Construction method of anticoagulant artificial blood vessel scaffold material

Abstract

The invention discloses a construction method of an anticoagulant artificial blood vessel scaffold material. The method includes: taking a rotating stainless steel pipe as a receiver, employing an electrospinning technology to prepare an organic macromolecular polymer, a mixture of a Cu2<+> complex catalyst and the organic macromolecular polymer, and the organic macromolecular polymer successively into a three-layer structured superfine fiber porous tubular scaffold material; and regulating the types and proportion of the Cu2<+> complex catalyst and the organic macromolecular polymer, as well as the electrospinning time of a three-layer electrospinning solution so as to control the release rate of NO. With a three-layer structure, the blood vessel scaffold material formed by the invention not only realizes loading of the Cu2<+> organic complex catalyst, but also improves the phenomenon of NO burst release catalyzed by an ordinary hybrid electrospun structure scaffold material, improves the loading stability of the Cu2<+> complex catalyst, and can leave the biological signal molecule NO to play a better role in inhibiting platelet adhesion, resisting platelet activation and inhibiting smooth muscle cell proliferation so as to improve its anticoagulant property.

Description

Technical field: [0001] The invention relates to a method for modifying the surface of a tissue engineering vascular stent material, in particular to a method for constructing an anticoagulant artificial vascular stent material. Background technique: [0002] There is a great demand for small-caliber blood vessels clinically, but the current small-caliber artificial blood vessels have a high rate of restenosis after implantation in the body. In order to clinically reduce the harm caused by thrombosis, anticoagulants are often used in medicine. However, long-term use of exogenous anticoagulants also has side effects, especially increasing the possibility of bleeding. [0003] Endothelial cells are natural regulators of blood vessel stability. Endothelial cells play an important role in antithrombosis, inhibition of platelet aggregation, and secretion of vasoactive factors. Molecules with antithrombotic, antiplatelet aggregation properties in endothelial cells include nitric...

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Problems solved by technology

Although it can play the purpose of catalyzing the release of NO, because this type of evenly mixed and loaded in vitro catalyst loading on the polymer microfiber is unstable, especially hydrophilic substances are easy to fall off from the surface of the polymer microfiber membrane, thereby make the local Cu 2+ If the concentration is too high, the release rate of NO is too fast, and there is a burst release phenomenon, which affects the persistence of NO release and limits its application in long-term implant materials to a large extent; local excessive Cu 2+ Concentration can also lead to material toxicity, which is the biggest limitation of using this type of material

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