Bezafibrate sustained-release composition
A sustained-release composition, the technology of bezafibrate, applied in the field of bezafibrate sustained-release composition, can solve the problems of difficult to meet the expansion of use, increase of individual differences, and decrease of repeatability in vivo, and the release rate can be easily controlled , low production cost, and small fluctuations in blood drug concentration
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Embodiment 1
[0037] Example 1: Each 1000 bezafibrate sustained-release capsules contains the following substances:
[0038] Bezafibrate 400.0g main medicine
[0039] Ethyl cellulose 20.0g film forming material
[0040] Lactose 16.0g filler
[0041] PVP 10.0g adhesive
[0042] Magnesium stearate 0.5g lubricant
[0043] HPMC 10.0g adhesive
[0044] Blank pellet core 30.0g mother core
[0045] 1. Weigh PVP and prepare it into adhesive solution;
[0046] 2. Place the blank pellet core in the coating machine, take the mixture of bezafibrate, lactose, etc., spray the powder with the binder, and dry to obtain the drug-containing pellets;
[0047]3. Take the above-mentioned drug-containing pellets and place them in the coating machine, the speed of the pan is 10-50 revolutions per minute, the temperature in the pan is 20-50 ℃, and the coating liquid (such as the aqueous suspension of ethyl cellulose) is sprayed continuously. , The trade name is Surelease) onto the drug-containing pellets, evenly coat ...
Embodiment 2
[0050] Example 2: Each 1000 bezafibrate sustained-release capsules contains the following substances:
[0051] Bezafibrate 400.0g main medicine
[0052] Acrylic resin 30.0g slow release layer film forming material
[0053] Starch 10.0g Prepare blank pellet core
[0054] Sugar 20.0g Prepare blank pellet core
[0055] Xanthan gum 5.0g adhesive
[0057] Triethyl citrate 3.0g plasticizer
[0058] 1. Weigh xanthan gum and prepare it into a binder solution;
[0059] 2. After preparing the blank pellet core with sugar and starch, place it in a coating machine, take a mixture of bezafibrate, lactose, etc., spray and coat with a binder, and then dry it to obtain medicated pellets;
[0060] 3. Take the above-mentioned drug-containing pellets and place it in the coating machine, the speed of the pan is 10-50 revolutions per minute, the temperature in the pan is 20-50 ℃, and the coating liquid (acrylic resin) is continuously sprayed onto the drug-containing pelle...
Embodiment 3
[0063] Example 3: Each 1000 bezafibrate sustained-release capsules contains the following substances:
[0064] Bezafibrate 200.0g main medicine
[0065] Ethyl cellulose 28.0g slow-release film-forming material
[0066] Microcrystalline cellulose 20.0g filler
[0067] Starch 65.0g filler
[0069] HPMC 10.0g adhesive
[0070] Kaboom 5.0g adhesive
[0071] 1. Weigh HPMC and Carbomer and prepare it into a binder solution;
[0072] 2. Mix bezafibrate, microcrystalline cellulose and starch uniformly, make soft material with a binder, and obtain medicated pellets after extrusion, spheronization, drying and sieving;
[0073] 3. Take the above-mentioned drug-containing pellets and place in the coating machine, the speed of the pan is 10-50 revolutions per minute, the temperature in the pan is 20-50 ℃, and the coating liquid (ethyl cellulose) is sprayed continuously to the drug-containing pellets. On top, evenly coat a layer of sustained-release film coating, an...
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