45results about How to "Control release time" patented technology

The invention provides an anti-infection biological ceramic artificial bone and application thereof. The artificial bone is prepared by the following method that biological ceramics, bioglass sintering auxiliary agents and bonding agents are mixed; the obtained mixture is formed to obtain a composite blank body; the bioglass sintering auxiliary agents are selected from silicate glass and / or phosphate glass; antibacterial ions and bone vascularization promotion ions are mixed in the bioglass sintering auxiliary agents; the antibacterial ions are selected from one or several kinds of materials from silver, gallium, copper and zinc; the bone vascularization promotion ions are selected from one or several kinds of materials from magnesium, strontium, iron, boron, cobalt and lithium; the total amount of substances of oxides of the antibacterial ions and oxides of the bone vascularization promotion ions accounts for 0.1 to 60 percent of the amount of substance of the bioglass sintering auxiliary agents; the mol ratio of the antibacterial ions to the bone vascularization promotion ions is (0.05 to 20):1; the composite blank body is sintered to obtain the biological ceramic artificial bone. The anti-infection biological ceramic artificial bone has the advantages of high intensity and low cell toxicity; the antibacterial ion release speed is controllable; the release time is long.

The invention relates to a multi-stage compounded sweetener and a preparation technology thereof, and belongs to the field of food additives. According to the multi-stage compound sweetener, the microscopic particles of the sweetener powder are in an inner-outer double-layer structure, the inner layer is an after-sweet compound layer, the outer layer is a before-sweet compound layer, the outer layer of the before-sweet compound layer is also wrapped by a sweet-inducing layer of a natural sweetener component which is used for presenting a natural sweetener flavor for the first mouth feel of foods. The technical scheme controls the gradient release of artificial sweeteners with different properties and mouth feel, so that the defects of insufficient sweetness, heavy metal taste and bitter and astringent taste of the sweeteners are eliminated by each other, and the whole sweetness is uniform and stable, and the compounded sweetener is close to a natural sweetener, and has no bitter and astringent taste and metal taste. More importantly, by processing the micro-structure of sweeteners and controlling the release time points of various high-power sweeteners, the technical scheme of theinvention blends out a proper mouth feel, and points out a new direction for the design of compound sweeteners.

The invention relates to a drug releasing method based on a 4D printing shape memory polymer structure. The invention aims at solving the problems that according to an existing sustained-release drug,the drug preparation technology is complex, preparation cost is higher, and repeatability is lower. Shape memory polymers and a drug are mixed at the indoor temperature, a shape memory polymer carrying the drug is obtained, an initial constructed drug releasing structure is prepared through a 4D printing technology, the structure is heated to the glass transition temperature, the initial constructed drug releasing structure is converted to a temporary constructed drug releasing structure with a smaller superficial area, the temporary constructed drug releasing structure is placed in the environment which is prepared for simulating human body fluid, external motivators are given, the initial constructed drug releasing structure is recovered, and the whole process is completed. According tothe method, the preparation cost is low, the method is simple, and it is due to the fact that 4D printing process parameters are consistent, the repeatability is high. The method is applied to the field of intelligent drug releasing.

The present invention discloses a drug controlled release catheter which consists of an inserting end which is used to insert in vivo and an urination end which is exposed to the outside. The urine leading port of the inserting end is communicated with the urination port of the urination end to form a urine leading channel. The present invention is characterized in that the tube wall of the inserting end at the position of urethra is provided with a drug release hole which is used to release outward drug liquid; the urination end of the urine leading pipe which is exposed to the outside is provided with a drug transmission pipe which is communicated with drug release hole through a drug transmission channel; the drug release hole and the drug transmission channel are separated from the urine leading channel. Since the present invention is provided with the drug release hole and the drug transmission pipe, when in use, the rapamycin or other drugs can be released through the drug transmission pipe and the drug release hole, so that urethral stricture relapse after operation can be prevented. The method can control the drug released amount and time conveniently according to the requirement.

The invention provides a seed coating agent. The seed coating agent is prepared from the following raw materials by mass: 5 to 20 parts of liquefied fiber polysaccharide, 0 to 20 parts of an active component of a pesticide, 0 to 0.5 part of triethylene diamine, 0 to 0.5 part of a silicon surfactant, 0 to 0.25 part of a tin catalyst and 5 to 20 parts of a diisocyanate compound. A preparation method for the seed coating agent comprises the following steps: uniformly mxing the liquefied fiber polysaccharide with a part of the active component of the pesticide so as to obtain a preparative solution A; uniformly mixing the preparative solution A with triethylene diamine, the silicon surfactant and the tin catalyst so as to obtain a preparative solution B; uniformly mixing the diisocyanate compound with the rest active component of the pesticide so as to obtain a preparative solution C; and uniformly mixing the preparative solution B with the preparative solution C so as to obtain the seed coating agent. Due to addition of the liquefied fiber polysaccharide, the seed coating agent with the liquefied fiber polysaccharide as a raw material has good biodegradability; and the seed coating agent has the advantages of rapid and simple operation, controllable release speed, etc.

The slow releasing urea is produced with polyvinyl acetate as coating polymer material and granular urea in the weight ratio of 1-3.1 to 100, preferably 2.041 to 100. The production process includes the steps of: sieving granular urea to obtain urea with grain size of 2-3 mm, dissolving polyvinyl acetate in solvent to obtain coating solution, coating urea with the coating solution in the required weight ratio, stoving, sieving and packing. The present invention has proper thickness of coating to regulate nitrogen releasing rate and amount for synchronizing the growth period of crop. The present invention has the features of low cost, reduced pollution of nitrogen fertilizer on environment and agricultural product, etc.

The invention discloses a two-stage type microneedle array patch capable of simultaneously realizing BCG vaccine inoculation and diagnosis. The two-stage type microneedle array patch comprises a microneedle array and a patch; the microneedle array is arranged on the patch; the microneedle comprises a soluble drug-loaded microneedle tip and an insoluble microneedle supporting end; the soluble drug-loaded microneedle tip is prepared by mixing a BCG vaccine, tubercle bacillus element microspheres and soluble auxiliary materials and performing freeze drying; and the tubercle bacillus element microspheres are prepared by combining slow-release auxiliary materials and tubercle bacillus elements. The BCG vaccine and the tubercle bacillus elements are gathered at the soluble microneedle drug-loaded tip at the same time; and the release time of the tubercle bacillus elements is controlled through a slow-release microsphere technology, so that two drug administration purposes of inoculating theBCG vaccine and diagnosing whether the BCG vaccine is successfully inoculated or not can be achieved through one-time drug administration. The invention further discloses a preparation method of the patch.

The invention discloses core-shell solid fertilizer rich in mineral substance. The core-shell solid fertilizer comprises the following raw materials in percentage by weight: A, 35 to 98.5 percent of at least one of chemical fertilizer particles in nitrogen fertilizer, phosphate fertilizer and potash fertilizer; B, 1 to 40 percent of coal or separated mineral particles from gangue before the gangueis burnt or subjected to chemical conversion; C, 0.5 to 25 percent of an adhesive, wherein the outer surface of the chemical fertilizer particles is coated with a plurality of mineral particles through the adhesive. The mineral particles are rich in medium trace elements, such as at least one of B, Ca, Cl, Cu, Fe, Mg, Mn, Mo, S and Zn, which are necessary for plant growth. The core-shell solid fertilizer can realize cost-optimal and high-efficiency utilization of mineral substance waste in coal chemical industry. The core-shell solid fertilizer can control the release rate of chemical fertilizer particles through the concentration of porous mineral substance particles and the thickness of a coating layer. The invention further discloses a preparation method of the core-shell solid fertilizer rich in mineral substance.

The invention discloses a solvent of artesunate for intramuscular injection, and particularly relates to a solvent of artesunate for intramuscular injection, which has a slow release function and is used by animals. The solvent is prepared from the following components in percentage by volume: 20% of 1,2-propanediol, 15% of ethanolamine, 15% of polyvinylpyrrolidone-K15, and the balance of sterilewater for injection. The solvent can realize high solubility and safety of artesunate well, has the advantage of slow release at the same time, can maintain effective plasma drug concentration of a drug for a long time in an organism, and reduces the times of drug administration; and compared with oral administration and intravenous injection, the intramuscular injection is easier to operate in veterinary clinical practice.

The invention belongs to the field of fertilizer sustained and controlled release, and concretely relates to a zinc-rich coating material, a preparation method of the material, a zinc-rich coated sustained and controlled release fertilizer, and a preparation method of the fertilizer. The zinc-rich coating material comprises, by weight, 65-80 parts of starch, 5-15 parts of lotus leaf powder, 1-5 parts of chelated zinc, 1-5 parts of Rubia cordifolia powder, 0-10 parts of humic acid and 0.2-5 parts of a cross-linking agent. The zinc-rich coated sustained and controlled release fertilizer comprises a fertilizer core and a zinc-rich coating for coating the fertilizer core, the fertilizer core is a water-soluble granular fertilizer, and the zinc-rich coating is produced from the zinc-rich coating material. The cheap and environmentally-friendly starch, lotus leaf powder, humic acid and other polymeric materials are adopted as main raw materials, and are blended with chelated zinc and Rubia cordifolia traditional Chinese medicine components to cross-link and modify the main raw materials in order to prepare the zinc-rich coating material and the zinc-rich coated sustained and controlled release fertilizer. The coating material can effectively prolong the water dissolving time and the time of degradation in water to realize slow release of the zinc element contained in the material and the fertilizer coated with the material.

The invention belongs to the technical field of resource utilization of solid waste, and aims at providing the self-compacting micro-expansive C55 concrete. To achieve the technical purpose, according to the technical scheme, the self-compacting micro-expansive C55 concrete is prepared from, by weight, 150-174 parts of finely-ground desulfuration residues, 350-406 parts of cement, 750-800 parts of river sand, 850-900 parts of crushed stone, 150-174 parts of water, 7.5-8.7 parts of activator and 7.0-8.1 parts of water reducing agent; the finely-ground desulfuration residues and the cement are binding materials, the total weight ratio of the activator to the cementing materials is 1.5%, the total weight ratio of the water reducing agent to the cementing materials is 1.4%, and the finely-ground desulfuration residues are prepared by grinding coal gangue desulfuration residues with a ball grinding mill and then sifting the coal gangue desulphurization residues with a 80-micrometer square hole sieve; the specific surface area of the finely-ground desulfuration residues is no less than 390 m<2> / kg; the C55 concrete has the advantages of being high in strength, self-compacting and micro-expansive, and can be widely applied to the field of construction.

A pharmaceutical composition for inhibition of tumor growth or metastasis which comprises an effective amount of Phyllanthus urinaria L. extracts, or the combination of the foregoing Phyllanthus urinaria L. extracts and pharmaceutical acceptable carries, adjuvants or excipients.

The invention discloses a production method of a fragrant silk fabric. The production method comprises the following steps of: dissolving beta-cyclodextrin and peppermint essence in a constant-temperature water bath pot with water, dropwise adding an emulsifier into the solution, slowly stirring the solution till solids are separated out, filtering the solution, washing the filtered solids with absolute ethyl alcohol, and drying the filtered solids to obtain powdered essence micro capsules; and uniformly dispersing the powdered essence micro capsules on silk fibers in a cotton carding procedure, and spinning and weaving the silk fibers to obtain the fragrant silk fabric. In such a mode, according to the production method of the fragrant silk fabric provided by the invention, as the peppermint essence is added into an original silk fabric, the coolness of the silk fabric is effectively improved, and people feel comfortable when wearing the fabric in summer; and by wrapping the essence, the releasing time of essence ingredients is effectively controlled, so that people are free from uncomfortableness caused by short-term release of the essence ingredients, and meanwhile, the influence of an ambient environment to the essence is avoided while clothes is worn or used.

The invention discloses plate-shaped part grooving equipment with an anti-blocking function, and relates to the technical field of plate-shaped part trepanning. The plate-shaped part grooving equipment with the anti-blocking function comprises a base, a supporting plate is fixed to the top end of the base, an adjustable clamp is arranged in the middle of the right side of the supporting plate, the right side of the supporting plate is slidably connected with a movable plate through a sliding rail, and a grooving device is fixedly embedded in the movable plate. According to the plate-shaped part grooving equipment with the anti-blocking function, an impact block is arranged in a grooving cutter to clean waste remaining in the grooving cutter after grooving is completed, in the rotating process of the grooving cutter, under the action of centrifugal force, two metal balls can move obliquely upwards at the same time, at the moment, the impact block is driven by an elastic pull rope to move upwards, and therefore the grooving cutter is prevented from being blocked. And meanwhile, the two first elastic pieces are compressed, and after the grooving cutter stops rotating, the impact block is rapidly reset through resilience force of the two first elastic pieces, so that residual waste materials in the grooving cutter are impacted.

The invention discloses the ingredients and the preparation method of an oral pulse pellet pharmaceutical preparation of metoprolol salts. The pharmaceutical preparation is a multi-layered coated pellet which has a basic structure of an immediate-release pellet core, an alkaline layer and a retardation layer containing remedium cardinale of 20 to 100 mg from inside to outside, wherein, the retardation layer contains polyacrylic resin 3, the weight increment of which is 100 to 240 percent of the immediate-release pellet core; the alkaline layer is a medicinal inorganic alkaline adjuvant, the weight of which is 10 to 30 percent of the immediate-release pellet core. After being taken, the pulse pellet begins to release immediately till a complete release is obtained after a time lag of 3 to 4hours and achieves the effect of one pulse release. The oral pulse pellet pharmaceutical preparation can effectively prevent angina pectoris, hyperpiesis and other diseases from being triggered due to the rise of blood pressure and heart rate within a few hours after a patient awakens and wakes up in the early morning.

The invention provides a seed coating, which is prepared from the following raw materials in parts by weight: 5 to 20 parts of polyhydric alcohol substances, 0 to 20 parts of pesticide active ingredients, 0 to 0.5 part of tri ethylene diamine, 0 to 0.5 part of silicon surfactants, 0 to 0.25 part of tin catalysts and 5 to 20 parts of diisocyanate compounds, wherein the polyhydric alcohol substances are liquefied plant fiber polysaccharides and polyether polyol. The seed coating has the advantages that the liquefied fiber polysaccharides are added; the seed coating using the liquefied fiber polysaccharides as the raw materials has high biodegradable performance, so that the operation is fast, simple and convenient; the release speed is controllable, and the like.

The invention relates to a multi-stage compound sweetener and a preparation process, belonging to the field of food additives. A multi-stage compound sweetener, the microscopic particles of the powder have an inner and outer double-layer structure, the inner layer is a post-sweet compound layer, the outer layer is a pre-sweet compound layer, and the outer layer of the pre-sweet compound layer The layer is also wrapped with a sweetness inducing layer of natural sweetener ingredients, which is used to present the flavor of natural sweeteners in the first mouthfeel of the food. This technical solution controls the gradient release of artificial sweeteners with different properties and tastes, and mutually eliminates the shortcomings of each sweetener, such as insufficient sweetness, heavy metal taste, and bitterness, so that the overall sweetness is uniform and stable, which is different from natural sweeteners. Close, without bitterness and metallic taste. More importantly, this technical solution proposes to control the release time points of various high-power sweeteners by processing the microstructure of sweeteners, so as to reconcile the appropriate taste, and points out a new direction for the design of compound sweeteners .

The invention provides a recombinant human interferon ε vaginal expansion suppository and a preparation method thereof. The vaginal expansion suppository comprises in parts by weight: 0.1-1.0 parts of recombinant human interferon ε, 10-50 parts of high molecular polymer, 50-200 parts of matrix and 100-500 parts of expansion carrier. The outer layer of the vaginal expansible suppository of the present invention is coated with a high molecular polymer, which effectively controls the release speed and release time of recombinant human interferon ε, so that the drug effect of the vaginal expansive suppository lasts up to 24 hours; The curative effect of recombinant human interferon ε was increased by 3-4 times with the combination of the extracts, the extract of Ziheche, the extract of wild lily and the extract of Scutellaria baicalensis.

The invention provides a recombinant human interferon α1b vaginal expansion suppository and a preparation method thereof. The vaginal expansion suppository comprises, in parts by weight: 0.01-1.0 parts of recombinant human interferon α1b, 10-50 parts of a high molecular polymer, and a matrix 50‑200 parts and swelling carrier 100‑500 parts. The vaginal expansion suppository of the present invention uses recombinant human interferon α1b suitable for Chinese people as the main active ingredient, and has a remarkable curative effect, and its outer layer is coated with a high molecular polymer, which controls the release speed and action time of the active ingredient, reduces the The number of daily administration is reduced, so that the recombinant human interferon α1b can be better absorbed, distributed and metabolized by the human body, with less toxic and side effects.

The present invention is related to a biodegradable carrier with adjustable zeta potentials and particle sizes, a method for making the same, and a pharmaceutical composition comprising the same. In such a method, a first solution comprising a first biodegradable macromolecule is prepared, and a second solution comprising a second biodegradable macromolecule is also prepared according to a desired zeta potential of a biodegradable carrier and further added into the first solution to form a mixture solution. The biodegradable carrier with the desired zeta potentials is formed by the attraction force between the different electric properties. Then, the mole number of the first biodegradable macromolecule and the second biodegradable macromolecule in the mixture solution are proportionally adjusted according to a desired particle size of the biodegradable carrier. Therefore, the zeta potential and the particle size of the biodegradable carrier are adjustable artificially.

The disclosure provides a flexible microneedle patch for transdermal drug delivery and a manufacturing method thereof. The flexible microneedle patch includes a flexible film substrate layer, a microneedle structure layer and a drug delivery layer. On the surface of the film substrate layer, the microneedle structure layer is an array formed by several cone structures, each cone structure surface has a pit structure, and the drug delivery layer is arranged on the surface of each cone structure. The flexible microneedle patch provided by the present disclosure has the advantages of low cost, mass production, precise control of drug carrying amount and release time, and the like.

The invention relates to medicine-containing slow-release granules for nasal mucosa. The medicine-containing slow-release granules comprise medicines and a biodegradable polymer, wherein the medicinesare 0.1-40% by weight in the medicine-containing slow-release granules, the biodegradable polymer is 60-99.9% by weight of the medicine-containing slow-release granules, the granule size of the medicine-containing slow-release granules is 0.5-250[mu]m, and the granule size is in normal distribution. The invention further provides an application of the medicine-containing slow-release granules. The medicine-containing slow-release granules for nasal mucosa can be directly applied to meatus nasi diseased regions. Specially, the medicines and the biodegradable polymer are mixed to prepare the granules in different size, and the size of the granules and the distribution of the granule size are controlled, so that control of the release time of the medicines can be achieved.

The invention relates to a colored granular solid toilet detergent which is prepared from the following components in parts by mass: 40-50 parts of sodium sulfate, 5 to 15 parts of an isomeric fatty alcohol-polyoxyethylene ether, 5 to 10 parts of sodium percarbonate, 3 to 5 parts of hydroxy propyl cellulose, 3 to 7 parts of edible starch, 5 to 8 parts of sodium stearate, 5 to 10 parts of deionizedwater, 1 to 3 parts of zinc diricinoleate, 1 to 3 parts of N-alkyl propylaminoglycine, 0.5 to 1 part of ethylenediamine tetraacetic acid disodium salt, 0.01 to 0.1 part of food-grade brilliant blue pigment and 0.1 to 0.3 part of a pine flavor essence. A preparation method comprises the following steps: (1) weighing and burdening: weighing the components according to the proportion, and respectively putting the components into respective special containers for later use; (2) stirring and mixing: blending an obtained mixture into a paste product with certain fluidity; and (3) molding the mixedpaste product into colored granular solid particles by using a granulator. The colored granular solid toilet detergent has the advantages of low dissolution rate, long acting time, constant and uniform release speed and better effect by using the special container.

The invention provides a bonding-type digestive tract support and a production method thereof. The bonding-type digestive tract support comprises a support body, diameters D of two end portions of the support body are 16-20mm, and an adhesive layer is arranged on the outer surface of the support body and composed of, by weight, 85-95 parts of high-molecular resin materials, 2-6 parts of ethylene-ethyl acrylate, 1-5 parts of zinc oxide, 0.5-3 parts of light calcium carbonate, 0.5-2 parts of clinoptilolite powder and 0.3-1 part of wool fat. Introduced bioactive oligopeptide can inhibit staphylococcus and the like to be adhered at infected parts, and the bonding-type digestive tract support has the advantages of conduciveness to rehabilitation of patients and the like.

The invention provides a seed coating. The seed coating comprises, by weight, 5-20 parts of polyols substances, 0-20 parts of pesticide active components, 0-0.5 part of triethylene diamine, 0-0.5 partof silicon surfactants, 0-0.25 part of tin catalysts and 5-20 parts of diisocyanate compounds. The polyols substances are liquefied animal fiber polysaccharides and polyether polyols. The seed coating has the advantages of high biodegradability, speediness, simplicity and convenience in operation, controllable release speed and the like.

The invention relates to the field of sustained-release technologies for medicines, in particular to a molecularly imprinted polymer with a controllable sustained-release function. The molecularly imprinted polymer has the advantages that methacrylic acid modified by beta-cyclodextrin is used as a functional monomer, atropine sulfate is used as a template molecule, class specific characteristics of molecularly imprinted polymers are combined with a sustained-release function of the beta-cyclodextrin, and accordingly the molecularly imprinted polymer with the controllable sustained-release function has long-acting medicine release time; the molecularly imprinted polymer with the controllable sustained-release function is customized for medicine template molecules and accordingly is high in selectivity for the released medicine template molecules.

The invention provides an anti-infection biological ceramic artificial bone and application thereof. The artificial bone is prepared by the following method that biological ceramics, bioglass sintering auxiliary agents and bonding agents are mixed; the obtained mixture is formed to obtain a composite blank body; the bioglass sintering auxiliary agents are selected from silicate glass and / or phosphate glass; antibacterial ions and bone vascularization promotion ions are mixed in the bioglass sintering auxiliary agents; the antibacterial ions are selected from one or several kinds of materials from silver, gallium, copper and zinc; the bone vascularization promotion ions are selected from one or several kinds of materials from magnesium, strontium, iron, boron, cobalt and lithium; the total amount of substances of oxides of the antibacterial ions and oxides of the bone vascularization promotion ions accounts for 0.1 to 60 percent of the amount of substance of the bioglass sintering auxiliary agents; the mol ratio of the antibacterial ions to the bone vascularization promotion ions is (0.05 to 20):1; the composite blank body is sintered to obtain the biological ceramic artificial bone. The anti-infection biological ceramic artificial bone has the advantages of high intensity and low cell toxicity; the antibacterial ion release speed is controllable; the release time is long.