62results about How to "Strong slow and controlled release performance" patented technology

The present invention relates to preparation process of sodium alginate / chitosan mixture gel capable of being used as biodegradable medicine carrier. The preparation process includes the following steps: 1. forming homogeneous transparent alginate and chitosan solution in 1-5 wt% concentration each with alginate in 5-95 wt% and chitosan in 5-95 wt%, and adding acetic acid; 2. preparing alginate / chitosan mixture sol; 3. dropping the sol into 1.5-3 wt% concentration calcium chloride or sodium sulfate solution; 4. preparing alginate / chitosan-calcium ion-sulfate radical double cross-linked gel grain; and 5. soaking in absolute ethanol for 2-5 min, vacuum drying to obtain alginate / chitosan mixture gel grain of 300-1000 micron grain size. The alginate / chitosan mixture gel grain of the present invention has high pH sensitivity and the preparation process is safe and simple.

The invention relates to a preparation technology and production method for an integrated new formulation of warming channel decoction. The raw material composition of the active ingredients comprises (by weight parts) evodia rutaecarpa 9, angelica 9, peony 6, chuanxiong 6, ginseng 6, cassia twig 6, tree peony bark 6, licorice 6, Rhizoma Pinelliae 6, ophiopogon root 9, and donkey-hide gelatin 6 (molten). Its production process includes performing supersonic gas stream crushing, alcohol and water extracting, supersonic wave crushing and extracting, decoction concentrating, supersonic spray drying, nano-grinding, high-pressure homogenization, and nanoparticles preparation. The preparation technology and production method focuses on the multi-collaborative, multi-targeted advantages of nano-carrier coupling technique, can significantly reduce production costs, significantly improve the quality of products, make drug targeting property and slow controlled release property stronger after scale production, realize inside and outside administration, and can prepare into pellicle to paste on human blood to be directly absorbed through the skin.

The invention relates to a drug releasing method based on a 4D printing shape memory polymer structure. The invention aims at solving the problems that according to an existing sustained-release drug,the drug preparation technology is complex, preparation cost is higher, and repeatability is lower. Shape memory polymers and a drug are mixed at the indoor temperature, a shape memory polymer carrying the drug is obtained, an initial constructed drug releasing structure is prepared through a 4D printing technology, the structure is heated to the glass transition temperature, the initial constructed drug releasing structure is converted to a temporary constructed drug releasing structure with a smaller superficial area, the temporary constructed drug releasing structure is placed in the environment which is prepared for simulating human body fluid, external motivators are given, the initial constructed drug releasing structure is recovered, and the whole process is completed. According tothe method, the preparation cost is low, the method is simple, and it is due to the fact that 4D printing process parameters are consistent, the repeatability is high. The method is applied to the field of intelligent drug releasing.

The present invention relates to a preparation technology and a production method for an integrated new formulation of a wu zi yan zong pill, wherein the raw materials of active ingredients comprise: 400 parts by weight of wolfberry, 400 parts by weight of semen cuscutae (stir-baked), 200 parts by weight of raspberry, 50 parts by weight of Chinese magnoliavine (steamed), and 100 parts by weight of plantain seed (stir-baked with salt). The production process of the integrated new formulation of wu zi yan zong pill comprises the following steps of: supersonic air-jet crushing, alcohol-water extraction, ultrasonic crushing extraction, water decocting concentration, supersonic spray drying, nanometer grinding, high pressure homogenization, nano particle preparation and the like. According to the invention, the advantages, such as multi-synergism, multi-target, embodied by a nano-carrier coupling technique, are focused to be taken of. After the integrated new formulation of wu zi yan zong pill decoction is subjected to scale production, the production cost can be greatly reduced, the quality of products is greatly improved and the targeting property and the sustained and controlled release performance of the medicament are enhanced. The internal and external administration of the integrated new formulation of wu zi yan zong pill decoction can be realized simultaneously, and can be respectively taken in four time slices according to midnight-noon ebb-flow and qi and blood flowing rule of a human body. The integrated new formulation of wu zi yan zong pill decoction can be further prepared into films and transdermal agents which are respectively stuck to different parts of a human body according to the midnight-noon ebb-flow and qi and blood flowing rule of the human body and can be directly absorbed through skin.

The present invention relates to a preparation technology and a production method for an integrated new formulation of a expelling stasis below the diaphragm decoction, wherein the raw materials of active ingredients comprise: 10 parts by weight of Chinese angelica, 6 parts by weight of ligusticum wallichii, 9 parts by weight of peach seeds, 6 parts by weight of red pheony root, 9 parts by weight of flying squirrel feces and the like. The production process of the integrated new formulation of expelling stasis below the diaphragm decoction comprises the following steps of: supersonic air-jet crushing, alcohol-water extraction, ultrasonic crushing extraction, water decocting concentration, supersonic spray drying, nanometer grinding, high pressure homogenization, nano particle preparation and the like. According to the invention, the advantages, such as multi-synergism, multi-target, embodied by a nano-carrier coupling technique, are focused to be taken of. After the integrated new formulation of expelling stasis below the diaphragm decoction is subjected to scale production, the production cost can be greatly reduced, the quality of products is greatly improved and the targeting property and the sustained and controlled release performance of the medicament are enhanced. The internal and external administration of the integrated new formulation of expelling stasis below the diaphragm decoction can be realized simultaneously, and can be respectively taken in four time slices according to midnight-noon ebb-flow and qi and blood flowing rule of a human body. The integrated new formulation of gexia stasis-expelling decoction can be further prepared into films and transdermal agents which are respectively stuck to different parts of a human body according to the midnight-noon ebb-flow and qi and blood flowing rule of the human body and can be directly absorbed through skin.

The present invention relates to a preparation technology and a production method for an integrated new formulation of a licorice heart-draining decoction, wherein the raw materials of active ingredients comprise: 15 parts by weight of licorice, 9 parts by weight of radix scutellariae, 6 parts by weight of coptis, 12 parts by weight of radix codonopsis, 9 parts by weight of pinellia ternate, 9 parts by weight of dried ginger, and 4 parts by weight of jujube. The production process of the integrated new formulation of licorice heart-draining decoction comprises the following steps of: supersonic air-jet crushing, alcohol-water extraction, ultrasonic crushing extraction, water decocting concentration, supersonic spray drying, nanometer grinding, high pressure homogenization, nano particle preparation and the like. According to the invention, the advantages, such as multi-synergism, multi-target, embodied by a nano-carrier coupling technique, are focused to be taken of. After the integrated new formulation of licorice heart-draining decoction is subjected to scale production, the production cost can be greatly reduced, the quality of products is greatly improved and the targeting property and the sustained and controlled release performance of the medicament are enhanced. The internal and external administration of the integrated new formulation of licorice heart-draining decoction can be realized simultaneously, and can be respectively taken in four time slices according to midnight-noon ebb-flow and qi and blood flowing rule of a human body. The integrated new formulation of licorice heart-draining decoction can be further prepared into films and transdermal agents which are respectively stuck to different parts of a human body according to the midnight-noon ebb-flow and qi and blood flowing rule of the human body and can be directly absorbed through skin.

The invention relates to a preparation technology and a production method of a new integrated dosage form of Evodia rutaecarpa Decoction. The raw material composition of the active ingredients is as follows: 9 parts of Evodia rutaecarpa, 9 parts of ginseng, 18 parts of ginger, and 4 parts of jujube. The production process includes: supersonic jet pulverization, alcohol-water extraction, ultrasonic pulverization and extraction, decoction and concentration, supersonic spray drying, nano-grinding, high-pressure milking, nano-particle preparation, etc. The present invention pays attention to the advantages of multi-synergy, multi-targeting and the like embodied by the combined use of nano-carrier technology. After large-scale production, the production cost can be greatly reduced, the product quality can be greatly improved, and the targeting and controlled release properties of the drug can be stronger. It can be administered both internally and externally, and can be taken in four time periods according to the meridian infusion and the flow of qi and blood in the human body. Film-forming agents and transdermal agents can also be prepared and attached to different parts of the human body according to the meridian infusion and the flow of human qi and blood, and can be directly absorbed through the skin.

The invention relates to a preparation technology and a production method of a new integrated dosage form of Sanzi Yangqin Decoction. The raw material composition of the active ingredients is as follows: 1 part of perilla seed, 1 part of white mustard seed and 1 part of radish seed. Its production process includes: supersonic airflow pulverization, alcohol water extraction, ultrasonic pulverization extraction, water decoction concentration, nano grinding, high pressure milk homogenization, nano particle preparation, etc. The invention pays attention to the advantages of multi-synergy and multi-targeting embodied by the combination technology of nano-carriers. After large-scale production, the production cost can be greatly reduced, the product quality can be greatly improved, and the targeting and sustained release of the drug can be strengthened. It can be administered both internally and externally, and can be taken in four time periods according to the meridian flow and the flow of blood in the human body. Film-forming agents and transdermal agents can also be prepared and pasted on different parts of the human body according to the meridian flow and the flow of human Qi and blood, and can be directly absorbed through the skin.

The invention relates to a preparation technology of a new integrated dosage form of Zuojin Pills and a production method thereof. The raw material composition of the active ingredients is as follows: 6 parts of Coptis chinensis and 1 part of Evodia rutaecarpa. Its production process includes: supersonic jet milling, alcohol-water extraction, ultrasonic pulverization and extraction, decoction and concentration, supersonic spray drying, high-pressure emulsification, nano-grinding, nano-particle preparation, etc. The invention pays attention to the advantages of multi-synergy and multi-targeting embodied by the combination technology of nano-carriers. After large-scale production, the production cost can be greatly reduced, the product quality can be greatly improved, and the targeting and sustained release of the drug can be strengthened. It can be administered both internally and externally, and can be taken in four time periods according to the meridian flow and the flow of blood in the human body. Film-forming agents and transdermal agents can also be prepared and pasted on different parts of the human body according to the meridian flow and the flow of human Qi and blood, and can be directly absorbed through the skin.

The invention relates to a technology and a method for preparing a novel combined formulation of jade-screen powder. The novel combined formulation of jade-screen powder comprises the following active ingredients in part by weight: 10 parts of astragalus, 10 parts of large headed atractylodes and 5 parts of ledebouriella root. The production process comprises the steps of: ethanol-water extraction, ultrasonic grinding extraction, microwave extraction, decocting concentration, supersonic spray drying, high-pressure homogenization, nano grinding, preparation of nano particles and the like. The invention has the advantages of emphasizing on the multiple synergism, multi-targeting action and the like of nano Chinese medicaments. When the technology and the method are used for industrial mass production, the production cost is greatly lowered, the product quality is improved, and the targeting property and the slow control-released property of the medicament are higher; and the medicament can be pasted on the human skin after being prepared into films, and the active ingredients can be absorbed through the skin for treatment.

The present invention relates to a preparation technology and a production method for an integrated new formulation of a turtle shell decocted pill, wherein the raw materials of active ingredients comprise: 12 parts by weight of turtle shell, 3 parts by weight of blackberrylily rhizome, 3 parts by weight of radix scutellariae, 6 parts by weight of radix bupleuri, 3 parts by weight of pillbug, 3 parts by weight of dry ginger, 3 parts by weight of rheum officinale, etc. The production process of the turtle shell decocted pill comprises the following steps of: supersonic air-jet crushing, alcohol-water extraction, ultrasonic crushing extraction, water decocting concentration, supersonic spray drying, nanometer grinding, high pressure homogenization, nano particle preparation and the like. According to the invention, the advantages, such as multi-synergism, multi-target, embodied by a nano-carrier coupling technique, are focused to be taken of. After the integrated new formulation of turtle shell decocted pill is subjected to scale production, the production cost can be greatly reduced, the quality of products is greatly improved and the targeting property, and the sustained and controlled release performance of the medicament are enhanced. The internal and external administration of the integrated new formulation of turtle shell decocted pill can be realized simultaneously, and the medicament can be separately taken in four time slices according to the midnight-noon ebb-flow and qi and the blood flowing rule of a human body. The integrated new formulation of turtle shell decocted pill can be further prepared into films and transdermal agents, which are respectively stuck to different parts of a human body according to the midnight-noon ebb-flow and qi and blood flowing rule of the human body, and can be directly absorbed through skin.

The invention relates to a Siqitang integrated novel dosage form and a production method of the novel dosage form. The raw material composition in part by weight of the effective components of the novel dosage form is as follows: 5 parts of Pinellia ternate, 4 parts of Poria cocos, 2 parts of Perilla frutescens leaf, and 3 parts of Magnolia officinalis. The production process comprises the steps of supersonic jet milling, alcohol water extraction, ultrasonic pulverization extraction, water decoction and concentration, supersonic spray drying, nano grinding, high pressure homogenization, nano particles preparation and the like. The invention pays attention to the advantages of multi-coordination, multi-target and the like showed by utilizing nano carrier combined technique, after large-scale production, the production cost can be greatly reduced, the product quality is greatly improved, and the targeting and sustained or controlled release properties of the drugs are strong. The products made in the invention can be dosed in vivo and in vitro simultaneously, and can be taked at four periods of time respectively according to midnight-noon ebb-flow and human qi and blood circulation rules. The effective components of Siqitang can also be prepared into a film-forming agent and a transdermal agent which is stick to different body parts according to midnight-noon ebb-flow and human qi and blood circulation rules for direct absorption through skin.

The invention relates to a preparation technology and a production method of a new integrated dosage form of Jichuan decoction. The raw material composition of the active ingredients is as follows: 15 parts of angelica, 6 parts of Achyranthes bidentata, 9 parts of Cistanche deserticola, 5 parts of Alisma, liter 3 parts of hemp, 3 parts of Citrus aurantium. Its production process includes: supersonic jet pulverization, alcohol water extraction, ultrasonic pulverization and extraction, water decoction and concentration, supersonic spray drying, nano grinding, high pressure emulsification, nano particle preparation, etc. The invention pays attention to the advantages of multi-synergy and multi-targeting embodied by the combination technology of nano-carriers. After large-scale production, the production cost can be greatly reduced, the product quality can be greatly improved, and the targeting and sustained release of the drug can be strengthened. It can be administered both internally and externally, and can be taken in four time periods according to the meridian flow and the flow of blood in the human body. Film-forming agents and transdermal agents can also be prepared and pasted on different parts of the human body according to the meridian flow and the flow of human Qi and blood, and can be directly absorbed through the skin.

The invention relates to a preparation technology and a production method of a new integrated dosage form of Fangji Huangqi Decoction. The raw material composition of the active ingredients is as follows: 12 parts of Fangji, 15 parts of Astragalus membranaceus, 6 parts of licorice and 9 parts of Atractylodes macrocephala. Its production process includes: supersonic jet pulverization, alcohol water extraction, ultrasonic pulverization and extraction, water decoction and concentration, supersonic spray drying, nano grinding, high pressure emulsification, nano particle preparation, etc. The invention pays attention to the advantages of multi-synergy and multi-targeting embodied by the combination technology of nano-carriers. After large-scale production, the production cost can be greatly reduced, the product quality can be greatly improved, and the targeting and sustained release of the drug can be strengthened. It can be administered both internally and externally, and can be taken in four time periods according to the meridian flow and the flow of blood in the human body. Film-forming agents and transdermal agents can also be prepared and pasted on different parts of the human body according to the meridian flow and the flow of human Qi and blood, and can be directly absorbed through the skin.

The invention relates to a preparation technology and production method for an integrated new formulation of Wuqin wine. The raw material composition of the active ingredients comprises (by weight parts) Umbellate pore 9, Rhizoma Alismatis 15, Rhizoma Atractylodis Macrocephalae 9, tuckahoe 12, and cassia twig 6. Its production process includes performing supersonic gas stream crushing, alcohol and water extracting, supersonic wave crushing and extracting, decoction concentrating, supersonic spray drying, nano-grinding, high-pressure homogenization, and nanoparticles preparation. The preparation technology and production method focuses on the multi-collaborative, multi-targeted advantages of nano-carrier coupling technique, can significantly reduce production costs, significantly improve the quality of products, make drug targeting property and slow controlled release property stronger after scale production, realize inside and outside administration, and can prepare into pellicle to paste on human blood to be directly absorbed through the skin.

The present invention relates to a preparation technology and a production method for an integrated new formulation of a cassia twig and oyster decoction, wherein the raw materials of active ingredients comprise: 9 parts by weight of cassia twig, 9 parts by weight of Chinese herbaceous peony, 9 parts by weight of ginger, 6 parts by weight of licorice, 12 parts by weight of Chinese-date, 9 parts by weight of fossil bone, and 9 parts by weight of oyster. The production process of the integrated new formulation comprises the following steps of: supersonic air-jet crushing, alcohol-water extraction, ultrasonic crushing extraction, water decocting concentration, supersonic spray drying, nanometer grinding, high pressure homogenization, nano particle preparation and the like. According to the invention, the advantages, such as multi-synergism, multi-target, embodied by a nano-carrier coupling technique, are focused to be taken of. After the integrated new formulation of cassia twig and oyster decoction is subjected to scale production, the production cost can be greatly reduced, the quality of products is greatly improved and the targeting property and the sustained and controlled release performance of the medicament are enhanced. The internal and external administration of the integrated new formulation of cassia twig and oyster decoction can be realized simultaneously, and can be respectively taken in four time slices according to midnight-noon ebb-flow and qi and blood flowing rule of a human body. The integrated new formulation of cassia twig and oyster decoction can be further prepared into films and transdermal agents which are respectively stuck to different parts of a human body according to the midnight-noon ebb-flow and qi and blood flowing rule of the human body and can be directly absorbed through skin.

The invention relates to a preparation technology and production method for an integrated new formulation of angelica peony wine. The raw material composition of the active ingredients comprises (by weight parts) angelica 9, peony 30, tuckahoe 12, Rhizoma Atractylodis Macrocephalae 12, Rhizoma Alismatis 15, and chuanxiong 9. Its production process includes performing supersonic gas stream crushing, alcohol and water extracting, supersonic wave crushing and extracting, decoction concentrating, supersonic spray drying, nano-grinding, high-pressure homogenization, and nanoparticles preparation. The preparation technology and production method focuses on the multi-collaborative, multi-targeted advantages of nano-carrier coupling technique, can significantly reduce production costs, significantly improve the quality of products, make drug targeting property and slow controlled release property stronger after scale production, realize inside and outside administration, and can prepare into pellicle to paste on human blood to be directly absorbed through the skin.

The present invention relates to a preparation technology and a production method for an integrated new formulation of a radix bupleuri, cassia twig and dry ginger decoction, wherein the raw materials of active ingredients comprise: 8 parts by weight of radix bupleuri, 3 parts by weight of cassia twig, 2 parts by weight of dry ginger,4 parts by weight of snakegourd root, 3 parts by weight of radix scutellariae, 2 parts by weight of oyster, and 2 parts by weight of honey-fried licorice root. The production process of the integrated new formulation comprises the following steps of: supersonic air-jet crushing, alcohol-water extraction, ultrasonic crushing extraction, water decocting concentration, supersonic spray drying, nanometer grinding, high pressure homogenization, nano particle preparation and the like. According to the invention, the advantages, such as multi-synergism, multi-target, embodied by a nano-carrier coupling technique, are focused to be taken of. After the integrated new formulation of radix bupleuri, cassia twig and dry ginger decoction is subjected to scale production, the production cost can be greatly reduced, the quality of products is greatly improved and the targeting property and the sustained and controlled release performance of the medicament are enhanced. The internal and external administration of the integrated new formulation of radix bupleuri, cassia twig and dry ginger decoction can be realized simultaneously, and can be respectively taken in four time slices according to midnight-noon ebb-flow and qi and blood flowing rule of a human body. The integrated new formulation of radix bupleuri, cassia twig and dry ginger decoction can be further prepared into films and transdermal agents which are respectively stuck to different parts of a human body according to the midnight-noon ebb-flow and qi and blood flowing rule of the human body and can be directly absorbed through skin.

The invention relates to a preparation technology and production method of a new integrated dosage form of Jinsuogujing pills. The raw material composition of the active ingredients is as follows: 60 parts of sand garden seeds, 60 parts of Gorgon fruit, 60 parts of lotus root, and 30 parts of keel , 30 servings of oysters. Its production process includes: supersonic jet pulverization, alcohol water extraction, ultrasonic pulverization and extraction, water decoction and concentration, supersonic spray drying, nano grinding, high pressure emulsification, nano particle preparation, etc. The invention pays attention to the advantages of multi-synergy and multi-targeting embodied by the combination technology of nano-carriers. After large-scale production, the production cost can be greatly reduced, the product quality can be greatly improved, and the targeting and sustained release of the drug can be strengthened. It can be administered both internally and externally, and can be taken in four time periods according to the meridian flow and the flow of blood in the human body. Film-forming agents and transdermal agents can also be prepared and pasted on different parts of the human body according to the meridian flow and the flow of human Qi and blood, and can be directly absorbed through the skin.

The invention relates to a preparation technology and production method of a new integrated dosage form of Wuwei Xiaoxiaoyin. The raw material composition of the active ingredients is as follows: 15 parts of honeysuckle, 12 parts of wild chrysanthemum, 12 parts of dandelion, 15 parts of Viola chinensis, 6 parts of purple geranium. Its production process includes: supersonic jet pulverization, alcohol water extraction, ultrasonic pulverization and extraction, water decoction and concentration, supersonic spray drying, nano grinding, high pressure emulsification, nano particle preparation, etc. The invention pays attention to the advantages of multi-synergy and multi-targeting embodied by the combination technology of nano-carriers. After large-scale production, the production cost can be greatly reduced, the product quality can be greatly improved, and the targeting and sustained release of the drug can be strengthened. It can be administered both internally and externally, and can be taken in four time periods according to the meridian flow and the flow of blood in the human body. Film-forming agents and transdermal agents can also be prepared and pasted on different parts of the human body according to the meridian flow and the flow of human Qi and blood, and can be directly absorbed through the skin.

The invention relates to a date soup integrated novel formulation preparation technology and a production method thereof. The novel formulation comprises the effective element material in parts by weight: 1 part of dates, 5 parts of fresh ginger and 3 parts of prepared licorice roots. The production process comprises supersonic airflow crushing, alcohol-water extracting, ultrasonic crushing extracting, water decoction extracting, supersonic spray drying, nanogrinding, high pressure homogenization, nanoparticle preparation and the like. The novel preparation emphasizes to use the advantages of multi-collaboration, multi-target and the like embodied by the nano carrier coupling technique. After a large-scale production, the novel preparation can greatly reduce the production cost, greatly improve the product quality, and can ensure that the targeting effect and the sustained and controlled release properties of the novel formulation become stronger. The novel formulation can be taken orally or used externally, and can be taken during four time periods according to the midnight-midday ebb flow and the qi-blood flow law of a human body. The novel preparation can also be prepared into a film agent or a transdermal agent to be applied to different parts of the human body according to the midnight-midday ebb flow and the qi-blood flow law of the human body, and can be directly absorbed through the skin.

The invention discloses a hydrogel emergency tobacco control patch formula and a method for preparing a tobacco control patch. The method for preparing the tobacco control patch comprises the steps that hydrogel is prepared by mixing 0.1%-2.0% of natural tobacco extracts, 1%-15% of nicotine clathrate compound, 0.5%-3.0% of mint extracts, 5.0%-10.0% of sodium polyacrylate, 0.5%-3.0% of sodium carboxymethylcellulose, 0.1%-2.0% of dihydroxyaluminium aminoacetate, 0.2%-1.0% of dihydroxysuccinic acid, 4.0%-8.0% of ethyl alcohol, 20.0%-30.0% of glycerinum and 45.0%-60.0% of purified water, and then the hydrogel is smeared on base cloth. The tobacco control patch prepared through the method is low in nicotine content, long in stipulated use time, good in even slow-release effect, safe, controllable, high in skin friendliness, good in adhering performance and convenient to carry and use, the preparation technique is simple, secondary pollution to the environment is avoided, and the tobacco addiction can be released and controlled.

The invention relates to a preparation technology and preparation method of a novel integrative Erchen decoction dosage form. The composition for effective components comprises the raw materials in proportion by weight: 15 parts of pinellia ternate, 15 parts of dried tangerine peel, 12 parts of poria cocos, 6 parts of licorice root, 5 parts of ginger and 1 part of dark plum. The production process comprises the steps of: alcohol water extraction, ultrasonic grinding and extraction, microwave extraction, decocting and condensation, supersonic spraying and drying, high-pressure emulsion homogenization, nano grinding, nano particle preparation and the like. The preparation technology and the preparation method stress on the advantages of the multi-coordinate and multi-target effect in nano traditional Chinese medicines, and the like. After the industrialized production is realized, the production cost can be reduced to a larger extent, the product quality is improved, and the target and the slow controlled release of medicines are further enhanced. After being produced into a film agent, the integrative Erchen decoction agent can be applied to skins of a human body to realize the treatment through percutaneous absorption.

The present invention relates to a preparation technology and a production method for an integrated new formulation of a sour jujube decoction, wherein the raw materials of active ingredients comprise: 30 parts by weight of sour jujube seed, 3 parts by weight of licorice, 6 parts by weight of anemarrhena rhizome, 6 parts by weight of poria, and 6 parts by weight of Sichuan lovage root. The production process of the integrated new formulation of sour jujube decoction comprises the following steps of: supersonic air-jet crushing, alcohol-water extraction, ultrasonic crushing extraction, water decocting concentration, supersonic spray drying, nanometer grinding, high pressure homogenization, nano particle preparation and the like. According to the invention, the advantages, such as multi-synergism, multi-target, embodied by a nano-carrier coupling technique, are focused to be taken of. After the integrated new formulation of sour jujube decoction is subjected to scale production, the production cost can be greatly reduced, the quality of products is greatly improved and the targeting property and the sustained and controlled release performance of the medicament are enhanced. The internal and external administration of the integrated new formulation of sour jujube decoction can be realized simultaneously, and can be respectively taken in four time slices according to midnight-noon ebb-flow and qi and blood flowing rule of a human body. The integrated new formulation of sour jujube decoction can be further prepared into films and transdermal agents which are respectively stuck to different parts of a human body according to the midnight-noon ebb-flow and qi and blood flowing rule of the human body and can be directly absorbed through skin.

The invention relates to a preparation process of integration-type novel formulation of Evodia rutaecarpa decoction and a production method thereof. The effective components of the novel formulation are made from the following raw materials (by weight parts): Evodia rutaecarpa 9, Panax ginseng (Radix Ginseng) 9, Zingiber officinale 18, and Ziziphus jujuba (Fructus Jujubae) 4. The production method includes the steps of supersonic airstream pulverization, alcohol-water extraction, ultrasonic pulverization and extraction, water decoction and concentration, supersonic spray-drying, nano-scale grinding, high-pressure emulsion and homogenization and nanoparticle preparation. The production method integrates the advantageous of the nano-carrier combination technique, such as multi-component synergism and multi-target. The large-scale production can greatly reduce the production cost, greatly improve the product quality and enhance the target property and sustained / controlled-release property of drugs. The novel formulation is administered by oral intake and external application during four time periods respectively based on the midnight-noon tidal flow and human qi-blood flow rule. The novel formulation is also processed to membranes and transdermal delivery agents which are applied to different parts of human body respectively according to the midnight-noon tidal flow and human qi-blood flow rule and can be directly absorbed by the skin.

The invention discloses an organic macromolecular controlled-release nitrogen-phosphorus fertilizer containing Zn and a preparation method for the fertilizer. The preparation method comprises the following steps: stirring and dissolving phosphoric acid and Zn powder according to a molar ratio of 2 to 1 to prepare a component A; reacting urea and formaldehyde at a molar ratio of (1.25-2) to 1 for 40-200 minutes under the condition that the pH value is 8-10 and the temperature ranges from 30 DEG C to 35 DEG C, heating to 50-60 DEG C, continuously reacting for 30-90 minutes, adding the component A, adjusting the temperature to be 70-100 DEG C, continuously reacting for 30-40 minutes, and when a reaction solution becomes pasty, performing granulation and drying. The method is simple; dihydric phosphate formed by Zn and phosphoric acid in the fertilizer reacts with a urea-formaldehyde condensation polymer, so that various nutritive elements such as N, P and Zn are connected to one macromolecular chain through chemical bonds, the nutritive elements are endowed with controlled-release performances, the utilization rate of the nutritive elements is increased, and the soil fixation amount of the nutritive elements is reduced.

The present invention relates to a preparation technology and a production method for an integrated new formulation of a licorice and monkshood decoction, wherein the raw materials of active ingredients comprise: 6 parts by weight of honey-fried licorice, 12 parts by weight of monkshood, 6 parts by weight of bighead atractylodes rhizome, and 12 parts by weight of cinnamon twig. The production process of the integrated new formulation of licorice and monkshood decoction comprises the following steps of: supersonic air-jet crushing, alcohol-water extraction, ultrasonic crushing extraction, water decocting concentration, supersonic spray drying, nanometer grinding, high pressure homogenization, nano particle preparation and the like. According to the invention, the advantages, such as multi-synergism, multi-target, embodied by a nano-carrier coupling technique, are focused to be taken of. After the integrated new formulation of licorice and monkshood decoction is subjected to scale production, the production cost can be greatly reduced, the quality of products is greatly improved and the targeting property and the sustained and controlled release performance of the medicament are enhanced. The internal and external administration of the integrated new formulation of licorice and monkshood decoction can be realized simultaneously, and can be respectively taken in four time slices according to midnight-noon ebb-flow and qi and blood flowing rule of a human body. The integrated new formulation of licorice and monkshood decoction can be further prepared into films and transdermal agents which are respectively stuck to different parts of a human body according to the midnight-noon ebb-flow and qi and blood flowing rule of the human body and can be directly absorbed through skin.

The invention relates to a preparation technology and a production method of a novel dual-purpose decoction integrated dosage form. The novel dual-purpose decoction integrated dosage form consists of the following raw material active ingredients in parts by weight: 4.4 parts of cassia bark core, 4 parts of dried ginger, 30 parts of liquoric root and 4.4 parts of apricot kernel. The production process comprises ultrasonic speed fluid energy milling, alcohol-water extraction, ultrasonic wave smashing and extracting, water decoction concentration, ultrasonic speed spray drying, nanometer grinding, high-pressure homogenization, nanoparticle preparation and the like. In the invention, the advantages of multi-coordination, multi-targeting and the like represented in a nano-carrier coupling technique are utilized. After large-scale production is performed, the production cost can be reduced greatly, the product quality can be enhanced greatly, and the targeting property and controlled release property of a medicament can be enhanced. A dual-purpose decoction can be administrated internally and externally, and can be taken at four time intervals according to midnight-noon ebb-flow and the qi-blood flow rule of a human body. The dual-purpose decoction can be prepared into a film forming agent and a transdermal agent which are attached to different positions of a human body respectively according to midnight-noon ebb-flow and the qi-blood flow rule of the human body and can be directly absorbed through skin.

The present invention relates to preparation process of sodium alginate / chitosan mixture gel capable of being used as biodegradable medicine carrier. The preparation process includes the following steps: 1. forming homogeneous transparent alginate and chitosan solution in 1-5 wt% concentration each with alginate in 5-95 wt% and chitosan in 5-95 wt%, and adding acetic acid; 2. preparing alginate / chitosan mixture sol; 3. dropping the sol into 1.5-3 wt% concentration calcium chloride or sodium sulfate solution; 4. preparing alginate / chitosan-calcium ion-sulfate radical double cross-linked gel grain; and 5. soaking in absolute ethanol for 2-5 min, vacuum drying to obtain alginate / chitosan mixture gel grain of 300-1000 micron grain size. The alginate / chitosan mixture gel grain of the present invention has high pH sensitivity and the preparation process is safe and simple.

The invention relates to a preparation technique and a production method for SHIZAO decoction in a novel integrative dosage form. The raw materials of effective components of the SHIZAO decoction include genkwa flower 1.5 parts, knoxia root 1.5 parts, kansui root 1.5 parts, and jujube 10 parts. The production method includes processes of supersonic airstream grinding, extraction with alcohol and water, ultrasonic grinding extraction, water decoction concentrating, supersonic spray drying, nano-grinding, high-pressure homogenization, and preparation of nanoparticles. The invention makes good use of merits of multi-synergism and multi-targeting of complex nano-carrier technology, reduces production cost by mass production, improves product quality, and improves targeting and sustained-controlled release properties of drugs. The SHIZAO decoction in the novel integrative dosage form is suitable for oral and topical administration, can be administered in four time periods according to midnight-noon ebb-flow and human body qi and blood flow rules, and can be prepared into films or transdermal agents to be attached on different parts of human body according to the midnight-noon ebb-flow and human body qi and blood flow rules to be directly absorbed through the skin.