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Titanium dioxide nanotube with good osteogenesis promoting function and preparation method thereof

A technology of titanium dioxide and nanotubes, applied in coatings, medical science, prostheses, etc., can solve the problems of poor integration between titanium-based implants and surrounding natural bone tissue, lack of potential for inducing osteogenesis, etc., and achieve good application prospects. Short cycle, effect of promoting osteogenic differentiation

Inactive Publication Date: 2017-05-17
XUZHOU NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage is that its surface is biologically inert and lacks the potential to induce osteogenesis, so that the integration of titanium-based implants with surrounding natural bone tissue is poor. How to improve the long-term stability of the combination of titanium-based implants and surrounding natural bone tissue is the key Common problems faced in clinical application
At present, there is no report that osteogenic growth peptide is used to modify titanium dioxide nanotubes to improve osseointegration through chemical linkage

Method used

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  • Titanium dioxide nanotube with good osteogenesis promoting function and preparation method thereof
  • Titanium dioxide nanotube with good osteogenesis promoting function and preparation method thereof
  • Titanium dioxide nanotube with good osteogenesis promoting function and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1. Preparation of titanium dioxide nanotubes with good bone-promoting effect

[0023] a. Cut the titanium material into 1 cm×1 cm titanium sheet, ultrasonically clean it with acetone, absolute ethanol and double distilled water for 20 minutes, and dry it in an oven at 37°C for later use;

[0024] b. Use the titanium sheet prepared in step a as the anode, the platinum sheet as the cathode, and the 0.27 mol / L ammonium fluoride solution prepared with a volume ratio of glycerol and double-distilled water of 1 to 1 as the electrolyte. After electrolysis under voltage for 1 h, the oxidized titanium sheet was ultrasonically cleaned for 2 min, dried, and finally placed in a muffle furnace and heated at 400 °C for 2 h to obtain titanium dioxide nanotubes with a diameter of 30 nm;

[0025] c. Prepare a dopamine hydrochloride solution with a concentration of 2 mg / mL using a 10 mmol / L tris buffer solution, and adjust the pH to 8.5, immerse the titanium dioxide nanotubes ...

Embodiment 2

[0027] Example 2. Preparation of Titanium Dioxide Nanotubes with Good Osteogenesis

[0028] a. Cut the titanium material into 1 cm×1 cm titanium sheet, ultrasonically clean it with acetone, absolute ethanol and double distilled water for 20 minutes, and dry it in an oven at 37°C for later use;

[0029] b, with the titanium sheet prepared in step a as the anode, the platinum sheet as the cathode, and the 0.27 mol / L ammonium fluoride solution prepared with a volume ratio of glycerol and double-distilled water of 1 to 1 as the electrolyte, at a constant temperature of 20 V After electrolysis under voltage for 1 h, the oxidized titanium sheet was ultrasonically cleaned for 2 min, dried, and finally placed in a muffle furnace and heated at 400 °C for 2 h to obtain titanium dioxide nanotubes with a diameter of 70 nm;

[0030] c. Using 10 mmol / L Tris buffer to prepare a dopamine hydrochloride solution with a concentration of 2 mg / mL, and adjusting the pH to 8.5, immersing the titaniu...

Embodiment 3

[0037] Example 3. Preparation of Titanium Dioxide Nanotubes with Good Osteogenesis

[0038]a. Cut the titanium material into 1 cm×1 cm titanium sheet, ultrasonically clean it with acetone, absolute ethanol and double distilled water for 20 minutes, and dry it in an oven at 37°C for later use;

[0039] b, using the titanium sheet prepared in step a as the anode, the platinum sheet as the cathode, and the 0.27 mol / L ammonium fluoride solution prepared with a volume ratio of glycerol and double-distilled water of 1 to 1 as the electrolyte, at a constant temperature of 30 V After electrolysis under voltage for 1 h, the oxidized titanium sheet was ultrasonically cleaned for 2 min, dried, and finally placed in a muffle furnace and heated at 400 °C for 2 h to prepare titanium dioxide nanotubes with a diameter of 100 nm;

[0040] c. Prepare a dopamine hydrochloride solution with a concentration of 2 mg / mL using a 10 mmol / L tris buffer solution, and adjust the pH to 8.5, immerse the ti...

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Abstract

The invention provides a titanium dioxide nanotube with a good osteogenesis promoting function and a preparation method thereof, and belongs to the field of biomedical materials. The method comprises the following steps that A, a titanium dioxide nanotube array is prepared on the surface of a titanium material; B, self-polymerization of dopamine on the surface of the nanotube array is conducted, and polydopamine is formed; C, osteogenic growth peptide is fixed to the surface of the nanotube array through the polydopamine, and the titanium dioxide nanotube with the good osteogenesis promoting function is obtained. On the one hand, the titanium dioxide nanotube array provides a proper topological structure for cell growth; and on the other hand, the osteoblast activity can be stimulated by the osteogenic growth peptide, through the synergistic effect of the nanometer topological structure and the osteogenic growth peptide, the osteoblast differentiation function is promoted, and thus the early osseointegration performance of the titanium material is improved.

Description

technical field [0001] The invention provides a titanium dioxide nanotube with good bone-promoting effect and a preparation method thereof, which belongs to the field of biomedical materials, relates to the nanostructuring of the titanium material surface, and also relates to the biological functionalization of the nano titanium material. Background technique [0002] Titanium and titanium alloys have been used as implant materials due to their good physical properties and are widely used in orthopedic clinical fields. The disadvantage is that its surface is biologically inert and lacks the potential to induce osteogenesis, so that the integration of titanium-based implants with surrounding natural bone tissue is poor. How to improve the long-term stability of the combination of titanium-based implants and surrounding natural bone tissue is the key Common problems faced by clinical application. [0003] At present, in order to improve the surface properties of titanium mate...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C25D11/26A61L27/06A61L27/34A61L27/54
CPCC25D11/26A61L27/06A61L27/34A61L27/54A61L2300/414A61L2430/02
Inventor 来敏金紫洋
Owner XUZHOU NORMAL UNIVERSITY
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