 reagents with HPLC grade water (all percentages are by volume). The working solution consisted of 4.5% hydrochloric acid, 12.25% sulfuric acid and 83.25% HPLC grade water. L605 cobalt-chromium stents were cleaned by sonicating in distilled water followed by sonication in ethanol followed by ethanol rinsing and air drying. The dried stents were immersed in a closed Pyrex tube containing 5 mL of the working solution, and gently shaken for 1 hour at 25° C. in a rotary bath. The stents were removed, rinsed thoroughly with HPLC grade water, and air dried. Figure 4A and 4B is a photograph of the surface of the stent after acid etching. It can be seen that when combined with Figure 1A an...

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Abstract

Disclosed herein are medical devices, such as stents, coated with calcium phosphate and processes for making the same. The stent can comprise a cobalt chromium alloy that has been treated to improve surface adhesion to the calcium phosphate and / or improve surface finish properties. A pharmaceutically active agent can be present in the calcium phosphate coating.

Description

[0001] related application [0002] Pursuant to Title 35, United States Code, Section 119(e), this application claims priority to US Provisional Application No. 60 / 978,988, filed October 10, 2007, which is hereby incorporated by reference in its entirety. technical field [0003] Medical devices, such as stents, coated with at least one calcium phosphate and processes for their manufacture are disclosed. Background technique [0004] Implantable medical devices have a wide range of applications, including orthopedic and dental substitutes and materials, vascular grafts, shunts and stents, and implants designed for sustained release of drugs. The devices may be fabricated from metals, alloys, polymers or ceramics. [0005] Arterial stents have been used for many years to prevent restenosis of arteries after balloon angioplasty (dilation) that have been narrowed by arteriosclerosis or other conditions. The occurrence of restenosis is associated with inflammation, migration a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/32A61L27/04A61L27/54C23F1/28C25D7/04
CPCC23F1/28C25D13/02C25D7/04A61L31/086C25D3/02C25D9/08A61L31/022
Inventor 马努斯·楚依
Owner MIV SCI HLDG
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