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Hierarchical porous chitosan/polylactic acid composite material and preparation method and application thereof

A hierarchical porous and composite material technology, applied in prosthetics, medical science, etc., can solve the problems of nutrients and metabolites hindering cell proliferation and tissue regeneration, so as to eliminate the risk of secondary surgery, promote adhesion and proliferation, The effect of rich sources of raw materials

Active Publication Date: 2015-05-27
佛山市领固胶粘科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, insufficient delivery of nutrients and metabolites is often the main problem hindering cell proliferation and tissue regeneration in the middle and later stages.

Method used

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  • Hierarchical porous chitosan/polylactic acid composite material and preparation method and application thereof
  • Hierarchical porous chitosan/polylactic acid composite material and preparation method and application thereof
  • Hierarchical porous chitosan/polylactic acid composite material and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0050] A preparation method of hierarchical porous chitosan / polylactic acid composite material, comprising the following steps:

[0051] (1) Add 1 mL of sodium bicarbonate solution with a mass concentration of 5% to 4 mL of a chitosan solution with a mass concentration of 3% and mix to obtain a mixed solution, then pour the mixed solution into a mold, shake for 5 minutes, and let stand for 15 minutes , to obtain the primary material; then the primary material was stored at -80°C for 24h, freeze-dried at -70°C for 24h, neutralized with NaOH solution with a mass concentration of 5%, washed with distilled water, stored at -80°C for 24h and freeze-dried at -70°C for 24h, Obtain chitosan matrix scaffold;

[0052] (2) Soak the chitosan-based scaffold obtained in step (1) in polylactic acid / dichloromethane solution with a mass concentration of 3%, stir for 30min (500r / min), then let it stand for 6h, and finally place it at 35°C, -1atm vacuum drying for 12h to obtain the hierarchical...

Embodiment 2

[0059] A preparation method of hierarchical porous chitosan / polylactic acid composite material, comprising the following steps:

[0060] (1) Mix the sodium bicarbonate solution with a mass concentration of 10% and the chitosan solution with a mass concentration of 6% at a volume ratio of 1:5, stir at a speed of 500r / min for 3min to obtain a mixed solution, and then mix The solution was poured into the mold and left to stand for 10 minutes to obtain the primary material; then the primary material was stored at -80°C for 24 hours, freeze-dried at -70°C for 24 hours, neutralized with 5% NaOH solution, washed with distilled water, and stored at -80°C. 24h and freeze-drying at -70°C for 24h to obtain a chitosan matrix scaffold;

[0061](2) Soak the chitosan matrix scaffold obtained in step (1) in polylactic acid / dichloromethane solution with a mass concentration of 6%, stir for 45min (500r / min), then let it stand for 12h, and finally place it at 35°C, -1atm vacuum drying for 12h t...

Embodiment 3

[0068] A preparation method of hierarchical porous chitosan / polylactic acid composite material, comprising the following steps:

[0069] (1) Mix the sodium carbonate solution with a mass concentration of 8% and the chitosan solution with a mass concentration of 4% at a volume ratio of 1:5, stir at a speed of 500r / min for 3min to obtain a mixed solution, let it stand for 10min and then The mixed solution was poured into the mold to obtain the primary material; then the primary material was stored at -80°C for 24 hours, freeze-dried at -70°C for 24 hours, neutralized with 5% NaOH solution, washed with distilled water, and stored at -80°C for 24 hours and freeze-drying at -70°C for 24 hours to obtain a chitosan matrix scaffold;

[0070] (2) Soak the chitosan-based scaffold obtained in step (1) in a polylactic acid / methylene chloride solution with a mass concentration of 6%, stir at a speed of 500r / min for 30min, then let it stand for 6h, and finally place it at 35°C , -1atm vacu...

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Abstract

The invention discloses a hierarchical porous chitosan / polylactic acid composite material and a preparation method and application thereof. The aximum wet compression modulus of the hierarchical porous chitosan / polylactic acid composite material is 0.20-0.52MPa and dry compression modules is 2.27-6.76MPap; the hierarchical porous chitosan / polylactic acid composite material has an artificially constructed longitudinal macro-pore of which the diameter is more than 500microns, and micro-pores of which the diameter is 2-500microns are distributed around the longitudinal macro-pore in all directions. The composite material disclosed by the invention has the advantages of relatively high crystallinity, good biological performance, adjustable degradation rate and proper mechanical property; the composite material has an internal porous structure similar to human bones and has a function of promoting bone tissue regeneration; moreover, due to the macro-porous structure, the composite material is more beneficial to growth of nerves and blood vessels and delivery of nutrient substances.

Description

technical field [0001] The invention belongs to the field of guiding bone tissue regeneration, and in particular relates to a hierarchical porous chitosan / polylactic acid composite material and its preparation method and application. Background technique [0002] Tissue engineering is an emerging discipline developed in recent decades. It refers to the application of principles and methods of life science and engineering to construct a biological device to maintain and promote the growth of human cells and tissues, thereby restoring, maintaining or improving damaged tissues. or organ function. In the construction process of tissue engineering, the three most important elements are scaffold materials, seed cells and signal guidance. The scaffold material is mainly to provide a stable growth space and metabolic field for cells. Under the guidance of signals, the seed cells undergo specific differentiation and further proliferation, and finally build a complete system. [000...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/38A61L27/44A61L27/56C08L5/08C08L67/04C08J9/08
Inventor 李立华李娜周长忍
Owner 佛山市领固胶粘科技有限公司
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