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Preparation method of mesoporous hydroxyapatite microspheres

A technology of mesoporous hydroxyapatite and microspheres, applied in chemical instruments and methods, phosphorus compounds, medical science, etc., can solve the problem that the surface structure of materials cannot be controlled, and the preparation process of mesoporous hydroxyapatite is complicated and cumbersome, etc. problems, achieve low cost, good biological activity, and simple process

Inactive Publication Date: 2021-04-06
佛山仙湖实验室
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the prior art, the preparation process of mesoporous hydroxyapatite with surface micro-nano structure is complex and cumbersome, and generally requires the preparation of precursor templates first, and the material cannot achieve the effect of controllable surface structure

Method used

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  • Preparation method of mesoporous hydroxyapatite microspheres
  • Preparation method of mesoporous hydroxyapatite microspheres
  • Preparation method of mesoporous hydroxyapatite microspheres

Examples

Experimental program
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Embodiment 1

[0039] A preparation method of mesoporous hydroxyapatite microspheres, comprising the steps of:

[0040] (1) Calcium nitrate tetrahydrate is dissolved in deionized water to form a 0.1mol / L calcium nitrate solution;

[0041] (2) Diammonium hydrogen phosphate is dissolved in deionized water to be configured as a 0.06mol / L diammonium hydrogen phosphate solution;

[0042] (3) Under stirring, add the diammonium hydrogen phosphate solution obtained in step (2) to the calcium nitrate solution obtained in step (1), add 1% (V / V) phytic acid solution and 1mol / L acetamide , to obtain a mixture;

[0043] (4) Adjust the pH of the mixed solution obtained in step (3) to 2 with 1mol / L nitric acid solution and sodium hydroxide solution, then add it to a polytetrafluoroethylene-lined hydrothermal reaction kettle, and perform a hydrothermal reaction at 180°C for 10 hours; after the reaction, the precipitate was centrifuged and washed, and dried in an oven at 60-80° C. to obtain mesoporous hydr...

Embodiment 2

[0046] A preparation method of mesoporous hydroxyapatite microspheres, comprising the steps of:

[0047] (1) Calcium nitrate tetrahydrate is dissolved in deionized water to form a 0.1mol / L calcium nitrate solution;

[0048] (2) Diammonium hydrogen phosphate is dissolved in deionized water to be configured as a 0.06mol / L diammonium hydrogen phosphate solution;

[0049] (3) Under stirring, add the diammonium hydrogen phosphate solution obtained in step (2) to the calcium nitrate solution obtained in step (1), add 1.5% (V / V) phytic acid solution and 1mol / L acetamide , to obtain a mixture;

[0050](4) Adjust the pH of the mixed solution obtained in step (3) to 2 with 1mol / L nitric acid solution and sodium hydroxide solution; then add it to a polytetrafluoroethylene-lined hydrothermal reaction kettle, and perform a hydrothermal reaction at 180°C for 10 hours After the reaction, the precipitate is centrifuged and washed, and dried in an oven at 60-80° C. to obtain mesoporous hydro...

Embodiment 3

[0053] A preparation method of mesoporous hydroxyapatite microspheres, comprising the steps of:

[0054] (1) Calcium nitrate tetrahydrate is dissolved in deionized water to form a 0.1mol / L calcium nitrate solution;

[0055] (2) Diammonium hydrogen phosphate is dissolved in deionized water to be configured as a 0.06mol / L diammonium hydrogen phosphate solution;

[0056] (3) Under stirring, add the diammonium hydrogen phosphate solution obtained in step (2) to the calcium nitrate solution obtained in step (1), add 2% (V / V) phytic acid solution and 1mol / L acetamide , to obtain a mixture;

[0057] (4) Adjust the pH of the mixed solution obtained in step (3) to 2 with 1mol / L nitric acid solution and sodium hydroxide solution; then add it to a polytetrafluoroethylene-lined hydrothermal reaction kettle, and perform a hydrothermal reaction at 180°C for 10 hours After the reaction, the precipitate is centrifuged and washed, and dried in an oven at 60-80° C. to obtain mesoporous hydrox...

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Abstract

The invention belonging to the field of biomedical materials, and discloses a preparation method of mesoporous hydroxyapatite microspheres. The preparation method comprises the following steps: mixing soluble phosphate, soluble calcium salt, a surfactant and a homogeneous precipitant, adjusting a pH value, carrying out a hydrothermal reaction, conducting centrifuging to obtain a precipitate, and drying the precipitate to obtain mesoporous hydroxyapatite microspheres, wherein the mass or volume concentration of the surfactant is 0.5%-3%. According to the preparation method, the surface morphology and the specific surface area of the mesoporous hydroxyapatite microspheres can be regulated and controlled by regulating the concentration of the surfactant; a related precursor template does not need to be prepared; process is simple, and cost is low; and the prepared mesoporous hydroxyapatite microspheres have good biological activity and biocompatibility and can be widely applied to the field of biomedicine.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a preparation method of mesoporous hydroxyapatite microspheres. Background technique [0002] Due to trauma, disease, aging and other reasons, a large number of bone tissue injuries are caused clinically. Hydroxyapatite [Ca 10 (PO 4 ) 6 Oh 2 or HAP], the most important inorganic component in natural bone and teeth, has attracted much attention due to its good osteoinductive and osteoconductive properties. Clinically, hydroxyapatite has been widely used as an important bone tissue defect repair material. [0003] Infection caused by orthopedic implants is an important reason for the failure of bone tissue defect repair. Infection leads to higher morbidity and mortality, prolongs the length of hospital stay of patients, and increases the cost of treatment for patients. However, conventional hydroxyapatite does not have anti-infective properties. As a new type...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32A61K47/02A61L27/12A61L27/50
CPCC01B25/325A61K47/02A61L27/12A61L27/50C01P2004/32C01P2004/61C01P2004/10C01P2004/03C01P2002/72C01P2002/82A61L2430/02
Inventor 戴红莲张焙智伍小沛韩颖超
Owner 佛山仙湖实验室
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