40 results about "Hyoscyamine" patented technology

The invention relates to an action of ferulic acid on enhancing the drug effect of some medicaments and a purpose thereof, wherein the medicaments mainly comprise alkaloid medicaments including matrine, kushenin, sophocarpine, hyoscyamine, narceine, hanfangchin A, jamaicin, morphine, codeine, evodiamine, strychnine, catharanthine, vincristine, taxol, verticine, peimine, peiminine, ephedrine, pseudoephedrine, wilfordine, triptolide, tripdiolide and the like, and flavonoid medicaments including puerarin, ginsenoside, ginsengenin, mangiferin, scutelloside, alkannin, meletin, rutin, hesperidin, daidzin, soybean isoflavone, daidzein, carthamin, catechin and the like. The ferulic acid and the medicaments can form a compound or a medicament compound, or the ferulic acid and the medicaments can generate a chemical reaction (including salification, esterification, amidation, ketonization, etherification and the like), and / or the ferulic acid and the medicaments can generate a synergistic effect and an additive effect.

A pharmaceutical dosage form which comprises two or more different hyoscyamine formulations, at least one of the formulations being an immediate release hyoscyamine formulation and at least one other one being a controlled release hyoscyamine formulation. This abstract is neither intended to define the invention disclosed in this specification nor intended to limit the scope of the invention in any way.

The invention provides a method for obtaining a regeneration plant of the woody stramonium with high yield of hyoscyamine and scopolamine by utilizing tissue culture technology to induce woody stramonium hairy root and relates to the method for inducing the regeneration plant of the woody stramonium hairy root to obtain the full woody stramonium plant which can produce hyoscyamine and scopolamine. The process of the invention is that first proper tissue culture technology is used for inducing the woody stramonium hairy root to obtain the woody stramonium regeneration plant. The regeneration plant is determined to be genetic transformation hairy root regeneration plant by molecule test and an HPLC test shows that the woody stramonium hairy root regeneration plant obtained from the tissue culture technology can produce hyoscyamine and scopolamine with a remarkably higher yield than wild plants. The method can provide a novel and sustainable medicinal herbs resource for the production of hyoscyamine and scopolamine.

The invention relates to the technical field of pesticide, in particular to a pesticide composition containing sanguinarine (macleaya alkaloids). The pesticide composition is prepared from, by weight, 0.1-30% of first pesticide, 0.1-80% of second pesticide, 5-80% of auxiliaries and 14.9-94.8% of a solvent or filler. The first pesticide is sanguinarine. The second pesticide comprises one of amino-oligosaccharin, cnidium lactone, spinosad, santonin, azadirachtin, wilforgine, neochamaejasmin, hyoscyamine and matrine. The auxiliaries comprise one or more of surfactant, a synergistic agent, an emulsifier, an anti-freezing agent, a dispersing agent, a wetting agent, a thickening agent, an ultraviolet protecting agent, a defoaming agent and an adhering agent. The pesticide belongs to plant source compound pesticide, the compound synergistic effect is remarkable, the pesticide composition can be used for preventing and treating various plant diseases, and pollution of chemical pesticide to the environment is reduced.

The invention provides a piglet colibacillosis lyophilized serum immunoglobulin preparation. The piglet colibacillosis lyophilized serum immunoglobulin preparation is composed of following components in parts by weight: 5.0-55.0 parts of saccharicterpenin, 0.005-0.01 parts of hyoscyamine, 55.0-95.0 parts of serum immunoglobulin. The piglet colibacillosis lyophilized serum immunoglobulin preparation disclosed by the invention has higher stability, can inhibit and kill colon bacillus more sustainably and more sufficiently, and has more remarkable anti-infection effects, so that the purpose of preventing and treating diarrhea of the piglet due to the colon bacillus can be realized more easily. Meanwhile, the piglet colibacillosis lyophilized serum immunoglobulin preparation is not only a pure natural environment-friendly type green and anti-infection drug without medicine residue, public hazard, drug tolerance and side effect, but is also an excellent medicine for replacing various harmful antibiotic medicines.

The invention discloses an extraction method of hyoscyamine and in particular relates to a method for Soxhlet and macroporous adsorption resin combined extraction and purification of hyoscyamine. The method mainly comprises the following steps: processing raw materials, performing biological enzymolysis, performing Soxhlet extraction, treating by a macroporous adsorption resin column, and concentrating to obtain hyoscyamine. The method is simple in process, high in extraction efficiency and easy for industrialized production.

The invention relates to a seed dressing agent as well as a preparation method and application thereof and belongs to the technical field of pesticide compounding, aiming at solving the technical problems of an existing process of producing a novel seed dressing agent by taking plant extract as a raw material that the cost of the raw material is high and the existing process is difficult to popularize and apply. The formula of the seed dressing agent comprises the following raw materials based on 100kg: 0.3kg to 0.7kg of athomin, 0.1kg to 0.4kg of hyoscyamine, 0.1kg to 0.4kg of a bacillus subtilis bacterium agent, 6kg to 10kg of herba houttuyniae and the balance of potassium fulvate. According to the seed dressing agent provided by the invention, bacteria carried by seeds are killed and inhibited by utilizing a biological method and a condition that the seeds are infected by soil-borne diseases is prevented; rodent damages, bird damages and underground insects are dispelled. The seed dressing agent is pesticide which accords with environment-friendly, healthy and sustainable development concept and also meets requirements of high efficiency, low toxin, low residues and broad-spectrum performance of environmental compatibility and belongs to environment-friendly pesticide. The preparation method of the seed dressing agent is simple and the cost of the raw materials is low. The seed dressing agent can be used as a seed dressing agent for seeds of corns, soybeans, rapeseeds, fruit and vegetables and rice.

The invention provides a method of genetically transforming the datura arborea by genetic engineering and obtaining the hairy root for producing hyoscyamine and scopolamine. The invention relates to a method of genetically transforming the datura arborea by agrobacterium rhizogenes. The genetically transforming can obtain the hairy root of the datura arborea used for producing hyoscyamine and scopolamine. The method can provide a continuous novel medicine source used for producing hyoscyamine and scopolamine.

The invention discloses a preparation method of hyoscyamine in Flos Daturae Innoxiae. The preparation method is characterized by comprising the following steps: a crude product of hyoscyamine is extracted from Flos Daturae Innoxiae by a chemical method; by alumina column chromatography, benzene-chloroform-isopropylamine is used as a mobile phase to carry out elution; and separation purification is carried out to obtain a pure product of hyoscyamine. The method has advantages of simple technology and stable product quality.

The invention discloses a scopolia acutangula hyoscyamine 6 Beta-hydroxylase gene which has a nucleotide sequence shown by SEQ ID NO.1, and also discloses a hyoscyamine 6 Beta-hydroxylase protein encoded by the SEQ ID NO.1 or containing an amino acid sequence shown by SEQ ID NO.2. In addition, the invention also discloses the application of the hyoscyamine 6 Beta-hydroxylase gene in expressing a eukaryotic cell in scopolia acutangula and improving the scopolamine content in transgenic rooting. The invention obviously improves the content of effective components in plant resources and can be used for improving the quality of traditional Chinese medicinal materials such as the scopolia acutangula, and the like.

The present disclosure relates to a paper deacidification agent composition and a deacidification method for acidified paper. The composition comprises alkaloid, a soluble tetraborate and a solvent, wherein the alkaloid comprises one or more of scopolamine, hyoscyamine, demethylated hyoscyamine and anisodamine. The paper deacidification agent composition can complex with alum in the acidified paper so as to prevent the aluminum ion water from separating out acids, and can form alkali residues on the papers so as to moderate the secondary acidification of the paper; the influences on the appearances and colors of the paper are not great; besides the deacidification, the folding resistance and tensile strength of the paper are strengthened; and the pH values of the paper after the deacidification is 7 to 8.5, thereby effectively prolonging the paper life of paintings and calligraphies.

A bactericidal disinfectant solution for Miscanthus and its preparation method. The disinfectant solution is made of the following raw materials in parts by weight: 1-2 parts of gallic acid, 0.1-0.2 parts of L-1,2-dehydro-α-cyperene, and 0.1-0.2 parts of calamus 0.1-0.2 parts of alkenediol, 0.4-0.6 parts of hyoscyamine, 0.4-0.6 parts of phosphatidic acid ethanolamine, 1-2 parts of Bletilla striata dihydrophenanthrenopyranol, 0.5-1.2 parts of methyl corydalis, 10 parts of violet water -15 parts, 0.2-0.5 parts of eucalyptol, 14-20 parts of modified plant extract, 260-300 parts of deionized water. The disinfectant of the present invention has the function of sterilization and disinfection, can kill 100% of the bacteria in pampas grass, and the disinfectant has a certain self-cleaning ability, the disinfectant after use can be reused after standing, and the disinfectant can be used repeatedly for 5-6 Second, the utilization rate is high, the viscosity of the disinfectant is low, it is not easy to stick to Miscanthus, and it can improve the anti-corrosion and flame-retardant properties of Miscanthus, greatly improving the service life of Miscanthus brooms.

The invention belongs to the technical field of biological engineering and discloses a recombinant bacterial strain and a method for catalytically synthesizing scopolamine by using the bacterial strain. The recombinant bacterial strain comprises exogenous acutangular anisodus root hyoscyamine 6 beta-hydroxylase genes and can convert a hydroxylase substrate into the scopolamine, wherein the conversion efficiency is 80 percent. The invention provides a method for producing the scopolamine with high medical value. The scopolamine can meet the important clinical requirement and is a novel high-quality medicinal resource.

The present invention provides a processing preparation method of a soil nematode prevention and control microcapsule-containing suspending agent. According to the present invention, hyoscyamine and other soil nematode prevention and control microcapsules are prepared by using the existing in-situ polymerization method or interfacial polymerization method, and mixing according to a certain ratio is performed to prepare the microcapsule-containing suspending agent, wherein the release rate of the microcapsule is controlled according to different mixing ratios; and the preparation has advantages of high initial release rate, long lasting period, high effective pesticide utilization rate, environment protection, low phytotoxicity, eluviation reducing, low environment pollution, and the like.

The invention relates to the technical field of extraction of traditional Chinese medicinal components, in particular to an extracting method for hyoscyamine and scopolamine in a prescription preparation. The extracting method at least comprises the following steps: sampling a prescription preparation, adding ethanol with the volume concentration of 70 to 80 percent, carrying out ultrasonic extraction, centrifuging, and evaporating supernate to dryness to obtain first residues; dissolving the first residues into an ammonia solution, adding trichloromethane for carrying out ultrasonic extraction, separating an extracting solution to obtain a trichloromethane solution, and evaporating the trichloromethane solution to dryness to obtain second residues; adding methanol with the volume concentration of 45 to 55 percent into the second residues, and carrying out ultrasonic extraction, thus obtaining an extracting solution containing the hyoscyamine and the scopolamine. According to the extracting method provided by the invention, the influence from other components in the prescription preparation is avoided; by organically combining different extracting and separating methods, the hyoscyamine and the scopolamine in the prescription preparation are extracted.

The present invention discloses a hyoscyamine aldehyde reductase synthase(HAR) and its application, the hyoscyamine aldehyde reductase synthase has an amino acid residue sequence shown as SEQ ID NO. 4, and a nucleotide sequence shown as SEQ ID NO. 3; the catalyzed reaction product hyoscyamine aldehyde after the prokaryotic expression is hyoscyamine, the hyoscyamine aldehyde is used to transform atropa belladonna, which can increase the content of hyoscyamine in atropa belladonna cell line, and has important meaning to increase the content of tropane alkaloids in atropa belladonna.

The invention discloses a liquid medicine for treating foot osmidrosis, which is prepared by placing one portion of radix stemonae, two portions of realgar, two portions of broom cypress fruit, and one portion of khosam into forty portions of edible vinegar. After three days of soaking, two layers of gauze filter the dregs, and 0.004 portion of hill hyoscyamine is added into the filtrate. The liquid medicine cures the foot osmidrosis by reducing fever, drying dampness, resisting bacterium, diminishing inflammation, reducing sweat gland secretion.

The invention provides a method for extracting scopolamine, hyoscyamine and pseudohyoscyamine from flos daturae. An impregnation method is combined with an acid extraction method, a water phase and an organic phase are respectively dissolved by using a weak base solution or an acid solution, the pH value is adjusted, chloroform is introduced for extraction, and through a self-made continuous tube type extraction device, a mixture of scopolamine, hyoscyamine and pseudohyoscyamine is obtained through continuous on-line multi-stage circular extraction separation. The method is simple, the extraction rate is high, and the method can be used as a means for large-scale extraction of flos daturae with different contents.

The invention discloses a medicine composition for treating diabetes and constipation and a preparation method thereof. Hyoscyamine is the raw material medicine, which is prepared by proportioning, and can be made into various dosage forms according to the conventional preparation process, and has remarkable curative effect in treating diabetes and constipation.

The invention discloses a glyphosate herbicide applicable to weeds in vegetable fields. The glyphosate herbicide comprises, by weight, 35-40 parts of gyphosate solutions, 3-5 parts of hyoscyamine, 1-4parts of coumarin, 2-4 parts of szechwan Chinaberry fruit extract, 2-4 parts of radix bupleuri extract, 1-3 parts of rhizoma anemarrhenae extract, 5-10 parts of cylindrosporium phalaenopsidis sawada,1-5 parts of synergists, 3-7 parts of fumed silica, 4-6 parts of rosemary oil, 3-5 parts of dispersing agents, 3-7 parts of diatomite, 2-8 parts of carboxymethylcellulose and 40-55 parts of deionizedwater. The glyphosate herbicide has the advantages that obvious spread-spectrum synergism, high safety and high herbicidal activity are achieved, majority of gramineous weeds and broad-leaf weeds canbe killed, and the weeding effect is enhanced; the herbicide can be degraded easily in crops, safety is high, side effects are avoided, and environment pollution is small; the preparation method is reasonable, operation is facilitated, production cycle is short, energy consumption is low, quality stability is high, and the glyphosate herbicide is easy to popularize and apply.

The invention relates to an atropa belladonna calmodulin AbCaM1 gene and a recombinant plant expression vector and applications thereof. The nucleotide sequence of the AbCaM1 gene is as shown in SEQ ID NO.1. A gene engineering method is adopted, and the AbCaM1 gene is transferred into atropa belladonna plants through the mediation of agrobacterium tumefaciens. Compared with wild atropa belladonna,the contents of hyoscyamine and scopolamine in the trans-AbCaM1 gene atropa belladonna are obviously improved. The establishment of the method provides a new idea for reducing the production cost andefficiently producing the hyoscyamine and the scopolamine.

The invention relates to an anisodus luridus ornithine decarboxylase ALODC gene as well as a recombinant expression vector and application thereof. By cloning the anisodus luridus ornithine decarboxylase ALODC gene, through an agrobacterium tumefaciens mediation method, the gene is transferred into anisodus luridus, a transgenic plant is obtained, after ALODC over-expression is conducted, the contents of putrescine and tropane alkaloids in the anisodus luridus plant can be significantly improved, and an ideal method is provided for effectively producing hyoscyamine and scopolamine by means ofa transgenic technology.

The invention discloses a hyoscyamine emulsion which is characterized by comprising the following components by weight: 5-12 parts of hyoscyamine, 10-23 parts of nicotine, 1-3 parts of sodium dodecyl sulfate, 1-2 parts of calcium ricinoleate, 1-2 parts of ethylene glycol and 65-75 parts of water; the formula is scientific and reasonable, the plant source insecticide is from nature, can be degraded in nature, generally may not pollute the environment and agricultural products, is relatively safe to people and livestock, small in harm to natural enemies of pests, and difficult for the pests to produce antibodies, and has the features of low toxicity and low residue.

The invention relates to an atropa belladonna calmodulin AbCaM1 gene and a recombinant plant expression vector and applications thereof. The nucleotide sequence of the AbCaM1 gene is as shown in SEQ ID NO.1. A gene engineering method is adopted, and the AbCaM1 gene is transferred into atropa belladonna plants through the mediation of agrobacterium tumefaciens. Compared with wild atropa belladonna,the contents of hyoscyamine and scopolamine in the trans-AbCaM1 gene atropa belladonna are obviously improved. The establishment of the method provides a new idea for reducing the production cost andefficiently producing the hyoscyamine and the scopolamine.

The invention belongs to the technical field of biological engineering and discloses a recombinant bacterial strain and a method for catalytically synthesizing scopolamine by using the bacterial strain. The recombinant bacterial strain comprises exogenous acutangular anisodus root hyoscyamine 6 beta-hydroxylase genes and can convert a hydroxylase substrate into the scopolamine, wherein the conversion efficiency is 80 percent. The invention provides a method for producing the scopolamine with high medical value. The scopolamine can meet the important clinical requirement and is a novel high-quality medicinal resource.

The present invention relates to stable orally disintegrating tablets of hyoscyamine or pharmaceutically acceptable salts thereof. The invention also relates to processes for the preparation of such tablets and use thereof.

The invention discloses a method for increasing tropane alkaloid content in belladonna hairy roots by using a calcium signal inhibitor, which is characterized in that extracellular Ca < 2 + > concentration is reduced by using a Ca < 2 + > specific chelating agent, or a Ca < 2 + > / CaM signal pathway in the belladonna hairy roots is inhibited by using a cell membrane Ca < 2 + > channel inhibitor or an intracellular Ca < 2 + > receptor calmodulin inhibitor, so that the content of tropane alkaloid in the belladonna hairy roots is increased. Therefore, the expression of related genes PMT, TRI, CYP80F1, H6H and ArAT4 in the synthetic route of the tropane alkaloids is induced, and the synthesis and accumulation of the tropane alkaloids hyoscyamine, anisodamine or scopolamine are promoted.

The invention provides a toughening treatment fluid for ironweed and a preparation method of the toughening treatment fluid. The toughening treatment fluid is prepared from the following raw materials in parts by weight: 10-18 parts of glycerinum, 0.5-1 part of 3,3',5-methoxybibenzyl, 0.2-0.4 part of acorenone, 1-1.5 parts of hyoscyamine, 0.8-1 part of dexamethasone, 0.1-0.2 part of limonene, 0.2-0.4 part of castor oil polyoxyethylene ether, 0.2-0.4 part of geraniol, 8-14 parts of a modified plant extracting solution and 260-280 parts of deionized water. The treatment fluid can permeate in the ironweed, leaking of juice of the ironweed is facilitated, so that the toughness of the ironweed is remarkably improved, herbal flavor of the ironweed can be removed, and a broom which is manufactured by the treated ironweed is durable, and is high in bacteria erosion resistance, excellent in acid-base resistance and salt mist resistance and quite high in yield strength.

The invention relates to the technical field of drug analysis and detection, in particular to an atropa belladonna liquid extract and a method for detecting atropine in a sample containing the atropabelladonna liquid extract. The atropa belladonna liquid extract or the sample containing the atropa belladonna liquid extract is detected by using high performance liquid chromatography, wherein the chromatographic column is a Chiral CD-Ph chiral chromatographic column, and the mobile phase is a mixed solution of acetonitrile and a phosphate buffer solution. The method can effectively detect the content of hyoscylamine in the atropa belladonna liquid extract or the sample containing the atropa belladonna liquid extract, can judge whether atropine is additionally added or not, and ensures the safety of raw material medicines and finished medicines.