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Peripheral drug eluting stent and preparation and application thereof

A technology for eluting stents and drugs, applied in medical science, surgery, coating, etc., can solve problems such as poor sustained release effect and affect the efficacy of peripheral drug-eluting stents, and achieve prevention of early burst release, prevention of restenosis, strong effect of drug action

Active Publication Date: 2017-12-22
北京永益润成科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] With the wide application of drug-eluting stent systems and the continuous development of new technologies, peripheral drug-eluting stents are now used instead of bare-metal stents in peripheral vascular interventional therapy. A serious shortcoming of the stent is the "burst release" phenomenon, that is, the drug release amount reaches about 70% within 24 hours after the stent is implanted, and the effective drug concentration in the subsequent release period is obviously insufficient, which seriously affects the peripheral drugs. Efficacy of Eluting Stents

Method used

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  • Peripheral drug eluting stent and preparation and application thereof
  • Peripheral drug eluting stent and preparation and application thereof
  • Peripheral drug eluting stent and preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] In the three peripheral drug-eluting stents provided in this embodiment, three drug coatings are sprayed on the outside of the three bare metal stents. The specific preparations of peripheral stents 1, 2, and 3 are as follows:

[0039] Preparation of spraying liquid for stent 1:

[0040] Drug configuration on the outer layer of the drug stent: Weigh 10mg PLGA (molecular weight 30000, PLA: PGA=70:30), add 10ml tetrahydrofuran, magnetically stir for 30-60min to completely dissolve the polymer;

[0041] Drug configuration in the middle layer of the drug stent: Weigh 20mgPTX and 10mgPLGA (molecular weight 20000, PLA:PGA=50:50), add 10ml tetrahydrofuran respectively, and magnetically stir for 30-60min to completely dissolve the polymer;

[0042] Drug configuration in the inner layer of the drug stent: Weigh 20 mg PTX and 10 mg PLGA (molecular weight: 20000, PLA: PGA = 80:20), add 10 ml of tetrahydrofuran, and magnetically stir for 30-60 minutes to completely dissolve the polymer.

[...

Embodiment 2

[0054] In the three peripheral drug-eluting stents provided in this embodiment, three drug coatings are sprayed on the outside of the three bare metal stents. The specific preparations of peripheral stents 4, 5, and 6 are as follows:

[0055] Preparation of spraying liquid for stent 4:

[0056] Drug configuration on the outer layer of the drug stent: Weigh 10mg PLGA (molecular weight 20000, PLA:PGA=70:30), add 10ml tetrahydrofuran, magnetically stir for 30-60min to completely dissolve the polymer;

[0057] Drug configuration in the middle layer of the drug stent: Weigh 30mgPTX and 10mgPLGA (molecular weight 20000, PLA:PGA=50:50), add 10ml tetrahydrofuran respectively, and magnetically stir for 30-60min to completely dissolve the polymer;

[0058] Drug configuration in the inner layer of the drug stent: Weigh 30 mg of PTX and 10 mg of PLGA (molecular weight: 20000, PLA: PGA = 80:20), add 10 ml of tetrahydrofuran, and magnetically stir for 30-60 minutes to completely dissolve the polyme...

Embodiment 3

[0070] In the three peripheral drug-eluting stents provided in this embodiment, three drug coatings are sprayed on the outside of the three bare metal stents. The specific preparations of peripheral stents 7, 8, 9 are as follows:

[0071] Preparation of spraying liquid for stent 7:

[0072] Drug configuration on the outer layer of the drug stent: Weigh 10mg PLGA (molecular weight 30000, PLA: PGA=70:30), add 10ml tetrahydrofuran, magnetically stir for 30-60min to completely dissolve the polymer;

[0073] Drug configuration in the middle layer of the drug stent: Weigh 30mgPTX and 10mgPLGA (molecular weight 20000, PLA:PGA=50:50), add 10ml tetrahydrofuran respectively, and magnetically stir for 30-60min to completely dissolve the polymer;

[0074] Drug configuration in the inner layer of the drug stent: Weigh 30 mg of PTX and 10 mg of PLGA (molecular weight: 20000, PLA: PGA = 80:20), add 10 ml of tetrahydrofuran, and magnetically stir for 30-60 minutes to completely dissolve the polymer. ...

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Abstract

The invention provides a peripheral drug eluting stent. A drug coating of the peripheral drug eluting stent is divided into an outer sustained-release layer, an intermediate drug sustained-release mixed layer and an inner drug sustained-release mixed layer. The outer sustained-release layer is PLGA with molecular weight being 30000, and PLA:PGA=70:30. The intermediate drug sustained-release mixed layer is a mixture of PTX and PLGA, wherein the molecular weight of PLGA is 20000, PLA:PGA=50:50, and the mass ratio of PTX to PLGA is 3:1. The inner drug sustained-release mixed layer is a mixture of PTX and PLGA, wherein the molecular weight of PLGA is 20000, PLA:PGA=80:20, and the mass ratio of PTX to PLGA is 3:1. The invention further relates to preparation and application of the peripheral drug eluting stent. The peripheral drug eluting stent can effectively treat peripheral artery stenosis, and the problem of in-stent restenosis after a traditional peripheral bare metal stent is implanted into the peripheral vessel is avoided.

Description

Technical field [0001] The invention relates to a peripheral drug eluting stent and its preparation and application. Background technique [0002] The incidence of peripheral vascular diseases has increased significantly in recent years, such as arteriosclerotic obliterans and arteriovenous thrombosis. At present, my country's professional technology for the treatment of peripheral vascular diseases is developing vigorously, traditional surgical techniques are constantly being improved, and the application of interventional treatment methods in clinical practice is also becoming more extensive. The clinical application of self-expanding peripheral vascular stents is an important milestone in the treatment of peripheral vascular stenosis diseases. However, the problem of in-stent restenosis caused by many traditional peripheral metal bare metal stents implanted in peripheral blood vessels has become more obvious. According to statistics, the medium and long-term restenosis rate ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/16A61L31/10A61L31/14B05D3/02B05D3/04B05D7/00
CPCA61L31/10A61L31/148A61L31/16A61L2300/216A61L2300/416A61L2300/604A61L2300/608A61L2420/06A61L2420/08B05D3/0254B05D3/0493B05D7/582C08L67/04
Inventor 果艳东石培国周挺胡堃赵艳
Owner 北京永益润成科技有限公司
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