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Metal ion cross-linked hydrogel as well as preparation method and application thereof

A technology for cross-linking hydrogels and metal ions, applied in gel preparation, chemical instruments and methods, colloid chemistry, etc., can solve the problem of uncontrollable release of metal ions, complex hydrogel preparation methods, and suitable metal ion cross-linking systems. narrow range and other problems, to achieve the effects of controllable gel time, good prospects for large-scale production, and mild preparation conditions

Active Publication Date: 2021-03-02
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to provide a metal ion cross-linked hydrogel and its preparation method and application, which solves the problems of complex preparation methods of the existing hydrogel, uncontrollable release of metal ions, and narrow application range of the metal ion cross-linking system

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  • Metal ion cross-linked hydrogel as well as preparation method and application thereof
  • Metal ion cross-linked hydrogel as well as preparation method and application thereof

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preparation example Construction

[0025] A kind of preparation method of metal ion cross-linked hydrogel of the present invention, comprises the following steps:

[0026] (1) Use the carbodiimide method to graft small organic molecules containing hydrazide groups on water-soluble polymers containing carboxyl groups, react at room temperature for 12 to 36 hours, and then go through dialysis-freeze-drying process or non-solvent precipitation process , to obtain a hydrazide polymer with a modification degree of 5% to 80%;

[0027] (2) Mixing the hydrazidated polymer aqueous solution and the metal ion solution evenly to obtain the metal ion cross-linked hydrogel.

[0028] The used reagent of the carbodiimide method described in step (1) is 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide, 1- The amount of (3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride is 1 to 1.2 times the molar number of carboxyl groups to be modified in the carboxyl-containing water-soluble polymer...

Embodiment 1

[0039]Sodium hyaluronate with a molecular weight of 200kDa is made into a solution with a mass percentage concentration of 1%; then, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide with a degree of modification of 1 times is added Hydrochloride and 1.1 times N-hydroxysuccinimide, followed by 3,3'-dithiodipropionylhydrazide with 10 times the number of hydrazide groups to be modified; at pH 5.0 After reacting at room temperature for 24 hours, use a dialysis bag with a molecular weight cut-off of 1000Da to dialyze water for 10 hours, and then freeze-dry at minus 20 degrees Celsius for 24 hours to obtain hydrazide hyaluronic acid with a modification degree of 20%. Finally, hydrazide The hyaluronic acid is made into an aqueous solution with a mass concentration of 3%, and is uniformly mixed with the calcium chloride solution to obtain a calcium ion cross-linked hyaluronic acid hydrogel, wherein the mass percentage concentration of the calcium ion is 0.1%.

[0040] The photo of the hy...

Embodiment 2

[0042] Sodium hyaluronate with a molecular weight of 200kDa is made into a solution with a mass percentage concentration of 1%; then, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide with a degree of modification of 1 times is added Hydrochloride and 1.1 times N-hydroxysuccinimide, followed by 3,3'-dithiodipropionylhydrazide with 10 times the number of hydrazide groups to be modified; at pH 5.0 After reacting at room temperature for 24 hours, use a dialysis bag with a molecular weight cut-off of 1000Da to dialyze water for 10 hours, and then freeze-dry at minus 20 degrees Celsius for 24 hours to obtain hydrazide hyaluronic acid with a modification degree of 20%. Finally, hydrazide The hyaluronic acid is made into an aqueous solution with a mass concentration of 3%, and is uniformly mixed with the silver nitrate solution to obtain a silver ion cross-linked hyaluronic acid hydrogel, wherein the mass percentage concentration of the silver ion is 0.2%.

[0043] The photo of the hydro...

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Abstract

The invention discloses metal ion cross-linked hydrogel and a preparation method and application thereof. Hydrazide group modified water-soluble macromolecules are prepared through a carbodiimide method, then a hydrazide polymer aqueous solution and a metal ion solution are mixed to be uniform, and the metal ion cross-linked hydrogel is obtained. The hydrogel disclosed by the invention takes metalions as a cross-linking agent, has the advantages of controllable gelling time, adjustable mechanical properties, self-healing property and the like, and is simple in preparation method, mild in process conditions and wide in applicable metal ion variety. The hydrogel disclosed by the invention has a wide application prospect in the fields of three-dimensional tumor model construction, tumor local treatment, biomedical diagnosis and treatment agents, wound antibacterial dressings, drug delivery, removal of heavy metal ions in sewage and the like.

Description

technical field [0001] The invention belongs to the technical field of hydrogels, and in particular relates to a metal ion crosslinked hydrogel, a preparation method and an application thereof. Background technique [0002] Hydrogel is a polymer system with a water content higher than 95% and a three-dimensional network structure. Due to the advantages of good biocompatibility, high water absorption rate, adjustable mechanical properties, and flexible preparation methods, hydrogels have important application value in the fields of biomedicine, medical beauty products, water treatment, 3D printing, and drug delivery. [0003] There are various methods for preparing hydrogels, which are mainly divided into two categories, namely chemically cross-linked hydrogels and physically cross-linked hydrogels. Chemically cross-linked hydrogel is a three-dimensional network structure system formed mainly through chemical cross-linking polymerization or the formation of covalent bonds be...

Claims

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Application Information

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IPC IPC(8): B01J13/00
CPCB01J13/0065
Inventor 钱军民纪利杰胥伟军
Owner XI AN JIAOTONG UNIV
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