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Copper ion antibacterial hydrogel as well as preparation method and application thereof

A technology of hydrogel and copper ions, which is applied in the field of medical hydrogels, can solve problems such as complex preparation methods, difficulty in effectively realizing the controlled release of copper ions, and unsatisfactory biocompatibility, so as to achieve good biocompatibility and avoid The problem of drug resistance, the effect of good mechanical properties

Active Publication Date: 2021-03-12
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a copper ion antibacterial hydrogel and its preparation method and application, which solves the problems of complex preparation methods of existing copper-containing antibacterial materials, difficulty in effectively realizing the controlled release of copper ions, and unsatisfactory biocompatibility

Method used

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  • Copper ion antibacterial hydrogel as well as preparation method and application thereof
  • Copper ion antibacterial hydrogel as well as preparation method and application thereof
  • Copper ion antibacterial hydrogel as well as preparation method and application thereof

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preparation example Construction

[0024] A preparation method of copper ion antibacterial hydrogel, comprising the following steps:

[0025] (1) Add carboxyl-containing water-soluble polymers with a molecular weight of 20kDa to 3000kDa, such as sodium hyaluronate, sodium alginate, polyglutamic acid, polyaspartic acid, and carboxymethylated polysaccharides such as carboxymethyl cellulose One of plain sodium, carboxymethyl chitin, carboxymethyl chitosan, etc., dissolved in water to make a solution with a mass concentration of 0.5% to 10%, then adjust the pH value to 4.5 to 6.5; then add 1 -(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide, and keep the pH value constant; then add an organic small molecule containing two hydrazide groups Molecules, namely 3,3'-dithiodipropionyl hydrazide, 2,2'-dithiodiacetylhydrazide, 4,4'-dithiodibutyric hydrazide, adipate dihydrazide, propanedi Acid dihydrazide, succinic acid dihydrazide, sebacic acid dihydrazide; after reacting at room tempera...

Embodiment 1

[0030] (1) Dissolve 1 gram of sodium hyaluronate with a molecular weight of 200kDa in 100mL of water to make a solution with a concentration of 1% by mass; then add 0.05 grams of N-hydroxysuccinimide and 0.6 grams of 3,3' -dithiodipropionyl hydrazide, and adjust the pH value to 5.5; then, add 5 mL of aqueous solution containing 0.072 gram of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, During this period, the pH value was maintained at 5.5; after reacting at room temperature for 36 hours, dialyzed against water for 2 days with a dialysis bag with a molecular weight cut-off of 3000 Da; finally, freeze-dried at minus 20 degrees Celsius for 36 hours to obtain hydrazide hyaluronic acid with a modification degree of 10% .

[0031] (2) Dissolving hyaluronic acid hydrazide in water to make a solution with a mass percent concentration of 3%, then adding copper-lysine complexes, and standing for 1 minute to obtain copper ions with a mass percent of 0.1% Antibacterial h...

Embodiment 2

[0036] (1) Dissolve 1 gram of sodium hyaluronate with a molecular weight of 2000kDa in 200mL of water to make a solution with a mass percent concentration of 0.5%; then add 0.15 grams of N-hydroxysuccinimide and 1.32 grams of adipic acid di hydrazide, and adjust the pH to 5.5; then, add 5 mL of aqueous solution containing 0.22 g of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, maintaining the pH at 5.5 After reacting at room temperature for 36 hours, use a dialysis bag with a molecular weight cut-off of 3000 Da to dialyze water for 2 days; finally freeze-dry at minus 20 degrees Celsius for 36 hours to obtain hydrazide hyaluronic acid with a modification degree of 30%.

[0037] (2) Dissolving hydrazidized hyaluronic acid in water to make a solution with a mass percent concentration of 0.5%, then adding copper chloride solution, and standing for 30 minutes to obtain a copper ion antibacterial hydrogel with a copper mass percent of 1%. .

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Abstract

The invention discloses a copper ion antibacterial hydrogel as well as a preparation method and application thereof. The preparation method comprises the following steps: firstly, grafting small molecules containing two hydrazide groups onto water-soluble macromolecules containing carboxyl by utilizing a carbodiimide method, and then uniformly mixing the obtained product with a copper salt solution, so as to obtain the copper ion antibacterial hydrogel. The preparation method has the advantages that the preparation method is simple and efficient, the process conditions are mild, the copper ions are both a cross-linking agent and an antibacterial agent, and the prepared hydrogel has the advantages of good mechanical property, injectability, self-repairability, excellent antibacterial property, biocompatibility and the like, and can be widely applied to skin wound protection, infection treatment, gynecologic inflammation treatment and the like.

Description

technical field [0001] The invention belongs to the technical field of medical hydrogels, and in particular relates to a copper ion antibacterial hydrogel, a preparation method and an application thereof. Background technique [0002] The skin is the largest tissue and organ of the human body, and it is also the first line of defense of the human body. It can protect the human body from external physical and chemical stimuli, as well as bacteria and viruses. However, when the skin is damaged or injured by the outside world, the wound surface will face the risk of infection, and in severe cases, it will endanger the life safety of the patient. At present, dressings such as gauze and bandages are commonly used in combination with antibiotics to prevent wound infection in clinical practice. However, traditional dressings such as gauze and bandages are easy to adhere to the wound because they are in a dry state. When they are replaced, they are likely to cause secondary damage t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08J3/24C08L5/08C08L1/08C08L5/04C08L77/04C08B37/08C08B37/04A61K9/06A61K33/34A61K47/61A61K47/64A61P17/02A61P31/04
CPCC08J3/075C08J3/24C08B37/0072C08B37/0084C08B15/06C08B37/003C08G69/48A61K33/34A61K9/06A61K47/61A61K47/645A61P31/04A61P17/02C08J2305/08C08J2301/08C08J2305/04C08J2377/04
Inventor 钱军民纪利杰胥伟军侯光晖
Owner XI AN JIAOTONG UNIV
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