Slow released tolterodine tartrate microcapsule and its prepn process
A technology of tolterol tartrate and sustained-release pellets, which is applied in the fields of pharmaceutical formulation, drug delivery, urinary system diseases, etc., can solve the problems of complicated process and sustained-release tablets, and achieve simple process, short production cycle and good economic benefits Effect
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Embodiment 1
[0017] Embodiment 1 Every 1000 tolterodine tartrate sustained-release pellet capsules contain the following materials:
[0018] Tolterodine Tartrate 4g
[0019] Sucrose 20g
[0020] Hypromellose (E5) 30g
[0021] Starch 80g
[0022] Acrylic resin (EUDRAGIT RS) 40g
[0023] Microcrystalline Cellulose 20g
[0024] For the preparation of the adhesive, accurately weigh hypromellose (E5), prepare a solution with water, and set aside.
[0025] Preparation of Micropills Take tolterodine tartrate, sucrose, starch, and acrylic resin through an 80-mesh sieve and mix thoroughly, add an appropriate amount of hypromellose (E5) solution, and make a soft material with moderate dryness and wetness according to routine. Extrusion-spheronization to make pellets.
[0026] The release range of the sustained-release pellets of tolterodine tartrate is 5-20% of the labeled amount released within 1 hour; 40-70% of the labeled amount released within 3 hours; released within 7 hours The dose is ...
Embodiment 2
[0027] Embodiment 2: the controlled-release formulation of every 1000 tolterodine tartrate contains the following substances:
[0028] Tolterodine Tartrate 4g
[0029] Sucrose 60g
[0030] Hypromellose (E5) 30g
[0031] Starch 20g
[0032] Acrylic resin (EUDRAGIT RS) 40g
[0033] Microcrystalline Cellulose 30g
[0034] The method of making is the same as above.
[0035] The release range of the sustained-release pellets of tolterodine tartrate is 5-20% of the labeled amount released within 1 hour; 40-70% of the labeled amount released within 3 hours; released within 7 hours The dose is greater than 75% of the labeled amount.
Embodiment 3
[0036] Embodiment 3: the controlled-release formulation of every 1000 tolterodine tartrate contains the following substances:
[0037] Tolterodine Tartrate 4g
[0038] Sucrose 55g
[0039] Hypromellose (E5) 30g
[0040] Starch 20g
[0041] Acrylic resin (EUDRAGIT RS) 25g
[0042] Microcrystalline Cellulose 30g
[0043] Stearic acid 10g
[0044] The method of making is the same as above.
[0045] The release range of the sustained-release pellets of tolterodine tartrate is 5-20% of the labeled amount released within 1 hour; 40-70% of the labeled amount released within 3 hours; released within 7 hours The dose is greater than 75% of the labeled amount.
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