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Prepn of sodium alginate/chitosan mixture gel

A technology of sodium alginate and chitosan, which is applied in the direction of medical preparations and pharmaceutical formulations of non-active ingredients, can solve the problems of limited application, poor performance of gel microspheres, difficulty, etc., and achieve strong pH sensitivity , good pH sensitivity, process safety effect

Inactive Publication Date: 2006-08-02
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, after sodium alginate is cross-linked by ions, because the carboxyl group and metal ions (such as calcium ions) are unstable above pH > 6.0, they will be rapidly decomposed as the pH value further increases, which limits its use in oral drug delivery systems. Applications
At the same time, the performance of the gel microspheres formed by the amino groups of anionic cross-linked chitosan is very poor, and it is very difficult to choose a pharmaceutical dosage form.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] The preparation method of drug-loaded sodium alginate / chitosan blended gel particles, weighed 0.04g of bovine serum albumin BSA, dissolved in 20mL of water, weighed 0.20g of chitosan, dissolved in it at 40°C, added dropwise 0.2mL acetic acid, stir to dissolve, then weigh 0.20g sodium alginate and disperse in it, add dropwise 0.1M sodium hydroxide to adjust the pH value to 5, continue stirring at 40°C for 20 minutes to prepare sodium alginate-chitosan blend Sol: the sodium alginate-chitosan blended sol is injected into sodium sulfate with a mass concentration of 2% with a 16# needle, soaked at room temperature to obtain sodium alginate / chitosan-sulfate ion single cross-linked gel particles , stirred for 15 minutes, transferred to a calcium chloride solution with a mass concentration of 2% and soaked for 10 minutes to prepare sodium alginate / chitosan-calcium ion-sulfate ion double cross-linked gel particles, soaked in absolute ethanol Vacuum drying for 2-5 minutes to prep...

Embodiment 2

[0017] A preparation method of sodium alginate / chitosan blended gel particles. Weigh 0.36g chitosan, dissolve it in 20mL distilled water at 40°C, add 0.2mL acetic acid dropwise, stir to dissolve, and then weigh 0.04g Disperse sodium alginate in it, add 0.1M sodium hydroxide dropwise to adjust the pH value to 5, and continue stirring at 40°C for 20 minutes to obtain a sodium alginate-chitosan blended sol; mix the sodium alginate-chitosan blended sol Use a 16# needle to inject a mass concentration of 2% sodium sulfate, soak at room temperature to obtain sodium alginate / chitosan-sulfate ion single cross-linked gel particles, and transfer to a mass concentration of 2% after stirring for 15 minutes Soak in calcium chloride solution for 10 minutes to prepare sodium alginate / chitosan-calcium ion-sulfate ion double cross-linked gel particles, soak in absolute ethanol for 2-5 minutes, and dry in vacuum to obtain the particle size Sodium alginate / chitosan blended gel particles distribut...

Embodiment 3

[0020] A preparation method of sodium alginate / chitosan blended gel particles. Weigh 0.20g chitosan, dissolve it in 20mL distilled water at 40°C, add 0.2mL acetic acid dropwise, stir to dissolve, and then weigh 0.20g Disperse sodium alginate in it, add 0.1M sodium hydroxide dropwise to adjust the pH value to 5, and continue stirring at 40°C for 20 minutes to obtain a sodium alginate-chitosan blended sol; mix the sodium alginate-chitosan blended sol Use a 16# needle to inject a mass concentration of 2% sodium sulfate, soak at room temperature to obtain sodium alginate / chitosan-sulfate ion single cross-linked gel particles, and transfer to a mass concentration of 2% after stirring for 15 minutes Soak in calcium chloride solution for 10 minutes to prepare sodium alginate / chitosan-calcium ion-sulfate ion double cross-linked gel particles, soak in absolute ethanol for 2-5 minutes, and dry in vacuum to obtain the particle size Sodium alginate / chitosan blended gel particles distribut...

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Abstract

The present invention relates to preparation process of sodium alginate / chitosan mixture gel capable of being used as biodegradable medicine carrier. The preparation process includes the following steps: 1. forming homogeneous transparent alginate and chitosan solution in 1-5 wt% concentration each with alginate in 5-95 wt% and chitosan in 5-95 wt%, and adding acetic acid; 2. preparing alginate / chitosan mixture sol; 3. dropping the sol into 1.5-3 wt% concentration calcium chloride or sodium sulfate solution; 4. preparing alginate / chitosan-calcium ion-sulfate radical double cross-linked gel grain; and 5. soaking in absolute ethanol for 2-5 min, vacuum drying to obtain alginate / chitosan mixture gel grain of 300-1000 micron grain size. The alginate / chitosan mixture gel grain of the present invention has high pH sensitivity and the preparation process is safe and simple.

Description

technical field [0001] The invention relates to a preparation method of a sodium alginate / chitosan blended gel particle as a biodegradable drug carrier. Background technique [0002] Sodium alginate and chitosan are natural polysaccharides that are widely studied at present. With their excellent bioadhesion, biocompatibility and non-toxic side effects, they have the potential to be developed as drug carriers. In addition, the two polysaccharides have carboxylate ions and amino groups respectively, showing pH-sensitive properties, and their medicinal prospects are mainly focused on pH-sensitive and slow-release drug carriers. However, after sodium alginate is cross-linked by ions, because the carboxyl group and metal ions (such as calcium ions) are unstable above pH > 6.0, they will be rapidly decomposed as the pH value further increases, which limits its use in oral drug delivery systems. Applications. At the same time, the performance of the gel microspheres formed by ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L5/04C08L5/08C08J3/075C08J3/16A61K47/36
Inventor 徐咏梅占昌友郑化黄进樊李红
Owner WUHAN UNIV OF TECH
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