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Date soup integrated novel formulation preparation technology and production method thereof

A production method and new dosage form technology, which is applied in the field of preparation of Zaotang integrated new dosage forms, can solve the problems of increased decline rate and decreased p/n value, and achieve the effect of strong slow and controlled release performance and wide target distribution

Inactive Publication Date: 2012-07-11
SUZHOU ZHIWEITANG BIOLOGICAL TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The p / n value of HBsAg can be significantly decreased by the action of ginger root extract and HBsAg for 1-3 hours, but the rate of decline does not increase after more than 3 hours

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] The following raw materials are prepared according to the aforementioned method: extracts, nanoparticles, microcapsules, and nanoparticles.

[0054] The composition of the raw materials used to make the active ingredients is——

[0055] 1 part of jujube, 5 parts of ginger, and 3 parts of roasted licorice.

[0056] The manufacturing process is as follows: After mixing the extract, nanoparticles, microcapsules, and nanoparticles in a GMP 10000 clean room in a ratio of 4:2:2:2, use the 2010 edition of "Chinese Pharmacopoeia" as part of a preparation and some hard capsules. According to the dosage standard, no auxiliary materials and preservatives are added, and the hard capsules are filled with a fully automatic capsule filling machine to make hard capsules. Then carry out internal and external packaging such as counting, bottling, sealing, pasting labels, coding, and packing. Finally, according to the production batch uniform instant sterilization, and issue a sterilizat...

Embodiment 2

[0058] The following raw materials are prepared according to the aforementioned method: water decoction concentrate, nanoliposome, nanoemulsion, and microemulsion.

[0059] The composition of the raw materials used to make the active ingredients is——

[0060] 1 part of jujube, 5 parts of ginger, and 3 parts of roasted licorice.

[0061] The manufacturing process is as follows: in a GMP10000 class clean room, the decoction concentrate, nanoliposome, nanoemulsion, and microemulsion are mixed according to the ratio of 4:2:2:2, and a preparation of the 2010 edition of "Chinese Pharmacopoeia" is used. Part of the soft capsule standard, without adding auxiliary materials and preservatives, adopts a fully automatic soft capsule filling machine to sub-pack soft capsules to make soft capsules. Then carry out internal and external packaging such as counting, bottling, sealing, pasting labels, coding, and packing. Finally, according to the production batch uniform instant sterilization...

Embodiment 3

[0063] The following raw materials are prepared according to the aforementioned method: extract, nanoparticle, and nanoemulsion.

[0064] The composition of the raw materials used to make the active ingredients is——

[0065] 1 part of jujube, 5 parts of ginger, and 3 parts of roasted licorice.

[0066] The manufacturing process is as follows: After mixing the extract, nanoparticles, and nanoemulsions in a 4:3:3 ratio in a GMP10000 clean room, the 2010 edition of the "Chinese Pharmacopoeia" Part I of the film preparation standard is used, and the film-forming material is made of Polyvinyl alcohol, made into film. Cartoning, sealing, sticking labels, printing codes, packing and other internal and external packaging. Finally, according to the production batch uniform instant sterilization, and issue a sterilization report. The size of each film is 2-40 square centimeters, and each film is applied for 1272 hours. The application site: neck, chest, back, abdomen, legs, soles of ...

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Abstract

The invention relates to a date soup integrated novel formulation preparation technology and a production method thereof. The novel formulation comprises the effective element material in parts by weight: 1 part of dates, 5 parts of fresh ginger and 3 parts of prepared licorice roots. The production process comprises supersonic airflow crushing, alcohol-water extracting, ultrasonic crushing extracting, water decoction extracting, supersonic spray drying, nanogrinding, high pressure homogenization, nanoparticle preparation and the like. The novel preparation emphasizes to use the advantages of multi-collaboration, multi-target and the like embodied by the nano carrier coupling technique. After a large-scale production, the novel preparation can greatly reduce the production cost, greatly improve the product quality, and can ensure that the targeting effect and the sustained and controlled release properties of the novel formulation become stronger. The novel formulation can be taken orally or used externally, and can be taken during four time periods according to the midnight-midday ebb flow and the qi-blood flow law of a human body. The novel preparation can also be prepared into a film agent or a transdermal agent to be applied to different parts of the human body according to the midnight-midday ebb flow and the qi-blood flow law of the human body, and can be directly absorbed through the skin.

Description

technical field [0001] The invention relates to a preparation technology of a new jujube soup integrated dosage form, and also relates to a preparation technology of a jujube soup integrated new dosage form and a production method thereof. Background technique [0002] Due to too many chemical components, the chemical reaction of compound decoction of traditional Chinese medicine has not yet been revealed its mysterious veil, but some mysterious black boxes of medicinal effects in traditional Chinese medicine prescriptions are hidden in the decoction of traditional Chinese medicine. Traditional Chinese medicine is modernized and only uses monomers and effective parts. Chinese herbal decoction concentrate cannot be discarded! When the traditional Chinese medicine prescription is decocted in water, due to the high temperature when the prescription is decocted together and the complex chemical environment in the solution, complexation, hydrolysis, oxidation, reduction and othe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K9/00A61P1/08A61P1/14
Inventor 杨洪舒
Owner SUZHOU ZHIWEITANG BIOLOGICAL TECH
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