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Chitin whisker/chitosan nanofiber double strengthened biodegradable polyester fiber composite material as well as preparation method and application thereof

A technology of biodegradable polyester and fiber composite materials, used in medical science, prosthesis, etc., can solve the problems that the mechanical properties of bone materials cannot be well met, the mechanical properties need to be further improved, and the rate of material degradation is difficult to control. , to achieve the effect of excellent osteogenic induction, excellent cytocompatibility, and excellent cell affinity

Active Publication Date: 2017-03-15
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, biodegradable polyester fiber scaffold materials still have the following shortcomings: (1) The mechanical strength of the material is average, which cannot well meet the requirements for the mechanical properties of bone materials; (2) The material is poor in hydrophilicity, which is not conducive to cell adhesion and proliferation; (3) The cytocompatibility is not ideal, and, lack of osteoinductivity, the ability to promote bone tissue healing is limited; (4) The degradation rate of the material is difficult to control
However, a single design introduces whisker materials into biodegradable polyester fiber scaffold materials, which has limited improvement on various properties of matrix materials. The mechanical properties of printed fiber scaffold materials still need to be further improved

Method used

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  • Chitin whisker/chitosan nanofiber double strengthened biodegradable polyester fiber composite material as well as preparation method and application thereof
  • Chitin whisker/chitosan nanofiber double strengthened biodegradable polyester fiber composite material as well as preparation method and application thereof
  • Chitin whisker/chitosan nanofiber double strengthened biodegradable polyester fiber composite material as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1: Preparation of chitin whisker (CHW) / poly(D,L-lactide) (PDLLA) fiber binary composite by electrospinning

[0044] The PDLLA solution was prepared by using chloroform and N,N-dimethylformamide dual solvent (volume ratio 6:4) to obtain an electrospinning solution with a mass volume (g / mL) concentration of 15%. According to the mass ratio of CHW / PDLLA as 2.5 / 97.5, 5 / 95, 10 / 90, 20 / 80 and 40 / 60, CHW was uniformly mixed in the solution respectively, and after magnetic stirring and ultrasonic dispersion, it was injected into the electrospinning solution to supply device, spinning under a static voltage of 22kV, the supply flow rate of the electrospinning liquid is 2.0mL / h, and the distance between the receiving plate and the needle of the syringe pump is 16cm, and the binary electrospinning CHW / PDLLA fiber is obtained. composite material.

Embodiment 2

[0045] Example 2: Preparation of CHW / poly(L-lactide) (PLLA) fiber binary composite by electrospinning

[0046] The PLLA solution was prepared by dichloromethane and N,N-dimethylformamide dual solvent (volume ratio: 7:3) to obtain an electrospinning solution with a mass volume (g / mL) concentration of 10%. According to the mass ratio of CHW / PLLA as 2.5 / 97.5, 5 / 95, 10 / 90, 20 / 80 and 40 / 60, CHW was uniformly mixed in the solution, and after magnetic stirring and ultrasonic dispersion, it was injected into the electrospinning solution to supply device, spinning under a static voltage of 15kV, the supply flow rate of the electrospinning liquid is 0.5mL / h, and the distance between the receiving plate and the needle of the syringe pump is 10cm, and the binary electrospun CHW / PLLA fiber is obtained. composite material.

Embodiment 3

[0047] Example 3: Preparation of CHW / poly(ε-caprolactone) (PCL) fiber binary composite material by electrospinning

[0048] The PCL solution was prepared by dichloromethane and N,N-dimethylformamide dual solvent (volume ratio: 7:3) to obtain an electrospinning solution with a mass volume (g / mL) concentration of 8%. According to the mass ratio of CHW / PCL as 2.5 / 97.5, 5 / 95, 10 / 90, 20 / 80 and 40 / 60, CHW was uniformly mixed in the solution respectively, and after magnetic stirring and ultrasonic dispersion, it was injected into the electrospinning solution to supply device, spinning under a static voltage of 12kV, the supply flow rate of the electrospinning liquid is 0.6mL / h, and the distance between the receiving plate and the needle of the syringe pump is 15cm, and the binary electrospun CHW / PCL fiber is obtained. composite material.

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Abstract

The invention belongs to the technical fields of nanometer bio-composite materials and tissue engineering, and discloses a chitin whisker / chitosan nanofiber double strengthened biodegradable polyester fiber composite material as well as a preparation method and application thereof. The preparation method comprises the following steps: treating chitin whiskers and biodegradable polyester by adopting an electrostatic spinning method or a 3D printing forming method to obtain a chitin whisker strengthened biodegradable polyester fiber scaffold, and introducing a chitosan nanofiber network into the fiber scaffold by utilizing a thermally induced phase separation method to obtain the chitin whisker / chitosan nanofiber double strengthened biodegradable polyester fiber composite material. According to the preparation method, the composite material with the structure that the chitin whisker strengthened biodegradable polyester fiber scaffold is provided, and chitosan nanofibers penetrate in the fiber scaffold and a fiber surface layer is obtained, has the ability of good hydrophilicity, excellent mechanical properties, good cell affinity and promoting healing of bone tissues, can be applied to the biomedical field and has good application prospect by particularly serving as a bone tissue repair material.

Description

technical field [0001] The invention belongs to the technical field of biological nanocomposite materials and tissue engineering, and in particular relates to a chitin whisker / chitosan nanofiber double-reinforced biodegradable polyester fiber composite material and a preparation method and application thereof. Background technique [0002] Bone defects or traumas caused by congenital, trauma, tumor and surgery are the most common and frequently occurring diseases in clinic. The market demand for bone tissue repair materials is very huge, and the proposal of bone tissue engineering has brought new opportunities for bone defect repair. hope. Tissue engineered fiber scaffolds can more effectively simulate the structure and function of natural extracellular matrix, and provide a good microenvironment for cell growth. In recent years, the fibrous scaffolds constructed by electrospinning and 3D printing have high specific surface area, high porosity and interconnected three-dimen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/20A61L27/58
Inventor 罗丙红刘桦文伟周长忍
Owner JINAN UNIVERSITY
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