Method for preparing degradable antibacterial medical dressing material

An anti-inflammatory drug and system technology, applied in the field of medicine, can solve the problems of poor industrialization prospects, high setting requirements, complicated operations, etc., and achieve the effects of controllable drug release rate, good cell compatibility, and simple operation.

Inactive Publication Date: 2020-11-24
JIANGSU HEMINGS NEW MATERIALS TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the method of solution casting is generally used to make the solution containing PLA to prepare porous membrane. This method is more complicated to operate, has higher requirements for settings, and the industrialization prospect is not good; at the same time, polylactic acid (PLA) is rarely combined with anti-inflammatory drugs. use

Method used

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  • Method for preparing degradable antibacterial medical dressing material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] S1. Establish a drug-loading system: laponite LAP and anti-inflammatory drugs are wrapped in laponite LAP with amoxicillin AMX in a mass ratio of 1:1 to form a "LAP-AMX" system;

[0023] S2. Dissolve polylactic acid (PLA) in chloroform solution to obtain a 12% w / v solution, mix it with the "LAP-AMX" system in S1, and stir it magnetically to fully dissolve it to obtain an electrospinning solution;

[0024] S3. Take 5ml of PLA / LAP / AMX solution for electrospinning, the conditions of the electrospinning equipment are: voltage 15kv, advancing speed 0.3ml / h, receiving distance 10cm, and collect the electrospun membrane; the formed PLA / LAP / The AMX membrane was dried in a fume hood at 25°C for 48 hours, and stored for future use, and a membrane with a three-dimensional porous structure was obtained.

Embodiment 2

[0026] A kind of method that can prepare degradable antibacterial medical dressing material, the steps are as follows:

[0027] S1. Establish a drug-loading system: laponite LAP and amoxicillin AMX are packaged in LAP with laponite LAP and amoxicillin AMX at a ratio of 0.1:1 to form a "LAP-AMX" system;

[0028] S2. Dissolve polycaprolactone PCL in dichloromethane solution to obtain a 20% w / v solution, mix it with the "LAP-AMX" system in S1, and stir it magnetically to fully dissolve it to obtain PCL / LAP / AMX Electrospinning solution;

[0029] S3. Take 7ml of PCL / LAP / AMX solution for electrospinning, the electrospinning operating parameters: voltage 20kv, advancing speed 1.0ml / h, receiving distance 12cm, and collect the electrospun membrane;

[0030] S4. The formed PLA / LAP / AMX electrospun membrane was dried in a fume hood at 40° C. for 36 hours, and stored for future use, that is, a membrane with a three-dimensional porous structure was obtained.

Embodiment 3

[0032] A kind of method that can prepare degradable antibacterial medical dressing material, the steps are as follows:

[0033] S1. Establish a drug-loading system: mix laponite LAP and anti-inflammatory drugs at a ratio of 0.5:1, and stir to make azithromycin AZM wrapped in laponite LAP to obtain the "LAP-AZM" system;

[0034] S2. Dissolve racemic polylactic acid PDLLA in N,N-dimethylformamide DMF solution to prepare a 50% w / v solution, mix it with the "LAP-AZM" mixture of S1, and stir it magnetically to make it Fully dissolved to obtain PDLLA / LAP / AZM electrospinning solution;

[0035] S3. Take 10ml of PDLLA / LAP / AZM solution for electrospinning, the electrospinning operating parameters: voltage 25kv, advancing speed 1.8ml / h, receiving distance 15cm, and collect the electrospun membrane;

[0036] S4. The formed PDLLA / LAP / AZM membrane was dried in a fume hood at 55° C. for 24 hours, and stored for future use, that is, a membrane with a three-dimensional porous structure was ob...

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Abstract

The invention discloses a method for preparing a degradable antibacterial medical dressing material. The method comprises the following steps: S1, establishing a drug-loading system: mixing laponite LAP and an anti-inflammatory drug according to a ratio of (0.1-1):1, and performing stirring to wrap the anti-inflammatory drug in the laponite LAP to prepare an LAP-anti-inflammatory drug system; andS2, dissolving polylactic acid PLA or polycaprolactone PCL or poly(DL-lactic acid) PDLLA in chloroform or dichloromethane or N,N-dimethylformamide DMF or hexafluoroisopropanol HFIP to prepare a solution of 10-50% w / v, then performing mixing with the LAP-anti-inflammatory drug system prepared in the S1, and performing magnetic stirring to make the mixture be dissolved to obtain an electro-spinningsolution. The whole method has the advantages such as simple operation, low cost, mild conditions, and environmental friendliness. The cytotoxicity detected by an MTT reagent shows that the dressing film material is non-cytotoxic, namely the cell compatibility is good. The in vitro drug release experiment shows that the dressing film material has a controllable drug release rate, and the drug loading efficiency is high.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a method for preparing a degradable antibacterial medical dressing material. Background technique [0002] In the past 30 years, driven by a huge population base and rapidly growing demand for medical services, China's medical device market has developed by leaps and bounds. Especially since the beginning of the 21st century, the industry as a whole has entered a stage of rapid growth. At the same time, the State Council's "Made in China 2025" proposed to improve the innovation ability and industrialization level of medical devices, focusing on the development of high-performance diagnostic and treatment equipment such as imaging equipment and medical robots, high-value medical consumables such as fully degradable vascular stents, and mobile devices such as wearable and remote diagnosis and treatment. medical products. [0003] Ideal materials for medical dressings should have good bioco...

Claims

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Application Information

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IPC IPC(8): A61L15/62A61L15/44A61L15/26A61L15/18
CPCA61L15/18A61L15/26A61L15/44A61L15/62A61L2300/216A61L2300/23A61L2300/404C08L67/04
Inventor 张甜王马约张天志张天毅
Owner JIANGSU HEMINGS NEW MATERIALS TECH CO LTD
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