Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Siqitang integrated novel dosage form and production method thereof

A production method and new dosage form technology, which is applied in the field of Siqi Decoction integrated new dosage form preparation, can solve the problems of slowness and blood sugar rise, and achieve the effect of strong slow and controlled release performance and wide target distribution

Inactive Publication Date: 2012-07-11
SUZHOU ZHIWEITANG BIOLOGICAL TECH +1
View PDF0 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Oral administration of perilla oil at 0.35 ml / kg to rabbits can increase blood sugar; after perilla aldehyde, the main component of perilla oil, is made into oxime, the effect of oral administration on raising blood sugar is stronger than that of perilla oil. Dissolving this oxime in olive oil Subcutaneous injection also works, but more slowly

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] The following raw materials are prepared according to the aforementioned method: extracts, nanoparticles, microcapsules, and nanoparticles.

[0057] The composition of the raw materials used to make the active ingredients is——

[0058] 5 parts of Pinellia, 4 parts of Poria, 2 parts of perilla leaves, and 3 parts of Magnolia officinalis.

[0059] The manufacturing process is as follows: in a GMP10000 class clean room, the extract, nanoparticles, microcapsules, and nanoparticles are mixed in a ratio of 4:2:2:2, and part of the hard capsules are used in the first part of the "Chinese Pharmacopoeia" of the 2010 edition. Standard, no auxiliary materials and preservatives are added, and hard capsules are filled with automatic capsule filling machines to make hard capsules. Then carry out internal and external packaging such as counting, bottling, sealing, pasting labels, coding, and packing. Finally, according to the production batch uniform instant sterilization, and issue...

Embodiment 2

[0061] The following raw materials are prepared according to the aforementioned method: water decoction concentrate, nanoliposome, nanoemulsion, and microemulsion.

[0062] The composition of the raw materials used to make the active ingredients is——

[0063] 5 parts of Pinellia, 4 parts of Poria, 2 parts of perilla leaves, and 3 parts of Magnolia officinalis.

[0064] The manufacturing process is as follows: in a GMP10000 class clean room, the decoction concentrate, nanoliposome, nanoemulsion, and microemulsion are mixed according to the ratio of 4:2:2:2, and a preparation of the 2010 edition of "Chinese Pharmacopoeia" is used. Part of the soft capsule standard, without adding auxiliary materials and preservatives, adopts a fully automatic soft capsule filling machine to sub-pack soft capsules to make soft capsules. Then carry out internal and external packaging such as counting, bottling, sealing, pasting labels, coding, and packing. Finally, according to the production ba...

Embodiment 3

[0066] The following raw materials are prepared according to the aforementioned method: extract, nanoparticle, and nanoemulsion.

[0067] The composition of the raw materials used to make the active ingredients is——

[0068] 5 parts of Pinellia, 4 parts of Poria, 2 parts of perilla leaves, and 3 parts of Magnolia officinalis.

[0069] The manufacturing process is as follows: After mixing the extract, nanoparticles, and nanoemulsions in a 4:3:3 ratio in a GMP10000 clean room, the 2010 edition of the "Chinese Pharmacopoeia" Part I of the film preparation standard is used, and the film-forming material is made of Polyvinyl alcohol, made into film. Cartoning, sealing, sticking labels, printing codes, packing and other internal and external packaging. Finally, according to the production batch uniform instant sterilization, and issue a sterilization report. The size of each film is 2-40 square centimeters, and each film is applied for 1272 hours. The application site: neck, ches...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a Siqitang integrated novel dosage form and a production method of the novel dosage form. The raw material composition in part by weight of the effective components of the novel dosage form is as follows: 5 parts of Pinellia ternate, 4 parts of Poria cocos, 2 parts of Perilla frutescens leaf, and 3 parts of Magnolia officinalis. The production process comprises the steps of supersonic jet milling, alcohol water extraction, ultrasonic pulverization extraction, water decoction and concentration, supersonic spray drying, nano grinding, high pressure homogenization, nano particles preparation and the like. The invention pays attention to the advantages of multi-coordination, multi-target and the like showed by utilizing nano carrier combined technique, after large-scale production, the production cost can be greatly reduced, the product quality is greatly improved, and the targeting and sustained or controlled release properties of the drugs are strong. The products made in the invention can be dosed in vivo and in vitro simultaneously, and can be taked at four periods of time respectively according to midnight-noon ebb-flow and human qi and blood circulation rules. The effective components of Siqitang can also be prepared into a film-forming agent and a transdermal agent which is stick to different body parts according to midnight-noon ebb-flow and human qi and blood circulation rules for direct absorption through skin.

Description

technical field [0001] The invention relates to a preparation technology of a new Siqi Tang integrated dosage form, and also relates to a preparation technology of a Siqi Tang integrated new dosage form and a production method thereof. Background technique [0002] Due to too many chemical components, the chemical reaction of compound decoction of traditional Chinese medicine has not yet been revealed its mysterious veil, but some mysterious black boxes of medicinal effects in traditional Chinese medicine prescriptions are hidden in the decoction of traditional Chinese medicine. Traditional Chinese medicine is modernized and only uses monomers and effective parts. Chinese herbal decoction concentrate cannot be discarded! When the traditional Chinese medicine prescription is decocted in water, due to the high temperature when the prescription is decocted together and the complex chemical environment in the solution, complexation, hydrolysis, oxidation, reduction and other re...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8888A61K9/00A61P43/00A61P11/10A61P11/06A61P1/08
Inventor 杨洪舒
Owner SUZHOU ZHIWEITANG BIOLOGICAL TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com