231 results about "No release" patented technology

Provided herein are methods of using gaseous nitric oxide and / or at least one nitric oxide source to or decrease sebum production in the skin of a subject. In some embodiments, the nitric oxide source includes small molecule and / or macromolecular NO-releasing compounds.

Biocompatible polymeric materials capable of providing in situ release of nitric oxide (NO) included diazeniumdiolated fumed silica as a filler in a multilayer polymer structure to release NO upon contact with water (blood). The blood-contacting polymer surface is preferably multi-layered so that the NO-releasing layer, containing the diazeniumdiolated fumed silica, is shielded from blood contact by one or more top (or base) coats. When in contact with blood, the NO released at the surface of the polymer prevents platelet activation and adhesion to the surface, thereby reducing platelet consumption, risk of thrombus formation and other clinical complications associated with interactions between blood and foreign materials.

Embodiments discussed herein generally include methods of fabricating MEMS devices within a structure. The MEMS device may be formed in a cavity above the structure, and additional metallization may occur above the MEMS device. The cavity may be formed by depositing an encapsulating layer over the sacrificial layers that enclose the MEMS device. The encapsulating layer may then be etched to expose portions of the sacrificial layers. The sacrificial layers are exposed because they extend through the sidewalls of the encapsulating layer. Therefore, no release holes are etched through the top of the encapsulating layer. An etchant then removes the sacrificial layers to free the MEMS device and form the cavity and an opening through the sidewall of the encapsulating layer. Another encapsulating layer may then be deposited to seal the cavity and the opening.

A novel sleep regulating pharmaceutical formulation is introduced, typically implementing two principal drugs having actions which are reversive to one another, yet incorporated into a unitary solid dosage, and prepared for oral administration before bedtime. Usually, structure is configured to initially release a calmative or other sleep-compatible substance by prompt dissolution. The initial release is followed by a specific period of delay, which in basic formulations entails no release of any drug, and which allows a nominal interval of sleep. At the terminus of the delay, a final agent is released to induce wakeup. Incorporation of agents of opposite action within a unitary dosage form renders utility which is uniquely appropriate to the invention. In a preferred embodiment, delay of release and final delivery of wakeup agent are arranged by a dialysis membrane which eventually bursts as a result of osmotic pressure generated by a hydrophilic core.

Provided according to embodiments of the invention are NO-releasing sol-gel coating formed from a sol precursor solution comprising a backbone alkoxysilane and a diazeniumdiolate-modified alkoxysilane. Further provided are methods of producing NO-releasing sol-gel coatings. Such methods may include (a) co-condensing a sol precursor solution comprising a backbone alkoxysilane and a diazeniumdiolate-modified alkoxysilane in a solvent to form a sol; (b) coating a substrate with the sol; and (c) drying the sol to form the NO-releasing sol-gel coating.

Extremely hydrophobic nitric oxide (NO) releasing polymers are disclosed. The extremely hydrophobic NO-releasing polymers provided are extensively cross-linked polyamine-derivatized divinylbenzene diazeniumdiolates. These polymers can be loaded with extremely high NO levels and designed to release NO in manners than mimic natural biological systems. The NO-releasing extremely hydrophobic polymers provided can maintain a sustained NO release for periods exceeding nine months. Also provided are related medical devices made using these NO-releasing extremely hydrophobic polymers.

Extremely hydrophobic nitric oxide (NO) releasing polymers are disclosed. The extremely hydrophobic NO-releasing polymers provided are extensively cross-linked polyamine-derivatized divinylbenzene diazeniumdiolates. These polymers can be loaded with extremely high NO levels and designed to release NO in manners than mimic natural biological systems. The NO-releasing extremely hydrophobic polymers provided can maintain a sustained NO release for periods exceeding nine months. Also provided are related medical devices made using these NO-releasing extremely hydrophobic polymers.

The present invention discloses a new use of NO-releasing NSAIDs, especially NO-releasing NSAIDs of the formula I, or a pharmaceutically acceptable salt or enantiomer thereof, for the manufacture of a medicament for the treatment of bacterial infections, especially caused or mediated by Helicobacter pylon.Disclosed is also the new use of a NO-releasing NSAID in combination with an acid susceptible proton pump inhibitor for the treatment of bacterial infections.

Nitric Oxide (NO)-releasing polymers useful as implantable medical devices and coatings therefore are provided. Specifically the implantable medical devices and / or coatings comprise NO-releasing biodegradable polymers derived from [1,4]oxazepan-7-one and its derivatives. The medical devices and coatings of the present invention can also be used for in situ controlled release delivery of additional bioactive agents and are useful for treating or preventing medical conditions such as restenosis, aneurysms and vulnerable plaque.

The invention discloses a preparation method of a copper ion mediated anticoagulant coating with function of in situ catalysis of NO release. The method includes steps of preparing an acidic buffer solution, and adding a compound with pyrogallol structure and certain concentration, a compound with amino or thiol, and copper ion soluble salt. The method of the invention has the advantages of simple operation, mild reaction conditions and easiness. The prepared coating has the advantages of controllable content of the units containing multiple amino or thiol compounds, and easily controlled loading amount of copper ion. The modified coating prepared by the method has excellent adhesion with a base material, and through act of the copper ions in the coating with the blood, the coating can conduct in situ catalyze the NO donor molecules in blood to continuously decompose and release NO molecules, thus realizing the inhibition of platelet activation and aggregation, inhibiting smooth muscle cell proliferation and migration, and protecting vascular endothelial layer function.

Disclosed are novel NO-releasing compounds which comprise a stabilized S-nitrosyl group and a free alcohol or a free thiol group. Also disclosed is a method of preparing the NO-releasing compounds. The method comprises reacting a polythiol or a thioalcohol with a nitrosylating agent. Also disclosed are medical devices coated with the disclosed compounds, methods of delivering NO to treatments sites in a subject by utilizing the medical devices and methods of sterilizing surfaces.

Provided according to embodiments of the invention are NO-releasing sol-gel coating formed from a sol precursor solution comprising a backbone alkoxysilane and a diazeniumdiolate-modified alkoxysilane. Further provided are methods of producing NO-releasing sol-gel coatings. Such methods may include (a) co-condensing a sol precursor solution comprising a backbone alkoxysilane and a diazeniumdiolate-modified alkoxysilane in a solvent to form a sol; (b) coating a substrate with the sol; and (c) drying the sol to form the NO-releasing sol-gel coating.

The invention discloses a method for preparing a coating with nitric oxide catalytic activity. The method comprises the following steps: mixing a selenium-containing compound, a sulfur-containing compound and a soluble copper salt with the NO catalytic activity with a compound of an o-phenol structure, a flavone compound and a flavonol compound or a flavanone compound in a buffer solution for polymerizing. The coating with the nitric oxide catalytic activity can be applied to surface modification of matrix materials of almost all the materials, geometrical shapes and topological structures. The double selenium bonds, double sulfur bonds, copper ions and phenolic hydroxyl group in the prepared coating with the nitric oxide (NO) catalytic activity have excellent free radical scavenging functions; and the selenium bonds, sulfur bonds and chelated copper ions contained in the material have the response functions on reduced glutathione (GSH). In addition, the copper ions contained in the coating have antibacterial functions. The coating is used for catalyzing NO release and also can be applied to all the fields related to free radical scavenging and GSH response functions.

A flexible package having an integrated reclose strip, and method for manufacturing same, constructed by modification to existing vertical form and fill packaging machines. The reclose strip comprises a length of tacky two-sided adhesive tape. The apparatus for applying a reclose strip is incorporated into the mechanism which supplies the continuous sheet of packaging material to the vertical form, fill, and seal machine. The invention involves producing a pillow pouch or vertical stand-up pouch having an integrated reclose strip from a single sheet of packaging film. In one aspect, the reclose strip comprises a release liner on one side after package formation. In one aspect, the reclose strip comprises no release liner and is attached along the longitudinal axis of the sheet of packaging material such that the reclose strip is disposed in a channel or recess in the fill tube. The reclose strip permits the package to be reclosed after initial opening without folding the package.

The invention discloses a rolled oil sludge purifying method. The method comprises the following steps: 1, natural settlement: naturally settling the rolled oil sludge, and extracting the upper layer oil liquid to obtain settled oil residues; 2, modification: adding a modifier into the settled oil residues obtained after the natural settlement, stirring, and allowing the obtained mixture to stand; 3, flocculation: adding a flocculating agent to the modified oil residues, stirring, and allowing the flocculated oil residues to stand; 4, centrifugation: centrifuging the flocculated oil residues to obtain a centrifuged oil liquid; 5, membrane separation: carrying out membrane separation on the upper layer oil liquid extracted after the natural settlement and the centrifuged oil liquid obtained after the centrifugation to obtain a clear oil liquid; 6, adsorption: adding an adsorbent to the clear oil liquid obtained after the membrane separation, and stirring; and 7, filtration: filtering the adsorbed oil liquid to obtain base oil. The rolled oil sludge purifying method has the advantages of no release of harmful gases, small influences on the environment, and short waste oil regeneration time.

The invention relates to a method for preparing a LiFePO4 anode material for a lithium ion battery. The method comprises the following steps that iron powder or mixed iron powder and iron oxide powder are taken as an iron source which is reacted with phosphoric acid, organic acid and the like to obtain bivalent iron salt; and then, Li salt is added to obtain LiFePO4 with regular appearance, uniform grain size and excellent electrical property after twice baking. The method has the advantages of simple and easily controlled technological process, low production cost of prepared product, stable and controllable product performance, no release of the three wastes and environmental protection, and can be used in industrial production.

A novel sleep regulating pharmaceutical formulation is introduced, typically implementing two principal drugs having actions which are reversive to one another, yet incorporated into a unitary solid dosage, and prepared for oral administration before bedtime. Usually, structure is configured to initially release a calmative or other sleep-compatible substance by prompt dissolution. The initial release is followed by a specific period of delay, which in basic formulations entails no release of any drug, and which allows a nominal interval of sleep. At the terminus of the delay, a final agent is released to induce wakeup. Incorporation of agents of opposite action within a unitary dosage form renders utility which is uniquely appropriate to the invention. In a preferred embodiment, delay of release and final delivery of wakeup agent are arranged by a dialysis membrane which eventually bursts as a result of osmotic pressure generated by a hydrophilic core.

The invention discloses a quaternary ammonium salt group-containing halide amine polymer antibacterial agent, and a preparation method and an application thereof. The compound has a structure represented by the formula (I). The preparation method comprises the steps: with (3-acrylamidopropyl)trimethylammonium chloride as a monomer reaction raw material, sodium persulfate as an initiator and water as a solvent, carrying out a reaction, removing the solvent in the product solution, purifying, drying to obtain a precursor, then carrying out halogenation, filtration and drying to obtain the antibacterial agent finished product. The application in textile antibacterial finishing comprises placing a textile in deionized water for soaking, then placing in an antibacterial agent precursor solution, next soaking in an polymerization anionic solution having the same concentration, washing, drying, and thus completing one time assembly; repeating the above methods, totally assembling for 5-20 times, and halogenating to obtain an antibacterial fabric. The antibacterial agent has excellent antimicrobial performance, has no release of formaldehyde, and is safe and non-toxic; when the antibacterial agent is applied in the textile antibacterial finishing, the prepared antibacterial cotton fabric has good antibacterial property and high antibacterial efficiency.

The invention relates to an environmentally-friendly high-performance geopolymer-based wood adhesive and a preparation method and application thereof. The geopolymer-based wood adhesive is prepared from the following raw materials (by weight): 100 parts of a base material, 1-20 parts of an organic dopant, 87.5-280 parts of an alkali activator, 0.3-1 part of an initiator, 1-2.4 parts of a couplingagent, 1-2.4 parts of an emulsifier, 0.4-1.6 parts of an antifoaming agent and 50-200 parts of water. After the organic dopant is solidified, a chain or net structure can be formed. Thus, the chain ornet structure and the geopolymer form interpenetrating networks to achieve the toughening modification effect, and a mechanical locking effect with the wood material can also be achieved. The geopolymer-based wood adhesive is green and environmentally friendly; the sources of raw materials are wide; production cost is low; and the process is simple. The geopolymer-based wood adhesive is non-flammable, has no release of formaldehyde and has good bonding performance. The geopolymer-based wood adhesive is instant to use when prepared and the formula can be adjusted flexibly. The geopolymer-basedwood adhesive can be used to glue wooden raw materials such as wood, bamboo, straw and the like and to prepare wooden composite materials such as particle boards, fiberboards, plywoods, reconstitutedwood / bamboo and the like, and has industrial application value.

A flexible package having an integrated reclose strip, and method for manufacturing same, constructed by modification to existing vertical form and fill packaging machines. The reclose strip comprises a length of tacky two-sided adhesive tape. The apparatus for applying a reclose strip is incorporated into the mechanism which supplies the continuous sheet of packaging material to the vertical form, fill, and seal machine. The invention involves producing a pillow pouch or vertical stand-up pouch having an integrated reclose strip from a single sheet of packaging film.. In one aspect, the reclose strip comprises a release liner on one side after package formation. In one aspect, the reclose strip comprises no release liner and is attached along the longitudinal axis of the sheet of packaging material such that the reclose strip is disposed in a channel or recess in the fill tube. The reclose strip permits the package to be reclosed after initial opening without folding the package.

The invention particularly relates to a halogen-free flame retardant prepolymer, and an application thereof in the manufacture of the copper clad laminate (CCL). The manufacture of the CCL comprises the following steps: taking and reacting the bismaleimides, allyl compound and phosphorus-containing compound for 10 to 120 minutes at the temperature of 80 to 160 DEG C to obtain the halogen-free flame retardant prepolymer; preparing the prepolymer into solution, stirring uniformly the solution to obtain a glue solution, coating the glue solution uniformly on an E-glass fiber cloth with smooth surface, and then baking the E-glass fiber cloth to prepare a B-rank prepreg; and cutting the B-rank prepreg into proper size according to the size of a pressing machine, overlapping a certain amount of prepregs, and pressing the prepregs with a copper foil with the same size on the top and a copper foil with the same size at the bottom in a hot pressing machine to obtain the CCL. The CCL has good flame retardant effect, no release of harmful gases during the burning, and the product after the solidification of the CCL has the advantages of good toughness, higher thermal decomposition temperature and lower dielectric loss.

The invention relates to a protein adhesive, a preparation method and application thereof. The protein adhesive consists of the following raw materials by weight: 10-30 parts of a protein substrate, 30-70 parts of water, 10-30 parts of a formaldehyde-free crosslinking agent, and 10-30 parts of a diluent. The protein adhesive prepared by the invention has the advantages of high initial adhesion, low viscosity, and high solid content that can be adjustable according to the actual production status. An artificial board made by the protein adhesive prepared by the invention not only has good bonding strength and water resistance, but also has no release of formaldehyde, and all indicators reach and exceed the standards of national Class II artificial boards.

The invention relates to an electrostatically driving piezoelectric detection bulk acoustic wave resonance three-axis microgyroscope and a manufacturing method thereof. The gyroscope comprises a disk vibrator with no release hole, a cylindrical supporting pillar, driving electrodes, equilibrium electrodes and isolation electrodes which are disposed on a substrate, and detection electrodes disposed on the disk vibrator, wherein the detection electrodes are disposed on the disk vibrator; and the driving electrodes, the equilibrium electrodes and the isolation electrodes are disposed on the substrate in a circumference manner and below the disk vibrator, and at the same time, have a gap with the disk vibrator. A piezoelectric effect is used as a detection principle by the gyroscope for extracting deformation signals; and at the same time, non-contact equilibrium electrodes are employed to apply electric potentials to lower electrodes, thereby optimizing the structure of the gyroscope. The gyroscope is manufactured by adopting an MEMS processing technology which is simple in manufacturing process, high in reliability and can guarantee relatively low cost and relatively high yield. Besides, the gyroscope is small in size and simple in structure, and is suitable for large-scale production.

Hydroxylated nebivolol metabolites increase NO release in human endothelial cell preparations in a concentration-dependent manner after acute administration. In addition, hydroxylated nebivolol metabolites (including but not limited to 4-hydroxy-6,6'difluoro) have the ability to increase NO release in human endothelial cells after chronic administration. The present invention provides hydroxylated nebivolol metabolites for use in the treatment of cardiovascular diseases. Furthermore, the present invention provides methods of treating and / or preventing vascular diseases by administering at least one hydroxylated metabolite of nebivolol capable of releasing a therapeutically effective amount of nebivolol to targets affected by vascular diseases. Nitric oxide.

The invention provides a diatomite micropowder-based interior wall paint capable of removing formaldehyde and peculiar smell in indoor air and a preparation method thereof, belonging to the field of diatom nano-materials. The diatomite micropowder-based interior wall paint provided by the invention overcomes the problems of low purifying efficiency and short-term purifying effect of toxic gas like formaldehyde in conventional interior wall paints, no release of negative ions, poor antibacterial and mildew-resistant effects and high cost in the prior art. The diatomite micropowder-based interior wall paint comprises, by weight, 30 to 40 parts of diatomite micropowder, 10 to 20 parts of a nanometer titanium dioxide / diatomite composite photocatalysis material, 11 to 21 parts of calcined kaolin, 5 to 15 parts of heavy calcium carbonate, 2 to 8 parts of light calcium carbonate, 0.5 to 2 parts of cellulose ether, 1 to 3 parts of lignocellulose, 1 to 5 parts of redispersible latex powder and 7 to 17 parts of white cement. The interior wall paint has formaldehyde and toluene purifying efficiency of 86.8 to 88.2% and 52.1 to 54.2%, respectively, formaldehyde and toluene purifying effect persistence of 72.8 to 74.0% and 34.8 to 36.0%, respectively, an average negative ion increasing amount of 126 to 131 / s.cm2 and an antibacterial rate of 92 to 94%.