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Piglet colibacillosis lyophilized serum immunoglobulin preparation and preparation process thereof

A technology of colibacillosis and serum immunity, which is applied in the direction of serum immunoglobulin, antibacterial immunoglobulin, freeze-dried delivery, etc., can solve the problems of difficult clinical wide acceptance, high price, and difficult implementation of use

Active Publication Date: 2013-04-03
中润合(北京)农业科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] For example, interferon, cytokines, etc., are difficult to be widely accepted clinically due to their high price. As for the use in animal infectious diseases, it is even more difficult to implement

Method used

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  • Piglet colibacillosis lyophilized serum immunoglobulin preparation and preparation process thereof
  • Piglet colibacillosis lyophilized serum immunoglobulin preparation and preparation process thereof
  • Piglet colibacillosis lyophilized serum immunoglobulin preparation and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0179] The infectious agent of this preparation is Escherichia coli (ETEC K88 K99 987P).

[0180] The components and parts by weight of the piglet colibacillosis freeze-dried serum immunoglobulin preparation of the present embodiment are as follows:

[0181] Saccharoterpenoids 12.0

[0182] Scopolamine 0.008

[0183] Serum immunoglobulin 88.0

[0184] The preparation of this example was prepared by the following method:

[0185] 1. Preparation of saccharoterpenoids

[0186] (1) Sugar extraction:

[0187] a. Take Atractylodes Rhizoma Atractylodes 40, Atractylodes Rhizoma 30, Muxiang 20 and Alisma orientalis 10 in proportion by weight, chopped, washed, soaked in cold water for 2 hours until the core of the medicine is fully soaked, then add water 12 times the total weight of the traditional Chinese medicine, and heat to After boiling, under the condition of 90 ℃, decoct for 180 minutes under the heat reflux concentration process and concentrate to obtain concentrated medici...

Embodiment 2

[0225] The infectious agent of this preparation is Escherichia coli (ETEC K88 K99 987P).

[0226] The components and parts by weight of the piglet colibacillosis freeze-dried serum immunoglobulin preparation of the present embodiment are as follows:

[0227] Saccharoterpenoids 55

[0228] Scopolamine 0.005

[0229] Serum immunoglobulin 55.0

[0230] The preparation method is basically the same as that of Example 1, except that the sugars and triterpenoid saponins in the saccharoterpenes are extracted from the following traditional Chinese medicines in parts by weight: Atractylodes Rhizoma 30, Atractylodes Rhizoma 40, Muxiang 15 and Alisma 15.

[0231] The quality standard is the same as that of Example 1.

Embodiment 3

[0233] The infectious agent of this preparation is Escherichia coli (ETEC K88 K99 987P).

[0234] The components and parts by weight of the piglet colibacillosis freeze-dried serum immunoglobulin preparation of the present embodiment are as follows:

[0235] Saccharoterpenoids 30

[0236] Scopolamine 0.0055

[0237] Serum Immunoglobulin 70

[0238] The preparation method is basically the same as in Example 1, except that the sugars and triterpenoid saponins in the saccharoterpenoids are all extracted from the following traditional Chinese medicines in parts by weight: Atractylodes Rhizoma 50, Atractylodes Rhizoma 20, Muxiang 15 and Alisma 15.

[0239] The quality standard is the same as that of Example 1.

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Abstract

The invention provides a piglet colibacillosis lyophilized serum immunoglobulin preparation. The piglet colibacillosis lyophilized serum immunoglobulin preparation is composed of following components in parts by weight: 5.0-55.0 parts of saccharicterpenin, 0.005-0.01 parts of hyoscyamine, 55.0-95.0 parts of serum immunoglobulin. The piglet colibacillosis lyophilized serum immunoglobulin preparation disclosed by the invention has higher stability, can inhibit and kill colon bacillus more sustainably and more sufficiently, and has more remarkable anti-infection effects, so that the purpose of preventing and treating diarrhea of the piglet due to the colon bacillus can be realized more easily. Meanwhile, the piglet colibacillosis lyophilized serum immunoglobulin preparation is not only a pure natural environment-friendly type green and anti-infection drug without medicine residue, public hazard, drug tolerance and side effect, but is also an excellent medicine for replacing various harmful antibiotic medicines.

Description

technical field [0001] The invention belongs to the field of biopharmaceuticals, and particularly relates to a freeze-dried serum immunoglobulin preparation for piglet colibacillosis and a preparation process thereof. Background technique [0002] Escherichia coli diarrhea in piglets is acute and the mortality rate is as high as 90%. Once the piglets become ill, they die in large numbers before they can be treated. Since the discovery of penicillin more than 80 years ago, a large number of antibiotics and synthetic chemicals have been successively developed. The invention and application of these drugs have greatly reduced the common clinical bacterial infections and mortality, including piglet Escherichia coli diarrheal disease. However, with the frequent use and long-term high-dose use of these drugs, bacteria have acquired drug resistance, and drug resistance genes present in bacterial chromosomes, plasmids and transposons can be transformed, transduced, combined and tr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/40A61K9/19A61P31/04C07K16/12C07K16/06A61K31/46A61K36/884
Inventor 李尚波苗玉和张勇飞舒秀伟
Owner 中润合(北京)农业科技有限公司
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