34results about How to "Release speed controllable" patented technology

The invention relates to a compound with antifouling activity and the distilling method as well as the application, in particular to an isoquinoline compound, and provides a compound with antifouling activity and the distilling method as well as the application. The compound is 3-methoxy-5 hydroxy-7-aldehyde group isoquinoline, and the molecular formula is C11H9NO3. Dry root of excoecaria agallocha is crushed to obtain root shivers; the shivers are dipped into solvents to obtain extracting solutions; the extracting solution goes through filtration and decompression, and the dry solvent is made into extracts; the extracts are scattered in water and distilled with ethyl acetate, which is removed to obtain crude products; the crude products are processed with petroleum aether; the acetone isused as eluent to purify the silica gel column, which is re-crystallized in the acetone. And then, methanol is used as solvents to refine the silica gel column to obtain the pure compound with the antifouling activity (3-methoxy-5 hydroxy-7-aldehyde group isoquinoline). The compound can be used for producing high-efficiency antifouling agents.

The invention discloses a copper ion antibacterial hydrogel and a preparation method thereof. First, a small molecule containing two hydrazide groups is grafted on a water-soluble polymer containing a carboxyl group by a carbodiimide method, and then combined with copper The salt solution is evenly mixed to obtain the copper ion antibacterial hydrogel. The advantages of the present invention are that the preparation method is simple and efficient, the process conditions are mild, the copper ion is both a cross-linking agent and an antibacterial agent, and the prepared hydrogel has good mechanical properties, injectability, self-repairability, excellent antibacterial properties and biocompatibility It can be widely used in skin wound protection, infection treatment and gynecological inflammation treatment.

The invention discloses a sandwich layer slow-release birth control material, which is formed by superposing hybrid material layers and complexing polymer-matrix composite material layers in a staggered mode, and the bottom layer and the top layer are the hybrid material layers consisting of polyving akohol and 10 to 40 weight percent of SiO2; the complexing polymer-matrix composite material layers consist of the polyving akohol, 10 and 40 weight percent of SiO2 and 10 and 40 weight percent of copper salt. The sandwich layer slow-release birth control material can release copper ions slowly, reduces the phenomenon of the burst release of the copper ions caused by the conventional metal copper birth-control device and the nanometer copper / low-density polyethylene birth-control device, and eliminate side effects such as massive hemorrhage, underbelly pain, pelvic inflammatory disease and the like caused by the burst release of the copper ions during initial implantation. The release process comprises that the copper ions dissociated in an intermediate layer of a composite material are diffused towards a surface layer under the action of concentration gradient; the copper ions diffused to the surface layer are diffused to an interface where the material is contacted with body fluid of a human body; and finally, the copper ions are diffused to the body fluid of the human body through the interface. The sandwich layer slow-release birth control material prolongs a path for diffusing medicaments, increases the resistance of medicament release, and slows down the release speed of the copper ions.

The invention provides polymer microspheres for profile control and water plugging in oilfields and a preparation method thereof. The polymer microspheres have a three-layer spherical structure, including a cationic inner core, a middle lipophilic shell, and an outer anionic hydrophilic shell. The cationic inner core includes acrylamide, cationic monomer and crosslinker copolymer, the middle lipophilic shell layer includes acrylamide, lipophilic monomer and crosslinker copolymer, and the outer anionic hydrophilic shell layer includes acrylamide, anionic monomer and crosslinker copolymers. The polymer microspheres prepared by the present invention have a controllable particle size range of 1-500 μm. When in use, the outer hydrophilic shell and the middle lipophilic shell gradually degrade with the extension of the hydration time, and the inner core has excellent water absorption and swelling properties. Performance, the size after full expansion reaches 30~1500μm, with good expansion performance and strong plugging performance. The polymer microsphere of the present invention is a solid powder, which is convenient for storage and has good stability, and has a validity period of 3-5 years. It does not need to add other additives during use and can be quickly dispersed in a solvent.

The invention discloses application of oleanolic acid in preparing a marine environment-friendly antifouling agent, and relates to an antifouling agent, in particular to application of a natural active material oleanolic acid as the marine environment-friendly antifouling agent. The oleanolic acid applied to a marine antifouling coating can prevent marine plants from adhering and growing on the surfaces of submarine artificial facilities such as the bottom of a ship, an offshore oil-gas platform, a buoyage, a wharf, a bridge pier, a seawater pipeline, an aquaculture net cage, and the like. The invention provides application of the oleanolic acid in preparing the marine environment-friendly antifouling agent and the marine antifouling coating.

The present invention provides one kind of slow releasing carrier material for implanted medicine. The slow releasing carrier material is prepared through mixing sebacic acid and glycerin in the weight ratio of 1 / 3 to 3 and polycondensation at 130-160 deg.c to produce prepolymer; mixing with certain amount of lactic acid, hydrolactic acid, polylactic acid or polyhydrolactic acid; setting the mixture in some shaping container and further synthesis reaction at 120-140 deg.c. It has certain degradation speed and shape. The present invention has the features of no negative effect of catalyst and solvent, excellent tissue reaction with less caused inflammation and fibrosis, no obvious degradation caused swelling, no in vitro macrophage toxicity, and capacity of maintaining the shape, surface integrity and mechanical strength during degradation.

The invention discloses a spinning solution, nuclear shell nanofiber as well as a preparation method and application thereof. A hydrophobic drug and polyvinyl alcohol (PVA) / polyethylene glycol-b-poly(p-dioxanone) (PEG-b-PPDO) are blended to obtain a spinning solution system, and the nuclear shell nanofiber is directly formed by utilizing a single-axis spinneret under a high-voltage electrostatic effect. The preparation method disclosed by the invention has the advantages of simple equipment, mild conditions, simple flow and low energy consumption, can be used for achieving the aims of high-efficiency embedding of the hydrophobic drug, controllable drug release speed and long sustained release time, and is very suitable for industrial production.

The alpha-cypermethrin anti-fouling preparation is one kind of efficient environment friendly marine use anti-fouling preparation prepared with artificially synthesized derivative of pyrethrin as the pyrethrum extract and has low cost, high efficiency and environment friendship. Alpha-cypermethrin has the molecular expression of C22H19Cl2NO3, molecular weight of 416.35 and molecular structure as shown.