The present invention relates to a preparation technology and a production method for an integrated new formulation of a licorice and monkshood decoction, wherein the raw materials of active ingredients comprise: 6 parts by weight of honey-fried licorice, 12 parts by weight of monkshood, 6 parts by weight of bighead atractylodes
rhizome, and 12 parts by weight of cinnamon
twig. The production process of the integrated new formulation of licorice and monkshood decoction comprises the following steps of: supersonic air-jet crushing,
alcohol-
water extraction, ultrasonic crushing extraction, water decocting concentration, supersonic
spray drying, nanometer
grinding,
high pressure homogenization, nano particle preparation and the like. According to the invention, the advantages, such as multi-synergism, multi-target, embodied by a nano-carrier
coupling technique, are focused to be taken of. After the integrated new formulation of licorice and monkshood decoction is subjected to scale production, the production cost can be greatly reduced, the quality of products is greatly improved and the targeting property and the sustained and
controlled release performance of the medicament are enhanced. The internal and external administration of the integrated new formulation of licorice and monkshood decoction can be realized simultaneously, and can be respectively taken in four time slices according to
midnight-
noon ebb-flow and qi and blood flowing rule of a
human body. The integrated new formulation of licorice and monkshood decoction can be further prepared into films and transdermal agents which are respectively stuck to different parts of a
human body according to the
midnight-
noon ebb-flow and qi and blood flowing rule of the
human body and can be directly absorbed through
skin.