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Graphene/anionic polysaccharide composite microsphere carrier and preparation method thereof

A technology of composite microspheres and graphene, applied in the direction of microcapsules, nanocapsules, pharmaceutical formulations, etc., can solve the problems of rapid disintegration of carrier structures, low bioavailability, and difficulty in controlled release, and achieve slow and reliable drug release rates. control, widely promote the application value, and enhance the effect of structural stability

Inactive Publication Date: 2017-03-29
JINAN UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The present invention aims at the low drug loading capacity of the single polyanionic polysaccharide microsphere carrier and the difficulty of controlled release, and when it is applied to the physiological environment of the human body, there may be rapid disintegration of the carrier structure and rapid release of the drug, resulting in low bioavailability and obvious side effects. The disadvantage is that it provides a method for preparing a graphene / anionic polysaccharide composite microsphere carrier with controllable particle size, stable structure, tolerance to the electrolyte environment of the human body, high drug loading capacity, and slow release

Method used

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  • Graphene/anionic polysaccharide composite microsphere carrier and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] At room temperature (25°C), add graphene oxide (GO) and carboxymethyl chitosan (CMCS) into deionized water, ultrasonically blend evenly, feed CMCS: 50mg / mL, GO: 5mg / mL; Driven by a micro-injection pump (3mL / h), the CMCS / GO mixed solution enters the electrostatic field (electric field voltage 10kV, plate distance 20cm) through a metal nozzle (Φ=250μm) and disperses into small droplets; Physical cross-linking and curing take place in the process. After centrifugation and purification, microspheres with a particle size better than 200 μm can be obtained. That is graphene oxide / carboxymethyl chitosan composite microspheres. The particle size and distribution of the product microspheres are regulated by the feed ratio and proportion of CMCS and GO, the injection speed and the electrostatic field force. The result is as figure 1 shown.

[0038] figure 1 It is the morphology characterization of graphene oxide / carboxymethyl chitosan (GO / CMCS) composite microspheres: (A) Ap...

Embodiment 2

[0042] At room temperature (25°C), add graphene oxide (GO) and sodium alginate (ALG) into deionized water, ultrasonically blend evenly, feed ALG: 40mg / mL, GO: 5mg / mL; Driven by (3mL / h), the ALG / GO mixed solution enters the electrostatic field (electric field voltage 10kV, plate distance 20cm) through the metal nozzle (Φ=250μm), and disperses into small droplets; Cross-linking, curing and forming. After centrifugation and purification, microspheres with a particle size better than 200 μm can be obtained. That is graphene oxide / sodium alginate composite microspheres. The particle size and distribution of the product microspheres are regulated by the feed ratio and proportion of ALG and GO, the injection speed and the electrostatic field force.

[0043]In the drug loading and in vitro release experiments, the product microspheres can effectively adsorb the model drug - Gatifloxacin (GFLX), and the drug loading can reach up to 0.28 mg / mg, which is higher than that of pure seawee...

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Abstract

The invention discloses graphene / anionic polysaccharide composite microsphere carrier and a preparation method thereof. A graphene support structure is constructed in anionic polysaccharide microspheres creatively, and fine regulation and control of particle sizes and composite structures of product microspheres are realized by regulation and control of feeding ratio and high-pressure injection conditions; the technology condition is simple and convenient, and raw material cost is low. The method is advantageous in that surfactants and chemical cross-linking agents which have toxicity and are difficult to remove are avoided; a high valence anionic cross-linking agent is used, physical interaction between graphene molecules and polysaccharide chains is matched, and one time solidification and shaping is carried out in order to obtain stable spherical structures. Structure stability of microspheres is substantially enhanced, and the carrier can better tolerate human body physiological salt environment; carrier preparation and medicine loading can be separated, in order to realize medicine loading after a mild condition, and completeness of medicament structure and function is protected to the largest extent; drug loading is substantially improved, and slow release is realized. The carrier and the method have wide promotion and application values.

Description

technical field [0001] The invention belongs to the field of controlled / sustained-release drug microcarriers, in particular to a graphene / anionic polysaccharide composite microsphere carrier and a preparation method thereof. Background technique [0002] (1) Preparation technology of anionic polysaccharide and its derivative microsphere carrier [0003] Anionic polysaccharides (carboxymethyl chitosan, sodium alginate, heparin, hyaluronic acid, etc.) have good biocompatibility and biodegradability, and are an excellent class of pharmaceutical carrier materials. The microsphere preparation methods mainly include emulsion method, spray drying method and the like. In order to avoid the toxicity and negative effects of emulsifiers and cross-linking agent residues, mild and efficient methods of dispersing granulation and physical cross-linking are preferred. For different application environments, matching polysaccharide carrier degradation and drug release is a technical diffic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/36A61K47/04A61K9/51A61K31/496
CPCA61K9/5115A61K9/5161A61K31/496
Inventor 施云峰薛巍陆雪飞闫昕
Owner JINAN UNIVERSITY
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