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Matrine microcapsule preparation and preparation method thereof

A technology of microcapsules and matrine, applied in the fields of botanical equipment and methods, pesticides, biocides, etc., can solve the problems of difficult to control the release rate, unsatisfactory field efficacy, and short duration of effect, etc. The effect of reducing the cost of prevention and treatment, reducing the frequency of medication, and prolonging the duration of effect

Inactive Publication Date: 2016-12-14
SHANDONG ACADEMY OF PESTICIDE SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, although there are reports on the preparation of microcapsules by in-situ polymerization or interfacial polymerization, there are generally problems such as difficulty in controlling the release rate and unsatisfactory drug efficacy in the field. Problems such as duration of validity are too short, the purpose of the present invention is exactly in order to coordinate the relationship between the two

Method used

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  • Matrine microcapsule preparation and preparation method thereof
  • Matrine microcapsule preparation and preparation method thereof
  • Matrine microcapsule preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1. Interfacial polymerization method 0.5% matrine microcapsule suspension.

[0040] Dissolve 5 parts of matrine crude oil in 3 parts of biodiesel, mix with 4 parts of oil-soluble capsule wall material diisocyanate (TDI), and add to 120 parts of 0.5% OP-10 aqueous solution (OP-10 is octal phenol poly Oxyethylene ether-10), after stirring rapidly at 1000r / min, 4 parts of glycerol were slowly added dropwise into the reaction vessel. Reduce the rotational speed to 300r / min, and keep warm at 35°C for 30min to obtain matrine microcapsules.

[0041] Add 5 parts of wetting agent Nongru 600#, 5 parts of sodium lignosulfonate as a dispersant and 4 parts of sodium hydroxymethylcellulose as a structure regulator, and stir evenly to suspend matrine microcapsules with a thickness of 0.5% multicystic wall agent.

[0042] Microcapsule average particle size d(μm)

Embodiment 2

[0043] Example 2. In-situ polymerization method 0.5% matrine multi-capsule wall thickness microcapsule suspension.

[0044] (1) Preparation of urea-formaldehyde resin prepolymer aqueous solution: Mix and dissolve 10 parts of urea and 24 parts of formaldehyde, add 42 parts of deionized water, adjust the pH to 8.0, and keep it at 70°C for 1 hour to obtain a mass fraction of 25% urea-formaldehyde resin prepolymer. polymer (UF) solution.

[0045] (2) preparation of matrine microcapsules:

[0046] a: 5 parts of matrine crude oil are dissolved in 3 parts of biodiesel to obtain capsule core oil phase, join in 60 parts of 3% UF aqueous solution (3% refers to the mass fraction of urea-formaldehyde resin prepolymer UF, by step (1) The prepared 25% urea-formaldehyde resin prepolymer solution was diluted to obtain, hereinafter the same), adding 2.5 parts of Tween 60 and 2 parts of dispersant NNO; 1000r / min stirred and dispersed into O / W emulsion; slowly adjusted pH to 2.5, then graduall...

Embodiment 3

[0058] Example 3, in-situ polymerization method 1.0% matrine multi-capsule wall thickness microcapsule suspension.

[0059] Method is the same as example 2, get 10 parts of matrine crude oil and be dissolved in 5 parts of biodiesel in the preparation process, agent a: 60 parts of UF prepolymer (4%), 3 parts of emulsifier styrene maleic anhydride, dispersant lignin 2 parts of sodium sulfonate, stirred at 1000r / min to form O / W emulsion. Agent b: 60 parts of UF prepolymer (5%), 3 parts of emulsifier styrene maleic anhydride, 3 parts of dispersant sodium lignosulfonate, stirred and dispersed at 1200r / min to form an O / W emulsion c: UF prepolymer Body (7%) 60 parts, emulsifier styrene maleic anhydride 4 parts, dispersant sodium lignosulfonate 4 parts, 1500r / min stirring and dispersing into O / W emulsion. Other processes are the same as in Example 2, and processed into 1.0% matrine multi-capsule wall thickness microcapsule suspension.

[0060] Its particle size and capsule wall thic...

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Abstract

The invention provides a matrine microcapsule preparation and a preparation method thereof. An in situ polymerization method or an interfacial polymerization method which exist is used for preparing matrine microcapsules, and raw materials are mixed according to a certain proportion and further processed into a microcapsule containing suspending agent; release rate of microcapsules is controlled according to different mixing proportions. An initial release rate of the preparation is high and persistent period is long; at the same time, the preparation has the advantages of high effective utilization rate of pesticides, environmental friendliness, light phytotoxicity, reduced leaching, low pollution for environments, and the like.

Description

technical field [0001] The invention belongs to the field of processing and application of pesticide formulations, and relates to the improvement technology of matrine microcapsules. Background technique [0002] Matrine is a quinolizidine alkaloid in Sophora genus plants such as Sophora flavescens and Sophora flavescens. Its outstanding advantages are broad spectrum, high efficiency, low toxicity, safe for humans and animals, harmless to natural enemies, and not easy for pests. It produces resistance and has no accumulation and residue in organisms, and has been widely used in the control of underground nematodes and agricultural and forestry pests. [0003] At present, domestic matrine is mainly processed into emulsifiable concentrates, water preparations and powders. Due to the large amount of organic solvents used, the harm to the environment is serious; and due to the high initial drug concentration, it is easy to cause phytotoxicity to crops. , the duration becomes sh...

Claims

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Application Information

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IPC IPC(8): A01N43/90A01N25/28A01N25/04A01P5/00A01P7/04
CPCA01N43/90A01N25/04A01N25/28
Inventor 庄占兴郭雯婷刘钰崔蕊蕊范金勇庄治国徐娜娜徐英王龙龙
Owner SHANDONG ACADEMY OF PESTICIDE SCI
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