31results about How to "Modulated release rate" patented technology

The invention provides an anti-infection biological ceramic artificial bone and application thereof. The artificial bone is prepared by the following method that biological ceramics, bioglass sintering auxiliary agents and bonding agents are mixed; the obtained mixture is formed to obtain a composite blank body; the bioglass sintering auxiliary agents are selected from silicate glass and / or phosphate glass; antibacterial ions and bone vascularization promotion ions are mixed in the bioglass sintering auxiliary agents; the antibacterial ions are selected from one or several kinds of materials from silver, gallium, copper and zinc; the bone vascularization promotion ions are selected from one or several kinds of materials from magnesium, strontium, iron, boron, cobalt and lithium; the total amount of substances of oxides of the antibacterial ions and oxides of the bone vascularization promotion ions accounts for 0.1 to 60 percent of the amount of substance of the bioglass sintering auxiliary agents; the mol ratio of the antibacterial ions to the bone vascularization promotion ions is (0.05 to 20):1; the composite blank body is sintered to obtain the biological ceramic artificial bone. The anti-infection biological ceramic artificial bone has the advantages of high intensity and low cell toxicity; the antibacterial ion release speed is controllable; the release time is long.

The invention relates to a preparation method of a polydopamine microcapsule oral insulin administration carrier. The preparation method comprises the following steps: dissolving insulin powder in an acidic solution, adding sodium chloride, and preparing insulin micro / nano particles by a salting-out process; dispersing the insulin micro / nano particles in a dopamine weakly-alkaline solution, and reacting under oscillation conditions to obtain a polydopamine-coated insulin core-shell structure; and finally, dispersing the polydopamine-coated insulin core-shell structure in a functional molecule solution, and modifying functional molecules on the surface, thereby obtaining the biocompatible polydopamine microcapsule oral insulin administration carrier capable of overcoming the intestinal tract barrier. The polydopamine microcapsule oral insulin administration carrier has the p-responsive insulin release behavior, has the advantages of favorable cell compatibility and the like, can overcome the intestinal tract barrier, and can be used for treating diabetes.

The invention belongs to the technical field of biomedicines, and particularly relates to a double-drug loaded thixotropic hydrogel for tumor local treatment and a preparation method thereof. The thixotropic hydrogel can be used for treating tumors by local injection including but not limited to intratumor injection, peritumoral injection and the like), and comprises the following components in percentage by mass: 1.2-18 percent of silk fibroin and 0.2-8 percent of hydroxy propyl cellulose, wherein the mass ratio of silk fibroin to hydroxy propyl cellulose is 1.5-9; and the anti-cancer medicament comprises 60-1900 mu g / mL curcumin and 10-3200 mu g / mL of doxorubicin hydrochloride. The drug loaded hydrogel has thixotropic syringeability and long-time drug sustained-release effect.

The invention relates to a long-acting nitrogen fertilizer containing nitrogen-fixing microorganisms. The long-acting nitrogen fertilizer is prepared from the following raw materials in parts by weight: 45 to 60 parts of urea, 2 to 6 parts of extract liquid of a urease inhibitor, 15 to 30 parts of humic acid, 10 to 20 parts of amino acid powder, 4 to 8 parts of extract liquid of a nitrification inhibitor, 4 to 8 parts of amino acid liquid, 0.5 to 1.5 parts of microorganism bacterial powder, 0.08 to 0.4 part of polyglutamic acid and 3.6 to 7.6 parts of glucosaminoglycan. According to the nitrogen fertilizer disclosed by the invention, the nitrogen-fixing microorganisms are combined with the nitrification inhibitor and the urease inhibitor, and various factors for regulating and controlling fixing and release of nitrogen are compounded and combined according to a scientific proportion and coating level, so that nitrogen release is effectively regulated and controlled, and nitrogen is guaranteed to be long-acting and effective.

The invention provides a bone repair material and a preparation method thereof. The material comprises hydrogel and magnesium-containing micro-nano particles. The mass percentage of magnesium is 0.1-15% based on the total mass of the bone repair material of 100%. The bone repair material provided by the invention can realize the purpose of regulating and controlling the release rate of magnesium ions by regulating and controlling the crosslinking density of hydrogel and the content of groups interacting with magnesium ions. Meanwhile, the bone repair material provided by the invention has large magnesium ion release amount and long magnesium ion release time.

The invention relates to an absorbable magnesium alloy staple having antibiosis and anti-inflammation functions, and a making method thereof. The staple is composed of a pure magnesium or magnesium alloy wire core with the surface containing a porous ceramic layer, an intermediate functional layer loaded with anti-inflammation medicines and copper ions with gelatin as a carrier, and a degradable high-molecular external surface layer. The copper ions and the anti-inflammation medicines are effectively loaded on the surface of the wire with gelatin as the carrier by adopting an electrophoresis-electrodeposition process, and the external surface layer of the staple is a degradable high-molecular layer having a protection effect. The staple can slowly release the copper ions having a sterilizing effect and the anti-inflammation medicines having an anti-inflammation effect in the use process. Additionally, the synergistic effect between the intermediate functional layer with the gelatin as the carrier and the external degradable high-molecular layer realizes the effective control of the medicine release rate and the staple degradation speed. The staple can be widely applied to the stitching or inosculation of the intestine, the stomach and other human body different positions, and has a wide application prospect.

The invention discloses an intrauterine device material capable of adjusting and controlling release rate of copper ions. The material comprises copper particles, low-density polyethylene and a soluble biological material. The weight percentage of the soluble biological material accounts for 0.5-10% of the total weight of the intrauterine device material, preferably 2.5-7.5%. The soluble biological material is one or both of glucose and starch. The intrauterine device made from the intrauterine device material can greatly improve the release rate of the copper particles under the condition of constant copper particle content in the Cu / LDPE composite material IUD, the time for the Cu / LDPE composite material IUD to release the minimum copper ion concentration to inhibit sperm activity capability in uterine liquid is greatly prolonged, and therefore, the purpose for prolonging the service life of the composite material IUD is achieved.

The invention belongs to the field of slow release fertilizer, and specifically discloses an efficient slow-release fertilizer for Armeniaca sibirica on hillside dry land. The fertilizer is characterized by including the following components by weight: micron calcined broiled fish bone meal, attapulgite clay, polyacrylamide, mesoporous silica nanoparticles, tamarind polysaccharide, konjac polysaccharide, calcium stearate, sodium oleate, chelated zinc, maleic anhydride, organic acid chelated titanium, medium trace element, Ginkgo biloba fermented powder, eucommia leaf fermented powder, fly maggot powder, and sugar residue. Attapulgite clay, tamarind polysaccharide and konjac polysaccharide are chelated to prepare a water absorbing and holding of slow -release coating material; while materials of different sizes are added to enrich the pore size of the coating material, control the nutrient release rate, reduce the degradation rate of the coating material, and prolong the fertilizer efficiency. The Ginkgo biloba leaf fermented powder, eucommia leaf fermented powder, fly maggot powder and sugar residue provide rich nutrition for Armeniaca sibirica and promote the efficient cultivation of Armeniaca sibirica.

The invention discloses a lipid-protein edible double-layer active membrane and a preparation method thereof. The preparation method comprises the following steps: respectively dissolving an alcohol-soluble protein and a water-soluble protein in an acetic acid-water solution, and adding a hydrophobic active substance into the alcohol-soluble protein and / or adding a hydrophilic active substance into the water-soluble protein to respectively obtain an alcohol-soluble protein solution and a water-soluble protein solution; uniformly mixing the alcohol-soluble protein solution with the water-soluble protein solution, and adding a plasticizer; and mixing the film forming solution with solid lipid, heating to a temperature being equal to or higher than the melting point of the lipid, carrying outhigh-speed shearing homogenization to form an emulsion, and casting to form the membrane. The preparation method is simple and convenient, and the protein-lipid double-layer active membrane can be prepared through one-time tape casting, so the drying time can be shortened, and the production efficiency can be improved. The active membrane has a good one-way water blocking effect and good mechanical properties, and the release rate of an active matter can be regulated by regulating the ratio of the alcohol-soluble protein to the water-soluble protein and the mass percentage of the lipid.

The invention belongs to the field of vegetative ecological concrete and particularly relates to a degradable aggregate having fertilizer efficiency slow releasing performance and a preparation methodthereof. The degradable aggregate comprises, by weight, 2-5 parts of cellulose ether, 2-10 parts of soluble starch, 75-91 parts of tartaric acid, 45-60 parts of magnesium oxide powder, 15-25 parts ofammonium dihydrogen phosphate, 2-8 parts of sodium aliphatate, 5-10 parts of aluminum powder, 5-10 parts of sodium hydrogencarbonate and 5-15 parts of Portland cement. The degradable aggregate adoptsmagnesium ammonium phosphate hexahydrate as a main component, the release rate of tartaric acid is regulated according to the coating thickness of tartaric acid and the porosity of the aggregate, andcorrespondingly the pH value of an aqueous solution in pores of the aggregate is changed, so that the prepared aggregate has excellent fertilizer efficiency slow releasing performance and degradableperformance.

The invention belongs to the technical field of marine antifouling materials, and particularly relates to a preparation method for self-polishing antifouling resin. The resin is a branched polymer with self-polishing performance, which is prepared by taking a double-bond-terminated polyester oligomer as a branched monomer, (methyl) acrylate as a monomer and active / controllable free radical polymerization as a means. In the using process of the resin, degradation of polyester chain segments in the resin and short primary chain length endow the resin with excellent self-polishing performance. The resin prepared by using the preparation method provided by the invention realizes self-polishing through degradation of branched chain segments in a polymer. According to the method, various functional vinyl monomers can be conveniently added into the resin preparation process to obtain self-polishing antifouling paint resin with different properties. Meanwhile, the preparation method provided by the invention is simple in operation method, low in cost and applicable to industrial production.

The invention belonging to the field of biomedical materials, and discloses a preparation method of mesoporous hydroxyapatite microspheres. The preparation method comprises the following steps: mixing soluble phosphate, soluble calcium salt, a surfactant and a homogeneous precipitant, adjusting a pH value, carrying out a hydrothermal reaction, conducting centrifuging to obtain a precipitate, and drying the precipitate to obtain mesoporous hydroxyapatite microspheres, wherein the mass or volume concentration of the surfactant is 0.5%-3%. According to the preparation method, the surface morphology and the specific surface area of the mesoporous hydroxyapatite microspheres can be regulated and controlled by regulating the concentration of the surfactant; a related precursor template does not need to be prepared; process is simple, and cost is low; and the prepared mesoporous hydroxyapatite microspheres have good biological activity and biocompatibility and can be widely applied to the field of biomedicine.

The invention discloses a traditional Chinese medicine composition and plaster used for treating vertebra column and vertebra lumbalis and a preparation method and application of plaster, and relatesto the field of Chinese herbal medicine. The traditional Chinese medicine composition used for treating vertebral column and vertebra lumbalis contains the following crude drugs in parts by weight: 30-50 parts of caulis spatholobi, 5-15 parts of safflower carthamus, 10-30 parts of eucommia ulmoides, 20-40 parts of rhizoma atractylodis macrocephalae, 15-25 parts of radix Clematidis, 20-40 parts ofradix paeoniae alba, 5-15 parts of frankincense, 20-40 parts of poria cocos, 10-30 parts of fructus psoraleae, 25-35 parts of papaya, 5-15 parts of myrrh, 15-25 parts of Chinese polyphaga, 15-25 partsof paniculate swallowwort root, 10-20 parts of radix angelicae pubescentis, 30-50 parts of polygonum cuspidatum, 25-35 parts of Chinese starjasmine stem, 15-25 parts of zaocys dhumnades, and 15-25 parts of radix stephaniae tetrandrae. The traditional Chinese medicine composition, by reasonable compatibility of the components, has a good treatment effect for old strain, lumbar muscle strain and vertebral column or lumbar vertebrae injuries, and is low in cost and fast to take effect.

The invention belongs to the technical field of biomedicines, and particularly relates to a double-drug loaded thixotropic hydrogel for tumor local treatment and a preparation method thereof. The thixotropic hydrogel can be used for treating tumors by local injection including but not limited to intratumor injection, peritumoral injection and the like), and comprises the following components in percentage by mass: 1.2-18 percent of silk fibroin and 0.2-8 percent of hydroxy propyl cellulose, wherein the mass ratio of silk fibroin to hydroxy propyl cellulose is 1.5-9; and the anti-cancer medicament comprises 60-1900 mu g / mL curcumin and 10-3200 mu g / mL of doxorubicin hydrochloride. The drug loaded hydrogel has thixotropic syringeability and long-time drug sustained-release effect.

The invention discloses a cabazitaxel oligo / polylactic acid coupled prodrug and a preparation method thereof. The preparation method is characterized in that cabazitaxel and oligo / polylactic acid undergo an esterification reaction under the action of a condensing agent and a catalyst to obtain the cabazitaxel oligo / polylactic acid coupled prodrug. The invention also discloses a cabazitaxel-oligo / polylactic acid coupled prodrug preparation, and a preparation method and an application thereof. The oligo / polylactic acid is covalently coupled with cabazitaxel, so the in vivo release rate of cabazitaxel is can be regulated, the precipitation of cabazitaxel, caused by strong release, is prevented, the in vivo cycle period of the cabazitaxel is prolonged, and the maximum tolerable dose is increased. The oligo / polylactic acid is approved for use by the US FDA and has an excellent application prospect. The cabazitaxel oligo / polylactic acid prodrug and an amphiphilic polymer PEG5k-PLA8k are assembled to form nanoparticles, and the nanoparticles have a passive targeting effect, and are easily retained in the tumor site by the EPR effect in order to greatly reduce the toxic and side effects ofthe drug on normal tissues.

The invention belongs to the field of phytoplankton ecological concrete, in particular to a degradable phosphate cement-based aggregate with fertilizer efficiency slow-releasing property and a preparation method thereof. The composition comprises the following components in parts by weight: 2-5 parts of molasses, 6-15 parts of soluble starch, 5-85 parts of citric acid powder, 40-55 parts of magnesium chloride, 15-25 parts of ammonium dihydrogen phosphate, 5-12 parts of glucose, 2-8 parts of sodium fatty acid, 5-10 parts of water-absorbent resin, 5-15 parts of Portland cement and 37-73 parts ofwater. As that magnesium ammonium phosphate hexahydrate is used as the main component, the pH value of the aqueous solution in the pores of the aggregate is changed by regulating the pH value of theaggregate using citric acid, thereby obtaining the aggregate with good fertilizer effect, slow release and degradability.

The invention discloses a camptothecin-polycaprolactone coupling prodrug, a preparation method thereof, a preparation, and a preparation method and application of the preparation. According to the invention, the camptothecin polycaprolactone coupling prodrug is obtained by esterification of a camptothecin drug and polycaprolactone. According to the invention, polycaprolactone is covalently coupled with camptothecin or 7-ethyl-10-hydroxycamptothecine, so that the release rate of camptothecine active molecules in vivo can be regulated and controlled, the camptothecine active molecules are prevented from being separated out due to burst release, and the circulation time of the camptothecine active molecules in vivo is prolonged. Meanwhile, polycaprolactone is approved to be used in the market by FDA in America, and has a good application prospect. The camptothecin-polycaprolactone prodrug and an auxiliary agent are assembled to form nanoparticles, the nanoparticles have a passive targeting effect, and can be retained at a tumor site through an EPR effect to reduce exposure to normal tissues, so that the anti-tumor effect of the drug is greatly improved, and the in-vivo side effects are reduced.

The invention discloses a cabazitaxel oligo / polylactic acid coupled prodrug and a preparation method thereof. The preparation method is characterized in that cabazitaxel and oligo / polylactic acid undergo an esterification reaction under the action of a condensing agent and a catalyst to obtain the cabazitaxel oligo / polylactic acid coupled prodrug. The invention also discloses a cabazitaxel-oligo / polylactic acid coupled prodrug preparation, and a preparation method and an application thereof. The oligo / polylactic acid is covalently coupled with cabazitaxel, so the in vivo release rate of cabazitaxel is can be regulated, the precipitation of cabazitaxel, caused by strong release, is prevented, the in vivo cycle period of the cabazitaxel is prolonged, and the maximum tolerable dose is increased. The oligo / polylactic acid is approved for use by the US FDA and has an excellent application prospect. The cabazitaxel oligo / polylactic acid prodrug and an amphiphilic polymer PEG5k-PLA8k are assembled to form nanoparticles, and the nanoparticles have a passive targeting effect, and are easily retained in the tumor site by the EPR effect in order to greatly reduce the toxic and side effects ofthe drug on normal tissues.

The invention discloses artificial skin capable of controllably releasing a drug and a preparation method. The preparation method comprises the steps: (1) preparing a biological material support of a three-dimensional porous structure; (2) coating bipolar viscosity molecules on the surface of the biological material support; (3) utilizing the bipolar viscosity molecules to adsorb drug; (4) soaking the materials into a solvent which can dissolve the support material, wherein a combined body of the support material, the viscosity molecules and the drug which are originally combined together is eluted, and microspheres with appropriate diameters can be generated on the surface of the support in situ. The microspheres are prepared from the support material, the viscosity molecules and the drug. By regulating a degradation rate of the microspheres, a release rate of the drug can be regulated.

The invention provides an anti-infection biological ceramic artificial bone and application thereof. The artificial bone is prepared by the following method that biological ceramics, bioglass sintering auxiliary agents and bonding agents are mixed; the obtained mixture is formed to obtain a composite blank body; the bioglass sintering auxiliary agents are selected from silicate glass and / or phosphate glass; antibacterial ions and bone vascularization promotion ions are mixed in the bioglass sintering auxiliary agents; the antibacterial ions are selected from one or several kinds of materials from silver, gallium, copper and zinc; the bone vascularization promotion ions are selected from one or several kinds of materials from magnesium, strontium, iron, boron, cobalt and lithium; the total amount of substances of oxides of the antibacterial ions and oxides of the bone vascularization promotion ions accounts for 0.1 to 60 percent of the amount of substance of the bioglass sintering auxiliary agents; the mol ratio of the antibacterial ions to the bone vascularization promotion ions is (0.05 to 20):1; the composite blank body is sintered to obtain the biological ceramic artificial bone. The anti-infection biological ceramic artificial bone has the advantages of high intensity and low cell toxicity; the antibacterial ion release speed is controllable; the release time is long.

The invention provides a hollow hydroxyapatite microsphere with a controllable bore diameter. The grain size of the microsphere is 400nm-7000nm; the microsphere surface has a thorn-shaped structure; a hollow structure is formed in the microsphere; and the crystal form is hydroxyapatite. The preparation method for the microsphere mainly comprises the following steps: preparing a calcium carbonate precursor, performing hydrothermal reaction and marking with rhodamine. The invention also researches an application of the microsphere in the field of a drug-loading slow release. After the invention researches the drug-loading efficiency, degradation rate and release rule of the microsphere prepared from lauryl sodium sulfate in different concentrations, a conclusion proves that the acquired hollow hydroxyapatite microsphere can achieve the most ideal drug-loading and drug-release effects when the concentration of the lauryl sodium sulfate is a critical micelle concentration. Besides, the invention innovatively realizes the combination of the microsphere with the rhodamine dye through an amino group on the surface of the hollow hydroxyapatite microsphere, so that the drug-loading microsphere is more easily positioned and traced in biological performance evaluation and action mechanism research.

The invention discloses a sodium nitrite-gelatin microsphere and a preparation method and application thereof. The preparation method comprises the following steps of: firstly, adding gelatin into deionized water, and stirring until the gelatin is completely dissolved to obtain a gelatin solution; then adding sodium nitrite into the gelatin solution, and continuously stirring until the sodium nitrite is completely dissolved to obtain a mixed solution; then adding glutamine transaminase into the mixed solution, and then stirring for reaction to obtain a cross-linked solution; then adding an emulsifier into an oil phase, then dropwise adding the cross-linked solution under the stirring condition, and continuously carrying out emulsification reaction under the stirring condition to form an emulsion; and finally, cooling the emulsion under the stirring condition, and carrying out operations such as ultrasonic treatment, suction filtration separation and washing to finally obtain the sodium nitrite-gelatin microsphere. The preparation method is simple in overall operation, and the prepared sodium nitrite-gelatin microsphere is smooth in surface and uniform in particle size, has the average particle size of 5-40 microns, can slowly release NO in a weak acidic environment, and can be applied to food antibacterial agents.

The invention provides a bone repair material and a preparation method thereof, comprising hydrogel and magnesium-containing micro-nano particles; wherein, based on the total mass of the bone repair material as 100%, the mass percentage of magnesium is 0.1- 15%. The bone repair material provided by the present invention can realize the purpose of regulating the release rate of magnesium ions by regulating the cross-linking density of the hydrogel and the content of interacting groups with magnesium ions; at the same time, the bone repair material provided by the present invention has a large release amount of magnesium ions and Magnesium ions are released for a long time.

The invention discloses a two-component modified polyurethane sustained or controlled release coating material with the chelation function, and belongs to the technical field of high polymer material preparation. The two-component modified polyurethane sustained or controlled release coating material is characterized in that a polyurethane prepolymer is synthesized through diisocyanate, castor oil and polyhydric alcohols at first, an unsaturated monomer is added before emulsification to lower viscosity, then chain extension is performed, and an unsaturated monomer with the chelation and hydrophilic function is introduced through in-site emulsion polymerization. By adjusting and controlling the crosslinking degree and hydrophility of the coating material, the nutrient release speed can be controlled so as to meet the requirements of different crops for nutrients. A chelation group in the material can activate medium trace elements in soil, and polyvinyl acetate and other hydrophilic chain segments have the moisture and fertilizer retention function, so that the fertilizer utilization rate is greatly improved, no organic solvent is used in the synthetic process, and the material is environmentally friendly and free of pollution.

The invention provides a preparation method and application of a silk fibroin frozen sponge capable of slowly releasing exosome. Compared with traditional methods, according to an embodiment of the invention, long-term storage of the silk fibroin frozen sponge in a frozen environment is realized; on the premise of ensuring that a scaffold structure is not damaged, and a release rate is reduced, scaffold degradation and exosome release are synchronously conducted; and the exosome release rate can be regulated and controlled only by regulating and controlling the degradation rate of the silk fibroin frozen sponge, so the silk fibroin frozen sponge has wide market prospects.

The invention discloses a lipid-protein edible bilayer active film and a preparation method thereof. The method comprises the following steps: respectively dissolving the prolamin and the water-soluble protein in the aqueous solution of acetic acid, adding a hydrophobic active substance to the prolamin and / or adding a hydrophilic active substance to the water-soluble protein to obtain the prolamin solution and the prolamin solution respectively. Water-soluble protein solution; mix prolamin solution and water-soluble protein solution evenly, and add plasticizer; mix film-forming solution and solid lipid, heat to above the melting point of lipid, and homogenize through high-speed shearing to form emulsion and flow extended film. The preparation process of the present invention is simple and simple, and a protein-lipid bilayer active film can be prepared by one-time casting, which can reduce drying time and improve production efficiency. The active film has good one-way water blocking effect and mechanical properties, and the release rate of active substances can be adjusted by adjusting the ratio of gliadin to water-soluble protein and the percentage of lipid mass.

The invention discloses a pH-responsive in-situ controlled-release titanium-based implant, a preparation method and application thereof. In the present invention, titanium-based implants are constructed on the surface of titanium-based implants through anodic oxidation to construct titanium dioxide nanotube structures, and then dopamine is used to introduce amino reaction sites on the top of titanium dioxide nanotubes, and then PMAA is grafted to it by amide reaction. Finally, the HHC36 polypeptide with antibacterial properties was loaded to obtain a pH-responsive in situ controlled-release titanium-based implant. The pH-responsive in-situ controlled-release titanium-based implant of the present invention can respond to the pH changes of the surrounding solution, regulate the release rate of antibacterial polypeptides, and has excellent antibacterial performance. In the 4th cycle sterilization experiment, it is effective against Escherichia coli and Pseudomonas aeruginosa. , Staphylococcus aureus and methicillin-resistant Staphylococcus aureus still have a bactericidal rate of more than 99%. The pH-responsive in-situ controlled-release titanium-based implant of the present invention aims at the difficult problem of bacterial infection of clinical titanium-based implants, and can reduce the risk of bacterial infection.