116 results about "Biliary ducts" patented technology

Medical devices for filtering fluids flowing through a lumen and a method of forming medical devices. The devices can be used in vascular channels, urinary tracts, biliary ducts and the like, and filter emboli and other debris generated at a treatment site.

The invention relates to a biodegradable stent composite material and a preparation method thereof. The degradable material has a multi-gradient composite structure, and comprises a matrix made of a medical metal or an alloy thereof, a chemical coupling layer attached to the surface of the matrix, a high polymer transition layer attached to the surface of the chemical coupling layer and a degradable high polymer functional layer fixed on the surface of the high polymer transition layer. The stent composite material has high mechanical property, degradation property and biocompatibility, also can absorb and carry needed therapeutic medicaments, and meets the requirement on clinical treatment. The degradable composite material can be used as stent materials of esophagi, biliary ducts, intestinal tracts, urethrae, tracheae and other non-vessel lumens and blood vessels, and also can be used for manufacturing artificial bones, bone nails, bone connectors, bone sutures, anchors for suture, intervertebral discs, hemostatic clamps, hemostatic forceps, hemostatic plates, hemostatic screws, tissue adhesives, sealants and other medical devices and products.

A biliary stent has a number of smooth-surfaced wings extending radially outwardly from a central region and extending longitudinally along substantially the entire length of the stent. A securement barb is located at one end of the stent and extends generally radially outwardly toward a side of the stent in cantilevered fashion at an angle less than or equal to 90°. The securement barb is angled such that it presents an outward-facing half-arrowhead profile. At least one end of the stent is smoothly or conically tapered. In one embodiment, the wings extend linearly along the stent; in another embodiment, the wings extend helically along the stent. Either embodiment may have a pigtail configuration at one or both ends.

The present invention, in an exemplary embodiment, provides a stent, which combines many of the excellent characteristics of both silicone and metal stents while eliminating the undesirable ones. In particular, a principal objective in accordance with the present invention is to provide a family of stents generally and a biliary stent in particular where the relative hardness / softness of regions of the stent can differ from other regions of the stent to provide additional patient comfort and resistance to radial forces. An exemplary embodiment also provides a family of stents with novel interstice configurations that facilitate flexibility, durability and / or proper installation. Additionally, the biliary stent in accordance with the present invention provides enhanced flow mechanics to ensure the adequate clearance of viscid fluids such as bile.

An embodiment of the present invention is useful for identifying tumor cells in bladder cancer washes, pleural effusions, biliary tumor cells and circulating tumor cells in whole blood. Subsequent analysis may identify therapeutic treatments based on a single cell analysis of activatable elements in cell signaling pathways. This analysis can be useful for diagnosis, prognosis, therapy selection and monitoring of solid tumor diseases.

The invention discloses a nucleic acid aptamer with a sequence containing DNA (deoxyribonucleic acid) segments shown by any of a sequence 1 and a sequence 2. The nucleic acid aptamer can also be derivatives obtained by various similar sequences high in homology or the sequence. The invention further discloses a screening method of the nucleic acid aptamer. The method includes: synthesizing a random single-strand DNA library and a primer, performing Cell-SELEX screening and PCR (polymerase chain reaction) library amplification, preparing a DNA single-strand library, and obtaining the nucleic acid aptamer through repeated screening, negative screening and several rounds of screening. The nucleic acid aptamer and derivatives thereof can be applied to recognizing human biliary duct carcinoma cell line QBC-939 or preparing a reagent box for detecting the human biliary duct carcinoma cell line QBC-939, has affinity and specificity higher than anti-keratin antibodies, and is free of immunogenicity, capable of being chemically synthesized, small in molecular weight, stable, easy to store and mark, and the like.

The invention discloses a water-soluble fullerene nano-material as well as a preparation method and an application thereof. A general structural formula of the water-soluble fullerene nano-material is shown as C2n(OH)x(Amino Acid)y, wherein n is less than or equal to 60 and is greater than or equal to 20, x is less than or equal to 50 and is greater than or equal to 0, y is less than or equal to 20 and is greater than or equal to 0 and Amino Acid is water-soluble amino acid. The nano-material provided by the invention is applied to preparation of medicines for treating tumors, wherein the tumors include at least one of liver cancer, lung cancer, colorectal cancer, renal cancer, pancreatic cancer, cancer in bones, breast cancer, ovarian cancer, prostatic cancer, esophagus cancer, gastric cancer, oral cancer, nose cancer, laryngeal cancer, cancer of biliary duct, cervical cancer, uterine cancer, testicle cancer, meningeoma, skin cancer, melanoma and sarcoma. The nano-material profvided by the invention is good in water solubility, good in affinity with organisms and low in preparation cost, and the nano-material can obviously block off tumor vessels and rapidly cut off nutrition supply to tumor tissues.

The present invention relates to a multipotent stem cell, multipotent cell populations, and an enriched multipotent cell population, each found in fetal, neonatal, pediatric, and adult biliary tree tissue and up to 72 hours post mortem (although preferentially, within 10 hours post mortem) and capable of maturing into multiple endodermal tissues that include liver, biliary and pancreatic tissues. The multipotent stem / progenitor cell and cell populations are found in peribiliary glands, and progenitors descending from them are present throughout the biliary tree including in the gallbladder. High numbers of the peribiliary glands are found in the branching locations of the biliary tree such as hilum, common hepatic duct, cystic duct, common duct, common hepato-pancreatic duct and gallbladder. Related multipotent cells, multipotent cell populations and their descendent progenitors are found throughout the biliary tree including in the gall bladder, which does not have peribiliary glands. Compositions comprising same, methods of identifying and isolating same, maintaining same in culture, expanding same in culture and differentiating or lineage restricting the same in vitro or in vivo to hepatic, biliary or pancreatic fates (e.g., as hepatocytes, cholangiocytes, and / or pancreatic islet cells) are also provided. Methods of using the multipotent cells and / or multipotent cell populations are also provided.

The invention discloses a guide wire navigation method for endoscopic biliary stent implantation for portal stenosis and a guide wire navigation system thereof. The method comprises the following steps: S1, receiving an input magnetic resonance pancreatic duct imaging image of a patient with portal stenosis; S2, performing image segmentation on the magnetic resonance pancreatic duct imaging imageof the patient with the hilar biliary stenosis based on an image segmentation method of deep learning, and predicting a navigation line from the tail end of the biliary duct to a hilar stenosis part;S3, receiving a real-time perspective image in an endoscopic retrograde cholangiopancreatography; S4, registering the two images according to the key points of the biliary duct on a magnetic resonance cholangiopancreatography image and the key points of the guide wire on the perspective image in the endoscopic retrograde cholangiopancreatography; and S5, displaying a registered composite image, and when the predicted navigation line in the composite image is not matched with the inserted guide wire, changing the position of the guide wire until the predicted navigation line is matched with the inserted guide wire. The method and the system can guide a doctor to perform biliary duct intubation, help the doctor to judge whether biliary duct intubation is correct or not, and reduce the use amount of a contrast media during an operation so as to reduce postoperative complications.

Bioluminescent endoscopy methods and compounds, wherein an anatomical object is examined by means of filling, perfusing, intubating, injecting, or otherwise administering a solution containing a bioluminescent substance or a mixture of luciferin and luciferase which produces bioluminescence, wherein a color or monochrome image of the object is constituted using the images and information based on bioluminescent emitted by the bioluminescent substance. Procedures are demonstrated which allow bioluminescent solutions to be perfused into certain tissue regions, such as but not limited to the common biliary duct, genitourinary tract, gastro-intestinal tract, cardiovascular system and lymphatic system wherein said structures may be conveniently visualized during surgery to avoid damage to these structures. Such images may also be combined with visual light images. Methods of detection of cancer cells using bioluminescence are provided. Preferred embodiments disclosed include membrane permeant coelenterazine analogs.

There is provided a method for controlling the movement of bile and / or gall stones in the biliary duct. The method comprises gently constricting (i.e., without substantially hampering the blood circulation in the tissue wall) at least one portion of the tissue wall to influence the movement of bile and / or gallstones in the biliary duct, and stimulating the constricted wall portion to cause contraction of the wall portion to further influence the movement of bile and / or gallstones in the biliary duct. The method can be used for restricting or stopping the movement of bile and / or gallstones in the biliary duct, or for actively moving the fluid in the biliary duct, with a low risk of injuring the biliary duct.

The invention belongs to the field of medicines, and relates to an application of a method for degrading all carbohydrate chains in the blood to be monosaccharide and detecting the monosaccharide in cancer detection. A sample in the method for degrading the blood to obtain the monosaccharide and detecting the monosaccharide is the blood, and the cancer includes lung cancer, gastric cancer, ovarian cancer, penis cancer, esophagus cancer, oral cancer, biliary duct cancer, breast cancer, adenocarcinoma perampullaire, rectal cancer and bladder cancer. The method has the characteristics of simplicity and easiness in operation steps, easiness in popularization, short detection time, low requirement on the instrument, low detection cost, less consumption of blood and the like. The result displays that based on the content of eight monosaccharides in the blood, not only can a normal person and a cancer patient be distinguished, but also different cancers can be distinguished. The method for simplifying glycomics knowledge and applying in the detection of the biomarker of blood is first created in the world.

The invention belongs to the field of medicines, and relates to an application of a method for degrading all carbohydrate chains in the blood to be monosaccharide and detecting the monosaccharide in cancer detection. A sample in the method for degrading the blood to obtain the monosaccharide and detecting the monosaccharide is the blood, and the cancer includes lung cancer, gastric cancer, ovarian cancer, penis cancer, esophagus cancer, oral cancer, biliary duct cancer, breast cancer, adenocarcinoma perampullaire, rectal cancer and bladder cancer. The method has the characteristics of simplicity and easiness in operation steps, easiness in popularization, short detection time, low requirement on the instrument, low detection cost, less consumption of blood and the like. The result displays that based on the content of eight monosaccharides in the blood, not only can a normal person and a cancer patient be distinguished, but also different cancers can be distinguished. The method for simplifying glycomics knowledge and applying in the detection of the biomarker of blood is first created in the world.

The invention discloses a degradable biliary duct drug-eluting stent, which consists of a biliary duct stent body and a biodegradable high-molecular polymer coating arranged on the surface of the biliary duct stent body. The biliary duct stent body is formed by mixed braiding of biodegradable metal wires and biodegradable high-molecular material silk threads. The biliary duct stent body is of a tubular structure. The two ends of the biliary duct stent body are shaped like trumpets that are open outwardly. The surface of the biliary duct stent body is a netted surface. The biodegradable high-molecular polymer coating carries drugs. The degradable biliary duct drug-eluting stent plays a mechanical supporting effect in a short period, is completely degraded after a treatment effect disappears, prevents tube wall tissues from being stimulated for a long period of time, effectively prevents the wall tissues from narrowing again after an operation, enables drug loaded fiber films to evenly wrap the surface of the stent body, and makes the drugs release slowly.

Herein disclosed are methods that are prognostic for neoplastic / preneoplastic disease in a subject vertebrate, wherein said disease is associated with a tissue that normally expresses MN, but which MN expression is lost or diminished upon carcinogenesis. Exemplary of the types of preneoplastic / neoplastic diseases subject to the prognostic methods of this invention are those of gastric mucosa, gallbladder, biliary ducts, and ductal cells of duodenal glands. An exemplary prognostic method comprises comparing the level of MN gene expression product in a tissue sample from the affected subject, with the average MN gene expression product level found in analogous preneoplastic / neoplastic tissue samples; an above average MN gene expression product level indicates poorer prognosis for the subject. MN gene expression products useful in the prognostic methods include MN protein, MN polypeptide, and / or MN nucleic acids.

The present invention relates to a multipotent stem cell, multipotent cell populations, and an enriched multipotent cell population, each found in fetal, neonatal, pediatric, and adult biliary tree tissue and up to 72 hours post mortem (although preferentially, within 10 hours post mortem) and capable of maturing into multiple endodermal tissues that include liver, biliary and pancreatic tissues. The multipotent stem / progenitor cell and cell populations are found in peribiliary glands, and progenitors descending from them are present throughout the biliary tree including in the gallbladder. High numbers of the peribiliary glands are found in the branching locations of the biliary tree such as hilum, common hepatic duct, cystic duct, common duct, common hepato-pancreatic duct and gallbladder. Related multipotent cells, multipotent cell populations and their descendent progenitors are found throughout the biliary tree including in the gall bladder, which does not have peribiliary glands. Compositions comprising same, methods of identifying and isolating same, maintaining same in culture, expanding same in culture and differentiating or lineage restricting the same in vitro or in vivo to hepatic, biliary or pancreatic fates (e.g., as hepatocytes, cholangiocytes, and / or pancreatic islet cells) are also provided. Methods of using the multipotent cells and / or multipotent cell populations are also provided.

A multifunctional medical magnetic metal scaffold for treating tumor and stenosis of biliary ducts, stomach and artenia coronaria is prepared from the existing medical scaffold through depositing the magnetic metal or alloy film containing medicine on its by chemical or electric plating method.

The present invention relates to a biliary tract interior support frame containing medicine and its preparation method. Said biliary tract interior support frame includes tubular supporting tube which can open cavitary tract of biliary duct and is equipped with several medicine-releasing holes. The inner wall of the invented tubular supporting tube has a layer of medicine-stored layer made up by mixing medicine and excipient. Several biliary tract interior suppert frames can be series-connected together. Said invention also provides the concrete steps of its preparation method.

Devices and methods for facilitating access to the pancreaticobiliary system are disclosed. In particular, the methods include bending a device having an elongate body with a first lumen, a second lumen, and respective first and second exit openings. The methods include inserting a first guidewire through the first lumen and out of the first exit opening to cannulate a pancreatic duct, and inserting a second guidewire through the second lumen and out of the second exit opening to cannulate a biliary duct.

The invention discloses a percutaneous transhepatic implanted multifunctional biliary drainage device. The percutaneous transhepatic implanted multifunctional biliary drainage device comprises a drainage tube, a flexible expansion stent, radioactive particle strips and a development mark part, wherein the flexible expansion stent is arranged at the right end part of the drainage tube; the radioactive particle strips are arranged on the flexible expansion stent; the development mark part is arranged on the drainage tube at two sides of the flexible expansion stent and is developed under imagingequipment; first drainage holes are formed in the drainage tube at the left side of the flexible expansion stent; and second drainage holes are formed in the drainage tube at the right side of the flexible expansion stent. The percutaneous transhepatic implanted multifunctional biliary drainage device has the advantages that the expansion stent is integrated on the drainage tube, a flexible airbag can expand an obstructive site while meeting bile drainage, and radioactive particles on the flexible airbag can carry out radiation therapy on tumor tissues at the obstructive site at the same time, so that the carrying time of patients is effectively shortened; the drainage tube can be linear and meets the requirements of bile drainage, obstruction expansion and tumor tissue treatment of single duct obstruction; and the drainage tube can be of a Y-shaped structure, and meets the treatment requirements of the patients with hilar biliary duct obstruction.

The invention relates to the technical field of gene engineering, and particularly discloses a bile duct cancer prognosis determination marker, a detection primer, a kit and application, the bile ductcancer prognosis determination marker is 5 lncRNAs, and the 5 lncRNAs are respectively HULC, AP000943.4, AC006504.8, AC090114.2 and AL359715.5. A method comprises the following steps: constructing abile duct cancer data set; constructing an LncRNA and gene differential expression profile; establishing an LncRNA related prognosis prediction model; verifying and diagnosing an LncRNA related prognosis prediction model; performing survival prediction that the prognosis LncRNA marker is independent of other clinical pathological characteristic variables; and performing co-expression and functionenrichment analysis: the Spearman correlation coefficient being greater than 0.50 is DPCG related to the LncRNA.

The invention discloses an efficient amplifying and culturing method for biliary epithelial cells in rabbit livers and belongs to the technical field of biological medicines. The efficient amplifying and culturing method comprises the following steps of: (1) separating, purifying and culturing the epithelial cells; (2) detecting cell growth lines; and (3) identifying the epithelial cells. The efficient amplifying and culturing method for the biliary epithelial cells, disclosed by the invention, has the advantages as follows: through a multi-step separating method, biliary epithelial cells with higher purities are obtained and a long-time multiplication culturing system for the biliary epithelial cells is established; a fact that the multiplication of the biliary epithelial cells in the livers can be obviously promoted through an Rho kinase inhibitor Y-27632 is first found; and the efficient amplifying and culturing method for the biliary epithelial cells, disclosed by the invention, has the advantages of simpler operation and the like, is suitable for promotion and application and can provide a platform for researches on a plurality of disease mechanisms including biliary atresia, primary biliary cirrhosis and the like.

The invention belongs to the technical field of medical instruments, and relates to a choledochoscope guiding device for laparoscopy. The guiding device is a tubular structure formed by connecting n helical sections; the cross section structure of each helical section comprises two horizontal sections located on different planes and a transitional section connected between the two horizontal sections; a pressing piece A is arranged on the inner side of the horizontal section close to the outer side plane in an extending manner; a pressing piece B is arranged on the outer side of the horizontal section close to the inner side plane; the pressing piece A of any helical section can be pressed with the pressing piece B of the adjacent helical section; the pressing piece B of any helical section can be pressed with the pressing piece A of the adjacent helical section; a cylindrical air bag is arranged on the outer wall of the tail end of the guiding device, and is connected with an air delivery pipe; the air delivery pipe is arranged along the outer wall of the guiding device. The choledochoscope guiding device for the laparoscopy can conveniently guide a choledochoscope to enter a biliary duct through the abdominal wall, and the guiding device can ensure that the choledochoscope keeps high maneuverability all the time in a microscopic operation treatment process.

The invention provides applications of fusion proteins E-cadherin-Fc, VE-cadherin-Fc and VEGF-Fc. The invention relates to the field of cell differentiation. Specifically, the invention relates to newapplications of epithelial cell cadherin (E-cadherin)-Fc fusion protein and / or vascular endothelial cell cadherin (VE-cadherin)-Fc fusion protein and / or endothelial cell growth factor (VEGF)-Fc fusion protein in promotion of differentiation of stem cells to hepatocyte-like cells, endothelial-like cells, islet-like cells or biliary epithelioid cells.

A method (200) and apparatus (1100) for generating quantitative data for biliary tree structures from volumetric medical imaging scan data. The method comprises performing segmentation (230; 300) of a volume of the medical imaging scan data to identify tubular biliary structures within the volume of the medical imaging scan data; for at least one segmented tubular biliary structure within the volume of the medical imaging scan data, computing (240; 800) at least one set of quantitative structural parameters for at least one location along the length of the tubular biliary structure; and outputting (250) quantitative biliary tree data comprising the at least one set of quantitative structural parameters for the at least one segmented tubular biliary structure.

The invention discloses vessel forceps. The vessel forceps comprise a first forceps body and a second forceps body which are hinged together, wherein the first forceps body comprises a first forceps mouth and a first forceps arm, the second forceps body comprises a second forceps mouth and a second forceps arm, the first forceps arm and the second forceps arm can be closed or opened by taking the hinging part as the moving center, and the first forceps mouth and the second forceps mouth are closed or opened under the driving of the first forceps arm and the second forceps arm; a plurality of first bulges are arranged on the closed face of the first forceps mouth, when the first forceps mouth and the second forceps mouth are closed, the plurality of first bulges contact the closed face of the second forceps mouth, when the structure is used for clamping the liver parenchymal tissue to be broken, the plurality of bulges can extrude blood vessels or biliary ducts distributed in the liver tissue to be positioned in the gaps among the bulges, so that the risk that a sharp multi-rack structure easily damages the biliary ducts or the blood vessels is reduced, and a doctor can carry out accurate clamping and dividing operations on the liver parenchyma.

The invention discloses surgical forceps for suturing. The surgical forceps are composed of a first forceps arm and a second forceps arm which are connected together through a near end; at a far end, the first forceps arm and the second forceps arm are respectively provided with a first accurate clamp and a second accurate clamp which are arc-shaped; one or more semicircular notches are respectively formed in corresponding positions of the inner sides of the first accurate clamp and the second accurate clamp, each notch extends from the upper surface to the lower surface, a chamfer is arranged on the junction of the upper surface and the inner side of each of the first accurate clamp and the second accurate clamp, and the chamfers of the first accurate clamp and the second accurate clamp are symmetrically arranged. The accurate clamps are taken as block linings, and when biliary ducts on two sides are sutured, a suture needle is not in direct contact with biliary duct walls, so that the suture needle is prevented from being sutured to the duct walls opposite to the biliary ducts which can be well sutured without enlarging the biliary duct space, and the surgical forceps do not cause adverse effect on patient's bodies.

The invention belongs to the field of the gene engineering, and particularly relates to an application of a long-chain non-coding RNA LINC00152 and a composition thereof in biliary duct cancer diagnosis and target drug treatment. In addition, the invention further relates to an application of a primer thereof for preparing a reagent of diagnosing colorectal cancer. Through researching expression of the long-chain non-coding RNA in a cellular level, a relation between the long-chain non-coding RNA and biliary duct cancer pathogenesis is disclosed. Molecular mechanisms of lncRNAs for controllingoccurrence and development of the biliary duct cancer are enriched through successful implementation of the research. It is disclosed that the LINC00152 can be used as a marker of biliary duct cancerdiagnosis and prognosis, and an experimental and theoretical basis is provided for early-stage biliary duct cancer clinical diagnosis and treatment.