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Thermo-sensitive coding microsphere carrier for drug controlled release and preparation method of microsphere carrier

A technology of drug controlled release and temperature sensitivity, which is applied in the fields of pharmaceutical formulation, drug delivery, liquid delivery, etc. It can solve the problems of uneven particle size and pore size of microspheres, reduce biological safety, and difficulty in residue determination, etc. The effect of drug rate, low cost and simple preparation method

Inactive Publication Date: 2016-12-14
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, in many technologies for preparing porous drug-loaded microspheres, it is necessary to add a pore-forming agent, which makes it difficult to determine the residue in the later stage and reduces biological safety; and the particle size and pore size of the microspheres prepared by the existing technology are not uniform. low rate, poor repeatability

Method used

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  • Thermo-sensitive coding microsphere carrier for drug controlled release and preparation method of microsphere carrier
  • Thermo-sensitive coding microsphere carrier for drug controlled release and preparation method of microsphere carrier
  • Thermo-sensitive coding microsphere carrier for drug controlled release and preparation method of microsphere carrier

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1 Preparation of NIPAM / acrylamide drug controlled release microsphere carrier:

[0035] 1. Preparation of ordered colloidal crystal microspheres: monodisperse SiO 2 Add deionized water to the nanoparticles to adjust the concentration to 20%-30% (w / v); use a glass microfluidic device to shear the colloidal solution into monodisperse droplets in the mobile phase, and place the droplet template in an oven for 80 °C to dry and solidify, remove surface or internal impurities, and place in a muffle furnace for calcination at 800 °C for 3 hours.

[0036]. NIPAM / acrylamide hydrogel filling: firstly, the prepared SiO 2 The colloidal crystal microspheres were subjected to hydrophilic treatment, soaked in a mixture of 70% concentrated sulfuric acid and 30% hydrogen peroxide for 12 hours to make the surface of the microspheres hydroxylated. After repeated cleaning with ultrapure water and drying with nitrogen, the colloidal crystal microspheres were immediately soaked i...

Embodiment 2

[0038] Example 2 Preparation of NIPAM / PEGDA drug controlled release microsphere carrier:

[0039] 1. Preparation of ordered colloidal crystal microspheres Preparation of ordered colloidal crystal microspheres: Add monodisperse PS nanoparticles to deionized water to adjust the concentration to 20%-30% (w / v); The solution was sheared into monodisperse droplets in the mobile phase, and the droplet template was dried and solidified in an oven at 80°C. After removing surface or internal impurities, it was calcined in a muffle furnace at 800°C for 3h.

[0040] . NIPAM / PEGDA hydrogel filling: firstly, the prepared PS colloidal crystal microspheres were hydrophilically treated, soaked in a mixture of 70% concentrated sulfuric acid and 30% hydrogen peroxide for 12 hours to hydroxylate the surface of the microspheres. After repeatedly washing with ultrapure water and blowing dry with nitrogen, the colloidal crystal microspheres can be soaked in a solution containing 30% (w / v) NIPAM,...

Embodiment 3

[0042] Example 3 Preparation of NIPAM / HEMA drug controlled release microsphere carrier:

[0043] 1. Preparation of ordered colloidal crystal microspheres: similar to Example 1.

[0044] 2. NIPAM / HEMA hydrogel filling: the prepared SiO 2 The colloidal crystal microspheres were subjected to hydrophilic treatment, soaked in a mixture of 70% concentrated sulfuric acid and 30% hydrogen peroxide for 12 hours to make the surface of the microspheres hydroxylated. After repeatedly washing with ultrapure water and blowing dry with nitrogen, the colloidal crystal microspheres can be soaked in a solution containing 30% (w / v) NIPAM, 5% (w / v) HEMA, 1 (v / v)% photoinitiated In the hydrogel polymerization precursor solution of the agent, the colloidal solution can be gelled after the microspheres change from white to colored and irradiated with ultraviolet rays for 1-2 minutes. Then the hydrogel microspheres are soaked in deionized water. Due to the different expansion coefficients inside ...

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Abstract

The invention discloses a thermo-sensitive coding microsphere carrier for drug controlled release and a preparation method of the microsphere carrier. The carrier is a hydrogel microsphere with an inverse opal structure. The main component of the microsphere is poly(N-isopropylacrylamide), which has a three-dimensional ordered nanometer porous structure for carrying multiple protein or polypeptide medicines. Contraction and expansion of nanometer holes can be controlled through temperature regulation, so that drug controlled release is achieved. The inverse opal hydrogel microsphere is prepared by taking a colloidal crystal microsphere as a template. The carrier is simple in preparation method, low in cost and convenient for large-scale production. The prepared coding carrier is non-toxic and is good in biocompatibility and controllability.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a temperature-sensitive coded drug controlled-release microsphere carrier and a preparation method thereof, especially for embedding protein or polypeptide drugs. Background technique [0002] In recent years, with the development of emerging biotechnology and genetic engineering, protein and polypeptide biochemical medicines have shown strong pharmacological effects, few side effects and rarely cause allergies in the treatment of dwarfism, liver cirrhosis and cancer and other difficult-to-cure diseases. Response and other characteristics have attracted much attention. Due to the poor stability of peptide and protein drugs, they are easily degraded in the stomach and intestines, so their bioavailability is low, so they are usually administered by injection. However, due to the short half-life of such drugs in the body, multiple injections are often required for cl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K47/32A61K9/00A61K9/06
CPCA61K9/1635A61K9/0002A61K9/06
Inventor 赵远锦张彬顾笑晓付繁繁刘羽霄
Owner SOUTHEAST UNIV
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