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Preparation technology and production method of a new integrated dosage form of Evodia decoction

A production method and a technology for a new dosage form, which are applied in the field of preparation of an integrated new dosage form of Wuzhuyu Decoction

Inactive Publication Date: 2011-12-21
SUZHOU ZHIWEITANG BIOLOGICAL TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Due to too many chemical components, the chemical reaction of compound decoction of traditional Chinese medicine has not yet been revealed its mysterious veil, but some mysterious black boxes of medicinal effects in traditional Chinese medicine prescriptions are hidden in the decoction of traditional Chinese medicine. Traditional Chinese medicine is modernized and only uses monomers and effective parts

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Prepare the following raw materials by the aforementioned method:

[0041] Extracts, nanoparticles, microcapsules, nanoparticles.

[0042] The composition of the raw materials used to make the active ingredients is——

[0043] 9 parts of Evodia rutaecarpa, 9 parts of ginseng, 18 parts of ginger, and 4 parts of jujube.

[0044] Its manufacturing process is as follows:

[0045] In the GMP10000 clean room, the extract, nanoparticles, microcapsules, and nanoparticles are mixed according to the ratio of 4:2:2:2, and the standards for hard capsules in the first part of the "Chinese Pharmacopoeia" of the 2010 edition are adopted, and no excipients are added. , preservatives, using a fully automatic capsule filling machine to fill hard capsules to make hard capsules. Then carry out internal and external packaging such as counting, bottling, sealing, pasting labels, coding, and packing. Finally, according to the production batch uniform instant sterilization, and issue a ster...

Embodiment 2

[0047] Prepare the following raw materials by the aforementioned method:

[0048] Water decoction concentrate, nano liposome, nanoemulsion, microemulsion.

[0049] The composition of the raw materials used to make the active ingredients is——

[0050] 9 parts of Evodia rutaecarpa, 9 parts of ginseng, 18 parts of ginger, and 4 parts of jujube.

[0051] Its manufacturing process is as follows:

[0052] In the GMP10000 clean room, the decoction concentrate, nanoliposome, nanoemulsion, and microemulsion were mixed in a ratio of 4:2:2:2, and the standards for some soft capsules in the first part of the "Chinese Pharmacopoeia" of the 2010 edition were used. , without adding auxiliary materials and preservatives, the soft capsules are made into soft capsules by using a fully automatic soft capsule filling machine. Then carry out internal and external packaging such as counting, bottling, sealing, labeling, coding, and packing. Finally, according to the production batch uniform ins...

Embodiment 3

[0054] Prepare the following raw materials by the aforementioned method:

[0055] Extract, nanoparticle, nanoemulsion.

[0056] The composition of the raw materials used to make the active ingredients is——

[0057] 9 parts of Evodia rutaecarpa, 9 parts of ginseng, 18 parts of ginger, and 4 parts of jujube.

[0058] Its manufacturing process is as follows:

[0059] In the GMP10000 clean room, after mixing the extract, nanoparticles, and nanoemulsions in a ratio of 4:3:3, the 2010 edition of the "Chinese Pharmacopoeia" Part I of the film preparation standard is adopted, and the film-forming material is polyvinyl alcohol. film former. Cartoning, sealing, sticking labels, printing codes, packing and other internal and external packaging. Finally, according to the production batch uniform instant sterilization, and issue a sterilization report. The size of each film is 2-40 square centimeters, and each film is applied for 12-72 hours. The application site: neck, chest, back, a...

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Abstract

The invention relates to a preparation technology and a production method of a new integrated dosage form of Evodia rutaecarpa Decoction. The raw material composition of the active ingredients is as follows: 9 parts of Evodia rutaecarpa, 9 parts of ginseng, 18 parts of ginger, and 4 parts of jujube. The production process includes: supersonic jet pulverization, alcohol-water extraction, ultrasonic pulverization and extraction, decoction and concentration, supersonic spray drying, nano-grinding, high-pressure milking, nano-particle preparation, etc. The present invention pays attention to the advantages of multi-synergy, multi-targeting and the like embodied by the combined use of nano-carrier technology. After large-scale production, the production cost can be greatly reduced, the product quality can be greatly improved, and the targeting and controlled release properties of the drug can be stronger. It can be administered both internally and externally, and can be taken in four time periods according to the meridian infusion and the flow of qi and blood in the human body. Film-forming agents and transdermal agents can also be prepared and attached to different parts of the human body according to the meridian infusion and the flow of human qi and blood, and can be directly absorbed through the skin.

Description

technical field [0001] The invention relates to a preparation technology of a new integrated dosage form of Evodia decoction, and also relates to a preparation technology of a new integrated dosage form of Evodia decoction and a production method thereof. Background technique [0002] Due to too many chemical components, the chemical reaction of compound decoction of traditional Chinese medicine has not yet been revealed its mysterious veil, but some mysterious black boxes of medicinal effects in traditional Chinese medicine prescriptions are hidden in the decoction of traditional Chinese medicine. Traditional Chinese medicine is modernized and only uses monomers and effective parts. Chinese herbal decoction concentrate cannot be discarded! When the traditional Chinese medicine prescription is decocted in water, due to the high temperature when the prescription is decocted together and the complex chemical environment in the solution, complexation, hydrolysis, oxidation, re...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61K9/14A61K9/16A61K9/127A61K9/107A61K9/50A61K9/70A61K9/10A61K9/00A61P1/04A61P15/00A61P1/08A61P25/00
Inventor 杨洪舒
Owner SUZHOU ZHIWEITANG BIOLOGICAL TECH
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