69results about How to "The release rate is easy to control" patented technology

The invention relates to carrier materials of medicament sustained controlled release, a process for preparing the carrier materials and usage, in particular relating to carrier materials of double shell medicament sustained controlled release of a hollow silicon dioxde micro-balloon coated by pluralities layers f polyelectrolyte membranes, and the making method and usage of the carrier materials of double shell medicament sustained controlled release. The materials are prepared by the hollow silicon dioxde micro-balloon and the compatible polyelectrolyte. An inner shell of the carrier material of double shell medicament sustained controlled release is the hollow silicon dioxde micro-balloon, and an outer shell is composed of polarities layers of the polyelectrolyte membranes. A cavity of the hollow silicon dioxde micro-balloon can be a container for carrying medicament, and the polarities layers of the polyelectrolyte membranes of the outer shell can control the release rate of medicament molecules under different external environments. The carrier materials of double shell medicament sustained controlled release of the invention have high medicament-carrying capacity, and have certain targeting function, and environmental stimulus response of the medicament is release-controllable.

The invention discloses a preparation method of porous microspheres composite with hydroxyapatite microspheres being capable of carrying drugs and bone cement, which belongs to the technical field of biological material preparation. The method comprises the following steps: the preparation of nano hydroxyapatite powders; the preparation of Alpha- tricalcium phosphate powders; the preparation of the hydroxyapatite microspheres; and the preparation of the porous microspheres composite with the hydroxyapatite microspheres and the bone cement. The method has the advantages that: the porosity of the porous microspheres composite with the hydroxyapatite microspheres and the bone cement, and the size of the microspheres can be easily controlled; the composite of the drugs can be carried out by the preparation process of the bone cement stuff, the drug-carrying rate is large and controllable; and the composite porous microspheres can be served as drug carriers or stents with integration of bone restoration and cure.

The invention relates to a biological glass base porous composite material of a degradable mechanical enhanced type and a preparation method thereof. The material takes a biological glass porous stent which comprises macroporous channels and mediated pore channels as matrix. Adjacent macroporous channels are mutually communicated. The internal and external surfaces of the macroporous channels and mediated pore channels are provided with gel layers which are assembled layer-to-layer by the biomolecules with positive and negative charges alternatively. The biological glass matrix is made from the components with the following weight percentage of 16-38 percent of CaO, 0-10 percent of P2O5, 45-80 percent of SiO2, 0-0.1 percent of SrO and 0-22.5 percent of Na2O. The releasing speed of the biological active ions of the biological glass base porous composite material which is similar to the extracellular matrix and is decorated by the layer-to-layer assembly of the charges of different polarity of the biomolecules can be effectively cut and controlled. The walls of the pore channels are beneficial to the adhesion growth of cells. The mechanical strength, the fracture toughness and the machinability are good. And the application of the regeneration treatment on the bone gear injury home position of a stress concentrated part can be satisfied.

The present invention relates to magnetically targeting controlled medicine releasing carrier material and its preparation process and use. The magnetically targeting controlled medicine releasing carrier material consists of one inside magnetic hollow microsphere and several film layers of biocompatible polyelectrolyte to form the shell. It is prepared with the magnetic hollow microsphere as template and through a layer-by-layer adsorption process to deposit the film layers of biocompatible polyelectrolyte. The hollow microsphere serves as the medicine container, while the polymer film layers control the release rate of the medicine under different outer conditions. The present invention has great medicine carrying capacity, ability of controlled release of medicine in different organism tissues, and outer magnetic field orientating and biological targeting functions.

The invention discloses a nitrogen fertilizer stabilizer composition. The nitrogen fertilizer stabilizer composition comprises the following components in part by weight: 1-60 parts of nitrapyrin, 1-15 parts of wall material, 2-10 parts of emulsifier, 0.05-0.3 parts of viscosity regulator, 2-10 parts of dispersing agent and 0.1-100 parts of water. The invention further provides a preparation method of the nitrogen fertilizer stabilizer composition. The preparation method of the nitrogen fertilizer stabilizer composition comprises the following steps of: heating and melting active components, adding the macromolecular wall material, and stirring uniformly; adding a mother liquid containing the active components and the wall material into an emulsifier-containing water solution under a shearing condition, and emulsifying into an oil-in-water state; and controlling grain size as required, wherein the nitrogen fertilizer stabilizer composition can be in a liquid or solid state; and liquid drops containing the active components react with water molecules to form the macromolecular wall material. Through addition of a nitrapyrin product, the nitrogen fertilizer stabilizer composition can improve the using efficiency of an ordinary nitrogen fertilizer by decreasing nitrogen leaching and denitrification, is good in compatibility with a variety of fertilizers, pesticides, weedicides and bactericides, and can be mixed therewith for application.

The invention belongs to the technical field of nanometer materials, in particular to a gold-shell-coated hollow polymer submicron sphere, a preparation method and application thereof. In the invention, polymer submicron spheres are used as templates, multi-layer coated polyelectrolytes are used as functional materials, and the surface is evenly coated with gold shells. The size of the hollow gold shell submicron sphere and the thickness of the gold shell can be controlled. At the same time, according to the Mie scattering theory, the gold-shell-coated hollow polymer submicron sphere can adjust its absorption in the near-infrared region, and can convert the light energy of the near-infrared laser into surrounding heat energy, which can be used as a heat-sensitive device for cancer treatment. material for killing malignant tumor cells. The material of the present invention can combine thermotherapy and sustained release of antineoplastic drugs and be used in cancer treatment.

The invention provides materials formula for a kind of hydrophilic jelly food with slow-release function and its preparation technique. Then materials formula in said invention is, water soluble or compound mucus, energy substance, water, jelly agent, acidity regulator, sweetener, pigment. Its process is making mixed jelly substance and carbohydrate into hydrophilic jelly food under certain conditions, the main components are jelly substance and carbohydrate and auxiliary additive.

The invention discloses a preparation method and use of a traditional Chinese medicine asiaticoside carrying core / shell structure nanometer fiber film. The traditional Chinese medicine asiaticoside carrying core / shell structure nanometer fiber film is prepared from a lactic acid / glycollic acid copolymer (PLGA) as a shell and polycaprolactone (PCL) as an inner core through a coaxial electrospinning method. The preparation method has the advantages of use of easily available raw materials, operation easiness, good controllability and large scale industrial production easiness. The traditional Chinese medicine asiaticoside carrying core / shell structure nanometer fiber film can be used for wound dressing and has the advantages of controllable drug loading amount, high drug utilization rate and excellent wound healing promoting effect.

The invention relates to a controlled-release compound fertilizer, which consists of the following components in parts by weight: 10-30 parts of a phosphogypsum-fly ash slow-release compound, 20-40 parts of a slow-release nitrogen fertilizer containing a urease inhibitor and a digesting bacteria inhibitor, 15-30 parts of a mixed potassium fertilizer and 2-4 parts of a trace element compound. In the invention, the phosphogypsum-fly ash slow-release compound is adopted, so that slow release of fertilizer nutrients is realized, the utilization ratio of the fertilizer is increased, pollution is eliminated, the environment is protected, resources are saved, and production cost is lowered; and the stable digesting bacteria inhibitor is used, so that the nitration and denitrification reaction rates are effectively lowered, leaching loss of the nitrogen fertilizer and release of the nitrogen fertilizer in the form of NO and NO2 gas are reduced, and the utilization ratio of the fertilizer is increased.

The present invention discloses the preparation process of nanometer tricalcium phosphate powder with slowly released metal ion. The preparation process adopts metal ion compound, calcium containing compound and phosphide as main material, and polyglycol as stabilizer, and includes reaction inside water solution at 0-5 deg.c to produce amorphous calcium phosphate containing metal ion, and the subsequent sintering at 800-1100 deg.c. The said preparation process can obtain nanometer tricalcium phosphate powder with controllable metal ion releasing rate and small particle size, and the nanometer tricalcium phosphate powder is used as bioactive material capable of promoting bone growth and inhibiting bone absorption. The preparation process is simple, feasible, simple in operation, low in cost and easy for industrial production.

The invention discloses metal ion cross-linked hydrogel and a preparation method and application thereof. Hydrazide group modified water-soluble macromolecules are prepared through a carbodiimide method, then a hydrazide polymer aqueous solution and a metal ion solution are mixed to be uniform, and the metal ion cross-linked hydrogel is obtained. The hydrogel disclosed by the invention takes metalions as a cross-linking agent, has the advantages of controllable gelling time, adjustable mechanical properties, self-healing property and the like, and is simple in preparation method, mild in process conditions and wide in applicable metal ion variety. The hydrogel disclosed by the invention has a wide application prospect in the fields of three-dimensional tumor model construction, tumor local treatment, biomedical diagnosis and treatment agents, wound antibacterial dressings, drug delivery, removal of heavy metal ions in sewage and the like.

The invention discloses a pesticide microcapsule with an easily-adjusted release rate. The pesticide microcapsule comprises a capsule core and a capsule material; the capsule material is polyurethaneobtained by cross-linking curing of isocyanate, a polyurethane soft segment and a chain extender, and the capsule material accounts for 2%-40% by mass of the pesticide microcapsule; and the capsule core includes an oil-soluble pesticide and an organic solvent, wherein the organic solvent accounts for 0-45% by mass of the pesticide microcapsule. According to the pesticide microcapsule provided by the invention, the oil-soluble pesticide is used as the capsule core and can cooperate with the capsule material in the preparation process to form the structurally-stable pesticide microcapsule; and the capsule material is obtained by a curing cross-linking reaction of the isocyanate, the polyurethane soft segment and the chain extender, the reaction speed is easy to control, and therefore the release rate of the pesticide microcapsule can be conveniently adjusted.

A slow-release compound of benzafibrate is a slow-release capsule, the main part of which are the slow-release pellets. The slow-release pellets comprise the benzafibrate served as the active component and the slow-release layer with slow-release property covering outer layer of the medical pellet. The other excipient comprises the excipient material with pharmaceutical approval after mixing with benzafibrate and the slow-release material with slow-release property. The ratio among the benzafibrate, the excipient material and the slow-release material (weight ratio) is 1 to 0.01 till 1 to 0.01 till 1. The compound can prolong residence time of the medicine in the stomach. The compound is also capable of controlling the drug release, reducing the administration times, reducing toxic and side effects and improving the treatment effect.

The invention relates to a subcutaneous medicine controllable release biological needle and a preparation method thereof. By adopting the biological needle, a medicine can be controlled to being released subcutaneously with slight pain, and in addition, the medicine can be administrated by a patient self. The biological needle comprises a needle shell part and a needle core part, wherein the needle shell part is made of a soluble polymer material; the needle core part is composed of accumulated medicine carrier microspheres. The biological needle is sufficient in mechanical property to puncture into skin and is rapidly dissolved to release medicine carrier microspheres carried by the biological needle, and the medicine carrier microspheres carried by the biological needle can be degraded subcutaneously to release the medicine. By adopting the subcutaneous medicine controllable release biological needle provided by the invention, a liver first-pass effect caused by an orally taken slowrelease tablet can be avoided, in addition, the defect that a subcutaneous implanting agent needs to be operated by a medical operator manually can be avoided, and both medicinal effects and economy can be greatly improved.

The invention provides a slow-release polluted sediment in-situ remediation material. The pH value of a silicate solution is adjusted to 3-4.5; an oxygen-containing anionic salt is added, the pH valueof the reaction system is adjusted to 2.2-2.6 under a stirring condition, a reaction is carried out for 60-120 min, cement is added, the obtained system is continuously stirred and reacted for 120-240 min, and the obtained system is dried to obtain the in-situ remediation material, wherein the feeding molar ratio of the oxygen-containing anionic salt to the silicate is controlled to be 1:2 to 10:1, and the feeding mass of the cement is 0.5-10 times of the sum of the mass of the oxygen-containing anionic salt and the mass of the silicate. The remediation material has the advantages of high active component content, slow and controllable release rate, and sustainable exertion of the treatment and remediation effects, can be applied to treatment of polluted rivers, lakes and other water bodies, and can also be applied to the treatment and remediation of polluted sites.

The invention relates to a fertilizer applicator and a fertilizer suitable for being used by the fertilizer applicator. The fertilizer applicator (1) can be divided into a fertilizer water flow guide pipe (1a), a fertilizer cavity (1b) and a cover (1c) from one end inserted into the soil; the fertilizer water flow guide pipe (1a) is a hollow pipe; the lower end (1a1) of the pipe (1a) is provided a through hole (1a1a); the upper end (1a2) of the pipe (1a) is connected and communicated with the fertilizer cavity (1b); a material (1d) capable of absorbing water and guiding water is contained in the fertilizer water flow guide pipe (1a); a structure (1e) capable of being used for regulating the fertilizer water flow guide quantity and a soil EC meter (1f) are also arranged on the fertilizer applicator. The fertilizer applicator has the advantages that the controllability on the fertilizer release speed to a certain degree is realized; the speed is adjustable according to the requirements; the slow release effect on the fertilizer is high; the continuous fertilizer supply to the plants can be realized; the fertilizer application labors can be reduced; various kinds of fertilizer damage due to improper fertilizer application can be effectively avoided; the fertilizer loss can be obviously reduced; the structure of the fertilizer applicator is simple; the use is convenient; no pollution is caused; the cost is low.

The invention relates to an antibacterial transparent dressing, a preparing method of the antibacterial transparent dressing and application of the antibacterial transparent dressing. The antibacterial transparent dressing comprises a polymer gel lining pad and a transparent protective film, wherein the polymer gel lining pad has moisture absorption performance and long-acting bacteriostasis performance; antibacterial drug is contained in the polymer gel lining pad; the polymer gel lining pad is prepared from materials of the following polymer monomers including hydroxyethyl methylacrylate, methyl methacrylate, cinnamic acid, alpha-cyanoacrylate, alpha-carboxymethyl crylic acid, methyl alpha-chloroacrylate and crylic acid-2-hydroxyl ethyl ester; the antibacterial drug is selected from chlorhexidine gluconate, chlorhexidine acetate, polyhexamethylene guanide salts and triclosan; the transparent protective film is a polyurethane thin film.

The invention provides a peripheral drug eluting stent. A drug coating of the peripheral drug eluting stent is divided into an outer sustained-release layer, an intermediate drug sustained-release mixed layer and an inner drug sustained-release mixed layer. The outer sustained-release layer is PLGA with molecular weight being 30000, and PLA:PGA=70:30. The intermediate drug sustained-release mixed layer is a mixture of PTX and PLGA, wherein the molecular weight of PLGA is 20000, PLA:PGA=50:50, and the mass ratio of PTX to PLGA is 3:1. The inner drug sustained-release mixed layer is a mixture of PTX and PLGA, wherein the molecular weight of PLGA is 20000, PLA:PGA=80:20, and the mass ratio of PTX to PLGA is 3:1. The invention further relates to preparation and application of the peripheral drug eluting stent. The peripheral drug eluting stent can effectively treat peripheral artery stenosis, and the problem of in-stent restenosis after a traditional peripheral bare metal stent is implanted into the peripheral vessel is avoided.

The slow released tolterodine tartate microcapsule preparation with homogeneous medicine release is one kind of slow release capsule with slow released microcapsule as main component, and the slow released microcapsule contains tolterodine tartate as the active component, slow releasing material and medicinal supplementary material in the weight ratio of 1-5 to 1-30 to 100-380. The preparation process of the slow released microcapsule includes the steps of mixing the main medicine component and the supplementary material, preparing the mixture into soft material, extruding and rounding. The slow released preparation can prolong the in vivo residence time of medicine, control the release of medicine, reduce medicine -taking times, lower the toxic side effect and raise curative effect.

The invention provides a matrine microcapsule preparation and a preparation method thereof. An in situ polymerization method or an interfacial polymerization method which exist is used for preparing matrine microcapsules, and raw materials are mixed according to a certain proportion and further processed into a microcapsule containing suspending agent; release rate of microcapsules is controlled according to different mixing proportions. An initial release rate of the preparation is high and persistent period is long; at the same time, the preparation has the advantages of high effective utilization rate of pesticides, environmental friendliness, light phytotoxicity, reduced leaching, low pollution for environments, and the like.

A preparing method of a controllable long-acting slow-release sodium nitrite corrosion inhibitor microcapsule is disclosed. The method includes (1) weighing dichloromethane, petroleum ether, Span 80 and hexadecyl trimethyl ammonium bromide in a certain mass ratio into a high-speed emulsifying machine, adding a mixed solution of styrene, methacrylic acid, glycidyl methacrylate and azobisisobutyronitrile in a certain mass ratio into the emulsifying machine, and transferring to a reaction kettle after a certain period of time of emulsification and dispersion, (2) adding sodium nitrite into the reaction kettle, performing a first stage reaction at 60-70 DEG C, raising the reaction temperature to 90-95 DEG C and performing a second stage reaction, and (3) cooling to room temperature, washing with water for twice, and colleting to obtain a sample. The sodium nitrite corrosion inhibitor microcapsule prepared by the method can achieve long-acting corrosion inhibition and has a wide application range.

The invention discloses graphene / anionic polysaccharide composite microsphere carrier and a preparation method thereof. A graphene support structure is constructed in anionic polysaccharide microspheres creatively, and fine regulation and control of particle sizes and composite structures of product microspheres are realized by regulation and control of feeding ratio and high-pressure injection conditions; the technology condition is simple and convenient, and raw material cost is low. The method is advantageous in that surfactants and chemical cross-linking agents which have toxicity and are difficult to remove are avoided; a high valence anionic cross-linking agent is used, physical interaction between graphene molecules and polysaccharide chains is matched, and one time solidification and shaping is carried out in order to obtain stable spherical structures. Structure stability of microspheres is substantially enhanced, and the carrier can better tolerate human body physiological salt environment; carrier preparation and medicine loading can be separated, in order to realize medicine loading after a mild condition, and completeness of medicament structure and function is protected to the largest extent; drug loading is substantially improved, and slow release is realized. The carrier and the method have wide promotion and application values.

A release-controlled Tuoteluoding tartrate for treating vesical disease is prepared from Tuoteluoding tartrate, C3-C20 aliphatic carboxylic acid or glycol, cellulose and its derivative, dextrin and polyvidone through mixing and granulating or tabletting. Its advantages are effective release control within 24 hr, simple preparing process and low cost.

The invention discloses a slow-release chlorine dioxide disinfection card taking zeolite as a carrier, and mainly relates to the field of chlorine dioxide disinfection. The invention relates to a chlorine dioxide sustained-release agent and a preparation method thereof, and aims to overcome the defects of unstable chlorine dioxide gas, short product preservation time and the like in the prior art. According to the invention, a natural zeolite material is used as a carrier and is compounded with sodium chlorite and a combined catalyst, and moisture and carbon dioxide in air are used for participating in a reaction to generate slow-release chlorine dioxide, so that the release rate of chlorine dioxide gas is artificially controllable, and bacteria and viruses are killed. The disinfection card has an ultra-long slow-release capability of more than 30 days, and plays an effective role in the aspects of protecting susceptible people from virus invasion, purifying harmful components in air and the like.

The invention discloses chloroacetamide herbicide capsule suspension and a production method thereof. The produced hloroacetamide herbicide capsule suspension is stable in quality and controllable inrelease rate, and has quick release efficacy and slow release efficacy at the same time; and the production method is simple to operate, easy to control, high in production efficiency and short in production time.

The present invention provides a processing preparation method of a soil nematode prevention and control microcapsule-containing suspending agent. According to the present invention, hyoscyamine and other soil nematode prevention and control microcapsules are prepared by using the existing in-situ polymerization method or interfacial polymerization method, and mixing according to a certain ratio is performed to prepare the microcapsule-containing suspending agent, wherein the release rate of the microcapsule is controlled according to different mixing ratios; and the preparation has advantages of high initial release rate, long lasting period, high effective pesticide utilization rate, environment protection, low phytotoxicity, eluviation reducing, low environment pollution, and the like.

The invention provides an in-situ treatment and repair method for polluted bottom mud, and the method comprises the following steps: (1) contacting or mixing a repair agent with the polluted bottom mud; (2) standing for reaction for 2-5 days; (3) contacting or mixing an immobilized composite microbial material with the polluted bottom mud; (4) standing for reaction for 5-20 days; and (5) during the process of the steps (1) and (3), oxygenating the polluted bottom mud for 2-3 times, wherein each time of oxygenating takes 15-30 minutes, and the 2-3 times of oxygenating are performed at time intervals of 30-60 minutes. Compared with dredging and other engineering methods, the in-situ remediation method for treating the polluted river bottom mud has the advantages of low engineering investmentcost, no influence on the surrounding environment in the process of engineering implementation, and gradual improvement of river microbial and microecological structures, and has excellent effect andlow cost by comprehensive utilization of physical, physical chemical, microbial and other means for treatment.

The invention discloses a medicine release speed controllable celecoxib porous microsphere for articular cavity injection and a preparation method of the celecoxib porous microsphere, and belongs to the technical field of pharmaceutical preparations. The porous microspheres are prepared from celecoxib and a high polymer material PLGA (poly (lactic-co-glycolic acid)); and the porous microspheres enable celecoxib to have a specific drug release characteristic, so that the drug can rapidly and effectively act on an inflammation part in a short time to play a rapid analgesic role, the drug can be slowly released in a later period to maintain the long-term detumescence and inflammation inhibition drug effects, the drug administration frequency is reduced, and the compliance of a patient is improved.

The invention provides slowly released type anti-rust microcapsules applied to steel reinforced concrete and a preparation method thereof. Each slowly released type anti-rust microcapsule applied to the steel reinforced concrete comprises a core material and a wall material, and is characterized in that the core material comprises an inorganic anti-rust agent and an auxiliary material; the wall material comprises a high molecular material capable of controlling releasing of the anti-rust agent; the core material is prepared from the following components in parts by weight: 100 parts of the inorganic anti-rust agent, 90 to 110 parts of microcrystalline cellulose and 2 to 4 parts of hydroxypropylmethyl cellulose. The slowly released type anti-rust microcapsules applied to the steel reinforced concrete, provided by the invention, have a smaller size, a relatively wide size regulation and control range and a higher drug loading ratio; the thickness of the wall material can be regulated and controlled according to requirements on a releasing speed and a period, so that the aim of controlling releasing is realized; the slowly released type anti-rust microcapsules applied to the steel reinforced concrete have the characteristics of simple preparation flow, high raw material utilization rate, high drug loading ratio, relatively wide size regulation and control range, long core material releasing period, controllable releasing speed and the like.